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[
{
"created": "2023-03-22T16:23:31.945683Z",
"panel_name": "Inherited ovarian cancer (without breast cancer)",
"panel_id": 143,
"panel_version": "4.1",
"user_name": "Arina Puzriakova",
"item_type": "panel",
"text": "Panel version 4.0 has been signed off on 2023-03-22",
"entity_name": null,
"entity_type": null
},
{
"created": "2023-03-22T16:23:01.238951Z",
"panel_name": "Inherited ovarian cancer (without breast cancer)",
"panel_id": 143,
"panel_version": "4.0",
"user_name": "Arina Puzriakova",
"item_type": "panel",
"text": "promoted panel to version 4.0",
"entity_name": null,
"entity_type": null
},
{
"created": "2023-01-30T17:40:50.141662Z",
"panel_name": "Inherited ovarian cancer (without breast cancer)",
"panel_id": 143,
"panel_version": "3.3",
"user_name": "Arina Puzriakova",
"item_type": "entity",
"text": "Tag Q2_22_MOI was removed from gene: BRCA1.\nTag Q2_22_expert_review was removed from gene: BRCA1.",
"entity_name": "BRCA1",
"entity_type": "gene"
},
{
"created": "2023-01-30T17:39:53.175987Z",
"panel_name": "Inherited ovarian cancer (without breast cancer)",
"panel_id": 143,
"panel_version": "3.3",
"user_name": "Arina Puzriakova",
"item_type": "entity",
"text": "commented on gene: BRCA1: The mode of inheritance of this gene has been updated to 'BOTH monoallelic and biallelic, autosomal or pseudoautosomal' following NHS Genomic Medicine Service approval.",
"entity_name": "BRCA1",
"entity_type": "gene"
},
{
"created": "2023-01-30T17:39:39.456796Z",
"panel_name": "Inherited ovarian cancer (without breast cancer)",
"panel_id": 143,
"panel_version": "3.2",
"user_name": "Arina Puzriakova",
"item_type": "entity",
"text": "Mode of inheritance for gene BRCA1 was changed from MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted to BOTH monoallelic and biallelic, autosomal or pseudoautosomal",
"entity_name": "BRCA1",
"entity_type": "gene"
},
{
"created": "2022-11-30T14:21:03.536676Z",
"panel_name": "Inherited ovarian cancer (without breast cancer)",
"panel_id": 143,
"panel_version": "3.1",
"user_name": "Eleanor Williams",
"item_type": "panel",
"text": "Panel version 3.0 has been signed off on 2022-11-30",
"entity_name": null,
"entity_type": null
},
{
"created": "2022-11-30T14:20:23.365226Z",
"panel_name": "Inherited ovarian cancer (without breast cancer)",
"panel_id": 143,
"panel_version": "3.0",
"user_name": "Eleanor Williams",
"item_type": "panel",
"text": "promoted panel to version 3.0",
"entity_name": null,
"entity_type": null
},
{
"created": "2022-06-09T09:58:21.563223Z",
"panel_name": "Inherited ovarian cancer (without breast cancer)",
"panel_id": 143,
"panel_version": "2.28",
"user_name": "Sarah Leigh",
"item_type": "entity",
"text": "changed review comment from: Comment on phenotypes: Association of BRIP1 and breast cancer has been refuted (https://search.clinicalgenome.org/kb/gene-validity/CGGCIEX:assertion_9910)\r\n{Breast cancer, early-onset, susceptibility to}, OMIM:114480;Hereditary breast carcinoma, MONDO:0016419; to: Comment on phenotypes: Association of BRIP1 and breast cancer has been refuted (https://search.clinicalgenome.org/kb/gene-validity/CGGCIEX:assertion_9910)\r\n{Breast cancer, early-onset, susceptibility to}, OMIM:114480;Hereditary breast carcinoma, MONDO:0016419. However, in PMID:31822495 they report very rare BRIP1 missense germline variants (minor allele frequency < 0.0001) in nearly 2% of 2,160 early-onset breast cancer and 1,199 ovarian cancer patients. Functional studies on 20 of these variants revealed 75% resulted in protein hypomorph or null products. The authors also reported that in a clinical cohort of >117,000 breast and ovarian cancer patients, the combined odds ratio associated with BRIP1 hypomorph or null missense carriers compared to the general population was 2.30 (95%CI=1.60-3.30, p<0.0001). ",
"entity_name": "BRIP1",
"entity_type": "gene"
},
{
"created": "2022-06-09T09:45:30.074095Z",
"panel_name": "Inherited ovarian cancer (without breast cancer)",
"panel_id": 143,
"panel_version": "2.28",
"user_name": "Sarah Leigh",
"item_type": "entity",
"text": "changed review comment from: Comment on phenotypes: Association of BRIP1 and breast cancer has been refuted (https://search.clinicalgenome.org/kb/gene-validity/CGGCIEX:assertion_9910)\r\n{Breast cancer, early-onset, susceptibility to}, OMIM:114480;Hereditary breast carcinoma, MONDO:0016419; to: Comment on phenotypes: Association of BRIP1 and breast cancer has been refuted (https://search.clinicalgenome.org/kb/gene-validity/CGGCIEX:assertion_9910)\r\n{Breast cancer, early-onset, susceptibility to}, OMIM:114480;Hereditary breast carcinoma, MONDO:0016419",
"entity_name": "BRIP1",
"entity_type": "gene"
},
{
"created": "2022-06-09T09:44:37.858755Z",
"panel_name": "Inherited ovarian cancer (without breast cancer)",
"panel_id": 143,
"panel_version": "2.28",
"user_name": "Sarah Leigh",
"item_type": "entity",
"text": "Publications for gene: BRIP1 were set to 26315354; 21964575; 29661970",
"entity_name": "BRIP1",
"entity_type": "gene"
},
{
"created": "2022-06-09T09:34:48.775678Z",
"panel_name": "Inherited ovarian cancer (without breast cancer)",
"panel_id": 143,
"panel_version": "2.27",
"user_name": "Sarah Leigh",
"item_type": "entity",
"text": "Phenotypes for gene: BRIP1 were changed from ovarian epithelial tumor, MONDO:0002229 to familial ovarian cancer, MONDO:0016248",
"entity_name": "BRIP1",
"entity_type": "gene"
},
{
"created": "2022-04-12T07:31:22.866977Z",
"panel_name": "Inherited ovarian cancer (without breast cancer)",
"panel_id": 143,
"panel_version": "2.26",
"user_name": "Sarah Leigh",
"item_type": "entity",
"text": "Added comment: Comment on phenotypes: Association of BRIP1 and breast cancer has been refuted (https://search.clinicalgenome.org/kb/gene-validity/CGGCIEX:assertion_9910)\r\n{Breast cancer, early-onset, susceptibility to}, OMIM:114480;Hereditary breast carcinoma, MONDO:0016419",
"entity_name": "BRIP1",
"entity_type": "gene"
},
{
"created": "2022-04-12T07:31:22.837904Z",
"panel_name": "Inherited ovarian cancer (without breast cancer)",
"panel_id": 143,
"panel_version": "2.26",
"user_name": "Sarah Leigh",
"item_type": "entity",
"text": "Phenotypes for gene: BRIP1 were changed from {Breast cancer, early-onset, susceptibility to}, OMIM:114480; Hereditary breast carcinoma, MONDO:0016419 to ovarian epithelial tumor, MONDO:0002229",
"entity_name": "BRIP1",
"entity_type": "gene"
},
{
"created": "2022-04-04T11:11:28.252089Z",
"panel_name": "Inherited ovarian cancer (without breast cancer)",
"panel_id": 143,
"panel_version": "2.25",
"user_name": "Arina Puzriakova",
"item_type": "entity",
