HBB

hemoglobin subunit beta
OMIM: 141900, Gene2Phenotype

7 panels

Panel	Reviews	Mode of inheritance	Details
Filter panels 7 panels
Green HBB in Hereditary Erythrocytosis Level 2: Haematology Version 2.17 Latest signed off version: v2.0 (22 Mar 2023)	review	MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted	Sources Expert Review Green Literature Phenotypes Erythrocytosis 6, OMIM:617980 Tags gene-therapy-trial
Red HBB in COVID-19 research Level 2: Viral research Version 1.146	review	Not set	Sources OMIM
Amber HBB in Cerebral vascular malformations Level 2: Neurology Version 4.10 Latest signed off version: v4.0 (30 Apr 2025)	review	BIALLELIC, autosomal or pseudoautosomal	Sources Expert Review Amber Yorkshire and North East GLH NHS GMS UKGTN Radboud University Medical Center, Nijmegen Literature Emory Genetics Laboratory Phenotypes Sickle cell anemia, OMIM:603903 Tags gene-therapy-trial
Green HBB in Cytopenias and congenital anaemias Level 3: Anaemias and red cell disorders Level 2: Haematological disorders Version 1.123	review	BOTH monoallelic and biallelic, autosomal or pseudoautosomal	Sources Expert Review Green Expert list Illumina TruGenome Clinical Sequencing Services UKGTN Radboud University Medical Center, Nijmegen Phenotypes Delta-beta thalassemia, OMIM:141749 Heinz body anemia, OMIM:140700 Hereditary persistence of fetal hemoglobin, OMIM:141749 Methemoglobinemia, beta type, OMIM:617971 Thalassemia, beta, OMIM:613985 Thalassemia-beta, dominant inclusion-body, OMIM:603902 Sickle cell anemia, OMIM:603903 Tags gene-therapy-trial cnv
Green HBB in Rare anaemia Level 2: Haematology Version 3.19 Latest signed off version: v3.0 (22 Mar 2023)	review	BOTH monoallelic and biallelic, autosomal or pseudoautosomal	Sources North West GLH Yorkshire and North East GLH London South GLH NHS GMS Expert Review Green Wessex and West Midlands GLH Phenotypes Delta-beta thalassemia, OMIM:141749 Heinz body anemia, OMIM:140700 Hereditary persistence of fetal hemoglobin, OMIM:141749 Methemoglobinemia, beta type, OMIM:617971 Thalassemia, beta, OMIM:613985 Thalassemia-beta, dominant inclusion-body, OMIM:603902 Sickle cell anemia, OMIM:603903
Green HBB in Sickle cell, thalassaemia and other haemoglobinopathies trait or carrier testing Level 2: Haematology Version 2.9 Latest signed off version: v2.2 (30 Apr 2025)	review	BOTH monoallelic and biallelic, autosomal or pseudoautosomal	Sources NHS GMS Expert Review Green Phenotypes Heinz body anemia, OMIM:140700 Delta-beta thalassemia, OMIM:141749 Hereditary persistence of fetal hemoglobin, OMIM:141749 Thalassemia-beta, dominant inclusion-body, OMIM:603902 Sickle cell disease, OMIM:603903 Thalassemia, beta, OMIM:613985 Methemoglobinemia, beta type, OMIM:617971 Erythrocytosis, familial, 6, OMIM:617980 dominant beta-thalassemia, MONDO:0011381 sickle cell disease, MONDO:0011382 beta-thalassemia HBB/LCRB, MONDO:0013517 hemoglobin M disease, MONDO:0018023 erythrocytosis, familial, 6, MONDO:0054801
Green HBB in Sickle cell, thalassaemia and other haemoglobinopathies Level 2: Haematology Version 2.9 Latest signed off version: v2.2 (30 Apr 2025)	review	BOTH monoallelic and biallelic, autosomal or pseudoautosomal	Sources Expert Review Green NHS GMS Phenotypes Heinz body anemia, OMIM:140700 Delta-beta thalassemia, OMIM:141749 Hereditary persistence of fetal hemoglobin, OMIM:141749 Thalassemia-beta, dominant inclusion-body, OMIM:603902 Sickle cell disease, OMIM:603903 Thalassemia, beta, OMIM:613985 Methemoglobinemia, beta type, OMIM:617971 Erythrocytosis, familial, 6, OMIM:617980 dominant beta-thalassemia, MONDO:0011381 sickle cell disease, MONDO:0011382 beta-thalassemia HBB/LCRB, MONDO:0013517 hemoglobin M disease, MONDO:0018023 erythrocytosis, familial, 6, MONDO:0054801