GABRA1

gamma-aminobutyric acid type A receptor alpha1 subunit
OMIM: 137160, Gene2Phenotype

5 panels

Panel Reviews Mode of inheritance Details
5 panels

Amber GABRA1 in Fetal anomalies


Version 1.73
Signed off v.1.2 on 17 Feb 2020

review MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
Sources
  • Expert Review Amber
  • PAGE DD-Gene2Phenotype
Phenotypes
  • EPILEPTIC ENCEPHALOPATHY
  • JUVENILE MYOCLONIC EPILEPSY

Amber GABRA1 in DDG2P


Version 2.8
Signed off v.2.2 on 13 Feb 2020

Component of the following Super Panels:

  • Paediatric disorders
  • review MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
    Sources
    • DD-Gene2Phenotype
    • Expert Review Amber
    Phenotypes
    • JUVENILE MYOCLONIC EPILEPSY 611136
    • EPILEPTIC ENCEPHALOPATHY

    Green GABRA1 in Genetic epilepsy syndromes

    Level 3: Inherited Epilepsy Syndromes
    Level 2: Neurology and neurodevelopmental disorders
    Version 2.89
    Signed off v.2.2 on 13 Feb 2020

    review MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
    Sources
    • Wessex and West Midlands GLH
    • NHS GMS
    • NIHRBR-RD Consortium SPEED_v3.0_20170404
    • Victorian Clinical Genetics Services
    • Expert
    • Expert Review Green
    Phenotypes
    • {Epilepsy, childhood absence, susceptibility to, 4} 611136
    • {Epilepsy, juvenile myoclonic, susceptibility to, 5} 611136

    Green GABRA1 in Intellectual disability

    Level 3: Neurodevelopmental disorders
    Level 2: Neurology and neurodevelopmental disorders
    Version 3.82
    Signed off v.3.2 on 13 Feb 2020

    Component of the following Super Panels:

  • Hypotonic infant
  • Paediatric disorders
  • White matter disorders - childhood onset
  • review MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
    Sources
    • Expert Review Green
    Phenotypes
    • JUVENILE MYOCLONIC EPILEPSY

    Green GABRA1 in Severe Paediatric Disorders


    Version 1.6

    review MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
    Sources
    • Next Generation Children Project
    • Expert Review Green
    • Expert list
    Phenotypes
    • {Epilepsy, childhood absence, susceptibility to, 4}, 611136
    • Epileptic encephalopathy, early infantile, 19, 615744
    • {Epilepsy, juvenile myoclonic, susceptibility to, 5}, 611136