1. Genes and Genomic Entities
  2. LCK

LCK

LCK proto-oncogene, Src family tyrosine kinase
OMIM: 153390, Gene2Phenotype

2 panels

Panel Reviews Mode of inheritance Details
2 panels
Green LCK in COVID-19 research


Level 2: Viral research
Version 1.146

review BIALLELIC, autosomal or pseudoautosomal
Sources
  • IUIS Classification February 2018
  • London North GLH
  • NHS GMS
  • GRID V2.0
  • Victorian Clinical Genetics Services
  • North West GLH
  • ESID Registry 20171117
  • Expert Review Green
  • NHS GMS
  • North West GLH
  • London North GLH
  • Expert Review Green
  • IUIS Classification February 2018
  • Victorian Clinical Genetics Services
  • ESID Registry 20171117
  • GRID V2.0
Phenotypes
  • Severe combined immunodeficiency due to LCK deficiency
  • Recurrent infections, immune dysregulation, autoimmunity
  • Combined immunodeficiency
  • Immunodeficiency 22, 615758
  • Immunodeficiencies affecting cellular and humoral immunity
  • LCK deficiency
Green LCK in Primary immunodeficiency or monogenic inflammatory bowel disease


Level 2: Immunology
Version 8.78
Latest signed off version: v8.0 (30 Apr 2025)

review BIALLELIC, autosomal or pseudoautosomal
Sources
  • Expert Review Green
  • Other
  • NHS GMS
  • North West GLH
  • London North GLH
  • IUIS Classification February 2018
  • Victorian Clinical Genetics Services
  • ESID Registry 20171117
  • GRID V2.0
Phenotypes
  • Immunodeficiency 22, 615758
  • LCK deficiency
  • Combined immunodeficiency
  • Severe combined immunodeficiency due to LCK deficiency
  • Recurrent infections, immune dysregulation, autoimmunity
  • Immunodeficiencies affecting cellular and humoral immunity