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[
{
"created": "2024-05-01T12:52:03.541417Z",
"panel_name": "Catecholaminergic polymorphic VT",
"panel_id": 214,
"panel_version": "4.6",
"user_name": "Achchuthan Shanmugasundram",
"item_type": "panel",
"text": "Panel version 4.5 has been signed off on 2024-05-01",
"entity_name": null,
"entity_type": null
},
{
"created": "2023-03-22T15:13:31.796379Z",
"panel_name": "Catecholaminergic polymorphic VT",
"panel_id": 214,
"panel_version": "4.1",
"user_name": "Arina Puzriakova",
"item_type": "panel",
"text": "Panel version 4.0 has been signed off on 2023-03-22",
"entity_name": null,
"entity_type": null
},
{
"created": "2023-03-22T15:13:09.655226Z",
"panel_name": "Catecholaminergic polymorphic VT",
"panel_id": 214,
"panel_version": "4.0",
"user_name": "Arina Puzriakova",
"item_type": "panel",
"text": "promoted panel to version 4.0",
"entity_name": null,
"entity_type": null
},
{
"created": "2023-01-30T11:56:38.241714Z",
"panel_name": "Catecholaminergic polymorphic VT",
"panel_id": 214,
"panel_version": "3.3",
"user_name": "Arina Puzriakova",
"item_type": "entity",
"text": "Tag Q3_21_rating was removed from gene: TECRL.",
"entity_name": "TECRL",
"entity_type": "gene"
},
{
"created": "2023-01-30T11:56:24.723085Z",
"panel_name": "Catecholaminergic polymorphic VT",
"panel_id": 214,
"panel_version": "3.3",
"user_name": "Arina Puzriakova",
"item_type": "entity",
"text": "Source Expert Review Green was added to TECRL.\nSource NHS GMS was added to TECRL.\nRating Changed from Amber List (moderate evidence) to Green List (high evidence)",
"entity_name": "TECRL",
"entity_type": "gene"
},
{
"created": "2023-01-30T11:56:07.984819Z",
"panel_name": "Catecholaminergic polymorphic VT",
"panel_id": 214,
"panel_version": "3.2",
"user_name": "Arina Puzriakova",
"item_type": "entity",
"text": "reviewed gene: TECRL: Rating: GREEN; Mode of pathogenicity: ; Publications: ; Phenotypes: ; Mode of inheritance: ",
"entity_name": "TECRL",
"entity_type": "gene"
},
{
"created": "2022-11-30T14:27:06.364227Z",
"panel_name": "Catecholaminergic polymorphic VT",
"panel_id": 214,
"panel_version": "3.1",
"user_name": "Arina Puzriakova",
"item_type": "panel",
"text": "Panel version 3.0 has been signed off on 2022-11-30",
"entity_name": null,
"entity_type": null
},
{
"created": "2022-11-30T14:26:15.449926Z",
"panel_name": "Catecholaminergic polymorphic VT",
"panel_id": 214,
"panel_version": "3.0",
"user_name": "Arina Puzriakova",
"item_type": "panel",
"text": "promoted panel to version 3.0",
"entity_name": null,
"entity_type": null
},
{
"created": "2022-11-15T13:32:23.950676Z",
"panel_name": "Catecholaminergic polymorphic VT",
"panel_id": 214,
"panel_version": "2.21",
"user_name": "Sarah Leigh",
"item_type": "entity",
"text": "Phenotypes for gene: CALM2 were changed from catecholaminergic polymorphic ventricular tachycardia, MONDO:0017990 to Long QT syndrome 15, OMIM:616249; long QT syndrome 15, MONDO:0014550",
"entity_name": "CALM2",
"entity_type": "gene"
},
{
"created": "2022-11-15T13:26:01.442594Z",
"panel_name": "Catecholaminergic polymorphic VT",
"panel_id": 214,
"panel_version": "2.20",
"user_name": "Sarah Leigh",
"item_type": "entity",
"text": "Publications for gene: CALM2 were set to 27114410; 27100291; 24917665",
"entity_name": "CALM2",
"entity_type": "gene"
},
{
"created": "2021-09-28T09:53:21.574877Z",
"panel_name": "Catecholaminergic polymorphic VT",
"panel_id": 214,
"panel_version": "2.19",
"user_name": "Ivone Leong",
"item_type": "entity",
"text": "Tag Q3_21_rating tag was added to gene: TECRL.",
"entity_name": "TECRL",
"entity_type": "gene"
},
{
"created": "2021-09-28T09:53:03.804256Z",
"panel_name": "Catecholaminergic polymorphic VT",
"panel_id": 214,
"panel_version": "2.19",
"user_name": "Ivone Leong",
"item_type": "entity",
"text": "edited their review of gene: TECRL: Added comment: This gene is associated with a phenotype in OMIM and not Gene2Phenotype. There is now sufficient evidence to support a gene-disease association. This gene should be rated Green at the next review.; Changed rating: GREEN",
"entity_name": "TECRL",
"entity_type": "gene"
},
{
"created": "2021-09-28T09:49:50.629204Z",
"panel_name": "Catecholaminergic polymorphic VT",
"panel_id": 214,
"panel_version": "2.19",
"user_name": "Ivone Leong",
"item_type": "entity",
"text": "Added comment: Comment on publications: PMID: 30790670. 1 case (13 yo) with compound het variants in TECRL (R196Q, which was previously reported and a novel splice variant) was diagnosed with CPVT3. The proband's older brother suddenly died at 12 yo but DNA was unavailable for testing. Both heterozygous parents were unaffected.\r\n\r\nPMID: 32173957. 4 families with novel homozygous/compound het TECRL variants (6 affected individuals). \r\n\r\nPMID: 33367594. 7 additional families (10 affected individuals) with compound het/homozygous variants in TECRL.",
"entity_name": "TECRL",
"entity_type": "gene"
},
{
"created": "2021-09-28T09:49:50.612489Z",
"panel_name": "Catecholaminergic polymorphic VT",
"panel_id": 214,
"panel_version": "2.19",
"user_name": "Ivone Leong",
"item_type": "entity",
"text": "Publications for gene: TECRL were set to 27861123",
"entity_name": "TECRL",
"entity_type": "gene"
},
{
"created": "2021-03-02T13:06:15.076017Z",
"panel_name": "Catecholaminergic polymorphic VT",
"panel_id": 214,
"panel_version": "2.18",
"user_name": "Ivone Leong",
"item_type": "entity",
"text": "Added comment: Comment on phenotypes: This gene is also associated with Short QT syndrome 3, OMIM:609622, Short QT syndrome type 3, MONDO:0012314, Atrial fibrillation, familial, 9, OMIM:613980, Atrial fibrillation, familial, 9, MONDO:0013513, Andersen syndrome, OMIM:170390, Andersen-Tawil syndrome, MONDO:0008222",
"entity_name": "KCNJ2",
"entity_type": "gene"
},
{
"created": "2021-03-02T13:06:15.055491Z",
"panel_name": "Catecholaminergic polymorphic VT",
"panel_id": 214,
"panel_version": "2.18",
"user_name": "Ivone Leong",
"item_type": "entity",
"text": "Phenotypes for gene: KCNJ2 were changed from Short QT syndrome 3, OMIM:609622; Short QT syndrome type 3, MONDO:0012314; Atrial fibrillation, familial, 9, OMIM:613980; Atrial fibrillation, familial, 9, MONDO:0013513; Andersen syndrome, OMIM:170390; Andersen-Tawil syndrome, MONDO:0008222 to catecholaminergic polymorphic ventricular tachycardia, MONDO:0017990",
"entity_name": "KCNJ2",
"entity_type": "gene"
},
{
"created": "2021-03-02T13:04:20.286575Z",
"panel_name": "Catecholaminergic polymorphic VT",
"panel_id": 214,
"panel_version": "2.17",
"user_name": "Ivone Leong",
"item_type": "entity",
"text": "Phenotypes for gene: KCNE1 were changed from Catecholaminergic polymorphic ventricular tachycardia; Long QT syndrome to catecholaminergic polymorphic ventricular tachycardia, MONDO:0017990",
"entity_name": "KCNE1",
"entity_type": "gene"
},
{
"created": "2021-03-02T13:04:04.098708Z",
"panel_name": "Catecholaminergic polymorphic VT",
