1. Genes and Genomic Entities
  2. HPGD

HPGD

15-hydroxyprostaglandin dehydrogenase
OMIM: 601688, Gene2Phenotype

6 panels

Panel Reviews Mode of inheritance Details
6 panels
Green HPGD in Autosomal recessive primary hypertrophic osteoarthropathy


Version 1.12
Latest signed off version: v1.5 (11 Nov 2020)

review BIALLELIC, autosomal or pseudoautosomal
Sources
  • London North GLH
  • NHS GMS
  • Expert Review Green
Phenotypes
  • Hypertrophic osteoarthropathy, primary, autosomal recessive 1 OMIM:259100
Green HPGD in Skeletal dysplasia

Level 3: Skeletal dysplasias
Level 2: Skeletal disorders
Version 4.65
Latest signed off version: v4.0 (22 Mar 2023)

Component of the following Super Panels:

  • Paediatric disorders

    		•  review BOTH monoallelic and biallelic, autosomal or pseudoautosomal
    Sources
    • NHS GMS
    • Expert Review Green
    Phenotypes
    • Cranioosteoarthropathy 259100
    • Digital clubbing, isolated congenital 119900
    • Hypertrophic osteoarthropathy, primary, autosomal recessive 1 259100
    Red HPGD in Fetal anomalies


    Version 3.169
    Latest signed off version: v3.0 (22 Mar 2023)

    		review BIALLELIC, autosomal or pseudoautosomal
    Sources
    • Expert Review Red
    • PAGE DD-Gene2Phenotype
    Phenotypes
    • CRANIOOSTEOARTHROPATHY
    Green HPGD in DDG2P


    Version 3.90
    Latest signed off version: v3.1 (22 Mar 2023)

    Component of the following Super Panels:

  • Paediatric disorders

    		•  review BIALLELIC, autosomal or pseudoautosomal
    Sources
    • DD-Gene2Phenotype
    • Expert Review Green
    Phenotypes
    • CRANIOOSTEOARTHROPATHY 259100
    Red HPGD in Intellectual disability - microarray and sequencing

    Level 3: Neurodevelopmental disorders
    Level 2: Neurology and neurodevelopmental disorders
    Version 5.550
    Latest signed off version: v5.0 (22 Mar 2023)

    Component of the following Super Panels:

  • Childhood onset leukodystrophy
  • Hypotonic infant
  • Paediatric disorders

    		•  review BIALLELIC, autosomal or pseudoautosomal
    Sources
    • Expert Review Red
    • BRIDGE study SPEED NEURO Tier1 Gene
    Phenotypes
    • Cranioosteoarthropathy, 259100
    • Hypertrophic osteoarthropathy, primary, autosomal recessive 1, 259100
    • Digital clubbing, isolated congenital, 119900
    Green HPGD in Severe Paediatric Disorders


    Version 1.184

    		review BIALLELIC, autosomal or pseudoautosomal
    Sources
    • Next Generation Children Project
    • Expert Review Green
    • Expert list
    Phenotypes
    • Hypertrophic osteoarthropathy, primary, autosomal recessive 1, 259100
    • Cranioosteoarthropathy, 259100
    • Digital clubbing, isolated congenital, 119900