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[
{
"created": "2024-01-24T18:24:52.819865Z",
"panel_name": "Adult solid tumours cancer susceptibility",
"panel_id": 245,
"panel_version": "2.29",
"user_name": "Arina Puzriakova",
"item_type": "entity",
"text": "Phenotypes for gene: PDGFRA were changed from Gastrointestinal stromal tumor to Gastrointestinal stromal tumor/GIST-plus syndrome, somatic or familial, OMIM:175510; Familial Gastrointestinal stromal tumour; Familial GIST",
"entity_name": "PDGFRA",
"entity_type": "gene"
},
{
"created": "2024-01-09T11:30:02.642131Z",
"panel_name": "Adult solid tumours cancer susceptibility",
"panel_id": 245,
"panel_version": "2.28",
"user_name": "Arina Puzriakova",
"item_type": "entity",
"text": "Phenotypes for gene: BAP1 were changed from Melanocytic Tumor syndrome, Familial Uveal Melanoma to Tumor predisposition syndrome 1, OMIM:614327; {Uveal melanoma, susceptibility to, 2}, OMIM:606661",
"entity_name": "BAP1",
"entity_type": "gene"
},
{
"created": "2023-08-22T15:30:17.087714Z",
"panel_name": "Adult solid tumours cancer susceptibility",
"panel_id": 245,
"panel_version": "2.25",
"user_name": "Arina Puzriakova",
"item_type": "entity",
"text": "Phenotypes for gene: PTCH1 were changed from Gorlin syndrome, BCC to Basal cell nevus syndrome 1, OMIM:109400; Gorlin syndrome",
"entity_name": "PTCH1",
"entity_type": "gene"
},
{
"created": "2022-11-18T10:01:05.072780Z",
"panel_name": "Adult solid tumours cancer susceptibility",
"panel_id": 245,
"panel_version": "2.24",
"user_name": "Arina Puzriakova",
"item_type": "entity",
"text": "Phenotypes for gene: TERT were changed from {Dyskeratosis congenita, autosomal recessive 4}, 613989; {Dyskeratosis congenita, autosomal dominant 2}, 613989 to Dyskeratosis congenita, autosomal dominant 2, OMIM:613989; Dyskeratosis congenita, autosomal recessive 4, OMIM:613989; Pulmonary fibrosis and/or bone marrow failure, telomere-related, 1, OMIM:614742; {Leukemia, acute myeloid}, OMIM:601626; {Melanoma, cutaneous malignant, 9}, OMIM:615134",
"entity_name": "TERT",
"entity_type": "gene"
},
{
"created": "2022-11-08T15:10:10.852477Z",
"panel_name": "Adult solid tumours cancer susceptibility",
"panel_id": 245,
"panel_version": "2.23",
"user_name": "Arina Puzriakova",
"item_type": "entity",
"text": "Phenotypes for gene: SUFU were changed from SUFU associated Medulloblastoma to Basal cell nevus syndrome, OMIM:109400; {Medulloblastoma}, OMIM:155255; {Meningioma, familial, susceptibility to}, OMIM:607174",
"entity_name": "SUFU",
"entity_type": "gene"
},
{
"created": "2022-08-30T13:55:43.969881Z",
"panel_name": "Adult solid tumours cancer susceptibility",
"panel_id": 245,
"panel_version": "2.22",
"user_name": "Arina Puzriakova",
"item_type": "entity",
"text": "Phenotypes for gene: SDHB were changed from Familial Paraganglioma and Pheochromocytoma to Paragangliomas 4, OMIM:115310; Pheochromocytoma, OMIM:171300; Paraganglioma and gastric stromal sarcoma, OMIM:606864; Gastrointestinal stromal tumor, OMIM:606764",
"entity_name": "SDHB",
"entity_type": "gene"
},
{
"created": "2022-04-20T13:02:55.184877Z",
"panel_name": "Adult solid tumours cancer susceptibility",
"panel_id": 245,
"panel_version": "2.21",
"user_name": "Arina Puzriakova",
"item_type": "entity",
"text": "Phenotypes for gene: FH were changed from Hereditary Leiomyomatosis and Renal Cell Cancer to Leiomyomatosis and renal cell cancer, OMIM:150800",
"entity_name": "FH",
"entity_type": "gene"
},
{
"created": "2022-04-13T10:55:47.598149Z",
"panel_name": "Adult solid tumours cancer susceptibility",
"panel_id": 245,
"panel_version": "2.20",
"user_name": "Arina Puzriakova",
"item_type": "entity",
"text": "Phenotypes for gene: PARN were changed from 616353 Dyskeratosis congenita, autosomal recessive 6; 616371 Pulmonary fibrosis and/or bone marrow failure, telomere-related, 4 to Dyskeratosis congenita, autosomal recessive 6, OMIM:616353; Pulmonary fibrosis and/or bone marrow failure, telomere-related, 4, OMIM:616371",
"entity_name": "PARN",
"entity_type": "gene"
},
{
"created": "2022-04-05T11:03:54.747289Z",
