FASLG

Fas ligand
OMIM: 134638, Gene2Phenotype

3 panels

Panel Reviews Mode of inheritance Details
3 panels

Green FASLG in COVID-19 research


Level 2: Viral research
Version 1.130

review BOTH monoallelic and biallelic (but BIALLELIC mutations cause a more SEVERE disease form), autosomal or pseudoautosomal
Sources
  • IUIS Classification February 2018
  • London North GLH
  • GOSH PID v.8.0
  • NHS GMS
  • GRID V2.0
  • Victorian Clinical Genetics Services
  • North West GLH
  • ESID Registry 20171117
  • Expert Review Green
  • NHS GMS
  • North West GLH
  • London North GLH
  • IUIS Classification February 2018
  • Victorian Clinical Genetics Services
  • Expert Review Green
  • ESID Registry 20171117
  • GRID V2.0
  • GOSH PID v.8.0
Phenotypes
  • Autoimmune lymphoproliferative syndrome, type IB, 601859
  • Diseases of Immune Dysregulation
  • Autoimmune lymphoproliferative syndrome, type IB (ALPS-FASG)
  • Splenomegaly, adenopathies, autoimmune cytopenias, SLE, soluble FasL is not elevated
  • Autoimmune lymphoproliferative syndrome (ALPS)

Green FASLG in Primary immunodeficiency


Version 2.573
Latest signed off version: v2.1 (24 Feb 2020)

review BIALLELIC, autosomal or pseudoautosomal
Sources
  • Expert Review Green
  • Other
  • NHS GMS
  • North West GLH
  • London North GLH
  • IUIS Classification February 2018
  • Victorian Clinical Genetics Services
  • ESID Registry 20171117
  • GRID V2.0
  • GOSH PID v.8.0
Phenotypes
  • Autoimmune lymphoproliferative syndrome, type IB, OMIM:601859
  • autoimmune lymphoproliferative syndrome type 1, MONDO:0011158
  • systemic lupus erythematosus (SLE)
Tags
  • Q2_22_MOI

Green FASLG in Severe Paediatric Disorders


Version 1.127

review MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
Sources
  • Next Generation Children Project
  • Expert Review Green
  • Expert list
Phenotypes
  • Autoimmune lymphoproliferative syndrome, type IB, 601859