FLG

filaggrin
OMIM: 135940, Gene2Phenotype

4 panels

Panel Reviews Mode of inheritance Details
4 panels
Green FLG in Ichthyosis and erythrokeratoderma


Level 2: Dermatology
Version 4.9
Latest signed off version: v4.0 (30 Apr 2025)

review MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
Sources
  • Expert Review Green
Phenotypes
  • Ichthyosis vulgaris, OMIM:146700
  • Dermatitis, atopic, susceptibility to, 2, OMIM:605803
  • ichthyosis vulgaris, MONDO:0024304
Tags
  • Q3_25_MOI
Green FLG in Palmoplantar keratodermas


Level 2: Dermatology
Version 4.9
Latest signed off version: v4.0 (30 Apr 2025)

review MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Sources
  • London North GLH
  • NHS GMS
  • Expert Review Green
Phenotypes
  • Ichthyosis vulgaris, OMIM:146700
  • Dermatitis, atopic, susceptibility to, 2, OMIM:605803
  • hereditary palmoplantar keratoderma, MONDO:0019272
Tags
  • Q3_25_MOI
Red FLG in Rare genetic inflammatory skin disorders


Level 2: Dermatology
Version 4.16
Latest signed off version: v4.0 (30 Apr 2025)

review BOTH monoallelic and biallelic (but BIALLELIC mutations cause a more SEVERE disease form), autosomal or pseudoautosomal
Sources
  • Expert Review Red
  • London North GLH
  • NHS GMS
Phenotypes
  • Ichthyosis vulgaris, OMIM:146700
  • Dermatitis, atopic, susceptibility to, 2, OMIM:605803
  • hereditary palmoplantar keratoderma, MONDO:0019272
Red FLG in DDG2P


Version 6.424
Latest signed off version: v6.0 (30 Apr 2025)

Component of the following Super Panels:

  • Paediatric disorders
  • review BIALLELIC, autosomal or pseudoautosomal
    Sources
    • DD-Gene2Phenotype
    • Expert Review Red
    Phenotypes
    • ICHTHYOSIS VULGARIS 146700