GLIS3

GLIS family zinc finger 3
OMIM: 610192, Gene2Phenotype

12 panels

Panel	Reviews	Mode of inheritance	Details
Filter panels 12 panels
Red GLIS3 in Genomic imprinting Version 0.149	review	MONOALLELIC, autosomal or pseudoautosomal, maternally imprinted (paternal allele expressed)	Sources Literature
No list GLIS3 in Multi-organ autoimmune diabetes Level 3: Disorders of unusual phenotypes Level 2: Endocrine disorders Version 1.11	review	BIALLELIC, autosomal or pseudoautosomal	Sources Expert Review Removed UKGTN Illumina TruGenome Clinical Sequencing Services Phenotypes Diabetes Mellitus, Neonatal, with Congenital Hypothyroidism Neonatal Diabetes Tags curated_removed
Green GLIS3 in Diabetes with additional phenotypes suggestive of a monogenic aetiology Level 3: Disorders of unusual phenotypes Level 2: Endocrine disorders Version 1.67	review	BIALLELIC, autosomal or pseudoautosomal	Sources Expert Review Green UKGTN Illumina TruGenome Clinical Sequencing Services Radboud University Medical Center, Nijmegen Phenotypes Diabetes mellitus, neonatal, with congenital hypothyroidism, 610199 -3 Diabetes Mellitus, Neonatal, with Congenital Hypothyroidism Diabetes Mellitus, Neonatal, With Congenital Hypothyroidism Neonatal Diabetes mellitus with congenital hypothyroidism
Green GLIS3 in Neonatal diabetes Level 3: Disorders of unusual phenotypes Level 2: Endocrine disorders Version 4.4 Latest signed off version: v4.0 (22 Mar 2023)	review	BIALLELIC, autosomal or pseudoautosomal	Sources NHS GMS Expert Review Green Eligibility statement prior genetic testing UKGTN Illumina TruGenome Clinical Sequencing Services Radboud University Medical Center, Nijmegen Phenotypes Diabetes mellitus, neonatal, with congenital hypothyroidism, OMIM:610199
Green GLIS3 in Familial diabetes Level 3: Disorders of unusual phenotypes Level 2: Endocrine disorders Version 1.67	review	BIALLELIC, autosomal or pseudoautosomal	Sources Expert Review Green Radboud University Medical Center, Nijmegen UKGTN Illumina TruGenome Clinical Sequencing Services Phenotypes Diabetes Mellitus, Neonatal, with Congenital Hypothyroidism Diabetes mellitus, neonatal, with congenital hypothyroidism, 610199 -3
No list GLIS3 in Monogenic diabetes Version 2.57 Latest signed off version: v2.2 (25 Feb 2020)	review	BIALLELIC, autosomal or pseudoautosomal	Sources Expert Review Removed Phenotypes Diabetes Mellitus, Neonatal, with Congenital Hypothyroidism Neonatal Diabetes mellitus with congenital hypothyroidism Diabetes Mellitus, Neonatal, With Congenital Hypothyroidism Diabetes mellitus, neonatal, with congenital hypothyroidism, 610199 -3 Tags curated_removed
Green GLIS3 in Fetal anomalies Version 3.155 Latest signed off version: v3.0 (22 Mar 2023)	review	BIALLELIC, autosomal or pseudoautosomal	Sources PAGE DD-Gene2Phenotype Expert Review Green Phenotypes DIABETES MELLITUS NEONATAL WITH CONGENITAL HYPOTHYROIDISM
Red GLIS3 in Rare syndromic craniosynostosis or isolated multisuture synostosis Level 3: Craniosynostosis syndromes Level 2: Skeletal disorders Version 4.179 Latest signed off version: v4.0 (22 Mar 2023)	review	BIALLELIC, autosomal or pseudoautosomal	Sources Literature Phenotypes craniosynostosis, MONDO:0015469
Green GLIS3 in DDG2P Version 3.87 Latest signed off version: v3.1 (22 Mar 2023) Component of the following Super Panels: Paediatric disorders	review	BIALLELIC, autosomal or pseudoautosomal	Sources DD-Gene2Phenotype Expert Review Green Phenotypes DIABETES MELLITUS NEONATAL WITH CONGENITAL HYPOTHYROIDISM 610199
Green GLIS3 in Intellectual disability - microarray and sequencing Level 3: Neurodevelopmental disorders Level 2: Neurology and neurodevelopmental disorders Version 5.532 Latest signed off version: v5.0 (22 Mar 2023) Component of the following Super Panels: Childhood onset leukodystrophy Hypotonic infant Paediatric disorders	review	BIALLELIC, autosomal or pseudoautosomal	Sources Expert Review Green BRIDGE study SPEED NEURO Tier1 Gene Phenotypes Diabetes mellitus, neonatal, with congenital hypothyroidism, 610199
Green GLIS3 in Congenital hypothyroidism Level 3: Thyroid disorders Level 2: Endocrine disorders Version 2.18 Latest signed off version: v2.2 (25 Feb 2020)	review	BIALLELIC, autosomal or pseudoautosomal	Sources Expert Review Green UKGTN Illumina TruGenome Clinical Sequencing Services Radboud University Medical Center, Nijmegen Phenotypes Congenital hypothyroidism Diabetes mellitus, neonatal, with congenital hypothyroidism, 610199 neonatal non-autoimmune diabetes mellitus severe congenital hypothyroidism variable cholestasis hepatic fibrosis congenital glaucoma polycystic kidneys dysmorphic facies sensorineural deafness
Green GLIS3 in Severe Paediatric Disorders Version 1.184	review	BIALLELIC, autosomal or pseudoautosomal	Sources Next Generation Children Project Expert Review Green Expert list Phenotypes Diabetes mellitus, neonatal, with congenital hypothyroidism, 610199