1. Genes and Genomic Entities
  2. TUBB2A

TUBB2A

tubulin beta 2A class IIa
OMIM: 615101, Gene2Phenotype

7 panels

Panel Reviews Mode of inheritance Details
7 panels
Red TUBB2A in Cerebral vascular malformations


Level 2: Neurology
Version 4.10
Latest signed off version: v4.0 (30 Apr 2025)

review Not set
Sources
  • Yorkshire and North East GLH
  • NHS GMS
  • Expert Review Red
  • UKGTN
Phenotypes
  • Cortical dysplasia, complex, with other brain malformations 5, OMIM:615763
  • Complex cortical dysplasia with other brain malformations 5, MONDO:0014337
Green TUBB2A in Malformations of cortical development


Level 2: Neurology
Version 7.38
Latest signed off version: v7.0 (30 Oct 2024)

Component of the following Super Panels:

  • Cerebral malformation

    		•  review MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
    Sources
    • Expert Review Green
    • UKGTN
    • Radboud University Medical Center, Nijmegen
    • Other
    Phenotypes
    • Cortical dysplasia, complex, with other brain malformations 5, OMIM:615763
    • Complex cortical dysplasia with other brain malformations 5, MONDO:0014337
    Green TUBB2A in Fetal anomalies


    Level 2: Fetal (including NIPD)
    Version 6.157
    Latest signed off version: v6.0 (30 Apr 2025)

    		review MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
    Sources
    • Expert Review Green
    • PAGE DD-Gene2Phenotype
    Phenotypes
    • Cortical dysplasia, complex, with other brain malformations 5, OMIM:615763
    • Complex cortical dysplasia with other brain malformations 5, MONDO:0014337
    Green TUBB2A in DDG2P


    Version 6.426
    Latest signed off version: v6.0 (30 Apr 2025)

    Component of the following Super Panels:

  • Paediatric disorders

    		•  review MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
    Sources
    • DD-Gene2Phenotype
    • Expert Review Green
    Phenotypes
    • CORTICAL DYSPLASIA, COMPLEX, WITH OTHER BRAIN MALFORMATIONS 5 615763
    Green TUBB2A in Early onset or syndromic epilepsy


    Level 2: Neurology
    Version 8.147
    Latest signed off version: v8.0 (30 Apr 2025)

    Component of the following Super Panels:

  • Paediatric disorders
  • Unexplained death in infancy and sudden unexplained death in childhood

    		•  review MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
    Sources
    • Expert Review Green
    • Wessex and West Midlands GLH
    • NHS GMS
    • Literature
    Phenotypes
    • Cortical dysplasia, complex, with other brain malformations 5, OMIM:615763
    • Complex cortical dysplasia with other brain malformations 5, MONDO:0014337
    Green TUBB2A in Intellectual disability


    Level 2: Developmental disorders
    Version 9.304
    Latest signed off version: v9.0 (30 Apr 2025)

    Component of the following Super Panels:

  • Childhood onset leukodystrophy
  • Hypotonic infant
  • Paediatric disorders

    		•  review MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
    Sources
    • Victorian Clinical Genetics Services
    • Expert Review Green
    Phenotypes
    • Cortical dysplasia, complex, with other brain malformations 5, OMIM:615763
    • Complex cortical dysplasia with other brain malformations 5, MONDO:0014337
    Red TUBB2A in Hereditary ataxia with onset in adulthood


    Level 2: Neurology
    Version 8.26
    Latest signed off version: v8.0 (30 Apr 2025)

    		review MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
    Sources
    • NHS GMS
    • Wessex and West Midlands GLH
    Phenotypes
    • Cortical dysplasia, complex, with other brain malformations 5, OMIM:615763
    • Complex cortical dysplasia with other brain malformations 5, MONDO:0014337