"text": "Tag Q2_22_MOI tag was added to gene: BRCA1.\nTag Q2_22_expert_review tag was added to gene: BRCA1.",
"entity_name": "BRCA1",
"entity_type": "gene"
},
{
"created": "2022-04-04T11:10:56.733259Z",
"panel_name": "Inherited ovarian cancer (without breast cancer)",
"panel_id": 143,
"panel_version": "2.25",
"user_name": "Arina Puzriakova",
"item_type": "entity",
"text": "Added comment: Comment on mode of inheritance: Although more rare, biallelic BRCA1 variants have been shown to also confer breast and ovarian cancer susceptibility (with or without FA‐like features), and multiple such cases have been reported worldwide (PMIDs: 23269703; 25472942; 31347298; 33477375). There are at least two unrelated individuals in literature who were diagnosed with ovarian carcinoma in association with biallelic germline BRCA1 variants.\r\n\r\nThis may warrant an MOI change from 'monoallelic' to 'both mono- and biallelic' to ensure these rarer cases are not missed; however this will be flagged for further review to confirm whether the GMS expert group agrees with the change.",
"entity_name": "BRCA1",
"entity_type": "gene"
},
{
"created": "2022-04-04T11:10:56.716327Z",
"panel_name": "Inherited ovarian cancer (without breast cancer)",
"panel_id": 143,
"panel_version": "2.25",
"user_name": "Arina Puzriakova",
"item_type": "entity",
"text": "Mode of inheritance for gene: BRCA1 was changed from MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted",
"entity_name": "BRCA1",
"entity_type": "gene"
},
{
"created": "2022-03-03T11:04:22.414931Z",
"panel_name": "Inherited ovarian cancer (without breast cancer)",
"panel_id": 143,
"panel_version": "2.24",
"user_name": "Arina Puzriakova",
"item_type": "entity",
"text": "Tag for-review was removed from gene: PALB2.",
"entity_name": "PALB2",
"entity_type": "gene"
},
{
"created": "2022-03-03T11:04:00.000094Z",
"panel_name": "Inherited ovarian cancer (without breast cancer)",
"panel_id": 143,
"panel_version": "2.24",
"user_name": "Arina Puzriakova",
"item_type": "entity",
"text": "edited their review of gene: PALB2: Added comment: The rating of this gene has been updated following NHS Genomic Medicine Service approval. It was agreed that there is enough evidence to rate this gene as Green.; Changed rating: GREEN",
"entity_name": "PALB2",
"entity_type": "gene"
},
{
"created": "2022-03-03T11:03:11.573253Z",
"panel_name": "Inherited ovarian cancer (without breast cancer)",
"panel_id": 143,
"panel_version": "2.23",
"user_name": "Arina Puzriakova",
"item_type": "entity",
"text": "Source Expert Review Green was added to PALB2.\nRating Changed from Red List (low evidence) to Green List (high evidence)",
"entity_name": "PALB2",
"entity_type": "gene"
},
{
"created": "2021-11-11T16:55:53.634845Z",
"panel_name": "Inherited ovarian cancer (without breast cancer)",
"panel_id": 143,
"panel_version": "2.22",
"user_name": "Arina Puzriakova",
"item_type": "entity",
"text": "Phenotypes for gene: AR were changed from Androgen insensitivity, 300068; Spinal and bulbar muscular atrophy of Kennedy, 313200; Androgen insensitivity, partial, with or without breast cancer, 312300; {Prostate cancer, susceptibility to}, 176807; Hypospadias 1, X-linked, 300633 to Androgen insensitivity, OMIM:300068; Androgen insensitivity, partial, with or without breast cancer, OMIM:312300",
"entity_name": "AR",
"entity_type": "gene"
},
{
"created": "2021-07-15T09:17:52.221075Z",
"panel_name": "Inherited ovarian cancer (without breast cancer)",
"panel_id": 143,
"panel_version": "2.21",
"user_name": "Arina Puzriakova",
"item_type": "entity",
"text": "Phenotypes for gene: ATM were changed from Ataxia-telangiectasia, 208900; Lymphoma, B-cell non-Hodgkin, somatic; {Breast cancer, susceptibility to}, 114480; Lymphoma, mantle cell; T-cell prolymphocytic leukemia, somatic; Breast and Ovarian Cancer to {Breast cancer, susceptibility to}, OMIM:114480",
"entity_name": "ATM",
"entity_type": "gene"
},
{
"created": "2021-03-03T14:31:36.148911Z",
"panel_name": "Inherited ovarian cancer (without breast cancer)",
"panel_id": 143,
"panel_version": "2.20",
"user_name": "Arina Puzriakova",
"item_type": "entity",
"text": "changed review comment from: Comment on phenotypes: This gene is also associated with Colorectal cancer, hereditary nonpolyposis, type 2 (MIM# 6093100; Mismatch repair cancer syndrome 1 (MIM# 276300); Muir-Torre syndrome (MIM# 158320); to: Comment on phenotypes: This gene is also associated with Colorectal cancer, hereditary nonpolyposis, type 2 (MIM# 609310); Mismatch repair cancer syndrome 1 (MIM# 276300); Muir-Torre syndrome (MIM# 158320)",
"entity_name": "MLH1",
"entity_type": "gene"
},
{
"created": "2021-03-03T13:58:11.192570Z",
"panel_name": "Inherited ovarian cancer (without breast cancer)",
"panel_id": 143,
"panel_version": "2.20",
"user_name": "Arina Puzriakova",
"item_type": "entity",
"text": "changed review comment from: Comment on phenotypes: This gene is also associated with {Breast cancer, male, susceptibility to} (MIM# 114480); Prostate cancer (MIM# 176807); Wilms tumor (MIM# 194070); {Medulloblastoma} (MIM# 155255); {Glioblastoma 3} (MIM# 613029); Fanconi anemia, complementation group D1 (MIM# 605724); to: Comment on phenotypes: This gene is also associated with {Breast cancer, male, susceptibility to} (MIM# 114480); Prostate cancer (MIM# 176807); {Pancreatic cancer 2} (MIM# 613347); Wilms tumor (MIM# 194070); {Medulloblastoma} (MIM# 155255); {Glioblastoma 3} (MIM# 613029); Fanconi anemia, complementation group D1 (MIM# 605724)",
"entity_name": "BRCA2",
"entity_type": "gene"
},
{
"created": "2021-03-03T12:33:16.303648Z",
"panel_name": "Inherited ovarian cancer (without breast cancer)",
"panel_id": 143,
"panel_version": "2.20",
"user_name": "Arina Puzriakova",
"item_type": "entity",
"text": "Added comment: Comment on phenotypes: This gene is also associated with Colorectal cancer, hereditary nonpolyposis, type 4 (MIM# 614337); Mismatch repair cancer syndrome 4 (MIM# 619101)",
"entity_name": "PMS2",
"entity_type": "gene"
},
{
"created": "2021-03-03T12:33:16.276587Z",
"panel_name": "Inherited ovarian cancer (without breast cancer)",
"panel_id": 143,
"panel_version": "2.20",
"user_name": "Arina Puzriakova",
"item_type": "entity",
"text": "Phenotypes for gene: PMS2 were changed from Breast and Ovarian Cancer to Ovarian cancer, MONDO:0008170",
"entity_name": "PMS2",
"entity_type": "gene"
},
{
"created": "2021-03-03T12:30:36.510076Z",
"panel_name": "Inherited ovarian cancer (without breast cancer)",
"panel_id": 143,
"panel_version": "2.19",
"user_name": "Arina Puzriakova",
"item_type": "entity",
