1. Genes and Genomic Entities
  2. CIC

CIC

capicua transcriptional repressor
OMIM: 612082, Gene2Phenotype

6 panels

Panel Reviews Mode of inheritance Details
6 panels
Green CIC in White matter disorders and cerebral calcification - childhood onset


Level 2: Neurology
Version 8.13
Latest signed off version: v8.6 (12 Aug 2026)

Component of the following Super Panels:

  • Leukodystrophy, childhood onset
  • Paediatric disorders

    		•  review MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
    Sources
    • Expert Review Green
    Phenotypes
    • Mental retardation, autosomal dominant 45 617600
    Green CIC in Inherited white matter disorders

    Level 3: White matter disorders
    Level 2: Neurology and neurodevelopmental disorders
    Version 1.186

    		review MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
    Sources
    • Expert Review Green
    • Literature
    Phenotypes
    • Mental retardation, autosomal dominant 45 617600
    Red CIC in Fetal anomalies


    Level 2: Fetal (including NIPD)
    Version 8.26
    Latest signed off version: v8.0 (12 Aug 2026)

    		review MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
    Sources
    • Expert Review Red
    • NHS GMS
    Phenotypes
    • Intellectual developmental disorder, autosomal dominant 45, OMIM:617600
    • intellectual developmental disorder, autosomal dominant 45, MONDO:0030910
    Green CIC in DDG2P


    Version 8.2
    Latest signed off version: v8.0 (12 Aug 2026)

    Component of the following Super Panels:

  • Paediatric disorders

    		•  review MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
    Sources
    • Expert Review Green
    • DD-Gene2Phenotype
    Phenotypes
    • CAPICUA, DROSOPHILA, HOMOLOG OF 612082
    Green CIC in Early onset or syndromic epilepsy


    Level 2: Neurology
    Version 9.94
    Latest signed off version: v9.56 (12 Aug 2026)

    Component of the following Super Panels:

  • Paediatric disorders
  • Unexplained death in infancy and sudden unexplained death in childhood

    		•  review MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
    Sources
    • Wessex and West Midlands GLH
    • NHS GMS
    • Literature
    • Expert Review Green
    • Expert Review Green
    • Literature
    Phenotypes
    • Mental retardation, autosomal dominant 45 617600
    Green CIC in Intellectual disability


    Level 2: Developmental disorders
    Version 11.72
    Latest signed off version: v11.0 (12 Aug 2026)

    Component of the following Super Panels:

  • Hypotonic infant
  • Leukodystrophy, childhood onset
  • Paediatric disorders

    		•  review MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
    Sources
    • Expert Review Green
    • Victorian Clinical Genetics Services
    Phenotypes
    • Mental retardation, autosomal dominant 45 617600