1. Genes and Genomic Entities
  2. ZEB1

ZEB1

zinc finger E-box binding homeobox 1
OMIM: 189909, Gene2Phenotype

5 panels

Panel Reviews Mode of inheritance Details
5 panels
Green ZEB1 in Corneal abnormalities

Level 3: Anterior segment abnormalities
Level 2: Ophthalmological disorders
Version 1.14

review MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Sources
  • Expert Review Green
  • GDL Corneal Abnormalities panel
  • Radboud University Medical Center, Nijmegen
Phenotypes
  • Corneal dystrophy, posterior polymorphous, 3, 609141
  • Posterior polymorphous corneal dystrophy 3 (PPCD3), AD
  • Fuchs endothelial corneal dystrophy
Green ZEB1 in Corneal dystrophy


Level 2: Ophthalmology
Version 4.7
Latest signed off version: v4.0 (30 Apr 2025)

review MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Sources
  • Expert Review Green
  • Wessex and West Midlands GLH
Phenotypes
  • Corneal dystrophy, posterior polymorphous, 3 609141
  • Corneal dystrophy, Fuchs endothelial, 6 613270
Green ZEB1 in Fetal anomalies


Level 2: Fetal (including NIPD)
Version 6.140
Latest signed off version: v6.0 (30 Apr 2025)

review MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
Sources
  • NHS GMS
  • Expert Review Green
Phenotypes
  • Anomalies of the corpus callosum
Red ZEB1 in DDG2P


Version 6.424
Latest signed off version: v6.0 (30 Apr 2025)

Component of the following Super Panels:

  • Paediatric disorders

    		•  review MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
    Sources
    • DD-Gene2Phenotype
    • Expert Review Red
    Phenotypes
    • CORNEAL DYSTROPHY FUCHS ENDOTHELIAL TYPE 6 613270
    • POSTERIOR POLYMORPHOUS CORNEAL DYSTROPHY TYPE 3 609141
    Red ZEB1 in Structural eye disease


    Level 2: Ophthalmology
    Version 4.37
    Latest signed off version: v4.0 (7 Aug 2024)

    		review MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
    Sources
    • NHS GMS
    Phenotypes
    • Corneal dystrophy, Fuchs endothelial, 6, 613270
    • Corneal dystrophy, posterior polymorphous, 3, 609141