1. Genes and Genomic Entities
  2. DNAJC6

DNAJC6

DnaJ heat shock protein family (Hsp40) member C6
OMIM: 608375, Gene2Phenotype

5 panels

Panel Reviews Mode of inheritance Details
5 panels
Green DNAJC6 in Parkinson Disease and Complex Parkinsonism

Level 3: Neurodegenerative disorders
Level 2: Neurology and neurodevelopmental disorders
Version 1.128

review BIALLELIC, autosomal or pseudoautosomal
Sources
  • Expert Review Green
  • Radboud University Medical Center, Nijmegen
Phenotypes
  • Parkinson disease 19b, early-onset, OMIM:615528
  • Parkinson disease 19a juvenile-onset, OMIM:615528
  • juvenile onset Parkinson disease 19A, MONDO:0014231
Green DNAJC6 in Neurodegenerative disorders, adult onset


Level 2: Neurology
Version 9.5
Latest signed off version: v9.4 (12 Aug 2026)

Component of the following Super Panels:

  • Adult-onset neurological disorders

    		•  review BIALLELIC, autosomal or pseudoautosomal
    Sources
    • Wessex and West Midlands GLH
    • Yorkshire and North East GLH
    • NHS GMS
    • London North GLH
    • Expert Review Green
    Phenotypes
    • Parkinson disease 19b, early-onset, OMIM:615528
    • Parkinson disease 19a juvenile-onset, OMIM:615528
    • juvenile onset Parkinson disease 19A, MONDO:0014231
    Green DNAJC6 in Early onset or syndromic epilepsy


    Level 2: Neurology
    Version 9.57
    Latest signed off version: v9.56 (12 Aug 2026)

    Component of the following Super Panels:

  • Paediatric disorders
  • Unexplained death in infancy and sudden unexplained death in childhood

    		•  review BIALLELIC, autosomal or pseudoautosomal
    Sources
    • Expert Review Green
    • Wessex and West Midlands GLH
    • NHS GMS
    • Victorian Clinical Genetics Services
    Phenotypes
    • Parkinson disease 19b, early-onset, OMIM:615528
    • Parkinson disease 19a juvenile-onset, OMIM:615528
    • juvenile onset Parkinson disease 19A, MONDO:0014231
    Green DNAJC6 in Dystonia, chorea or related movement disorder, adult onset


    Level 2: Neurology
    Version 6.8
    Latest signed off version: v6.7 (12 Aug 2026)

    Component of the following Super Panels:

  • Adult-onset neurological disorders

    		•  review BIALLELIC, autosomal or pseudoautosomal
    Sources
    • NHS GMS
    • London North GLH
    • Expert Review Green
    Phenotypes
    • Parkinson disease 19b, early-onset, OMIM:615528
    • Parkinson disease 19a juvenile-onset, OMIM:615528
    • juvenile onset Parkinson disease 19A, MONDO:0014231
    Green DNAJC6 in Dystonia, chorea or related movement disorder, childhood onset


    Level 2: Neurology
    Version 8.14
    Latest signed off version: v8.13 (12 Aug 2026)

    		review BIALLELIC, autosomal or pseudoautosomal
    Sources
    • NHS GMS
    • Expert Review Green
    • Literature
    Phenotypes
    • Parkinson disease 19b, early-onset, OMIM:615528
    • Parkinson disease 19a juvenile-onset, OMIM:615528
    • juvenile onset Parkinson disease 19A, MONDO:0014231