"panel_id": 214,
"panel_version": "2.16",
"user_name": "Ivone Leong",
"item_type": "entity",
"text": "Phenotypes for gene: ANK2 were changed from catecholaminergic polymorphic ventricular tachycardia to catecholaminergic polymorphic ventricular tachycardia, MONDO:0017990",
"entity_name": "ANK2",
"entity_type": "gene"
},
{
"created": "2021-03-02T13:03:44.713792Z",
"panel_name": "Catecholaminergic polymorphic VT",
"panel_id": 214,
"panel_version": "2.15",
"user_name": "Ivone Leong",
"item_type": "entity",
"text": "Phenotypes for gene: TECRL were changed from Ventricular tachycardia, catecholaminergic polymorphic, 3 614021 to Ventricular tachycardia, catecholaminergic polymorphic, 3, OMIM:614021",
"entity_name": "TECRL",
"entity_type": "gene"
},
{
"created": "2021-03-02T13:03:26.973338Z",
"panel_name": "Catecholaminergic polymorphic VT",
"panel_id": 214,
"panel_version": "2.14",
"user_name": "Ivone Leong",
"item_type": "entity",
"text": "Phenotypes for gene: TRDN were changed from Ventricular tachycardia, catecholaminergic polymorphic, 5, with or without muscle weakness (615441); catecholaminergic polymorphic ventricular tachycardia; Ventricular tachycardia, catecholaminergic polymorphic, 5, with or without muscle weakness to Ventricular tachycardia, catecholaminergic polymorphic, 5, with or without muscle weakness, OMIM:615441",
"entity_name": "TRDN",
"entity_type": "gene"
},
{
"created": "2021-03-02T13:02:52.085137Z",
"panel_name": "Catecholaminergic polymorphic VT",
"panel_id": 214,
"panel_version": "2.13",
"user_name": "Ivone Leong",
"item_type": "entity",
"text": "Added comment: Comment on phenotypes: This gene is also associated with Arrhythmogenic right ventricular dysplasia 2 (600996)",
"entity_name": "RYR2",
"entity_type": "gene"
},
{
"created": "2021-03-02T13:02:52.072346Z",
"panel_name": "Catecholaminergic polymorphic VT",
"panel_id": 214,
"panel_version": "2.13",
"user_name": "Ivone Leong",
"item_type": "entity",
"text": "Phenotypes for gene: RYR2 were changed from Ventricular tachycardia, catecholaminergic polymorphic, 1; Ventricular tachycardia, catecholaminergic polymorphic, 1 (604772); Arrhythmogenic right ventricular dysplasia 2 (600996); Catecholaminergic polymorphic ventricular tachycardia; catecholaminergic polymorphic ventricular tachycardia to Ventricular tachycardia, catecholaminergic polymorphic, 1, OMIM:604772",
"entity_name": "RYR2",
"entity_type": "gene"
},
{
"created": "2021-03-02T13:02:11.627258Z",
"panel_name": "Catecholaminergic polymorphic VT",
"panel_id": 214,
"panel_version": "2.12",
"user_name": "Ivone Leong",
"item_type": "entity",
"text": "Phenotypes for gene: CASQ2 were changed from Ventricular tachycardia, catecholaminergic polymorphic, 2 (611938); Ventricular tachycardia, catecholaminergic polymorphic, 2 to Ventricular tachycardia, catecholaminergic polymorphic, 2, OMIM:611938",
"entity_name": "CASQ2",
"entity_type": "gene"
},
{
"created": "2021-03-02T13:01:54.737790Z",
"panel_name": "Catecholaminergic polymorphic VT",
"panel_id": 214,
"panel_version": "2.11",
"user_name": "Ivone Leong",
"item_type": "entity",
"text": "Added comment: Comment on phenotypes: This gene is also associated with Long QT syndrome 16,618782",
"entity_name": "CALM3",
"entity_type": "gene"
},
{
"created": "2021-03-02T13:01:54.720532Z",
"panel_name": "Catecholaminergic polymorphic VT",
"panel_id": 214,
"panel_version": "2.11",
"user_name": "Ivone Leong",
"item_type": "entity",
"text": "Phenotypes for gene: CALM3 were changed from ?Ventricular tachycardia, catecholaminergic polymorphic 6, 618782; Long QT syndrome 16,618782 to ?Ventricular tachycardia, catecholaminergic polymorphic 6, OMIM:618782",
"entity_name": "CALM3",
"entity_type": "gene"
},
{
"created": "2021-03-02T13:01:18.136384Z",
"panel_name": "Catecholaminergic polymorphic VT",
"panel_id": 214,
"panel_version": "2.10",
"user_name": "Ivone Leong",
"item_type": "entity",
"text": "Added comment: Comment on phenotypes: This gene is also associated with Long QT syndrome 15, 616249",
"entity_name": "CALM2",
"entity_type": "gene"
},
{
"created": "2021-03-02T13:01:18.117712Z",
"panel_name": "Catecholaminergic polymorphic VT",
"panel_id": 214,
"panel_version": "2.10",
"user_name": "Ivone Leong",
"item_type": "entity",
"text": "Phenotypes for gene: CALM2 were changed from Long QT syndrome 15, 616249 to catecholaminergic polymorphic ventricular tachycardia, MONDO:0017990",
"entity_name": "CALM2",
"entity_type": "gene"
},
{
"created": "2021-03-02T13:00:53.714786Z",
"panel_name": "Catecholaminergic polymorphic VT",
"panel_id": 214,
"panel_version": "2.9",
"user_name": "Ivone Leong",
"item_type": "entity",
"text": "Phenotypes for gene: CALM1 were changed from Ventricular tachycardia, catecholaminergic polymorphic, 4 (614916) to Ventricular tachycardia, catecholaminergic polymorphic, 4, OMIM:614916",
"entity_name": "CALM1",
"entity_type": "gene"
},
{
"created": "2021-03-02T13:00:46.228017Z",
"panel_name": "Catecholaminergic polymorphic VT",
"panel_id": 214,
"panel_version": "2.8",
"user_name": "Ivone Leong",
"item_type": "entity",
"text": "Added comment: Comment on phenotypes: This gene is also associated with Long QT syndrome 14 (616247)",
"entity_name": "CALM1",
"entity_type": "gene"
},
{
"created": "2021-03-02T13:00:46.214822Z",
"panel_name": "Catecholaminergic polymorphic VT",
"panel_id": 214,
"panel_version": "2.8",
"user_name": "Ivone Leong",
"item_type": "entity",
"text": "Phenotypes for gene: CALM1 were changed from Long QT syndrome 14 (616247); Ventricular tachycardia, catecholaminergic polymorphic, 4 (614916); catecholaminergic polymorphic ventricular tachycardia to Ventricular tachycardia, catecholaminergic polymorphic, 4 (614916)",
"entity_name": "CALM1",
"entity_type": "gene"
},
{
"created": "2020-12-24T14:39:52.305089Z",
"panel_name": "Catecholaminergic polymorphic VT",
"panel_id": 214,
"panel_version": "2.7",
"user_name": "Arina Puzriakova",
"item_type": "entity",
"text": "Phenotypes for gene: KCNJ2 were changed from catecholaminergic polymorphic ventricular tachycardia; Atrial fibrillation, familial, 9 (613980); Andersen syndrome (170390); Short QT syndrome 3 (609622) to Short QT syndrome 3, OMIM:609622; Short QT syndrome type 3, MONDO:0012314; Atrial fibrillation, familial, 9, OMIM:613980; Atrial fibrillation, familial, 9, MONDO:0013513; Andersen syndrome, OMIM:170390; Andersen-Tawil syndrome, MONDO:0008222",
"entity_name": "KCNJ2",
"entity_type": "gene"
},
{
"created": "2020-08-20T13:56:32.155877Z",
"panel_name": "Catecholaminergic polymorphic VT",
"panel_id": 214,
"panel_version": "2.6",
"user_name": "Ivone Leong",
"item_type": "panel",
"text": "Panel version has been signed off",
"entity_name": null,
"entity_type": null
},
{
"created": "2020-05-11T16:07:34.350290Z",
"panel_name": "Catecholaminergic polymorphic VT",
"panel_id": 214,
"panel_version": "2.4",
"user_name": "Eleanor Williams",
"item_type": "entity",
