F2

coagulation factor II, thrombin
OMIM: 176930, Gene2Phenotype

4 panels

Panel	Reviews	Mode of inheritance	Details
Filter panels 4 panels
Green F2 in Inherited bleeding disorders Level 3: Haemostasis disorders Level 2: Haematological and immunological disorders Version 1.182	review	BOTH monoallelic and biallelic (but BIALLELIC mutations cause a more SEVERE disease form), autosomal or pseudoautosomal	Sources Illumina TruGenome Clinical Sequencing Services UKGTN Radboud University Medical Center, Nijmegen Expert Review Green BRIDGE Study Tier 1 Gene Phenotypes Prothrombin deficiency Thrombophilia Due To Thrombin Defect Dysprothrombinemia 613679 Hypoprothrombinemia 613679 Thrombophilia due to thrombin defect 188050 Prothrombin-Related Thrombophilia
Green F2 in Thrombophilia with a likely monogenic cause Level 2: Haematology Version 2.10 Latest signed off version: v2.2 (22 Mar 2023)	review	BOTH monoallelic and biallelic (but BIALLELIC mutations cause a more SEVERE disease form), autosomal or pseudoautosomal	Sources North West GLH Yorkshire and North East GLH London South GLH NHS GMS Expert Review Green Wessex and West Midlands GLH Phenotypes 188050 Thrombophilia due to thrombin defect 613679 Hypoprothrombinemia 613679 Dysprothrombinemia 613679 Factor II deficiency
Green F2 in Bleeding and platelet disorders Level 2: Haematology Version 4.6 Latest signed off version: v4.0 (30 Apr 2025)	review	BIALLELIC, autosomal or pseudoautosomal	Sources Wessex and West Midlands GLH North West GLH Yorkshire and North East GLH Expert Review Green NHS GMS London South GLH Phenotypes 613679 Factor II deficiency
Green F2 in Factor II deficiency Level 2: Haematology Version 1.3 Latest signed off version: v1.0 (14 Sep 2023)	review	BIALLELIC, autosomal or pseudoautosomal	Sources Expert Review Green NHS GMS Phenotypes Dysprothrombinemia, OMIM:613679 Hypoprothrombinemia, OMIM:613679 congenital prothrombin deficiency, MONDO:0013361