FASLG

Fas ligand
OMIM: 134638, Gene2Phenotype

3 panels

Panel	Reviews	Mode of inheritance	Details
Filter panels 3 panels
Green FASLG in COVID-19 research Level 2: Viral research Version 1.142	review	BOTH monoallelic and biallelic (but BIALLELIC mutations cause a more SEVERE disease form), autosomal or pseudoautosomal	Sources IUIS Classification February 2018 London North GLH GOSH PID v.8.0 NHS GMS GRID V2.0 Victorian Clinical Genetics Services North West GLH ESID Registry 20171117 Expert Review Green NHS GMS North West GLH London North GLH IUIS Classification February 2018 Victorian Clinical Genetics Services Expert Review Green ESID Registry 20171117 GRID V2.0 GOSH PID v.8.0 Phenotypes Autoimmune lymphoproliferative syndrome, type IB, 601859 Diseases of Immune Dysregulation Autoimmune lymphoproliferative syndrome, type IB (ALPS-FASG) Splenomegaly, adenopathies, autoimmune cytopenias, SLE, soluble FasL is not elevated Autoimmune lymphoproliferative syndrome (ALPS)
Green FASLG in Primary immunodeficiency or monogenic inflammatory bowel disease Version 4.202 Latest signed off version: v4.0 (22 Mar 2023)	review	BOTH monoallelic and biallelic (but BIALLELIC mutations cause a more SEVERE disease form), autosomal or pseudoautosomal	Sources Expert Review Green Other NHS GMS North West GLH London North GLH IUIS Classification February 2018 Victorian Clinical Genetics Services ESID Registry 20171117 GRID V2.0 GOSH PID v.8.0 Phenotypes Autoimmune lymphoproliferative syndrome, type IB, OMIM:601859 autoimmune lymphoproliferative syndrome type 1, MONDO:0011158 systemic lupus erythematosus (SLE)
Green FASLG in Severe Paediatric Disorders Version 1.184	review	MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown	Sources Next Generation Children Project Expert Review Green Expert list Phenotypes Autoimmune lymphoproliferative syndrome, type IB, 601859