"text": "Phenotypes for gene: CALM3 were changed from to ?Ventricular tachycardia, catecholaminergic polymorphic 6, 618782; Long QT syndrome 16,618782",
"entity_name": "CALM3",
"entity_type": "gene"
},
{
"created": "2020-02-19T16:17:17.580204Z",
"panel_name": "Catecholaminergic polymorphic VT",
"panel_id": 214,
"panel_version": "2.3",
"user_name": "Sarah Leigh",
"item_type": "panel",
"text": "Panel version has been signed off",
"entity_name": null,
"entity_type": null
},
{
"created": "2019-12-13T12:22:11.401929Z",
"panel_name": "Catecholaminergic polymorphic VT",
"panel_id": 214,
"panel_version": "2.1",
"user_name": "Ivone Leong",
"item_type": "panel",
"text": "Panel types changed to Rare Disease 100K; GMS Rare Disease Virtual; GMS Rare Disease; Component Of Super Panel; GMS signed-off",
"entity_name": null,
"entity_type": null
},
{
"created": "2019-12-09T14:24:03.099299Z",
"panel_name": "Catecholaminergic polymorphic VT",
"panel_id": 214,
"panel_version": "2.0",
"user_name": "Ivone Leong",
"item_type": "panel",
"text": "promoted panel to version 2.0",
"entity_name": null,
"entity_type": null
},
{
"created": "2019-12-09T14:23:40.015103Z",
"panel_name": "Catecholaminergic polymorphic VT",
"panel_id": 214,
"panel_version": "1.30",
"user_name": "Ivone Leong",
"item_type": "panel",
"text": "Panel types changed to Rare Disease 100K; GMS Rare Disease; Component Of Super Panel; GMS signed-off",
"entity_name": null,
"entity_type": null
},
{
"created": "2019-12-09T13:36:56.789310Z",
"panel_name": "Catecholaminergic polymorphic VT",
"panel_id": 214,
"panel_version": "1.29",
"user_name": "Ivone Leong",
"item_type": "entity",
"text": "Mode of inheritance for gene: CALM3 was changed from Unknown to MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown",
"entity_name": "CALM3",
"entity_type": "gene"
},
{
"created": "2019-12-09T13:25:37.793390Z",
"panel_name": "Catecholaminergic polymorphic VT",
"panel_id": 214,
"panel_version": "1.28",
"user_name": "Ivone Leong",
"item_type": "entity",
"text": "Source Expert Review Green was added to CALM3.\nRating Changed from Amber List (moderate evidence) to Green List (high evidence)",
"entity_name": "CALM3",
"entity_type": "gene"
},
{
"created": "2019-12-09T13:19:29.539041Z",
"panel_name": "Catecholaminergic polymorphic VT",
"panel_id": 214,
"panel_version": "1.27",
"user_name": "Kate Thomson",
"item_type": "entity",
"text": "reviewed gene: CALM3: Rating: GREEN; Mode of pathogenicity: ; Publications: ; Phenotypes: ; Mode of inheritance: ",
"entity_name": "CALM3",
"entity_type": "gene"
},
{
"created": "2019-12-04T10:02:42.299515Z",
"panel_name": "Catecholaminergic polymorphic VT",
"panel_id": 214,
"panel_version": "1.26",
"user_name": "Ivone Leong",
"item_type": "panel",
"text": "Panel types changed to Rare Disease 100K; GMS Rare Disease; Component Of Super Panel",
"entity_name": null,
"entity_type": null
},
{
"created": "2019-11-18T15:09:34.725744Z",
"panel_name": "Catecholaminergic polymorphic VT",
"panel_id": 214,
"panel_version": "1.25",
"user_name": "Ivone Leong",
"item_type": "entity",
"text": "reviewed gene: CALM3: Rating: AMBER; Mode of pathogenicity: None; Publications: ; Phenotypes: ; Mode of inheritance: None",
"entity_name": "CALM3",
"entity_type": "gene"
},
{
"created": "2019-11-18T14:59:53.864594Z",
"panel_name": "Catecholaminergic polymorphic VT",
"panel_id": 214,
"panel_version": "1.25",
"user_name": "Ivone Leong",
"item_type": "entity",
"text": "reviewed gene: TECRL: Rating: AMBER; Mode of pathogenicity: None; Publications: ; Phenotypes: ; Mode of inheritance: None",
"entity_name": "TECRL",
"entity_type": "gene"
},
{
"created": "2019-11-18T14:58:18.513929Z",
"panel_name": "Catecholaminergic polymorphic VT",
"panel_id": 214,
"panel_version": "1.25",
"user_name": "Ivone Leong",
"item_type": "entity",
"text": "reviewed gene: TRDN: Rating: GREEN; Mode of pathogenicity: None; Publications: ; Phenotypes: ; Mode of inheritance: None",
"entity_name": "TRDN",
"entity_type": "gene"
},
{
"created": "2019-11-18T14:58:11.595371Z",
"panel_name": "Catecholaminergic polymorphic VT",
"panel_id": 214,
"panel_version": "1.25",
"user_name": "Ivone Leong",
"item_type": "entity",
"text": "edited their review of gene: RYR2: Added comment: Submitted on behalf of the GMS Cardiology specialist group. The group has agreed that this gene should be Green on this panel.; Changed rating: GREEN",
"entity_name": "RYR2",
"entity_type": "gene"
},
{
"created": "2019-11-18T14:58:04.667167Z",
"panel_name": "Catecholaminergic polymorphic VT",
"panel_id": 214,
"panel_version": "1.25",
"user_name": "Ivone Leong",
"item_type": "entity",
"text": "reviewed gene: CASQ2: Rating: GREEN; Mode of pathogenicity: None; Publications: ; Phenotypes: ; Mode of inheritance: None",
"entity_name": "CASQ2",
"entity_type": "gene"
},
{
"created": "2019-11-18T14:57:40.126090Z",
"panel_name": "Catecholaminergic polymorphic VT",
"panel_id": 214,
"panel_version": "1.25",
"user_name": "Ivone Leong",
"item_type": "entity",
"text": "reviewed gene: CALM2: Rating: GREEN; Mode of pathogenicity: None; Publications: ; Phenotypes: ; Mode of inheritance: None",
"entity_name": "CALM2",
"entity_type": "gene"
},
{
"created": "2019-11-18T14:57:25.238318Z",
"panel_name": "Catecholaminergic polymorphic VT",
"panel_id": 214,
"panel_version": "1.25",
"user_name": "Ivone Leong",
"item_type": "entity",
"text": "reviewed gene: CALM1: Rating: GREEN; Mode of pathogenicity: None; Publications: ; Phenotypes: ; Mode of inheritance: None",
"entity_name": "CALM1",
"entity_type": "gene"
},
{
"created": "2019-10-02T11:14:32.426846Z",
"panel_name": "Catecholaminergic polymorphic VT",
"panel_id": 214,
"panel_version": "1.25",
"user_name": "Ellen McDonagh",
"item_type": "entity",
"text": "Publications for gene: CALM3 were set to ",
"entity_name": "CALM3",
"entity_type": "gene"
},
{
"created": "2019-10-01T10:50:50.382392Z",
"panel_name": "Catecholaminergic polymorphic VT",
"panel_id": 214,
"panel_version": "1.24",
"user_name": "Ivone Leong",
"item_type": "entity",
"text": "Phenotypes for gene: TECRL were changed from to Ventricular tachycardia, catecholaminergic polymorphic, 3 614021",
"entity_name": "TECRL",
"entity_type": "gene"
},
{
"created": "2019-10-01T10:50:42.017490Z",
"panel_name": "Catecholaminergic polymorphic VT",
"panel_id": 214,
"panel_version": "1.23",
"user_name": "Ivone Leong",
"item_type": "entity",
"text": "Publications for gene: TECRL were set to ",
"entity_name": "TECRL",
"entity_type": "gene"
},
{
"created": "2019-09-30T12:08:05.194572Z",
"panel_name": "Catecholaminergic polymorphic VT",
"panel_id": 214,
"panel_version": "1.22",
"user_name": "Ivone Leong",
"item_type": "entity",
"text": "Added comment: Comment on mode of inheritance: MOI was corrected.",
"entity_name": "RYR2",
"entity_type": "gene"
},
{
"created": "2019-09-30T12:08:05.161535Z",
"panel_name": "Catecholaminergic polymorphic VT",
"panel_id": 214,
"panel_version": "1.22",
"user_name": "Ivone Leong",
"item_type": "entity",
