1. Genes and Genomic Entities
  2. TRPM4

TRPM4

transient receptor potential cation channel subfamily M member 4
OMIM: 606936, Gene2Phenotype

3 panels

Panel Reviews Mode of inheritance Details
3 panels
Amber TRPM4 in Progressive cardiac conduction disease


Level 2: Cardiology
Version 2.13
Latest signed off version: v2.10 (30 Apr 2025)

Component of the following Super Panels:

  • Sudden unexplained death or survivors of a cardiac event
  • Unexplained death in infancy and sudden unexplained death in childhood

    		•  review MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
    Sources
    • South West GLH
    • London South GLH
    • Expert Review Amber
    • Wessex and West Midlands GLH
    Phenotypes
    • Progressive familial heart block, type IB, OMIM:604559
    Red TRPM4 in Short QT syndrome


    Level 2: Cardiology
    Version 3.16
    Latest signed off version: v3.14 (30 Apr 2025)

    Component of the following Super Panels:

  • Cardiac arrhythmias
  • Sudden unexplained death or survivors of a cardiac event
  • Unexplained death in infancy and sudden unexplained death in childhood

    		•  review MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
    Sources
    • North West GLH
    • Brugada syndrome (Version 1.7)
    Phenotypes
    • Progressive familial heart block, type IB (604559)
    Red TRPM4 in Brugada syndrome and cardiac sodium channel disease


    Level 2: Cardiology
    Version 3.14
    Latest signed off version: v3.12 (30 Apr 2025)

    Component of the following Super Panels:

  • Cardiac arrhythmias
  • Sudden unexplained death or survivors of a cardiac event
  • Unexplained death in infancy and sudden unexplained death in childhood

    		•  review MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
    Sources
    • Expert Review Red
    • South West GLH
    • North West GLH
    • Oxford Medical Genetics Laboratory
    Phenotypes
    • Brugada syndrome, MONDO:0015263