"text": "Phenotypes for gene: RAD51D were changed from {Breast-ovarian cancer, familial, susceptibility to, 4}, 614291; Breast and Ovarian Cancer; Breast and Ovarian Cancer Susceptibility to {Breast-ovarian cancer, familial, susceptibility to, 4}, OMIM:614291; Breast-ovarian cancer, familial, susceptibility to, 4, MONDO:0013669",
"entity_name": "RAD51D",
"entity_type": "gene"
},
{
"created": "2021-03-03T12:30:08.469476Z",
"panel_name": "Inherited ovarian cancer (without breast cancer)",
"panel_id": 143,
"panel_version": "2.18",
"user_name": "Arina Puzriakova",
"item_type": "entity",
"text": "Publications for gene: RAD51D were set to ",
"entity_name": "RAD51D",
"entity_type": "gene"
},
{
"created": "2021-03-03T12:29:18.994646Z",
"panel_name": "Inherited ovarian cancer (without breast cancer)",
"panel_id": 143,
"panel_version": "2.17",
"user_name": "Arina Puzriakova",
"item_type": "entity",
"text": "Added comment: Comment on phenotypes: This gene is also associated with Fanconi anemia, complementation group O (MIM# 613390)",
"entity_name": "RAD51C",
"entity_type": "gene"
},
{
"created": "2021-03-03T12:29:18.973910Z",
"panel_name": "Inherited ovarian cancer (without breast cancer)",
"panel_id": 143,
"panel_version": "2.17",
"user_name": "Arina Puzriakova",
"item_type": "entity",
"text": "Phenotypes for gene: RAD51C were changed from Fanconi anemia, complementation group O, 613390; {Breast-ovarian cancer, familial, susceptibility to, 3}, 613399; Breast and Ovarian Cancer; Breast and Ovarian Cancer Susceptibility to {Breast-ovarian cancer, familial, susceptibility to, 3}, OMIM:613399; Breast-ovarian cancer, familial, susceptibility to, 3, MONDO:0013253",
"entity_name": "RAD51C",
"entity_type": "gene"
},
{
"created": "2021-03-03T12:27:06.778467Z",
"panel_name": "Inherited ovarian cancer (without breast cancer)",
"panel_id": 143,
"panel_version": "2.16",
"user_name": "Arina Puzriakova",
"item_type": "entity",
"text": "Publications for gene: RAD51C were set to ",
"entity_name": "RAD51C",
"entity_type": "gene"
},
{
"created": "2021-03-03T12:24:44.643519Z",
"panel_name": "Inherited ovarian cancer (without breast cancer)",
"panel_id": 143,
"panel_version": "2.15",
"user_name": "Arina Puzriakova",
"item_type": "entity",
"text": "Added comment: Comment on phenotypes: This gene is also associated with {Endometrial cancer, familial} (MIM# 608089); Colorectal cancer, hereditary nonpolyposis, type 5 (MIM# 614350); Mismatch repair cancer syndrome 2 (MIM# 619097)",
"entity_name": "MSH6",
"entity_type": "gene"
},
{
"created": "2021-03-03T12:24:44.616113Z",
"panel_name": "Inherited ovarian cancer (without breast cancer)",
"panel_id": 143,
"panel_version": "2.15",
"user_name": "Arina Puzriakova",
"item_type": "entity",
"text": "Phenotypes for gene: MSH6 were changed from Breast and Ovarian Cancer to Ovarian cancer, MONDO:0008170",
"entity_name": "MSH6",
"entity_type": "gene"
},
{
"created": "2021-03-03T12:23:06.666418Z",
"panel_name": "Inherited ovarian cancer (without breast cancer)",
"panel_id": 143,
"panel_version": "2.14",
"user_name": "Arina Puzriakova",
"item_type": "entity",
"text": "Publications for gene: MSH6 were set to ",
"entity_name": "MSH6",
"entity_type": "gene"
},
{
"created": "2021-03-03T12:21:47.175630Z",
"panel_name": "Inherited ovarian cancer (without breast cancer)",
"panel_id": 143,
"panel_version": "2.13",
"user_name": "Arina Puzriakova",
"item_type": "entity",
"text": "Added comment: Comment on phenotypes: This gene is also associated with Colorectal cancer, hereditary nonpolyposis, type 1 (MIM# 120435); Mismatch repair cancer syndrome 2 (MIM# 619096); Muir-Torre syndrome (MIM# 158320)",
"entity_name": "MSH2",
"entity_type": "gene"
},
{
"created": "2021-03-03T12:21:47.143739Z",
"panel_name": "Inherited ovarian cancer (without breast cancer)",
"panel_id": 143,
"panel_version": "2.13",
"user_name": "Arina Puzriakova",
"item_type": "entity",
"text": "Phenotypes for gene: MSH2 were changed from Breast and Ovarian Cancer to Ovarian cancer, MONDO:0008170",
"entity_name": "MSH2",
"entity_type": "gene"
},
{
"created": "2021-03-03T12:19:59.835739Z",
"panel_name": "Inherited ovarian cancer (without breast cancer)",
"panel_id": 143,
"panel_version": "2.12",
"user_name": "Arina Puzriakova",
"item_type": "entity",
"text": "Publications for gene: MSH2 were set to ",
"entity_name": "MSH2",
"entity_type": "gene"
},
{
"created": "2021-03-03T12:18:31.927677Z",
"panel_name": "Inherited ovarian cancer (without breast cancer)",
"panel_id": 143,
"panel_version": "2.11",
"user_name": "Arina Puzriakova",
"item_type": "entity",
"text": "Added comment: Comment on phenotypes: This gene is also associated with Colorectal cancer, hereditary nonpolyposis, type 2 (MIM# 6093100; Mismatch repair cancer syndrome 1 (MIM# 276300); Muir-Torre syndrome (MIM# 158320)",
"entity_name": "MLH1",
"entity_type": "gene"
},
{
"created": "2021-03-03T12:18:31.900155Z",
"panel_name": "Inherited ovarian cancer (without breast cancer)",
"panel_id": 143,
"panel_version": "2.11",
"user_name": "Arina Puzriakova",
"item_type": "entity",
"text": "Phenotypes for gene: MLH1 were changed from Adult Glioma; Colorectal; Endometrial Carcinoma; Hepatopancreatobiliary; Ovarian to Ovarian cancer, MONDO:0008170",
"entity_name": "MLH1",
"entity_type": "gene"
},
{
"created": "2021-03-03T11:59:28.771401Z",
"panel_name": "Inherited ovarian cancer (without breast cancer)",
"panel_id": 143,
"panel_version": "2.10",
"user_name": "Arina Puzriakova",
"item_type": "entity",
"text": "Publications for gene: MLH1 were set to ",
"entity_name": "MLH1",
"entity_type": "gene"
},
{
"created": "2021-03-03T11:58:47.721786Z",
"panel_name": "Inherited ovarian cancer (without breast cancer)",
"panel_id": 143,
"panel_version": "2.9",
"user_name": "Arina Puzriakova",
"item_type": "entity",
"text": "Added comment: Comment on phenotypes: This gene is also associated with Fanconi anemia, complementation group J (MIM# 609054)",
"entity_name": "BRIP1",
"entity_type": "gene"
},
{
"created": "2021-03-03T11:58:47.700409Z",
"panel_name": "Inherited ovarian cancer (without breast cancer)",
"panel_id": 143,
"panel_version": "2.9",
"user_name": "Arina Puzriakova",
"item_type": "entity",
"text": "Phenotypes for gene: BRIP1 were changed from ?Breast cancer, early-onset, 114480; Fanconi anemia, complementation group J, 609054; Breast and Ovarian Cancer; Breast Cancer to {Breast cancer, early-onset, susceptibility to}, OMIM:114480; Hereditary breast carcinoma, MONDO:0016419",
"entity_name": "BRIP1",
"entity_type": "gene"
},
{
"created": "2021-03-03T11:55:24.993714Z",
"panel_name": "Inherited ovarian cancer (without breast cancer)",
"panel_id": 143,
"panel_version": "2.8",
"user_name": "Arina Puzriakova",
"item_type": "entity",