"text": "Mode of inheritance for gene: RYR2 was changed from BIALLELIC, autosomal or pseudoautosomal to MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown",
"entity_name": "RYR2",
"entity_type": "gene"
},
{
"created": "2019-09-27T14:03:07.099267Z",
"panel_name": "Catecholaminergic polymorphic VT",
"panel_id": 214,
"panel_version": "1.21",
"user_name": "James Eden",
"item_type": "entity",
"text": "reviewed gene: TECRL: Rating: AMBER; Mode of pathogenicity: None; Publications: 27861123; Phenotypes: Ventricular tachycardia, catecholaminergic polymorphic, 3 614021; Mode of inheritance: BIALLELIC, autosomal or pseudoautosomal",
"entity_name": "TECRL",
"entity_type": "gene"
},
{
"created": "2019-09-24T08:31:35.921891Z",
"panel_name": "Catecholaminergic polymorphic VT",
"panel_id": 214,
"panel_version": "1.21",
"user_name": "Ivone Leong",
"item_type": "entity",
"text": "Phenotypes for gene: CALM2 were changed from Long QT syndrome 15 to Long QT syndrome 15, 616249",
"entity_name": "CALM2",
"entity_type": "gene"
},
{
"created": "2019-09-18T13:44:37.598225Z",
"panel_name": "Catecholaminergic polymorphic VT",
"panel_id": 214,
"panel_version": "1.20",
"user_name": "Matthew Edwards",
"item_type": "entity",
"text": "reviewed gene: CALM2: Rating: GREEN; Mode of pathogenicity: None; Publications: 24917665; Phenotypes: Long QT syndrome 15; Mode of inheritance: None; Current diagnostic: yes",
"entity_name": "CALM2",
"entity_type": "gene"
},
{
"created": "2019-09-12T10:21:50.412330Z",
"panel_name": "Catecholaminergic polymorphic VT",
"panel_id": 214,
"panel_version": "1.20",
"user_name": "Ivone Leong",
"item_type": "entity",
"text": "Publications for gene: RYR2 were set to 27761157; 19121813",
"entity_name": "RYR2",
"entity_type": "gene"
},
{
"created": "2019-09-12T10:18:26.318502Z",
"panel_name": "Catecholaminergic polymorphic VT",
"panel_id": 214,
"panel_version": "1.19",
"user_name": "Ivone Leong",
"item_type": "entity",
"text": "Publications for gene: CASQ2 were set to 27761157; 19121813",
"entity_name": "CASQ2",
"entity_type": "gene"
},
{
"created": "2019-09-12T10:00:37.239698Z",
"panel_name": "Catecholaminergic polymorphic VT",
"panel_id": 214,
"panel_version": "1.18",
"user_name": "Ivone Leong",
"item_type": "entity",
"text": "Phenotypes for gene: CALM1 were changed from Ventricular tachycardia, catecholaminergic polymorphic, 4; Long QT syndrome 14 (616247); Ventricular tachycardia, catecholaminergic polymorphic, 4 (614916); catecholaminergic polymorphic ventricular tachycardia to Long QT syndrome 14 (616247); Ventricular tachycardia, catecholaminergic polymorphic, 4 (614916); catecholaminergic polymorphic ventricular tachycardia",
"entity_name": "CALM1",
"entity_type": "gene"
},
{
"created": "2019-09-09T16:15:21.334806Z",
"panel_name": "Catecholaminergic polymorphic VT",
"panel_id": 214,
"panel_version": "1.17",
"user_name": "Ivone Leong",
"item_type": "panel",
"text": "List of related panels changed from Catecholaminergic Polymorphic Ventricular Tachycardia to Catecholaminergic Polymorphic Ventricular Tachycardia; R129",
"entity_name": null,
"entity_type": null
},
{
"created": "2019-03-25T17:20:35.820373Z",
"panel_name": "Catecholaminergic polymorphic VT",
"panel_id": 214,
"panel_version": "1.14",
"user_name": "Ellen McDonagh",
"item_type": "entity",
"text": "Classified gene: TECRL as Amber List (moderate evidence)",
"entity_name": "TECRL",
"entity_type": "gene"
},
{
"created": "2019-03-25T17:20:35.817520Z",
"panel_name": "Catecholaminergic polymorphic VT",
"panel_id": 214,
"panel_version": "1.14",
"user_name": "Ellen McDonagh",
"item_type": "entity",
"text": "Added comment: Comment on list classification: Gene submitted by the South West GLH. Promoted from Red to Amber for discussion with the NHSE GMS cardio specialist grou.",
"entity_name": "TECRL",
"entity_type": "gene"
},
{
"created": "2019-03-25T17:20:35.797061Z",
"panel_name": "Catecholaminergic polymorphic VT",
"panel_id": 214,
"panel_version": "1.14",
"user_name": "Ellen McDonagh",
"item_type": "entity",
"text": "Gene: tecrl has been classified as Amber List (Moderate Evidence).",
"entity_name": "TECRL",
"entity_type": "gene"
},
{
"created": "2019-03-25T16:30:35.381642Z",
"panel_name": "Catecholaminergic polymorphic VT",
"panel_id": 214,
"panel_version": "1.13",
"user_name": "Rebecca Whittington",
"item_type": "entity",
"text": "commented on gene: KCNJ2: Andersen syndrome (OMIM 170390), Atrial fibrillation, familial, 9 (OMIM 613980), Short QT syndrome 3 (OMIM 609622)",
"entity_name": "KCNJ2",
"entity_type": "gene"
},
{
"created": "2019-03-25T16:30:35.371229Z",
"panel_name": "Catecholaminergic polymorphic VT",
"panel_id": 214,
"panel_version": "1.13",
"user_name": "Rebecca Whittington",
"item_type": "entity",
"text": "commented on gene: KCNE1: Jervell and Lange-Nielsen syndrome 2 (OMIM 612347 - AR), Long QT syndrome 5 (OMIM 613695 - AD)",
"entity_name": "KCNE1",
"entity_type": "gene"
},
{
"created": "2019-03-25T16:30:35.360162Z",
"panel_name": "Catecholaminergic polymorphic VT",
"panel_id": 214,
"panel_version": "1.13",
"user_name": "Rebecca Whittington",
"item_type": "entity",
"text": "commented on gene: ANK2: Cardiac arrhythmia, ankyrin-B-related (OMIM 600919), Long QT syndrome 4 (OMIM 600919)",
"entity_name": "ANK2",
"entity_type": "gene"
},
{
"created": "2019-03-25T16:30:35.349643Z",
"panel_name": "Catecholaminergic polymorphic VT",
"panel_id": 214,
"panel_version": "1.13",
"user_name": "Rebecca Whittington",
"item_type": "entity",
"text": "commented on gene: TRDN: Ventricular tachycardia, catecholaminergic polymorphic, 5, with or without muscle weakness (OMIM 615441)",
"entity_name": "TRDN",
"entity_type": "gene"
},
{
"created": "2019-03-25T16:30:35.337068Z",
"panel_name": "Catecholaminergic polymorphic VT",
"panel_id": 214,
"panel_version": "1.13",
"user_name": "Rebecca Whittington",
"item_type": "entity",
"text": "commented on gene: RYR2: Arrhythmogenic right ventricular dysplasia 2 (OMIM 600996), Ventricular tachycardia, catecholaminergic polymorphic, 1 (OMIM 604772)",
"entity_name": "RYR2",
"entity_type": "gene"
},
{
"created": "2019-03-25T16:30:35.321798Z",
"panel_name": "Catecholaminergic polymorphic VT",
"panel_id": 214,
"panel_version": "1.13",
"user_name": "Rebecca Whittington",
"item_type": "entity",
"text": "commented on gene: CASQ2: Ventricular tachycardia, catecholaminergic polymorphic, 2 (OMIM 611938)",
"entity_name": "CASQ2",
"entity_type": "gene"
},
{
"created": "2019-03-25T16:30:35.309535Z",
"panel_name": "Catecholaminergic polymorphic VT",
"panel_id": 214,
"panel_version": "1.13",
"user_name": "Rebecca Whittington",
"item_type": "entity",
"text": "commented on gene: CALM1: Long QT syndrome 14 (OMIM 616247).Ventricular tachycardia, catecholaminergic polymorphic, 4 (OMIM 614916).",
"entity_name": "CALM1",
"entity_type": "gene"
},
{
"created": "2019-03-25T16:30:35.298412Z",
"panel_name": "Catecholaminergic polymorphic VT",
"panel_id": 214,
"panel_version": "1.13",
