LGI1

leucine rich glioma inactivated 1
OMIM: 604619, Gene2Phenotype

3 panels

Panel	Reviews	Mode of inheritance	Details
Filter panels 3 panels
No list LGI1 in DDG2P Version 6.447 Latest signed off version: v6.0 (30 Apr 2025) Component of the following Super Panels: Paediatric disorders	review	MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown	Sources Expert Review Removed DD-Gene2Phenotype Phenotypes AUTOSOMAL DOMINANT PARTIAL EPILEPSY WITH AUDITORY FEATURES 600512 Tags curated_removed
Green LGI1 in Early onset or syndromic epilepsy Level 2: Neurology Version 8.167 Latest signed off version: v8.0 (30 Apr 2025) Component of the following Super Panels: Paediatric disorders Unexplained death in infancy and sudden unexplained death in childhood	review	BOTH monoallelic and biallelic (but BIALLELIC mutations cause a more SEVERE disease form), autosomal or pseudoautosomal	Sources Wessex and West Midlands GLH NHS GMS NIHRBR-RD Consortium SPEED_v3.0_20170404 Expert Review Green UKGTN Phenotypes Epilepsy, familial temporal lobe, 1, OMIM:600512 developmental and epileptic encephalopathy, MONDO:0100620
Red LGI1 in Intellectual disability Level 2: Developmental disorders Version 9.345 Latest signed off version: v9.0 (30 Apr 2025) Component of the following Super Panels: Childhood onset leukodystrophy Hypotonic infant Paediatric disorders	review	BIALLELIC, autosomal or pseudoautosomal	Sources Expert Review Red Expert Review Red Phenotypes Epilepsy, familial temporal lobe, 1, OMIM:600512 developmental and epileptic encephalopathy, MONDO:0100620