"text": "Publications for gene: BRIP1 were set to ",
"entity_name": "BRIP1",
"entity_type": "gene"
},
{
"created": "2021-03-03T11:53:52.203238Z",
"panel_name": "Inherited ovarian cancer (without breast cancer)",
"panel_id": 143,
"panel_version": "2.7",
"user_name": "Arina Puzriakova",
"item_type": "entity",
"text": "Added comment: Comment on phenotypes: This gene is also associated with {Breast cancer, male, susceptibility to} (MIM# 114480); Prostate cancer (MIM# 176807); Wilms tumor (MIM# 194070); {Medulloblastoma} (MIM# 155255); {Glioblastoma 3} (MIM# 613029); Fanconi anemia, complementation group D1 (MIM# 605724)",
"entity_name": "BRCA2",
"entity_type": "gene"
},
{
"created": "2021-03-03T11:53:52.174839Z",
"panel_name": "Inherited ovarian cancer (without breast cancer)",
"panel_id": 143,
"panel_version": "2.7",
"user_name": "Arina Puzriakova",
"item_type": "entity",
"text": "Phenotypes for gene: BRCA2 were changed from {Breast-ovarian cancer, familial, 2}, 612555; Fanconi anemia, complementation group D1, 605724; Prostate cancer, 176807; {Breast cancer, male, susceptibility to}, 114480; Wilms tumor, 194070; {Medulloblastoma}, 155255; {Glioblastoma 3},; Hereditary Breast and Ovarian Cancer ; Hereditary Breast and Ovarian Cancer Syndrome; Breast and Ovarian Cancer; High Risk Breast Cancer ; Breast cancer to {Breast-ovarian cancer, familial, 2}, OMIM:612555; Hereditary breast ovarian cancer syndrome, MONDO:0003582",
"entity_name": "BRCA2",
"entity_type": "gene"
},
{
"created": "2021-03-03T11:46:39.406322Z",
"panel_name": "Inherited ovarian cancer (without breast cancer)",
"panel_id": 143,
"panel_version": "2.6",
"user_name": "Arina Puzriakova",
"item_type": "entity",
"text": "Added comment: Comment on phenotypes: This gene is also associated with 'Pancreatic cancer, susceptibility to, 4' (MIM# 614320) and 'Fanconi anemia, complementation group S' (MIM# 617883)",
"entity_name": "BRCA1",
"entity_type": "gene"
},
{
"created": "2021-03-03T11:46:39.378675Z",
"panel_name": "Inherited ovarian cancer (without breast cancer)",
"panel_id": 143,
"panel_version": "2.6",
"user_name": "Arina Puzriakova",
"item_type": "entity",
"text": "Phenotypes for gene: BRCA1 were changed from {Breast-ovarian cancer, familial, 1}, 604370; {Pancreatic cancer, susceptibility to, 4}, 614320; Hereditary Breast and Ovarian Cancer ; Hereditary Breast and Ovarian Cancer Syndrome; Breast and Ovarian Cancer; High Risk Breast Cancer ; Breast cancer to {Breast-ovarian cancer, familial, 1}, OMIM:604370; Hereditary breast ovarian cancer syndrome, MONDO:0003582",
"entity_name": "BRCA1",
"entity_type": "gene"
},
{
"created": "2020-12-01T11:08:42.330038Z",
"panel_name": "Inherited ovarian cancer (without breast cancer)",
"panel_id": 143,
"panel_version": "2.5",
"user_name": "Arina Puzriakova",
"item_type": "entity",
"text": "Tag for-review tag was added to gene: PALB2.",
"entity_name": "PALB2",
"entity_type": "gene"
},
{
"created": "2020-12-01T11:08:22.287827Z",
"panel_name": "Inherited ovarian cancer (without breast cancer)",
"panel_id": 143,
"panel_version": "2.5",
"user_name": "Arina Puzriakova",
"item_type": "entity",
"text": "changed review comment from: Comment on list classification: Kept rating Red, as it remains unclear whether the risk is sufficiently high to warrant the inclusion of PALB2 in the ovarian cancer gene panel.; to: Comment on list classification: Kept rating Red, but this gene will be flagged for review (added 'for-review' tag) at the next GMS panel update to assess whether the risk is sufficiently high to warrant inclusion of PALB2 on the ovarian cancer gene panel in the context of two recent publications (PMIDs: 31841383 and 32546565) identified by the expert reviewer.",
"entity_name": "PALB2",
"entity_type": "gene"
},
{
"created": "2020-11-25T09:39:16.797191Z",
"panel_name": "Inherited ovarian cancer (without breast cancer)",
"panel_id": 143,
"panel_version": "2.5",
"user_name": "marc tischkowitz",
"item_type": "entity",
"text": "commented on gene: PALB2: From the key paper (Yang 2020):\r\nTable 3 - 16% risk to age 80 ( 95% CI 8-28%) if 2 first degree relatives affected at age 50, 11% risk to age 80 (95% CI 6-21) if mother and maternal grandmother diagnosed at age 50. \r\n\r\nTherefore clinically actionable if there is a strong family history.\r\n\r\nThis paper and that of Song 2020 supersede previous published studies which are based on many fewer cases.",
"entity_name": "PALB2",
"entity_type": "gene"
},
{
"created": "2020-10-27T15:29:10.887296Z",
"panel_name": "Inherited ovarian cancer (without breast cancer)",
"panel_id": 143,
"panel_version": "2.5",
"user_name": "Arina Puzriakova",
"item_type": "entity",
"text": "Publications for gene: PALB2 were set to ",
"entity_name": "PALB2",
"entity_type": "gene"
},
{
"created": "2020-10-27T15:28:51.567154Z",
"panel_name": "Inherited ovarian cancer (without breast cancer)",
"panel_id": 143,
"panel_version": "2.4",
"user_name": "Arina Puzriakova",
"item_type": "entity",
"text": "Classified gene: PALB2 as Red List (low evidence)",
"entity_name": "PALB2",
"entity_type": "gene"
},
{
"created": "2020-10-27T15:28:51.561653Z",
"panel_name": "Inherited ovarian cancer (without breast cancer)",
"panel_id": 143,
"panel_version": "2.4",
"user_name": "Arina Puzriakova",
"item_type": "entity",
"text": "Added comment: Comment on list classification: Kept rating Red, as it remains unclear whether the risk is sufficiently high to warrant the inclusion of PALB2 in the ovarian cancer gene panel.",
"entity_name": "PALB2",
"entity_type": "gene"
},
{
"created": "2020-10-27T15:28:51.532529Z",
"panel_name": "Inherited ovarian cancer (without breast cancer)",
"panel_id": 143,
"panel_version": "2.4",
"user_name": "Arina Puzriakova",
"item_type": "entity",
"text": "Gene: palb2 has been classified as Red List (Low Evidence).",
"entity_name": "PALB2",
"entity_type": "gene"
},
{
"created": "2020-10-27T15:26:53.253278Z",
"panel_name": "Inherited ovarian cancer (without breast cancer)",
"panel_id": 143,
"panel_version": "2.3",
"user_name": "Arina Puzriakova",
"item_type": "entity",
"text": "reviewed gene: PALB2: Rating: ; Mode of pathogenicity: None; Publications: ; Phenotypes: ; Mode of inheritance: MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted",
"entity_name": "PALB2",
"entity_type": "gene"
},
{
"created": "2020-10-14T13:25:55.714670Z",
"panel_name": "Inherited ovarian cancer (without breast cancer)",
"panel_id": 143,
"panel_version": "2.3",
"user_name": "marc tischkowitz",
"item_type": "entity",