"user_name": "Rebecca Whittington",
"item_type": "entity",
"text": "commented on gene: TECRL: Ventricular tachycardia, catecholaminergic polymorphic, 3 (OMIM 614021)",
"entity_name": "TECRL",
"entity_type": "gene"
},
{
"created": "2019-03-25T16:30:35.287128Z",
"panel_name": "Catecholaminergic polymorphic VT",
"panel_id": 214,
"panel_version": "1.13",
"user_name": "Rebecca Whittington",
"item_type": "entity",
"text": "commented on gene: CALM3: No links to phenotypes on OMIM",
"entity_name": "CALM3",
"entity_type": "gene"
},
{
"created": "2019-03-25T16:30:35.275873Z",
"panel_name": "Catecholaminergic polymorphic VT",
"panel_id": 214,
"panel_version": "1.13",
"user_name": "Rebecca Whittington",
"item_type": "entity",
"text": "commented on gene: CALM2: Long QT syndrome 15 (OMIM 616249). Overlapping phenotype with CPVT",
"entity_name": "CALM2",
"entity_type": "gene"
},
{
"created": "2019-03-25T16:27:41.139311Z",
"panel_name": "Catecholaminergic polymorphic VT",
"panel_id": 214,
"panel_version": "1.12",
"user_name": "Rebecca Whittington",
"item_type": "entity",
"text": "commented on gene: KCNJ2: No evidence for this gene assoc with CPVT. PMID:27761157",
"entity_name": "KCNJ2",
"entity_type": "gene"
},
{
"created": "2019-03-25T16:27:41.124641Z",
"panel_name": "Catecholaminergic polymorphic VT",
"panel_id": 214,
"panel_version": "1.12",
"user_name": "Rebecca Whittington",
"item_type": "entity",
"text": "commented on gene: KCNE1: No evidence for this gene assoc with CPVT. ",
"entity_name": "KCNE1",
"entity_type": "gene"
},
{
"created": "2019-03-25T16:27:41.111776Z",
"panel_name": "Catecholaminergic polymorphic VT",
"panel_id": 214,
"panel_version": "1.12",
"user_name": "Rebecca Whittington",
"item_type": "entity",
"text": "commented on gene: ANK2: No evidence for this gene assoc with CPVT. PMID:27761157.",
"entity_name": "ANK2",
"entity_type": "gene"
},
{
"created": "2019-03-25T16:27:41.095912Z",
"panel_name": "Catecholaminergic polymorphic VT",
"panel_id": 214,
"panel_version": "1.12",
"user_name": "Rebecca Whittington",
"item_type": "entity",
"text": "commented on gene: TRDN: Literature evidence including functional / family testing. PMID:22422768. PMID: 25922419",
"entity_name": "TRDN",
"entity_type": "gene"
},
{
"created": "2019-03-25T16:27:41.077717Z",
"panel_name": "Catecholaminergic polymorphic VT",
"panel_id": 214,
"panel_version": "1.12",
"user_name": "Rebecca Whittington",
"item_type": "entity",
"text": "commented on gene: RYR2: Lots of literature evidence for this gene / established gene. PMID: 26018045. PMID:26114861. PMID:19926015.",
"entity_name": "RYR2",
"entity_type": "gene"
},
{
"created": "2019-03-25T16:27:41.061521Z",
"panel_name": "Catecholaminergic polymorphic VT",
"panel_id": 214,
"panel_version": "1.12",
"user_name": "Rebecca Whittington",
"item_type": "entity",
"text": "commented on gene: CASQ2: Literature evidence (inc cosegregation, functional). PMID:27157848. PMID:29178653. PMID: 21618644",
"entity_name": "CASQ2",
"entity_type": "gene"
},
{
"created": "2019-03-25T16:27:41.041875Z",
"panel_name": "Catecholaminergic polymorphic VT",
"panel_id": 214,
"panel_version": "1.12",
"user_name": "Rebecca Whittington",
"item_type": "entity",
"text": "commented on gene: CALM1: Literature evidence -see PMID Refs (including functional). PMID: 23040497. PMID:28491771. PMID: 23388215",
"entity_name": "CALM1",
"entity_type": "gene"
},
{
"created": "2019-03-25T16:27:41.026414Z",
"panel_name": "Catecholaminergic polymorphic VT",
"panel_id": 214,
"panel_version": "1.12",
"user_name": "Rebecca Whittington",
"item_type": "entity",
"text": "commented on gene: TECRL: Only one entry linked to one paper for cardiac arrhythmia but showed homozygosity for splice mutation that segregated in the family. Possible overlapping phenotype with LQTS. 3 different families described in the paper (2016): PMID:27861123",
"entity_name": "TECRL",
"entity_type": "gene"
},
{
"created": "2019-03-25T16:27:41.008743Z",
"panel_name": "Catecholaminergic polymorphic VT",
"panel_id": 214,
"panel_version": "1.12",
"user_name": "Rebecca Whittington",
"item_type": "entity",
"text": "commented on gene: CALM3: Some recent evidence in 2016 as found in patient and mother with CPVT (functional effect on calcium binding) - see ref: PMID:27516456",
"entity_name": "CALM3",
"entity_type": "gene"
},
{
"created": "2019-03-25T16:27:40.993802Z",
"panel_name": "Catecholaminergic polymorphic VT",
"panel_id": 214,
"panel_version": "1.12",
"user_name": "Rebecca Whittington",
"item_type": "entity",
"text": "commented on gene: CALM2: Literature evidence -see refs. PMID: 24917665. PMID:26969752. PMID: 23388215.",
"entity_name": "CALM2",
"entity_type": "gene"
},
{
"created": "2019-03-25T16:24:49.929781Z",
"panel_name": "Catecholaminergic polymorphic VT",
"panel_id": 214,
"panel_version": "1.11",
"user_name": "Rebecca Whittington",
"item_type": "entity",
"text": "reviewed gene: KCNJ2: Rating: RED; Mode of pathogenicity: ; Publications: ; Phenotypes: ; Mode of inheritance: MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted; Current diagnostic: yes",
"entity_name": "KCNJ2",
"entity_type": "gene"
},
{
"created": "2019-03-25T16:24:49.919812Z",
"panel_name": "Catecholaminergic polymorphic VT",
"panel_id": 214,
"panel_version": "1.11",
"user_name": "Rebecca Whittington",
"item_type": "entity",
"text": "reviewed gene: KCNE1: Rating: RED; Mode of pathogenicity: ; Publications: ; Phenotypes: ; Mode of inheritance: BOTH monoallelic and biallelic, autosomal or pseudoautosomal; Current diagnostic: yes",
"entity_name": "KCNE1",
"entity_type": "gene"
},
{
"created": "2019-03-25T16:24:49.910144Z",
"panel_name": "Catecholaminergic polymorphic VT",
"panel_id": 214,
"panel_version": "1.11",
"user_name": "Rebecca Whittington",
"item_type": "entity",
"text": "reviewed gene: ANK2: Rating: RED; Mode of pathogenicity: ; Publications: ; Phenotypes: ; Mode of inheritance: MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted; Current diagnostic: yes",
"entity_name": "ANK2",
"entity_type": "gene"
},
{
"created": "2019-03-25T16:24:49.900188Z",
"panel_name": "Catecholaminergic polymorphic VT",
"panel_id": 214,
"panel_version": "1.11",
"user_name": "Rebecca Whittington",
"item_type": "entity",
"text": "reviewed gene: TRDN: Rating: GREEN; Mode of pathogenicity: ; Publications: ; Phenotypes: ; Mode of inheritance: BIALLELIC, autosomal or pseudoautosomal; Current diagnostic: yes",
"entity_name": "TRDN",
"entity_type": "gene"
},
{
"created": "2019-03-25T16:24:49.886913Z",
"panel_name": "Catecholaminergic polymorphic VT",
"panel_id": 214,
"panel_version": "1.11",
"user_name": "Rebecca Whittington",
"item_type": "entity",
"text": "reviewed gene: RYR2: Rating: GREEN; Mode of pathogenicity: ; Publications: ; Phenotypes: ; Mode of inheritance: BIALLELIC, autosomal or pseudoautosomal; Current diagnostic: yes",
"entity_name": "RYR2",
"entity_type": "gene"
},
{
"created": "2019-03-25T16:24:49.873975Z",
