IRAK4

interleukin 1 receptor associated kinase 4
OMIM: 606883, Gene2Phenotype

3 panels

Panel Reviews Mode of inheritance Details
3 panels

Green IRAK4 in COVID-19 research


Level 2: Viral research
Version 1.80

review BIALLELIC, autosomal or pseudoautosomal
Sources
  • IUIS Classification February 2018
  • London North GLH
  • NHS GMS
  • GRID V2.0
  • Victorian Clinical Genetics Services
  • North West GLH
  • ESID Registry 20171117
  • Expert Review Green
  • NHS GMS
  • North West GLH
  • London North GLH
  • IUIS Classification February 2018
  • Victorian Clinical Genetics Services
  • Expert Review Green
  • ESID Registry 20171117
  • GRID V2.0
Phenotypes
  • Defects with susceptibility to mycobacterial infection (MSMD)
  • Defects of TLR/NFkappa-B signalling
  • Invasive pneumococcal disease, recurrent isolated, 1, 6107
  • IRAK4 deficiency, 610799
  • Defects in Intrinsic and Innate Immunity
  • Bacterial infections (pyogens)

Green IRAK4 in Primary immunodeficiency


Version 2.478
Latest signed off version: v2.1 (24 Feb 2020)

review BIALLELIC, autosomal or pseudoautosomal
Sources
  • NHS GMS
  • North West GLH
  • London North GLH
  • IUIS Classification February 2018
  • Victorian Clinical Genetics Services
  • Expert Review Green
  • ESID Registry 20171117
  • GRID V2.0
Phenotypes
  • IRAK4 deficiency, 610799
  • Invasive pneumococcal disease, recurrent isolated, 1, 6107
  • Defects of TLR/NFkappa-B signalling
  • Defects with susceptibility to mycobacterial infection (MSMD)
  • Bacterial infections (pyogens)
  • Defects in Intrinsic and Innate Immunity

Green IRAK4 in Severe Paediatric Disorders


Version 1.84

review BIALLELIC, autosomal or pseudoautosomal
Sources
  • Next Generation Children Project
  • Expert Review Green
  • Expert list
Phenotypes
  • Invasive pneumococcal disease, recurrent isolated, 1, 610799
  • IRAK4 deficiency, 607676