TYK2

tyrosine kinase 2
OMIM: 176941, Gene2Phenotype

4 panels

Panel Reviews Mode of inheritance Details
4 panels
Red TYK2 in Severe multi-system atopic disease with high IgE

Level 3: Atopy
Level 2: Dermatological disorders
Version 1.9

review Not set
Sources
  • Emory Genetics Laboratory
Phenotypes
  • Hyper IgE syndromes
Red TYK2 in Gastrointestinal epithelial barrier disorders

Level 3: Gastrointestinal disorders
Level 2: Gastroenterological disorders
Version 1.76

review Not set
Sources
  • Other
Phenotypes
  • Crohn disease
Green TYK2 in COVID-19 research


Level 2: Viral research
Version 1.147

review BIALLELIC, autosomal or pseudoautosomal
Sources
  • IUIS Classification February 2018
  • London North GLH
  • NHS GMS
  • GRID V2.0
  • Victorian Clinical Genetics Services
  • North West GLH
  • ESID Registry 20171117
  • Expert Review Green
  • NHS GMS
  • North West GLH
  • London North GLH
  • Expert Review Green
  • IUIS Classification February 2018
  • Victorian Clinical Genetics Services
  • ESID Registry 20171117
  • GRID V2.0
Phenotypes
  • Hyper IgE syndrome (HIES)
  • Defects in Intrinsic and Innate Immunity
  • Immunodeficiency 35 611521
  • Susceptibility to intracellular bacteria (mycobacteria, Salmonella), viruses, +/- elevated IgE
Green TYK2 in Primary immunodeficiency or monogenic inflammatory bowel disease


Level 2: Immunology
Version 8.85
Latest signed off version: v8.0 (30 Apr 2025)

review BIALLELIC, autosomal or pseudoautosomal
Sources
  • NHS GMS
  • North West GLH
  • London North GLH
  • Expert Review Green
  • IUIS Classification February 2018
  • Victorian Clinical Genetics Services
  • ESID Registry 20171117
  • GRID V2.0
Phenotypes
  • Immunodeficiency 35 611521
  • Hyper IgE syndrome (HIES)
  • Susceptibility to intracellular bacteria (mycobacteria, Salmonella), viruses, +/- elevated IgE
  • Defects in Intrinsic and Innate Immunity