1. Genes and Genomic Entities
  2. KCNK18

KCNK18

potassium two pore domain channel subfamily K member 18
OMIM: 613655, Gene2Phenotype

6 panels

Panel Reviews Mode of inheritance Details
6 panels
Amber KCNK18 in Brain channelopathy

Level 3: Channelopathies
Level 2: Neurology and neurodevelopmental disorders
Version 1.83

review Not set
Sources
  • Expert Review Amber
  • UKGTN
Phenotypes
  • MIGRAINE, WITH OR WITHOUT AURA, SUSCEPTIBILITY TO, 13
Amber KCNK18 in Paroxysmal central nervous system disorders


Level 2: Neurology
Version 4.3
Latest signed off version: v4.0 (30 Apr 2025)

review MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
Sources
  • Expert Review Amber
  • NHS GMS
  • London North GLH
  • Wessex and West Midlands GLH
Phenotypes
  • Migraine, with or without aura, susceptibility to, 13, 613656
Red KCNK18 in Adult onset neurodegenerative disorder


Level 2: Neurology
Version 8.21
Latest signed off version: v8.0 (30 Apr 2025)

Component of the following Super Panels:

  • Adult-onset neurological disorders

    		•  review Unknown
    Sources
    • Wessex and West Midlands GLH
    • Yorkshire and North East GLH
    • Expert Review Red
    • London North GLH
    • NHS GMS
    • South West GLH
    Phenotypes
    • MIGRAINE, WITH OR WITHOUT AURA, SUSCEPTIBILITY TO, 13
    Red KCNK18 in Hereditary ataxia with onset in adulthood


    Level 2: Neurology
    Version 8.30
    Latest signed off version: v8.0 (30 Apr 2025)

    Component of the following Super Panels:

  • Adult-onset neurological disorders

    		•  review MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
    Sources
    • Expert Review Red
    • London North GLH
    • NHS GMS
    • Wessex and West Midlands GLH
    • Brain channelopathy v1.46
    Phenotypes
    • Susceptibility to migraine with/without arua 13, 613656
    • MIGRAINE, WITH OR WITHOUT AURA, SUSCEPTIBILITY TO, 13
    Red KCNK18 in Adult onset dystonia, chorea or related movement disorder


    Level 2: Neurology
    Version 5.5
    Latest signed off version: v5.0 (30 Apr 2025)

    Component of the following Super Panels:

  • Adult-onset neurological disorders

    		•  review Not set
    Sources
    • Expert Review Red
    • London North GLH
    • NHS GMS
    • South West GLH
    Phenotypes
    • MIGRAINE, WITH OR WITHOUT AURA, SUSCEPTIBILITY TO, 13
    Red KCNK18 in Childhood onset dystonia, chorea or related movement disorder


    Level 2: Neurology
    Version 7.25
    Latest signed off version: v7.0 (30 Apr 2025)

    		review Unknown
    Sources
    • South West GLH
    • Expert Review Red
    • London North GLH
    Phenotypes
    • MIGRAINE, WITH OR WITHOUT AURA, SUSCEPTIBILITY TO, 13