1. Genes and Genomic Entities
  2. HPGD

HPGD

15-hydroxyprostaglandin dehydrogenase
OMIM: 601688, Gene2Phenotype

5 panels

Panel Reviews Mode of inheritance Details
5 panels
Green HPGD in Autosomal recessive primary hypertrophic osteoarthropathy


Level 2: Dermatology
Version 1.17
Latest signed off version: v1.5 (11 Nov 2020)

review BIALLELIC, autosomal or pseudoautosomal
Sources
  • London North GLH
  • NHS GMS
  • Expert Review Green
Phenotypes
  • Hypertrophic osteoarthropathy, primary, autosomal recessive 1 OMIM:259100
Green HPGD in Skeletal dysplasia


Level 2: Musculoskeletal
Version 8.34
Latest signed off version: v8.0 (30 Apr 2025)

Component of the following Super Panels:

  • Paediatric disorders

    		•  review BOTH monoallelic and biallelic, autosomal or pseudoautosomal
    Sources
    • NHS GMS
    • Expert Review Green
    Phenotypes
    • Cranioosteoarthropathy 259100
    • Digital clubbing, isolated congenital 119900
    • Hypertrophic osteoarthropathy, primary, autosomal recessive 1 259100
    Red HPGD in Fetal anomalies


    Level 2: Fetal (including NIPD)
    Version 6.140
    Latest signed off version: v6.0 (30 Apr 2025)

    		review BIALLELIC, autosomal or pseudoautosomal
    Sources
    • Expert Review Red
    • PAGE DD-Gene2Phenotype
    Phenotypes
    • CRANIOOSTEOARTHROPATHY
    Green HPGD in DDG2P


    Version 6.424
    Latest signed off version: v6.0 (30 Apr 2025)

    Component of the following Super Panels:

  • Paediatric disorders

    		•  review BIALLELIC, autosomal or pseudoautosomal
    Sources
    • DD-Gene2Phenotype
    • Expert Review Green
    Phenotypes
    • CRANIOOSTEOARTHROPATHY 259100
    Red HPGD in Intellectual disability


    Level 2: Developmental disorders
    Version 9.285
    Latest signed off version: v9.0 (30 Apr 2025)

    Component of the following Super Panels:

  • Childhood onset leukodystrophy
  • Hypotonic infant
  • Paediatric disorders

    		•  review BIALLELIC, autosomal or pseudoautosomal
    Sources
    • Expert Review Red
    • BRIDGE study SPEED NEURO Tier1 Gene
    Phenotypes
    • Cranioosteoarthropathy, 259100
    • Hypertrophic osteoarthropathy, primary, autosomal recessive 1, 259100
    • Digital clubbing, isolated congenital, 119900