"panel_name": "Catecholaminergic polymorphic VT",
"panel_id": 214,
"panel_version": "1.11",
"user_name": "Rebecca Whittington",
"item_type": "entity",
"text": "reviewed gene: CASQ2: Rating: GREEN; Mode of pathogenicity: ; Publications: ; Phenotypes: ; Mode of inheritance: BIALLELIC, autosomal or pseudoautosomal; Current diagnostic: yes",
"entity_name": "CASQ2",
"entity_type": "gene"
},
{
"created": "2019-03-25T16:24:49.862422Z",
"panel_name": "Catecholaminergic polymorphic VT",
"panel_id": 214,
"panel_version": "1.11",
"user_name": "Rebecca Whittington",
"item_type": "entity",
"text": "reviewed gene: CALM1: Rating: GREEN; Mode of pathogenicity: ; Publications: ; Phenotypes: ; Mode of inheritance: MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted; Current diagnostic: yes",
"entity_name": "CALM1",
"entity_type": "gene"
},
{
"created": "2019-03-25T16:24:49.850768Z",
"panel_name": "Catecholaminergic polymorphic VT",
"panel_id": 214,
"panel_version": "1.11",
"user_name": "Rebecca Whittington",
"item_type": "entity",
"text": "reviewed gene: TECRL: Rating: GREEN; Mode of pathogenicity: ; Publications: ; Phenotypes: ; Mode of inheritance: BIALLELIC, autosomal or pseudoautosomal",
"entity_name": "TECRL",
"entity_type": "gene"
},
{
"created": "2019-03-25T16:24:49.838451Z",
"panel_name": "Catecholaminergic polymorphic VT",
"panel_id": 214,
"panel_version": "1.11",
"user_name": "Rebecca Whittington",
"item_type": "entity",
"text": "reviewed gene: CALM3: Rating: AMBER; Mode of pathogenicity: ; Publications: ; Phenotypes: ; Mode of inheritance: Unknown",
"entity_name": "CALM3",
"entity_type": "gene"
},
{
"created": "2019-03-25T16:24:49.826009Z",
"panel_name": "Catecholaminergic polymorphic VT",
"panel_id": 214,
"panel_version": "1.11",
"user_name": "Rebecca Whittington",
"item_type": "entity",
"text": "reviewed gene: CALM2: Rating: GREEN; Mode of pathogenicity: ; Publications: ; Phenotypes: ; Mode of inheritance: MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted",
"entity_name": "CALM2",
"entity_type": "gene"
},
{
"created": "2019-03-19T17:06:38.622411Z",
"panel_name": "Catecholaminergic polymorphic VT",
"panel_id": 214,
"panel_version": "1.10",
"user_name": "Matthew Edwards",
"item_type": "entity",
"text": "reviewed gene: TRDN: Rating: GREEN; Mode of pathogenicity: None; Publications: ; Phenotypes: CPVT 5; Mode of inheritance: BIALLELIC, autosomal or pseudoautosomal",
"entity_name": "TRDN",
"entity_type": "gene"
},
{
"created": "2019-03-19T17:03:23.977509Z",
"panel_name": "Catecholaminergic polymorphic VT",
"panel_id": 214,
"panel_version": "1.10",
"user_name": "Matthew Edwards",
"item_type": "entity",
"text": "reviewed gene: RYR2: Rating: GREEN; Mode of pathogenicity: None; Publications: ; Phenotypes: CPVT, ARVC; Mode of inheritance: MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown",
"entity_name": "RYR2",
"entity_type": "gene"
},
{
"created": "2019-03-19T16:58:36.346479Z",
"panel_name": "Catecholaminergic polymorphic VT",
"panel_id": 214,
"panel_version": "1.10",
"user_name": "Matthew Edwards",
"item_type": "entity",
"text": "reviewed gene: CASQ2: Rating: GREEN; Mode of pathogenicity: None; Publications: 16908766; Phenotypes: ; Mode of inheritance: BIALLELIC, autosomal or pseudoautosomal",
"entity_name": "CASQ2",
"entity_type": "gene"
},
{
"created": "2019-03-19T16:51:26.480384Z",
"panel_name": "Catecholaminergic polymorphic VT",
"panel_id": 214,
"panel_version": "1.10",
"user_name": "Matthew Edwards",
"item_type": "entity",
"text": "reviewed gene: CALM1: Rating: GREEN; Mode of pathogenicity: None; Publications: ; Phenotypes: CPVT, LQTS 14; Mode of inheritance: MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown",
"entity_name": "CALM1",
"entity_type": "gene"
},
{
"created": "2019-03-04T21:13:38.967027Z",
"panel_name": "Catecholaminergic polymorphic VT",
"panel_id": 214,
"panel_version": "1.10",
"user_name": "Ellen McDonagh",
"item_type": "entity",
"text": "Classified gene: CALM3 as Amber List (moderate evidence)",
"entity_name": "CALM3",
"entity_type": "gene"
},
{
"created": "2019-03-04T21:13:38.964590Z",
"panel_name": "Catecholaminergic polymorphic VT",
"panel_id": 214,
"panel_version": "1.10",
"user_name": "Ellen McDonagh",
"item_type": "entity",
"text": "Added comment: Comment on list classification: This gene-disease was discussed in the NHSE GMS Cardiology Specialist Group meeting call on 25th January 2019, and it was confirmed that this should be promoted from Red to Amber.",
"entity_name": "CALM3",
"entity_type": "gene"
},
{
"created": "2019-03-04T21:13:38.949776Z",
"panel_name": "Catecholaminergic polymorphic VT",
"panel_id": 214,
"panel_version": "1.10",
"user_name": "Ellen McDonagh",
"item_type": "entity",
"text": "Gene: calm3 has been classified as Amber List (Moderate Evidence).",
"entity_name": "CALM3",
"entity_type": "gene"
},
{
"created": "2019-02-21T17:05:33.112597Z",
"panel_name": "Catecholaminergic polymorphic VT",
"panel_id": 214,
"panel_version": "1.9",
"user_name": "Ellen McDonagh",
"item_type": "entity",
"text": "gene: TECRL was added\ngene: TECRL was added to Catecholaminergic polymorphic VT. Sources: South West GLH\nMode of inheritance for gene: TECRL was set to BIALLELIC, autosomal or pseudoautosomal",
"entity_name": "TECRL",
"entity_type": "gene"
},
{
"created": "2019-02-21T17:05:33.057195Z",
"panel_name": "Catecholaminergic polymorphic VT",
"panel_id": 214,
"panel_version": "1.9",
"user_name": "Ellen McDonagh",
"item_type": "entity",
"text": "Source South West GLH was added to KCNJ2.",
"entity_name": "KCNJ2",
"entity_type": "gene"
},
{
"created": "2019-02-21T17:05:32.991167Z",
"panel_name": "Catecholaminergic polymorphic VT",
"panel_id": 214,
"panel_version": "1.9",
"user_name": "Ellen McDonagh",
"item_type": "entity",
"text": "Source South West GLH was added to KCNE1.\nMode of inheritance for gene KCNE1 was changed from Unknown to BOTH monoallelic and biallelic, autosomal or pseudoautosomal",
"entity_name": "KCNE1",
"entity_type": "gene"
},
{
"created": "2019-02-21T17:05:32.925639Z",
"panel_name": "Catecholaminergic polymorphic VT",
"panel_id": 214,
"panel_version": "1.9",
"user_name": "Ellen McDonagh",
"item_type": "entity",
"text": "Source South West GLH was added to CALM3.\nMode of inheritance for gene CALM3 was changed from to Unknown",
"entity_name": "CALM3",
"entity_type": "gene"
},
{
"created": "2019-02-21T17:05:32.865073Z",
"panel_name": "Catecholaminergic polymorphic VT",
"panel_id": 214,
"panel_version": "1.9",
"user_name": "Ellen McDonagh",
"item_type": "entity",
"text": "Source South West GLH was added to ANK2.\nMode of inheritance for gene ANK2 was changed from to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted",
"entity_name": "ANK2",
"entity_type": "gene"
},
{
"created": "2019-02-21T17:05:32.804983Z",
"panel_name": "Catecholaminergic polymorphic VT",
"panel_id": 214,
"panel_version": "1.9",
"user_name": "Ellen McDonagh",
"item_type": "entity",
