GLIS3

GLIS family zinc finger 3
OMIM: 610192, Gene2Phenotype

10 panels

Panel Reviews Mode of inheritance Details
10 panels

No list GLIS3 in Multi-organ autoimmune diabetes

Level 3: Disorders of unusual phenotypes
Level 2: Endocrine disorders
Version 1.8

review BIALLELIC, autosomal or pseudoautosomal
Sources
  • Expert Review Removed
  • UKGTN
  • Illumina TruGenome Clinical Sequencing Services
Phenotypes
  • Diabetes Mellitus, Neonatal, with Congenital Hypothyroidism
  • Neonatal Diabetes

Green GLIS3 in Diabetes with additional phenotypes suggestive of a monogenic aetiology

Level 3: Disorders of unusual phenotypes
Level 2: Endocrine disorders
Version 1.59

review BIALLELIC, autosomal or pseudoautosomal
Sources
  • Expert Review Green
  • UKGTN
  • Illumina TruGenome Clinical Sequencing Services
  • Radboud University Medical Center, Nijmegen
Phenotypes
  • Diabetes mellitus, neonatal, with congenital hypothyroidism, 610199 -3
  • Diabetes Mellitus, Neonatal, with Congenital Hypothyroidism
  • Diabetes Mellitus, Neonatal, With Congenital Hypothyroidism
  • Neonatal Diabetes mellitus with congenital hypothyroidism

Green GLIS3 in Diabetes - neonatal onset

Level 3: Disorders of unusual phenotypes
Level 2: Endocrine disorders
Version 2.3
Signed off v.2.2 on 19 Feb 2020

review BIALLELIC, autosomal or pseudoautosomal
Sources
  • NHS GMS
  • Expert Review Green
  • Eligibility statement prior genetic testing
  • UKGTN
  • Illumina TruGenome Clinical Sequencing Services
  • Radboud University Medical Center, Nijmegen
Phenotypes
  • Diabetes mellitus, neonatal, with congenital hypothyroidism, 610199
  • Neonatal Diabetes mellitus with congenital hypothyroidism

Green GLIS3 in Familial diabetes

Level 3: Disorders of unusual phenotypes
Level 2: Endocrine disorders
Version 1.38

review BIALLELIC, autosomal or pseudoautosomal
Sources
  • Expert Review Removed
  • Expert Review Green
  • Radboud University Medical Center, Nijmegen
  • UKGTN
  • Illumina TruGenome Clinical Sequencing Services
Phenotypes
  • Diabetes Mellitus, Neonatal, with Congenital Hypothyroidism
  • Diabetes mellitus, neonatal, with congenital hypothyroidism, 610199 -3

No list GLIS3 in Monogenic diabetes


Version 2.3
Signed off v.2.2 on 25 Feb 2020

review BIALLELIC, autosomal or pseudoautosomal
Sources
  • Expert Review Removed
Phenotypes
  • Diabetes Mellitus, Neonatal, with Congenital Hypothyroidism
  • Neonatal Diabetes mellitus with congenital hypothyroidism
  • Diabetes Mellitus, Neonatal, With Congenital Hypothyroidism
  • Diabetes mellitus, neonatal, with congenital hypothyroidism, 610199 -3

Green GLIS3 in Fetal anomalies


Version 1.108
Signed off v.1.92 on 21 Aug 2020

review BIALLELIC, autosomal or pseudoautosomal
Sources
  • PAGE DD-Gene2Phenotype
  • Expert Review Green
Phenotypes
  • DIABETES MELLITUS NEONATAL WITH CONGENITAL HYPOTHYROIDISM

Green GLIS3 in DDG2P


Version 2.11
Signed off v.2.2 on 13 Feb 2020

Component of the following Super Panels:

  • Paediatric disorders
  • review BIALLELIC, autosomal or pseudoautosomal
    Sources
    • DD-Gene2Phenotype
    • Expert Review Green
    Phenotypes
    • DIABETES MELLITUS NEONATAL WITH CONGENITAL HYPOTHYROIDISM 610199

    Green GLIS3 in Intellectual disability

    Level 3: Neurodevelopmental disorders
    Level 2: Neurology and neurodevelopmental disorders
    Version 3.500
    Signed off v.3.2 on 13 Feb 2020

    Component of the following Super Panels:

  • Hypotonic infant
  • Paediatric disorders
  • White matter disorders - childhood onset
  • review BIALLELIC, autosomal or pseudoautosomal
    Sources
    • Expert Review Green
    • Expert Review Amber
    • BRIDGE study SPEED NEURO Tier1 Gene
    Phenotypes
    • Diabetes mellitus, neonatal, with congenital hypothyroidism, 610199

    Green GLIS3 in Congenital hypothyroidism

    Level 3: Thyroid disorders
    Level 2: Endocrine disorders
    Version 2.3
    Signed off v.2.2 on 25 Feb 2020

    review BIALLELIC, autosomal or pseudoautosomal
    Sources
    • Expert Review Green
    • UKGTN
    • Illumina TruGenome Clinical Sequencing Services
    • Radboud University Medical Center, Nijmegen
    Phenotypes
    • Congenital hypothyroidism
    • Diabetes mellitus, neonatal, with congenital hypothyroidism, 610199
    • neonatal non-autoimmune diabetes mellitus
    • severe congenital hypothyroidism
    • variable cholestasis
    • hepatic fibrosis
    • congenital glaucoma
    • polycystic kidneys
    • dysmorphic facies
    • sensorineural deafness

    Green GLIS3 in Severe Paediatric Disorders


    Version 1.12

    review BIALLELIC, autosomal or pseudoautosomal
    Sources
    • Next Generation Children Project
    • Expert Review Green
    • Expert list
    Phenotypes
    • Diabetes mellitus, neonatal, with congenital hypothyroidism, 610199