"text": "reviewed gene: PALB2: Rating: GREEN; Mode of pathogenicity: Loss-of-function variants (as defined in pop up message) DO NOT cause this phenotype - please provide details in the comments; Publications: PMID: 31841383: PMID: 32546565; Phenotypes: breast cancer, ovarian cancer, pancreatic cancer; Mode of inheritance: MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted; Current diagnostic: yes",
"entity_name": "PALB2",
"entity_type": "gene"
},
{
"created": "2020-03-04T11:04:16.259614Z",
"panel_name": "Inherited ovarian cancer (without breast cancer)",
"panel_id": 143,
"panel_version": "2.3",
"user_name": "Catherine Snow",
"item_type": "panel",
"text": "Panel version has been signed off",
"entity_name": null,
"entity_type": null
},
{
"created": "2019-08-16T09:48:34.598314Z",
"panel_name": "Inherited ovarian cancer (without breast cancer)",
"panel_id": 143,
"panel_version": "2.0",
"user_name": "Ivone Leong",
"item_type": "panel",
"text": "promoted panel to version 2.0",
"entity_name": null,
"entity_type": null
},
{
"created": "2019-08-16T09:46:51.315072Z",
"panel_name": "Inherited ovarian cancer (without breast cancer)",
"panel_id": 143,
"panel_version": "1.10",
"user_name": "Ivone Leong",
"item_type": "panel",
"text": "Panel types changed to Rare Disease 100K; GMS Rare Disease; GMS signed-off",
"entity_name": null,
"entity_type": null
},
{
"created": "2019-07-31T12:24:47.410220Z",
"panel_name": "Inherited ovarian cancer (without breast cancer)",
"panel_id": 143,
"panel_version": "1.9",
"user_name": "Ivone Leong",
"item_type": "entity",
"text": "commented on gene: PMS2",
"entity_name": "PMS2",
"entity_type": "gene"
},
{
"created": "2019-07-31T12:24:07.921394Z",
"panel_name": "Inherited ovarian cancer (without breast cancer)",
"panel_id": 143,
"panel_version": "1.9",
"user_name": "Ivone Leong",
"item_type": "entity",
"text": "commented on gene: RAD51D",
"entity_name": "RAD51D",
"entity_type": "gene"
},
{
"created": "2019-07-31T12:24:03.527958Z",
"panel_name": "Inherited ovarian cancer (without breast cancer)",
"panel_id": 143,
"panel_version": "1.9",
"user_name": "Ivone Leong",
"item_type": "entity",
"text": "commented on gene: RAD51C",
"entity_name": "RAD51C",
"entity_type": "gene"
},
{
"created": "2019-07-31T12:24:00.235761Z",
"panel_name": "Inherited ovarian cancer (without breast cancer)",
"panel_id": 143,
"panel_version": "1.9",
"user_name": "Ivone Leong",
"item_type": "entity",
"text": "commented on gene: MSH6",
"entity_name": "MSH6",
"entity_type": "gene"
},
{
"created": "2019-07-31T12:23:55.901853Z",
"panel_name": "Inherited ovarian cancer (without breast cancer)",
"panel_id": 143,
"panel_version": "1.9",
"user_name": "Ivone Leong",
"item_type": "entity",
"text": "commented on gene: MSH2",
"entity_name": "MSH2",
"entity_type": "gene"
},
{
"created": "2019-07-31T12:23:52.323943Z",
"panel_name": "Inherited ovarian cancer (without breast cancer)",
"panel_id": 143,
"panel_version": "1.9",
"user_name": "Ivone Leong",
"item_type": "entity",
"text": "commented on gene: MLH1",
"entity_name": "MLH1",
"entity_type": "gene"
},
{
"created": "2019-07-31T12:23:48.117967Z",
"panel_name": "Inherited ovarian cancer (without breast cancer)",
"panel_id": 143,
"panel_version": "1.9",
"user_name": "Ivone Leong",
"item_type": "entity",
"text": "commented on gene: BRIP1",
"entity_name": "BRIP1",
"entity_type": "gene"
},
{
"created": "2019-07-31T12:23:41.968303Z",
"panel_name": "Inherited ovarian cancer (without breast cancer)",
"panel_id": 143,
"panel_version": "1.9",
"user_name": "Ivone Leong",
"item_type": "entity",
"text": "commented on gene: BRCA2",
"entity_name": "BRCA2",
"entity_type": "gene"
},
{
"created": "2019-07-31T12:23:28.077977Z",
"panel_name": "Inherited ovarian cancer (without breast cancer)",
"panel_id": 143,
"panel_version": "1.9",
"user_name": "Ivone Leong",
"item_type": "entity",
"text": "commented on gene: BRCA1",
"entity_name": "BRCA1",
"entity_type": "gene"
},
{
"created": "2019-07-31T12:17:53.828670Z",
"panel_name": "Inherited ovarian cancer (without breast cancer)",
"panel_id": 143,
"panel_version": "1.9",
"user_name": "Ivone Leong",
"item_type": "panel",
"text": "List of related panels changed from Familial ovarian cancer to Familial ovarian cancer; R207",
"entity_name": null,
"entity_type": null
},
{
"created": "2019-01-29T16:32:56.199921Z",
"panel_name": "Inherited ovarian cancer (without breast cancer)",
"panel_id": 143,
"panel_version": "1.7",
"user_name": "Ivone Leong",
"item_type": "entity",
"text": "Publications for gene: BRCA2 were set to ",
"entity_name": "BRCA2",
"entity_type": "gene"
},
{
"created": "2019-01-29T16:32:44.076603Z",
"panel_name": "Inherited ovarian cancer (without breast cancer)",
"panel_id": 143,
"panel_version": "1.6",
"user_name": "Ivone Leong",
"item_type": "entity",
"text": "Publications for gene: BRCA1 were set to ",
"entity_name": "BRCA1",
"entity_type": "gene"
},
{
"created": "2019-01-29T16:32:14.108330Z",
"panel_name": "Inherited ovarian cancer (without breast cancer)",
"panel_id": 143,
"panel_version": "1.5",
"user_name": "Rachel Robinson",
"item_type": "entity",
"text": "reviewed gene: RAD51D: Rating: GREEN; Mode of pathogenicity: ; Publications: 29661970; Phenotypes: ; Mode of inheritance: ; Current diagnostic: yes",
"entity_name": "RAD51D",
"entity_type": "gene"
},
{
"created": "2019-01-29T16:32:14.099363Z",
"panel_name": "Inherited ovarian cancer (without breast cancer)",
"panel_id": 143,
"panel_version": "1.5",
"user_name": "Rachel Robinson",
"item_type": "entity",
"text": "reviewed gene: RAD51C: Rating: GREEN; Mode of pathogenicity: ; Publications: 29661970; Phenotypes: ; Mode of inheritance: ; Current diagnostic: yes",
"entity_name": "RAD51C",
"entity_type": "gene"
},
{
"created": "2019-01-29T16:32:14.089868Z",
"panel_name": "Inherited ovarian cancer (without breast cancer)",
"panel_id": 143,
"panel_version": "1.5",
"user_name": "Rachel Robinson",
"item_type": "entity",
"text": "reviewed gene: MSH6: Rating: GREEN; Mode of pathogenicity: ; Publications: 29661970; Phenotypes: ; Mode of inheritance: ; Current diagnostic: yes",
"entity_name": "MSH6",
"entity_type": "gene"
},
{
"created": "2019-01-29T16:32:14.080308Z",
"panel_name": "Inherited ovarian cancer (without breast cancer)",
"panel_id": 143,
"panel_version": "1.5",
"user_name": "Rachel Robinson",
"item_type": "entity",
"text": "reviewed gene: MSH2: Rating: GREEN; Mode of pathogenicity: ; Publications: 29661970; Phenotypes: ; Mode of inheritance: ; Current diagnostic: yes",
"entity_name": "MSH2",
"entity_type": "gene"
},
{
"created": "2019-01-29T16:32:14.070888Z",
"panel_name": "Inherited ovarian cancer (without breast cancer)",
"panel_id": 143,
"panel_version": "1.5",
"user_name": "Rachel Robinson",
"item_type": "entity",