"text": "Source South West GLH was added to TRDN.",
"entity_name": "TRDN",
"entity_type": "gene"
},
{
"created": "2019-02-21T17:05:32.737486Z",
"panel_name": "Catecholaminergic polymorphic VT",
"panel_id": 214,
"panel_version": "1.9",
"user_name": "Ellen McDonagh",
"item_type": "entity",
"text": "Source South West GLH was added to RYR2.\nMode of inheritance for gene RYR2 was changed from MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown to BIALLELIC, autosomal or pseudoautosomal",
"entity_name": "RYR2",
"entity_type": "gene"
},
{
"created": "2019-02-21T17:05:32.673263Z",
"panel_name": "Catecholaminergic polymorphic VT",
"panel_id": 214,
"panel_version": "1.9",
"user_name": "Ellen McDonagh",
"item_type": "entity",
"text": "Source South West GLH was added to CASQ2.",
"entity_name": "CASQ2",
"entity_type": "gene"
},
{
"created": "2019-02-21T17:05:32.606445Z",
"panel_name": "Catecholaminergic polymorphic VT",
"panel_id": 214,
"panel_version": "1.9",
"user_name": "Ellen McDonagh",
"item_type": "entity",
"text": "Source South West GLH was added to CALM2.\nMode of inheritance for gene CALM2 was changed from MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted",
"entity_name": "CALM2",
"entity_type": "gene"
},
{
"created": "2019-02-21T17:05:32.544676Z",
"panel_name": "Catecholaminergic polymorphic VT",
"panel_id": 214,
"panel_version": "1.9",
"user_name": "Ellen McDonagh",
"item_type": "entity",
"text": "Source South West GLH was added to CALM1.\nMode of inheritance for gene CALM1 was changed from MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted",
"entity_name": "CALM1",
"entity_type": "gene"
},
{
"created": "2019-02-20T14:17:08.672488Z",
"panel_name": "Catecholaminergic polymorphic VT",
"panel_id": 214,
"panel_version": "1.8",
"user_name": "Ellen McDonagh",
"item_type": "entity",
"text": "edited their review of gene: CALM3: Added comment: This gene was part of an initial gene list collated by Matthew Edwards Royal Brompton Hospital sent 16th Jan 2019 on behalf of the London South GLH for review by the GMS Cardiology Specialist Group. Only gene symbol from the Royal Brompton gene panel was provided - suggested initial gene rating and evidence for inclusion not provided with the list.; Changed rating: AMBER",
"entity_name": "CALM3",
"entity_type": "gene"
},
{
"created": "2019-02-20T14:17:08.661553Z",
"panel_name": "Catecholaminergic polymorphic VT",
"panel_id": 214,
"panel_version": "1.8",
"user_name": "Ellen McDonagh",
"item_type": "entity",
"text": "edited their review of gene: TRDN: Added comment: This gene was part of an initial gene list collated by Matthew Edwards Royal Brompton Hospital sent 16th Jan 2019 on behalf of the London South GLH for review by the GMS Cardiology Specialist Group. Only gene symbol from the Royal Brompton gene panel was provided - suggested initial gene rating and evidence for inclusion not provided with the list.; Changed rating: AMBER",
"entity_name": "TRDN",
"entity_type": "gene"
},
{
"created": "2019-02-20T14:17:08.650273Z",
"panel_name": "Catecholaminergic polymorphic VT",
"panel_id": 214,
"panel_version": "1.8",
"user_name": "Ellen McDonagh",
"item_type": "entity",
"text": "edited their review of gene: RYR2: Added comment: This gene was part of an initial gene list collated by Matthew Edwards Royal Brompton Hospital sent 16th Jan 2019 on behalf of the London South GLH for review by the GMS Cardiology Specialist Group. Only gene symbol from the Royal Brompton gene panel was provided - suggested initial gene rating and evidence for inclusion not provided with the list.; Changed rating: AMBER",
"entity_name": "RYR2",
"entity_type": "gene"
},
{
"created": "2019-02-20T14:17:08.638805Z",
"panel_name": "Catecholaminergic polymorphic VT",
"panel_id": 214,
"panel_version": "1.8",
"user_name": "Ellen McDonagh",
"item_type": "entity",
"text": "edited their review of gene: CASQ2: Added comment: This gene was part of an initial gene list collated by Matthew Edwards Royal Brompton Hospital sent 16th Jan 2019 on behalf of the London South GLH for review by the GMS Cardiology Specialist Group. Only gene symbol from the Royal Brompton gene panel was provided - suggested initial gene rating and evidence for inclusion not provided with the list.; Changed rating: AMBER",
"entity_name": "CASQ2",
"entity_type": "gene"
},
{
"created": "2019-02-20T14:17:08.627934Z",
"panel_name": "Catecholaminergic polymorphic VT",
"panel_id": 214,
"panel_version": "1.8",
"user_name": "Ellen McDonagh",
"item_type": "entity",
"text": "edited their review of gene: CALM2: Added comment: This gene was part of an initial gene list collated by Matthew Edwards Royal Brompton Hospital sent 16th Jan 2019 on behalf of the London South GLH for review by the GMS Cardiology Specialist Group. Only gene symbol from the Royal Brompton gene panel was provided - suggested initial gene rating and evidence for inclusion not provided with the list.; Changed rating: AMBER",
"entity_name": "CALM2",
"entity_type": "gene"
},
{
"created": "2019-02-20T14:17:08.617057Z",
"panel_name": "Catecholaminergic polymorphic VT",
"panel_id": 214,
"panel_version": "1.8",
"user_name": "Ellen McDonagh",
"item_type": "entity",
"text": "edited their review of gene: CALM1: Added comment: This gene was part of an initial gene list collated by Matthew Edwards Royal Brompton Hospital sent 16th Jan 2019 on behalf of the London South GLH for review by the GMS Cardiology Specialist Group. Only gene symbol from the Royal Brompton gene panel was provided - suggested initial gene rating and evidence for inclusion not provided with the list.; Changed rating: AMBER",
"entity_name": "CALM1",
"entity_type": "gene"
},
{
"created": "2019-02-20T13:58:08.901837Z",
"panel_name": "Catecholaminergic polymorphic VT",
"panel_id": 214,
"panel_version": "1.7",
"user_name": "Ellen McDonagh",
"item_type": "entity",
"text": "Source London South GLH was added to CALM3.",
"entity_name": "CALM3",
"entity_type": "gene"
},
{
"created": "2019-02-20T13:58:08.840484Z",
"panel_name": "Catecholaminergic polymorphic VT",
"panel_id": 214,
"panel_version": "1.7",
"user_name": "Ellen McDonagh",
"item_type": "entity",
"text": "Source London South GLH was added to TRDN.",
"entity_name": "TRDN",
"entity_type": "gene"
},
{
"created": "2019-02-20T13:58:08.767539Z",
"panel_name": "Catecholaminergic polymorphic VT",
"panel_id": 214,
"panel_version": "1.7",
"user_name": "Ellen McDonagh",
"item_type": "entity",
"text": "Source London South GLH was added to RYR2.",
"entity_name": "RYR2",
"entity_type": "gene"
},
{
"created": "2019-02-20T13:58:08.695440Z",
"panel_name": "Catecholaminergic polymorphic VT",
"panel_id": 214,
"panel_version": "1.7",
"user_name": "Ellen McDonagh",
"item_type": "entity",
"text": "Source London South GLH was added to CASQ2.",
"entity_name": "CASQ2",
"entity_type": "gene"
},
{
"created": "2019-02-20T13:58:08.628850Z",
"panel_name": "Catecholaminergic polymorphic VT",
"panel_id": 214,
