CASQ1

calsequestrin 1
OMIM: 114250, Gene2Phenotype

4 panels

Panel Reviews Mode of inheritance Details
4 panels
Amber CASQ1 in Rhabdomyolysis and metabolic muscle disorders


Level 2: Neurology
Version 5.14
Latest signed off version: v5.4 (30 Apr 2025)

Component of the following Super Panels:

  • Hypotonic infant
  • Other rare neuromuscular disorders
  • review MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
    Sources
    • Expert Review Amber
    • Literature
    Phenotypes
    • Myopathy, vacuolar, with CASQ1 aggregates, OMIM:616231
    Tags
    • Q3_25_promote_green
    Red CASQ1 in Congenital myopathy


    Level 2: Neurology
    Version 6.45
    Latest signed off version: v6.0 (30 Apr 2025)

    Component of the following Super Panels:

  • Hypotonic infant
  • Other rare neuromuscular disorders
  • review MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
    Sources
    • Expert Review Red
    • NHS GMS
    • London South GLH
    • UCL
    Phenotypes
    • Myopathy, vacuolar, with CASQ1 aggregates, OMIM:616231
    • myopathy due to calsequestrin and SERCA1 protein overload, MONDO:0014546
    Amber CASQ1 in Limb girdle muscular dystrophies, myofibrillar myopathies and distal myopathies


    Level 2: Neurology
    Version 5.29
    Latest signed off version: v5.0 (30 Apr 2025)

    Component of the following Super Panels:

  • Hypotonic infant
  • Other rare neuromuscular disorders
  • review MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
    Sources
    • Expert Review Amber
    • Yorkshire and North East GLH
    • NHS GMS
    • Expert Review
    Phenotypes
    • Myopathy, vacuolar, with CASQ1 aggregates, OMIM:616231
    Amber CASQ1 in Acute rhabdomyolysis


    Level 2: Neurology
    Version 2.7
    Latest signed off version: v2.0 (30 Apr 2025)

    review MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
    Sources
    • Expert Review Amber
    • Literature
    Phenotypes
    • Myopathy, vacuolar, with CASQ1 aggregates, OMIM:616231
    Tags
    • Q3_25_promote_green