"text": "reviewed gene: MLH1: Rating: GREEN; Mode of pathogenicity: ; Publications: 29661970; Phenotypes: ; Mode of inheritance: ; Current diagnostic: yes",
"entity_name": "MLH1",
"entity_type": "gene"
},
{
"created": "2019-01-29T16:32:14.061504Z",
"panel_name": "Inherited ovarian cancer (without breast cancer)",
"panel_id": 143,
"panel_version": "1.5",
"user_name": "Rachel Robinson",
"item_type": "entity",
"text": "reviewed gene: BRIP1: Rating: GREEN; Mode of pathogenicity: ; Publications: 29661970; Phenotypes: ; Mode of inheritance: ; Current diagnostic: yes",
"entity_name": "BRIP1",
"entity_type": "gene"
},
{
"created": "2019-01-29T16:32:14.052081Z",
"panel_name": "Inherited ovarian cancer (without breast cancer)",
"panel_id": 143,
"panel_version": "1.5",
"user_name": "Rachel Robinson",
"item_type": "entity",
"text": "reviewed gene: BRCA2: Rating: GREEN; Mode of pathogenicity: ; Publications: 29661970; Phenotypes: ; Mode of inheritance: ; Current diagnostic: yes",
"entity_name": "BRCA2",
"entity_type": "gene"
},
{
"created": "2019-01-29T16:32:14.042262Z",
"panel_name": "Inherited ovarian cancer (without breast cancer)",
"panel_id": 143,
"panel_version": "1.5",
"user_name": "Rachel Robinson",
"item_type": "entity",
"text": "reviewed gene: BRCA1: Rating: GREEN; Mode of pathogenicity: ; Publications: 29661970; Phenotypes: ; Mode of inheritance: ; Current diagnostic: yes",
"entity_name": "BRCA1",
"entity_type": "gene"
},
{
"created": "2019-01-29T16:32:14.031240Z",
"panel_name": "Inherited ovarian cancer (without breast cancer)",
"panel_id": 143,
"panel_version": "1.5",
"user_name": "Lara Hawkes",
"item_type": "entity",
"text": "reviewed gene: PMS2: Rating: AMBER; Mode of pathogenicity: ; Publications: ; Phenotypes: ; Mode of inheritance: ",
"entity_name": "PMS2",
"entity_type": "gene"
},
{
"created": "2019-01-29T16:32:14.021487Z",
"panel_name": "Inherited ovarian cancer (without breast cancer)",
"panel_id": 143,
"panel_version": "1.5",
"user_name": "Lara Hawkes",
"item_type": "entity",
"text": "reviewed gene: RAD51D: Rating: GREEN; Mode of pathogenicity: ; Publications: ; Phenotypes: ; Mode of inheritance: ",
"entity_name": "RAD51D",
"entity_type": "gene"
},
{
"created": "2019-01-29T16:32:14.011873Z",
"panel_name": "Inherited ovarian cancer (without breast cancer)",
"panel_id": 143,
"panel_version": "1.5",
"user_name": "Lara Hawkes",
"item_type": "entity",
"text": "reviewed gene: RAD51C: Rating: GREEN; Mode of pathogenicity: ; Publications: ; Phenotypes: ; Mode of inheritance: ",
"entity_name": "RAD51C",
"entity_type": "gene"
},
{
"created": "2019-01-29T16:32:14.002248Z",
"panel_name": "Inherited ovarian cancer (without breast cancer)",
"panel_id": 143,
"panel_version": "1.5",
"user_name": "Lara Hawkes",
"item_type": "entity",
"text": "reviewed gene: MSH6: Rating: GREEN; Mode of pathogenicity: ; Publications: ; Phenotypes: ; Mode of inheritance: ",
"entity_name": "MSH6",
"entity_type": "gene"
},
{
"created": "2019-01-29T16:32:13.993037Z",
"panel_name": "Inherited ovarian cancer (without breast cancer)",
"panel_id": 143,
"panel_version": "1.5",
"user_name": "Lara Hawkes",
"item_type": "entity",
"text": "reviewed gene: MSH2: Rating: GREEN; Mode of pathogenicity: ; Publications: ; Phenotypes: ; Mode of inheritance: ",
"entity_name": "MSH2",
"entity_type": "gene"
},
{
"created": "2019-01-29T16:32:13.984074Z",
"panel_name": "Inherited ovarian cancer (without breast cancer)",
"panel_id": 143,
"panel_version": "1.5",
"user_name": "Lara Hawkes",
"item_type": "entity",
"text": "reviewed gene: MLH1: Rating: GREEN; Mode of pathogenicity: ; Publications: ; Phenotypes: ; Mode of inheritance: ",
"entity_name": "MLH1",
"entity_type": "gene"
},
{
"created": "2019-01-29T16:32:13.974889Z",
"panel_name": "Inherited ovarian cancer (without breast cancer)",
"panel_id": 143,
"panel_version": "1.5",
"user_name": "Lara Hawkes",
"item_type": "entity",
"text": "reviewed gene: BRIP1: Rating: GREEN; Mode of pathogenicity: ; Publications: ; Phenotypes: ; Mode of inheritance: ",
"entity_name": "BRIP1",
"entity_type": "gene"
},
{
"created": "2019-01-29T16:32:13.965365Z",
"panel_name": "Inherited ovarian cancer (without breast cancer)",
"panel_id": 143,
"panel_version": "1.5",
"user_name": "Lara Hawkes",
"item_type": "entity",
"text": "reviewed gene: BRCA2: Rating: GREEN; Mode of pathogenicity: ; Publications: ; Phenotypes: ; Mode of inheritance: ",
"entity_name": "BRCA2",
"entity_type": "gene"
},
{
"created": "2019-01-29T16:32:13.954862Z",
"panel_name": "Inherited ovarian cancer (without breast cancer)",
"panel_id": 143,
"panel_version": "1.5",
"user_name": "Lara Hawkes",
"item_type": "entity",
"text": "reviewed gene: BRCA1: Rating: GREEN; Mode of pathogenicity: ; Publications: ; Phenotypes: ; Mode of inheritance: ",
"entity_name": "BRCA1",
"entity_type": "gene"
},
{
"created": "2019-01-29T16:30:12.807644Z",
"panel_name": "Inherited ovarian cancer (without breast cancer)",
"panel_id": 143,
"panel_version": "1.4",
"user_name": "Ivone Leong",
"item_type": "entity",
"text": "Source Expert List was added to PMS2.",
"entity_name": "PMS2",
"entity_type": "gene"
},
{
"created": "2019-01-29T16:30:12.731089Z",
"panel_name": "Inherited ovarian cancer (without breast cancer)",
"panel_id": 143,
"panel_version": "1.4",
"user_name": "Ivone Leong",
"item_type": "entity",
"text": "Source Expert List was added to RAD51D.\nSource NHS GMS was added to RAD51D.\nRating Changed from Green List (high evidence) to Green List (high evidence)",
"entity_name": "RAD51D",
"entity_type": "gene"
},
{
"created": "2019-01-29T16:30:12.673107Z",
"panel_name": "Inherited ovarian cancer (without breast cancer)",
"panel_id": 143,
"panel_version": "1.4",
"user_name": "Ivone Leong",
"item_type": "entity",
"text": "Source Expert List was added to RAD51C.\nSource NHS GMS was added to RAD51C.\nRating Changed from Green List (high evidence) to Green List (high evidence)",
"entity_name": "RAD51C",
"entity_type": "gene"
},
{
"created": "2019-01-29T16:30:12.614646Z",
"panel_name": "Inherited ovarian cancer (without breast cancer)",
"panel_id": 143,
"panel_version": "1.4",
"user_name": "Ivone Leong",
"item_type": "entity",
"text": "Source Expert List was added to MSH6.\nSource NHS GMS was added to MSH6.\nRating Changed from Green List (high evidence) to Green List (high evidence)",
"entity_name": "MSH6",
"entity_type": "gene"
},
{
"created": "2019-01-29T16:30:12.339465Z",
"panel_name": "Inherited ovarian cancer (without breast cancer)",
"panel_id": 143,
"panel_version": "1.4",
"user_name": "Ivone Leong",
"item_type": "entity",
"text": "Source Expert List was added to MSH2.\nSource NHS GMS was added to MSH2.\nRating Changed from Green List (high evidence) to Green List (high evidence)",
