PPP1R12A

protein phosphatase 1 regulatory subunit 12A
OMIM: 602021, Gene2Phenotype

6 panels

Panel Reviews Mode of inheritance Details
6 panels
Green PPP1R12A in Malformations of cortical development


Level 2: Neurology
Version 7.30
Latest signed off version: v7.0 (30 Oct 2024)

Component of the following Super Panels:

  • Cerebral malformation
  • review MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
    Sources
    • Expert Review Green
    • Literature
    Phenotypes
    • Genitourinary and/or/brain malformation syndrome, OMIM:618820
    Green PPP1R12A in Differences in sex development


    Level 2: Endocrinology
    Version 4.14
    Latest signed off version: v4.5 (1 May 2024)

    review MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
    Sources
    • Expert Review Green
    • Literature
    Phenotypes
    • Genitourinary and/or/brain malformation syndrome, 618820
    Amber PPP1R12A in Holoprosencephaly - NOT chromosomal


    Level 2: Neurology
    Version 5.7
    Latest signed off version: v5.1 (30 Oct 2024)

    Component of the following Super Panels:

  • Cerebral malformation
  • review MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
    Sources
    • Expert Review Amber
    • Expert list
    Phenotypes
    • Genitourinary and/or/brain malformation syndrome, 618820
    Tags
    • watchlist
    Red PPP1R12A in Fetal anomalies


    Level 2: Fetal (including NIPD)
    Version 6.140
    Latest signed off version: v6.0 (30 Apr 2025)

    review MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
    Sources
    • Expert Review Red
    • NHS GMS
    Phenotypes
    • holoprosencephaly
    • disorder of sex development
    • Intellectual disability
    Green PPP1R12A in DDG2P


    Version 6.424
    Latest signed off version: v6.0 (30 Apr 2025)

    Component of the following Super Panels:

  • Paediatric disorders
  • review MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
    Sources
    • DD-Gene2Phenotype
    • Expert Review Green
    Phenotypes
    • PPP1R12A-related Holoprosencephaly Spectrum and Urogenital Malformations
    Green PPP1R12A in Intellectual disability


    Level 2: Developmental disorders
    Version 9.279
    Latest signed off version: v9.0 (30 Apr 2025)

    Component of the following Super Panels:

  • Childhood onset leukodystrophy
  • Hypotonic infant
  • Paediatric disorders
  • review MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
    Sources
    • Expert Review Green
    • Expert list
    Phenotypes
    • Genitourinary and/or/brain malformation syndrome, 618820