Respiratory ciliopathies including non-CF bronchiectasis
Gene: TTC25Added new-gene-name tag, new approved HGNC gene symbol for TTC25 is ODAD4Created: 24 Feb 2021, 5:11 p.m. | Last Modified: 24 Feb 2021, 5:11 p.m.
Panel Version: 1.43
On Royal Brompton diagnostic panel, although no pathogenic variants found as yet. Gene codes for ODA complex protein and Wallmeier et al 2016 paper is very good evidence for rare cause of PCD.Created: 21 Aug 2019, 7:01 p.m. | Last Modified: 21 Aug 2019, 7:01 p.m.
Panel Version: 0.150
Mode of inheritance
BIALLELIC, autosomal or pseudoautosomal
Phenotypes
Ciliary dyskinesia, primary, 35
Publications
Variants in this GENE are reported as part of current diagnostic practice
Initial gene list and info collated by Ian Berry Leeds Genetics Laboratory November 2018 on behalf of the GMS Respiratory specialist test group. Gene Symbol submitted: TTC25; Suggested initial gene rating: Green; Evidence for inclusion: OMIM PCD gene or intersection of >2 panels; Evidence for exclusion: none given; Technical notes (e.g. non-coding/CNV mutations requiring coverage?): none givenCreated: 5 Dec 2018, 1:54 p.m.
Phenotypes for gene: TTC25 were changed from Ciliary dyskinesia, primary 35, 617092 to Ciliary dyskinesia, primary, 35, OMIM:617092
Publications for gene: TTC25 were set to 27486780
Tag new-gene-name tag was added to gene: TTC25.
Phenotypes for gene: TTC25 were changed from to Ciliary dyskinesia, primary 35, 617092
Publications for gene: TTC25 were set to
Mode of inheritance for gene: TTC25 was changed from to BIALLELIC, autosomal or pseudoautosomal
Source Expert Review Green was added to TTC25. Rating Changed from Red List (low evidence) to Green List (high evidence)
gene: TTC25 was added gene: TTC25 was added to Respiratory ciliopathies including non-CF bronchiectasis. Sources: NHS GMS Mode of inheritance for gene: TTC25 was set to