JAK2

Janus kinase 2
OMIM: 147796, Gene2Phenotype

7 panels

Panel Reviews Mode of inheritance Details
7 panels
Green JAK2 in Hereditary Erythrocytosis


Level 2: Haematology
Version 2.17
Latest signed off version: v2.0 (22 Mar 2023)

review BOTH monoallelic and biallelic, autosomal or pseudoautosomal
Sources
  • Expert Review Green
  • NHS GMS
  • Expert list
Phenotypes
  • Hereditary erythrocytosis
  • Erythrocytosis, somatic, OMIM:133100
Tags
  • somatic
Red JAK2 in Gastrointestinal epithelial barrier disorders

Level 3: Gastrointestinal disorders
Level 2: Gastroenterological disorders
Version 1.76

review Not set
Sources
  • Other
Phenotypes
  • Crohn disease
Red JAK2 in Cytopenias and congenital anaemias

Level 3: Anaemias and red cell disorders
Level 2: Haematological disorders
Version 1.123

review Other - please specify in evaluation comments
Sources
  • Expert Review Red
  • BRIDGE consortium (NIHRBR-RD)
Phenotypes
  • Myeloproliferative neoplasms (MPN)
  • Acute myeloid leukaemia (AML)
Tags
  • somatic
No list JAK2 in Mosaic skin disorders - deep sequencing


Level 2: Dermatology
Version 3.27
Latest signed off version: v3.0 (30 Apr 2025)

review MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Sources
  • Expert Review Removed
  • London North GLH
  • NHS GMS
Phenotypes
  • Myelofibrosis
Tags
  • curated_removed
No list JAK2 in Multiple monogenic benign skin tumours


Level 2: Dermatology
Version 2.5
Latest signed off version: v2.0 (30 Nov 2022)

review BOTH monoallelic and biallelic, autosomal or pseudoautosomal
Sources
  • Expert Review Removed
  • London North GLH
  • NHS GMS
Phenotypes
  • Myelofibrosis
Tags
  • curated_removed
Red JAK2 in Non-syndromic familial congenital anorectal malformations

Level 3: Gastrointestinal disorders
Level 2: Gastroenterological disorders
Version 1.14

review Not set
Sources
  • Literature
Phenotypes
  • anorectal malformation
Green JAK2 in Thrombocythaemia


Level 2: Haematology
Version 1.12
Latest signed off version: v1.1 (30 Sep 2020)

review MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
Sources
  • NHS GMS
  • Expert Review Green
Phenotypes
  • Thrombocythemia 3, 614521
Tags
  • somatic