"entity_name": "MSH2",
"entity_type": "gene"
},
{
"created": "2019-01-29T16:30:12.263389Z",
"panel_name": "Inherited ovarian cancer (without breast cancer)",
"panel_id": 143,
"panel_version": "1.4",
"user_name": "Ivone Leong",
"item_type": "entity",
"text": "Source Expert List was added to MLH1.\nSource NHS GMS was added to MLH1.\nRating Changed from Green List (high evidence) to Green List (high evidence)",
"entity_name": "MLH1",
"entity_type": "gene"
},
{
"created": "2019-01-29T16:30:11.959367Z",
"panel_name": "Inherited ovarian cancer (without breast cancer)",
"panel_id": 143,
"panel_version": "1.4",
"user_name": "Ivone Leong",
"item_type": "entity",
"text": "Source Expert List was added to BRIP1.\nSource NHS GMS was added to BRIP1.\nRating Changed from Green List (high evidence) to Green List (high evidence)",
"entity_name": "BRIP1",
"entity_type": "gene"
},
{
"created": "2019-01-29T16:30:11.890803Z",
"panel_name": "Inherited ovarian cancer (without breast cancer)",
"panel_id": 143,
"panel_version": "1.4",
"user_name": "Ivone Leong",
"item_type": "entity",
"text": "Source Expert List was added to BRCA2.\nSource NHS GMS was added to BRCA2.\nRating Changed from Green List (high evidence) to Green List (high evidence)",
"entity_name": "BRCA2",
"entity_type": "gene"
},
{
"created": "2019-01-29T16:30:11.776770Z",
"panel_name": "Inherited ovarian cancer (without breast cancer)",
"panel_id": 143,
"panel_version": "1.4",
"user_name": "Ivone Leong",
"item_type": "entity",
"text": "Source Expert List was added to BRCA1.\nSource NHS GMS was added to BRCA1.\nRating Changed from Green List (high evidence) to Green List (high evidence)",
"entity_name": "BRCA1",
"entity_type": "gene"
},
{
"created": "2018-11-16T14:12:58.778316Z",
"panel_name": "Inherited ovarian cancer (without breast cancer)",
"panel_id": 143,
"panel_version": "1.2",
"user_name": "Ellen McDonagh",
"item_type": "panel",
"text": "Panel name changed from Familial ovarian cancer to Inherited ovarian cancer (without breast cancer)\nList of related panels changed from to Familial ovarian cancer\nPanel types changed to Rare Disease 100K; GMS Rare Disease",
"entity_name": null,
"entity_type": null
},
{
"created": "2017-08-29T13:18:24.715000Z",
"panel_name": "Familial ovarian cancer",
"panel_id": 143,
"panel_version": null,
"user_name": "Treena Cranston",
"item_type": "entity",
"text": "reviewed RAD51D",
"entity_name": "RAD51D",
"entity_type": "gene"
},
{
"created": "2017-08-29T13:14:44.420000Z",
"panel_name": "Familial ovarian cancer",
"panel_id": 143,
"panel_version": null,
"user_name": "Treena Cranston",
"item_type": "entity",
"text": "reviewed RAD51C",
"entity_name": "RAD51C",
"entity_type": "gene"
},
{
"created": "2017-08-29T13:09:22.056000Z",
"panel_name": "Familial ovarian cancer",
"panel_id": 143,
"panel_version": null,
"user_name": "Treena Cranston",
"item_type": "entity",
"text": "reviewed MSH6",
"entity_name": "MSH6",
"entity_type": "gene"
},
{
"created": "2017-08-29T13:08:52.289000Z",
"panel_name": "Familial ovarian cancer",
"panel_id": 143,
"panel_version": null,
"user_name": "Treena Cranston",
"item_type": "entity",
"text": "reviewed MSH2",
"entity_name": "MSH2",
"entity_type": "gene"
},
{
"created": "2017-08-29T13:07:57.982000Z",
"panel_name": "Familial ovarian cancer",
"panel_id": 143,
"panel_version": null,
"user_name": "Treena Cranston",
"item_type": "entity",
"text": "reviewed MLH1",
"entity_name": "MLH1",
"entity_type": "gene"
},
{
"created": "2017-08-29T13:07:03.013000Z",
"panel_name": "Familial ovarian cancer",
"panel_id": 143,
"panel_version": null,
"user_name": "Treena Cranston",
"item_type": "entity",
"text": "reviewed BRIP1",
"entity_name": "BRIP1",
"entity_type": "gene"
},
{
"created": "2017-08-29T12:58:40.556000Z",
"panel_name": "Familial ovarian cancer",
"panel_id": 143,
"panel_version": null,
"user_name": "Treena Cranston",
"item_type": "entity",
"text": "reviewed BRCA2",
"entity_name": "BRCA2",
"entity_type": "gene"
},
{
"created": "2017-08-29T12:57:56.448000Z",
"panel_name": "Familial ovarian cancer",
"panel_id": 143,
"panel_version": null,
"user_name": "Treena Cranston",
"item_type": "entity",
"text": "reviewed BRCA1",
"entity_name": "BRCA1",
"entity_type": "gene"
},
{
"created": "2017-07-31T11:40:30.826000Z",
"panel_name": "Familial ovarian cancer",
"panel_id": 143,
"panel_version": null,
"user_name": "Ellen McDonagh",
"item_type": "panel",
"text": "promoted panel to version 1",
"entity_name": null,
"entity_type": null
},
{
"created": "2017-05-30T11:37:18.169000Z",
"panel_name": "Familial ovarian cancer",
"panel_id": 143,
"panel_version": null,
"user_name": "Ellen McDonagh",
"item_type": "entity",
"text": "commented on PMS2",
"entity_name": "PMS2",
"entity_type": "gene"
},
{
"created": "2017-05-30T11:37:18.169000Z",
"panel_name": "Familial ovarian cancer",
"panel_id": 143,
"panel_version": null,
"user_name": "Ellen McDonagh",
"item_type": "entity",
"text": "classified PMS2 as amber",
"entity_name": "PMS2",
"entity_type": "gene"
},
{
"created": "2017-05-30T11:31:34.099000Z",
"panel_name": "Familial ovarian cancer",
"panel_id": 143,
"panel_version": null,
"user_name": "Ellen McDonagh",
"item_type": "entity",
"text": "marked MSH2 as ready",
"entity_name": "MSH2",
"entity_type": "gene"
},
{
"created": "2017-05-30T11:31:29.325000Z",
"panel_name": "Familial ovarian cancer",
"panel_id": 143,
"panel_version": null,
"user_name": "Ellen McDonagh",
"item_type": "entity",
"text": "marked MSH2 as ready",
"entity_name": "MSH2",
"entity_type": "gene"
},
{
"created": "2017-05-30T11:30:02.728000Z",
"panel_name": "Familial ovarian cancer",
"panel_id": 143,
"panel_version": null,
"user_name": "Ellen McDonagh",
"item_type": "entity",
"text": "marked MSH6 as ready",
"entity_name": "MSH6",
"entity_type": "gene"
},
{
"created": "2017-05-30T11:29:24.514000Z",
"panel_name": "Familial ovarian cancer",
"panel_id": 143,
"panel_version": null,
"user_name": "Ellen McDonagh",
"item_type": "entity",
"text": "marked RAD51C as ready",
"entity_name": "RAD51C",
"entity_type": "gene"
},
{
"created": "2017-05-30T11:28:35.396000Z",
"panel_name": "Familial ovarian cancer",
"panel_id": 143,
"panel_version": null,
"user_name": "Ellen McDonagh",
"item_type": "entity",
"text": "marked RAD51D as ready",
"entity_name": "RAD51D",
"entity_type": "gene"
},
{
"created": "2017-05-30T11:28:27.690000Z",
"panel_name": "Familial ovarian cancer",
"panel_id": 143,
"panel_version": null,
"user_name": "Ellen McDonagh",
"item_type": "entity",
"text": "classified RAD51D as green",
"entity_name": "RAD51D",
"entity_type": "gene"
},
{
"created": "2017-05-30T11:28:27.689000Z",
"panel_name": "Familial ovarian cancer",
