Childhood solid tumours
Gene: GPR161Removed the gene-checked tag as this gene now has a relevant phenotype associated with it in OMIM.Created: 21 Nov 2022, 4:25 p.m. | Last Modified: 21 Nov 2022, 4:25 p.m.
Panel Version: 2.38
The rating of this gene has been updated following NHS Genomic Medicine Service approval.Created: 3 Mar 2022, 11:11 a.m. | Last Modified: 3 Mar 2022, 11:11 a.m.
Panel Version: 2.25
Comment on list classification: There is enough evidence for this gene to be rated GREEN at the next major review.Created: 5 Aug 2020, 3:01 p.m. | Last Modified: 5 Aug 2020, 3:01 p.m.
Panel Version: 2.9
PMID: 31609649 (2020) - Heterozygous germline variants were identified in 6 unrelated patients with infant-onset sonic hedgehog medulloblastoma (median age, 1.5 years). No additional germline or somatic driver events were detected. 5/6 cases demonstrated biallelic inactivation of GPR151 as a result of a somatic copy-neutral loss of heterozygosity event on chromosome 1q. This event was absent among GPR161 wild-type medulloblastoma tumours.
PMID: 29386106 (2018) - Loss of Gpr161 activity was consistent with medulloblastoma pathogenesis in a mouse model, where Gpr161 deletion increased downstream activity of the sonic hedgehog pathway. Earlier deletion of Gpr161 during embryogenesis increased tumour incidence and severity.
Sources: LiteratureCreated: 5 Aug 2020, 3 p.m.
Mode of inheritance
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
Phenotypes
Medulloblastoma predisposition
Publications
Phenotypes for gene: GPR161 were changed from Medulloblastoma predisposition to {Medulloblastoma predisposition syndrome}, OMIM:155255
Tag gene-checked was removed from gene: GPR161.
Tag gene-checked tag was added to gene: GPR161.
Tag for-review was removed from gene: GPR161.
Source Expert Review Green was added to GPR161. Rating Changed from Amber List (moderate evidence) to Green List (high evidence)
Gene: gpr161 has been classified as Amber List (Moderate Evidence).
Tag for-review tag was added to gene: GPR161.
gene: GPR161 was added gene: GPR161 was added to Tumour predisposition - childhood onset. Sources: Literature Mode of inheritance for gene: GPR161 was set to MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown Publications for gene: GPR161 were set to 29386106; 31609649 Phenotypes for gene: GPR161 were set to Medulloblastoma predisposition Review for gene: GPR161 was set to GREEN