IL21

Amber IL21 in Infantile enterocolitis & monogenic inflammatory bowel disease

Level 3: Gastrointestinal disorders
Level 2: Gastroenterological disorders
Version 1.43

Sources

• Expert Review Amber
• Expert list

Phenotypes

• IL21 deficiency (Combined variable immunodeficiency-like)
• severe diarrhea and inflammatory bowel disease
• Early-onset inflammatory bowel disease

Green IL21 in COVID-19 research

Level 2: Viral research
Version 1.141

Sources

• Expert Review Green
• IUIS Classification February 2018
• IUIS Classification December 2019
• GRID V2.0
• Victorian Clinical Genetics Services
• IUIS Classification December 2019
• IUIS Classification February 2018
• Victorian Clinical Genetics Services
• GRID V2.0

Phenotypes

• Immunodeficiency, common variable, 11, 615767
• Severe early onset colitis, recurrent sinopulmonary infections
• Immunodeficiencies affecting cellular and humoral immunity

Amber IL21 in Primary immunodeficiency or monogenic inflammatory bowel disease

Version 4.201
Latest signed off version: v4.0 (22 Mar 2023)

Sources

• Expert Review Amber
• Other
• IUIS Classification December 2019
• IUIS Classification February 2018
• Victorian Clinical Genetics Services
• GRID V2.0

Phenotypes

• Immunodeficiency, common variable, 11 , OMIM:615767
• Severe early onset colitis, recurrent sinopulmonary infections
• Immunodeficiencies affecting cellular and humoral immunity

Amber IL21 in Severe Paediatric Disorders

Version 1.184

Sources

• Next Generation Children Project
• Expert Review Amber
• Expert list

Phenotypes

• ?Immunodeficiency, common variable, 11, 615767