1. Genes and Genomic Entities
  2. CHMP3

CHMP3

charged multivesicular body protein 3
OMIM: 610052, Gene2Phenotype

3 panels

Panel Reviews Mode of inheritance Details
3 panels
Red CHMP3 in Hereditary spastic paraplegia, childhood onset


Level 2: Neurology
Version 9.8
Latest signed off version: v9.7 (12 Aug 2026)

review BIALLELIC, autosomal or pseudoautosomal
Sources
  • Expert Review Red
  • Literature
Phenotypes
  • Complex spastic quadriplegia associated with developmental delay and seizures
Red CHMP3 in Early onset or syndromic epilepsy


Level 2: Neurology
Version 9.57
Latest signed off version: v9.56 (12 Aug 2026)

Component of the following Super Panels:

  • Paediatric disorders
  • Unexplained death in infancy and sudden unexplained death in childhood

    		•  review BIALLELIC, autosomal or pseudoautosomal
    Sources
    • Expert Review Red
    • Literature
    Phenotypes
    • Complex spastic quadriplegia associated with developmental delay and seizures
    Red CHMP3 in Intellectual disability


    Level 2: Developmental disorders
    Version 11.1
    Latest signed off version: v11.0 (12 Aug 2026)

    Component of the following Super Panels:

  • Hypotonic infant
  • Leukodystrophy, childhood onset
  • Paediatric disorders

    		•  review BIALLELIC, autosomal or pseudoautosomal
    Sources
    • Expert Review Red
    • Literature
    Phenotypes
    • Complex spastic quadriplegia associated with developmental delay and seizures