1. Genes and Genomic Entities
  2. LAT

LAT

linker for activation of T-cells
OMIM: 602354, Gene2Phenotype

6 panels

Panel Reviews Mode of inheritance Details
6 panels
Green LAT in COVID-19 research


Level 2: Viral research
Version 1.141

review BIALLELIC, autosomal or pseudoautosomal
Sources
  • IUIS Classification February 2018
  • SCID v1.6
  • A- or hypo-gammaglobulinaemia v1.25
  • London North GLH
  • NHS GMS
  • North West GLH
  • Combined B and T cell defect v1.12
  • Expert Review Green
  • NHS GMS
  • North West GLH
  • London North GLH
  • Expert Review Green
  • IUIS Classification February 2018
  • SCID v1.6
  • Combined B and T cell defect v1.12
  • A- or hypo-gammaglobulinaemia v1.25
Phenotypes
  • Immunodeficiencies affecting cellular and humoral immunity
  • Immunodeficiency 52, 617514
  • Adenopathy, splenomegaly, recurrent infections, autoimmunity
Amber LAT in Inherited bleeding disorders

Level 3: Haemostasis disorders
Level 2: Haematological and immunological disorders
Version 1.177

review BIALLELIC, autosomal or pseudoautosomal
Sources
  • Expert Review Amber
  • Other
Phenotypes
  • Immunodeficiency 52, 617514
Tags
  • watchlist
Green LAT in Primary immunodeficiency or monogenic inflammatory bowel disease


Version 4.201
Latest signed off version: v4.0 (22 Mar 2023)

review BIALLELIC, autosomal or pseudoautosomal
Sources
  • Expert Review Green
  • Other
  • NHS GMS
  • North West GLH
  • London North GLH
  • IUIS Classification February 2018
  • SCID v1.6
  • Combined B and T cell defect v1.12
  • A- or hypo-gammaglobulinaemia v1.25
Phenotypes
  • Immunodeficiency 52, 617514
  • Adenopathy, splenomegaly, recurrent infections, autoimmunity
  • Immunodeficiencies affecting cellular and humoral immunity
Amber LAT in Cytopenias and congenital anaemias

Level 3: Anaemias and red cell disorders
Level 2: Haematological disorders
Version 1.118

review BIALLELIC, autosomal or pseudoautosomal
Sources
  • Expert Review Amber
  • Other
Phenotypes
  • Immunodeficiency 52, 617514
Tags
  • watchlist
Amber LAT in Cytopenia - NOT Fanconi anaemia


Version 3.32
Latest signed off version: v3.0 (22 Mar 2023)

review BIALLELIC, autosomal or pseudoautosomal
Sources
  • North West GLH
  • NHS GMS
  • Expert Review Amber
  • Wessex and West Midlands GLH
Phenotypes
  • Immunodeficiency 52, 617514
Green LAT in Severe Paediatric Disorders


Version 1.184

review BIALLELIC, autosomal or pseudoautosomal
Sources
  • Next Generation Children Project
  • Expert Review Green
  • Expert list
Phenotypes
  • Immunodeficiency 52, 617514