"panel_version": "1.7",
"user_name": "Ellen McDonagh",
"item_type": "entity",
"text": "Source London South GLH was added to CALM2.\nRating Changed from Green List (high evidence) to Green List (high evidence)",
"entity_name": "CALM2",
"entity_type": "gene"
},
{
"created": "2019-02-20T13:58:08.564674Z",
"panel_name": "Catecholaminergic polymorphic VT",
"panel_id": 214,
"panel_version": "1.7",
"user_name": "Ellen McDonagh",
"item_type": "entity",
"text": "Source London South GLH was added to CALM1.",
"entity_name": "CALM1",
"entity_type": "gene"
},
{
"created": "2019-02-15T09:00:27.205325Z",
"panel_name": "Catecholaminergic polymorphic VT",
"panel_id": 214,
"panel_version": "1.6",
"user_name": "James Eden",
"item_type": "entity",
"text": "edited their review of gene: RYR2: Changed publications: 19121813, 27761157, 16391617",
"entity_name": "RYR2",
"entity_type": "gene"
},
{
"created": "2019-02-14T13:38:37.813217Z",
"panel_name": "Catecholaminergic polymorphic VT",
"panel_id": 214,
"panel_version": "1.6",
"user_name": "James Eden",
"item_type": "entity",
"text": "reviewed gene: TRDN: Rating: GREEN; Mode of pathogenicity: ; Publications: 26200674; Phenotypes: Ventricular tachycardia, catecholaminergic polymorphic, 5, with or without muscle weakness (615441); Mode of inheritance: BIALLELIC, autosomal or pseudoautosomal; Current diagnostic: yes",
"entity_name": "TRDN",
"entity_type": "gene"
},
{
"created": "2019-02-14T13:38:37.799895Z",
"panel_name": "Catecholaminergic polymorphic VT",
"panel_id": 214,
"panel_version": "1.6",
"user_name": "James Eden",
"item_type": "entity",
"text": "reviewed gene: RYR2: Rating: GREEN; Mode of pathogenicity: ; Publications: 19121813, 27761157; Phenotypes: Arrhythmogenic right ventricular dysplasia 2 (600996), Ventricular tachycardia, catecholaminergic polymorphic, 1 (604772); Mode of inheritance: MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown; Current diagnostic: yes",
"entity_name": "RYR2",
"entity_type": "gene"
},
{
"created": "2019-02-14T13:38:37.787176Z",
"panel_name": "Catecholaminergic polymorphic VT",
"panel_id": 214,
"panel_version": "1.6",
"user_name": "James Eden",
"item_type": "entity",
"text": "reviewed gene: KCNJ2: Rating: RED; Mode of pathogenicity: ; Publications: 27761157; Phenotypes: Andersen syndrome (170390), Atrial fibrillation, familial, 9 (613980), Short QT syndrome 3 (609622); Mode of inheritance: MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted; Current diagnostic: yes",
"entity_name": "KCNJ2",
"entity_type": "gene"
},
{
"created": "2019-02-14T13:38:37.774475Z",
"panel_name": "Catecholaminergic polymorphic VT",
"panel_id": 214,
"panel_version": "1.6",
"user_name": "James Eden",
"item_type": "entity",
"text": "reviewed gene: CASQ2: Rating: GREEN; Mode of pathogenicity: ; Publications: 19121813, 27761157; Phenotypes: Ventricular tachycardia, catecholaminergic polymorphic, 2 (611938); Mode of inheritance: BIALLELIC, autosomal or pseudoautosomal; Current diagnostic: yes",
"entity_name": "CASQ2",
"entity_type": "gene"
},
{
"created": "2019-02-14T13:38:37.761102Z",
"panel_name": "Catecholaminergic polymorphic VT",
"panel_id": 214,
"panel_version": "1.6",
"user_name": "James Eden",
"item_type": "entity",
"text": "reviewed gene: CALM1: Rating: GREEN; Mode of pathogenicity: ; Publications: 19121813, 27761157; Phenotypes: Long QT syndrome 14 (616247), Ventricular tachycardia, catecholaminergic polymorphic, 4 (614916); Mode of inheritance: MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown; Current diagnostic: yes",
"entity_name": "CALM1",
"entity_type": "gene"
},
{
"created": "2019-02-14T13:26:38.453014Z",
"panel_name": "Catecholaminergic polymorphic VT",
"panel_id": 214,
"panel_version": "1.5",
"user_name": "Ellen McDonagh",
"item_type": "entity",
"text": "Source North West GLH was added to TRDN.\nAdded phenotypes Ventricular tachycardia, catecholaminergic polymorphic, 5, with or without muscle weakness (615441) for gene: TRDN\nPublications for gene TRDN were changed from to 26200674\nRating Changed from Green List (high evidence) to Green List (high evidence)",
"entity_name": "TRDN",
"entity_type": "gene"
},
{
"created": "2019-02-14T13:26:38.395273Z",
"panel_name": "Catecholaminergic polymorphic VT",
"panel_id": 214,
"panel_version": "1.5",
"user_name": "Ellen McDonagh",
"item_type": "entity",
"text": "Source North West GLH was added to RYR2.\nAdded phenotypes Arrhythmogenic right ventricular dysplasia 2 (600996); Ventricular tachycardia, catecholaminergic polymorphic, 1 (604772) for gene: RYR2\nPublications for gene RYR2 were changed from to 27761157; 19121813\nRating Changed from Green List (high evidence) to Green List (high evidence)",
"entity_name": "RYR2",
"entity_type": "gene"
},
{
"created": "2019-02-14T13:26:38.336831Z",
"panel_name": "Catecholaminergic polymorphic VT",
"panel_id": 214,
"panel_version": "1.5",
"user_name": "Ellen McDonagh",
"item_type": "entity",
"text": "Source North West GLH was added to KCNJ2.\nMode of inheritance for gene KCNJ2 was changed from to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted\nAdded phenotypes Atrial fibrillation, familial, 9 (613980); Andersen syndrome (170390); Short QT syndrome 3 (609622) for gene: KCNJ2\nPublications for gene KCNJ2 were changed from to 27761157",
"entity_name": "KCNJ2",
"entity_type": "gene"
},
{
"created": "2019-02-14T13:26:38.279746Z",
"panel_name": "Catecholaminergic polymorphic VT",
"panel_id": 214,
"panel_version": "1.5",
"user_name": "Ellen McDonagh",
"item_type": "entity",
"text": "Source North West GLH was added to CASQ2.\nAdded phenotypes Ventricular tachycardia, catecholaminergic polymorphic, 2 (611938) for gene: CASQ2\nPublications for gene CASQ2 were changed from to 27761157; 19121813\nRating Changed from Green List (high evidence) to Green List (high evidence)",
"entity_name": "CASQ2",
"entity_type": "gene"
},
{
"created": "2019-02-14T13:26:38.222593Z",
"panel_name": "Catecholaminergic polymorphic VT",
"panel_id": 214,
"panel_version": "1.5",
"user_name": "Ellen McDonagh",
"item_type": "entity",
"text": "Source North West GLH was added to CALM1.\nAdded phenotypes Long QT syndrome 14 (616247); Ventricular tachycardia, catecholaminergic polymorphic, 4 (614916) for gene: CALM1\nPublications for gene CALM1 were changed from to 27761157; 19121813\nRating Changed from Green List (high evidence) to Green List (high evidence)",
"entity_name": "CALM1",
"entity_type": "gene"
},
{
"created": "2018-11-16T14:19:12.762919Z",
"panel_name": "Catecholaminergic polymorphic VT",
"panel_id": 214,
"panel_version": "1.3",
"user_name": "Ellen McDonagh",
"item_type": "panel",
"text": "Panel name changed from Catecholaminergic Polymorphic Ventricular Tachycardia to Catecholaminergic polymorphic VT\nList of related panels changed from to Catecholaminergic Polymorphic Ventricular Tachycardia\nPanel types changed to Rare Disease 100K; GMS Rare Disease",
"entity_name": null,
"entity_type": null
}
]