FGG

fibrinogen gamma chain
OMIM: 134850, Gene2Phenotype

4 panels

Panel Reviews Mode of inheritance Details
4 panels

Green FGG in Inherited bleeding disorders

Level 3: Haemostasis disorders
Level 2: Haematological and immunological disorders
Version 1.164

review BOTH monoallelic and biallelic (but BIALLELIC mutations cause a more SEVERE disease form), autosomal or pseudoautosomal
Sources
  • Other
  • Radboud University Medical Center, Nijmegen
  • Expert Review Green
  • BRIDGE Study Tier 1 Gene
Phenotypes
  • Fibrinogen deficiency
  • Dysfibrinogenemia,congenital,616004
  • Dysfibrinogenemia, congenita
  • Hypodysfibrinogenemia

Green FGG in Thrombophilia


Version 1.20
Latest signed off version: v1.2 (3 Mar 2020)

review BOTH monoallelic and biallelic (but BIALLELIC mutations cause a more SEVERE disease form), autosomal or pseudoautosomal
Sources
  • North West GLH
  • Yorkshire and North East GLH
  • London South GLH
  • NHS GMS
  • Expert Review Green
  • Wessex and West Midlands GLH
Phenotypes
  • Afibrinogenemia, congenital, OMIM:202400
  • Hypofibrinogenemia, congenital, OMIM:202400
  • Dysfibrinogenemia, congenital, OMIM:616004
  • Hypodysfibrinogenemia, OMIM:616004
  • Thrombophilia, MONDO:0002305

Green FGG in Bleeding and platelet disorders


Version 1.31
Latest signed off version: v1.2 (3 Mar 2020)

review BOTH monoallelic and biallelic (but BIALLELIC mutations cause a more SEVERE disease form), autosomal or pseudoautosomal
Sources
  • North West GLH
  • Yorkshire and North East GLH
  • London South GLH
  • NHS GMS
  • Expert Review Green
  • Wessex and West Midlands GLH
Phenotypes
  • 202400 Afibrinogenemia, congenital
  • 616004 Hypodysfibrinogenemia, congenital
  • 616004 Dysfibrinogenemia, congenital

Green FGG in Severe Paediatric Disorders


Version 1.84

review BOTH monoallelic and biallelic, autosomal or pseudoautosomal
Sources
  • Next Generation Children Project
  • Expert Review Green
  • Expert list
Phenotypes
  • Dysfibrinogenemia, congenital, 616004
  • Hypodysfibrinogenemia, 616004
  • Afibrinogenemia, congenital, 202400
  • Hypofibrinogenemia, congenital, 202400