"panel_id": 143,
"panel_version": null,
"user_name": "Ellen McDonagh",
"item_type": "entity",
"text": "commented on RAD51D",
"entity_name": "RAD51D",
"entity_type": "gene"
},
{
"created": "2017-05-30T11:28:09.842000Z",
"panel_name": "Familial ovarian cancer",
"panel_id": 143,
"panel_version": null,
"user_name": "Ellen McDonagh",
"item_type": "entity",
"text": "classified RAD51C as green",
"entity_name": "RAD51C",
"entity_type": "gene"
},
{
"created": "2017-05-30T11:28:09.841000Z",
"panel_name": "Familial ovarian cancer",
"panel_id": 143,
"panel_version": null,
"user_name": "Ellen McDonagh",
"item_type": "entity",
"text": "commented on RAD51C",
"entity_name": "RAD51C",
"entity_type": "gene"
},
{
"created": "2017-05-30T11:27:40.265000Z",
"panel_name": "Familial ovarian cancer",
"panel_id": 143,
"panel_version": null,
"user_name": "Ellen McDonagh",
"item_type": "entity",
"text": "classified MSH6 as green",
"entity_name": "MSH6",
"entity_type": "gene"
},
{
"created": "2017-05-30T11:27:10.050000Z",
"panel_name": "Familial ovarian cancer",
"panel_id": 143,
"panel_version": null,
"user_name": "Ellen McDonagh",
"item_type": "entity",
"text": "classified MSH2 as green",
"entity_name": "MSH2",
"entity_type": "gene"
},
{
"created": "2017-05-30T11:26:30.649000Z",
"panel_name": "Familial ovarian cancer",
"panel_id": 143,
"panel_version": null,
"user_name": "Ellen McDonagh",
"item_type": "entity",
"text": "classified MLH1 as green",
"entity_name": "MLH1",
"entity_type": "gene"
},
{
"created": "2017-05-30T11:24:31.845000Z",
"panel_name": "Familial ovarian cancer",
"panel_id": 143,
"panel_version": null,
"user_name": "Ellen McDonagh",
"item_type": "entity",
"text": "classified BRCA1 as green",
"entity_name": "BRCA1",
"entity_type": "gene"
},
{
"created": "2017-05-30T11:21:26.112000Z",
"panel_name": "Familial ovarian cancer",
"panel_id": 143,
"panel_version": null,
"user_name": "Ellen McDonagh",
"item_type": "entity",
"text": "classified MSH6 as green",
"entity_name": "MSH6",
"entity_type": "gene"
},
{
"created": "2017-05-30T11:21:26.111000Z",
"panel_name": "Familial ovarian cancer",
"panel_id": 143,
"panel_version": null,
"user_name": "Ellen McDonagh",
"item_type": "entity",
"text": "commented on MSH6",
"entity_name": "MSH6",
"entity_type": "gene"
},
{
"created": "2017-05-30T11:20:41.382000Z",
"panel_name": "Familial ovarian cancer",
"panel_id": 143,
"panel_version": null,
"user_name": "Ellen McDonagh",
"item_type": "entity",
"text": "classified MSH2 as green",
"entity_name": "MSH2",
"entity_type": "gene"
},
{
"created": "2017-05-30T11:20:41.380000Z",
"panel_name": "Familial ovarian cancer",
"panel_id": 143,
"panel_version": null,
"user_name": "Ellen McDonagh",
"item_type": "entity",
"text": "commented on MSH2",
"entity_name": "MSH2",
"entity_type": "gene"
},
{
"created": "2017-05-30T10:58:54.125000Z",
"panel_name": "Familial ovarian cancer",
"panel_id": 143,
"panel_version": null,
"user_name": "Ellen McDonagh",
"item_type": "entity",
"text": "marked MLH1 as ready",
"entity_name": "MLH1",
"entity_type": "gene"
},
{
"created": "2017-05-30T10:57:17.963000Z",
"panel_name": "Familial ovarian cancer",
"panel_id": 143,
"panel_version": null,
"user_name": "Ellen McDonagh",
"item_type": "entity",
"text": "classified MLH1 as green",
"entity_name": "MLH1",
"entity_type": "gene"
},
{
"created": "2017-05-30T10:57:17.962000Z",
"panel_name": "Familial ovarian cancer",
"panel_id": 143,
"panel_version": null,
"user_name": "Ellen McDonagh",
"item_type": "entity",
"text": "commented on MLH1",
"entity_name": "MLH1",
"entity_type": "gene"
},
{
"created": "2017-05-30T10:56:07.306000Z",
"panel_name": "Familial ovarian cancer",
"panel_id": 143,
"panel_version": null,
"user_name": "Ellen McDonagh",
"item_type": "entity",
"text": "marked BRIP1 as ready",
"entity_name": "BRIP1",
"entity_type": "gene"
},
{
"created": "2017-05-30T10:54:43.855000Z",
"panel_name": "Familial ovarian cancer",
"panel_id": 143,
"panel_version": null,
"user_name": "Ellen McDonagh",
"item_type": "entity",
"text": "marked BRCA2 as ready",
"entity_name": "BRCA2",
"entity_type": "gene"
},
{
"created": "2017-05-30T10:54:25.429000Z",
"panel_name": "Familial ovarian cancer",
"panel_id": 143,
"panel_version": null,
"user_name": "Ellen McDonagh",
"item_type": "entity",
"text": "classified BRCA2 as green",
"entity_name": "BRCA2",
"entity_type": "gene"
},
{
"created": "2017-05-30T10:54:25.428000Z",
"panel_name": "Familial ovarian cancer",
"panel_id": 143,
"panel_version": null,
"user_name": "Ellen McDonagh",
"item_type": "entity",
"text": "commented on BRCA2",
"entity_name": "BRCA2",
"entity_type": "gene"
},
{
"created": "2017-05-30T10:04:07.503000Z",
"panel_name": "Familial ovarian cancer",
"panel_id": 143,
"panel_version": null,
"user_name": "Ellen McDonagh",
"item_type": "entity",
"text": "classified BRCA1 as green",
"entity_name": "BRCA1",
"entity_type": "gene"
},
{
"created": "2017-05-30T10:04:07.502000Z",
"panel_name": "Familial ovarian cancer",
"panel_id": 143,
"panel_version": null,
"user_name": "Ellen McDonagh",
"item_type": "entity",
"text": "commented on BRCA1",
"entity_name": "BRCA1",
"entity_type": "gene"
},
{
"created": "2017-05-28T17:49:07.568000Z",
"panel_name": "Familial ovarian cancer",
"panel_id": 143,
"panel_version": null,
"user_name": "Clare Turnbull",
"item_type": "entity",
"text": "reviewed MSH2",
"entity_name": "MSH2",
"entity_type": "gene"
},
{
"created": "2017-05-28T17:47:53.845000Z",
"panel_name": "Familial ovarian cancer",
"panel_id": 143,
"panel_version": null,
"user_name": "Clare Turnbull",
"item_type": "entity",
"text": "reviewed BRCA2",
"entity_name": "BRCA2",
"entity_type": "gene"
},
{
"created": "2017-05-26T14:12:34.436000Z",
"panel_name": "Familial ovarian cancer",
"panel_id": 143,
"panel_version": null,
"user_name": "Ellen McDonagh",
"item_type": "panel",
"text": "approved panel",
"entity_name": null,
"entity_type": null
},
{
"created": "2017-05-26T14:10:45.565000Z",
"panel_name": "Familial ovarian cancer",
"panel_id": 143,
"panel_version": null,
"user_name": "Ellen McDonagh",
"item_type": "entity",
"text": "classified TP53 as red",
"entity_name": "TP53",
"entity_type": "gene"
},
{
"created": "2017-05-26T14:10:24.377000Z",
"panel_name": "Familial ovarian cancer",
"panel_id": 143,
"panel_version": null,
"user_name": "Ellen McDonagh",
"item_type": "entity",
"text": "classified BRCA2 as red",
"entity_name": "BRCA2",
"entity_type": "gene"
},
{
"created": "2017-05-26T14:10:17.706000Z",
"panel_name": "Familial ovarian cancer",
"panel_id": 143,
"panel_version": null,
"user_name": "Ellen McDonagh",
"item_type": "entity",
"text": "classified BRCA1 as red",
"entity_name": "BRCA1",
"entity_type": "gene"
}
]