1. Genes and Genomic Entities
  2. IL21

IL21

interleukin 21
OMIM: 605384, Gene2Phenotype

3 panels

Panel Reviews Mode of inheritance Details
3 panels
Amber IL21 in Infantile enterocolitis & monogenic inflammatory bowel disease

Level 3: Gastrointestinal disorders
Level 2: Gastroenterological disorders
Version 1.45

review BIALLELIC, autosomal or pseudoautosomal
Sources
  • Expert Review Amber
  • Expert list
Phenotypes
  • IL21 deficiency (Combined variable immunodeficiency-like)
  • severe diarrhea and inflammatory bowel disease
  • Early-onset inflammatory bowel disease
Green IL21 in COVID-19 research


Level 2: Viral research
Version 1.147

review BIALLELIC, autosomal or pseudoautosomal
Sources
  • Expert Review Green
  • IUIS Classification February 2018
  • IUIS Classification December 2019
  • GRID V2.0
  • Victorian Clinical Genetics Services
  • IUIS Classification December 2019
  • IUIS Classification February 2018
  • Victorian Clinical Genetics Services
  • GRID V2.0
Phenotypes
  • Immunodeficiency, common variable, 11, 615767
  • Severe early onset colitis, recurrent sinopulmonary infections
  • Immunodeficiencies affecting cellular and humoral immunity
Amber IL21 in Primary immunodeficiency or monogenic inflammatory bowel disease


Level 2: Immunology
Version 8.85
Latest signed off version: v8.0 (30 Apr 2025)

review BIALLELIC, autosomal or pseudoautosomal
Sources
  • Expert Review Amber
  • Other
  • IUIS Classification December 2019
  • IUIS Classification February 2018
  • Victorian Clinical Genetics Services
  • GRID V2.0
Phenotypes
  • Immunodeficiency, common variable, 11 , OMIM:615767
  • Severe early onset colitis, recurrent sinopulmonary infections
  • Immunodeficiencies affecting cellular and humoral immunity