"panel_name": "Adult solid tumours cancer susceptibility",
"panel_id": 245,
"panel_version": "2.19",
"user_name": "Arina Puzriakova",
"item_type": "entity",
"text": "Phenotypes for gene: EPCAM were changed from Lynch syndrome to Colorectal cancer, hereditary nonpolyposis, type 8, OMIM:613244",
"entity_name": "EPCAM",
"entity_type": "gene"
},
{
"created": "2022-04-05T08:54:33.266484Z",
"panel_name": "Adult solid tumours cancer susceptibility",
"panel_id": 245,
"panel_version": "2.18",
"user_name": "Arina Puzriakova",
"item_type": "entity",
"text": "Phenotypes for gene: BRIP1 were changed from predisposition to ovarian cancer to {Breast cancer, early-onset, susceptibility to}, OMIM:114480",
"entity_name": "BRIP1",
"entity_type": "gene"
},
{
"created": "2022-04-04T14:13:50.100448Z",
"panel_name": "Adult solid tumours cancer susceptibility",
"panel_id": 245,
"panel_version": "2.17",
"user_name": "Arina Puzriakova",
"item_type": "entity",
"text": "Phenotypes for gene: BRCA2 were changed from Hereditary Breast and Ovarian Cancer to {Breast-ovarian cancer, familial, 2}, OMIM:612555; {Breast cancer, male, susceptibility to}, OMIM:114480; {Prostate cancer}, OMIM:176807",
"entity_name": "BRCA2",
"entity_type": "gene"
},
{
"created": "2022-04-04T09:59:29.234979Z",
"panel_name": "Adult solid tumours cancer susceptibility",
"panel_id": 245,
"panel_version": "2.16",
"user_name": "Arina Puzriakova",
"item_type": "entity",
"text": "Phenotypes for gene: BRCA1 were changed from Hereditary Breast and Ovarian Cancer to {Breast-ovarian cancer, familial, 1}, OMIM:604370; Fanconi anemia, complementation group S, OMIM:617883",
"entity_name": "BRCA1",
"entity_type": "gene"
},
{
"created": "2022-02-28T15:02:58.842230Z",
"panel_name": "Adult solid tumours cancer susceptibility",
"panel_id": 245,
"panel_version": "2.15",
"user_name": "Arina Puzriakova",
"item_type": "entity",
"text": "Phenotypes for gene: KIT were changed from Gastro-Intestinal Stromal Tumor to Gastrointestinal stromal tumor, familial, OMIM:606764",
"entity_name": "KIT",
"entity_type": "gene"
},
{
"created": "2021-07-28T13:57:54.079355Z",
"panel_name": "Adult solid tumours cancer susceptibility",
"panel_id": 245,
"panel_version": "2.14",
"user_name": "Arina Puzriakova",
"item_type": "entity",
"text": "Phenotypes for gene: CDKN1B were changed from Thyroid cancer; Pituitary adenoma to Multiple endocrine neoplasia, type IV, OMIM:610755; Thyroid cancer; Pituitary adenoma",
"entity_name": "CDKN1B",
"entity_type": "gene"
},
{
"created": "2021-07-15T09:49:31.165896Z",
"panel_name": "Adult solid tumours cancer susceptibility",
"panel_id": 245,
"panel_version": "2.13",
"user_name": "Arina Puzriakova",
"item_type": "entity",
"text": "Phenotypes for gene: ATM were changed from Ataxia Telangiectasia to Ataxia-telangiectasia, OMIM:208900",
"entity_name": "ATM",
"entity_type": "gene"
},
{
"created": "2021-06-30T11:44:10.865262Z",
"panel_name": "Adult solid tumours cancer susceptibility",
"panel_id": 245,
"panel_version": "2.12",
"user_name": "Arina Puzriakova",
"item_type": "entity",
"text": "Phenotypes for gene: ACD were changed from 616553 ?Dyskeratosis congenita 6 and 7 to Dyskeratosis congenita, autosomal dominant 6, OMIM:616553; Dyskeratosis congenita, autosomal recessive 7, OMIM:616553",
"entity_name": "ACD",
"entity_type": "gene"
},
{
"created": "2021-06-18T10:39:34.378584Z",
"panel_name": "Adult solid tumours cancer susceptibility",
"panel_id": 245,
"panel_version": "2.11",
"user_name": "Arina Puzriakova",
"item_type": "entity",
"text": "Phenotypes for gene: MAX were changed from Familial Pheochromocytoma, adrenal to {Pheochromocytoma, susceptibility to}, OMIM:171300; Familial Pheochromocytoma, adrenal",
"entity_name": "MAX",
"entity_type": "gene"
},
{
"created": "2021-05-26T12:07:13.201614Z",
"panel_name": "Adult solid tumours cancer susceptibility",
"panel_id": 245,
"panel_version": "2.10",
"user_name": "Arina Puzriakova",
"item_type": "entity",
"text": "Phenotypes for gene: POLH were changed from Xeroderma pigmentosum, variant type, 278750 to Xeroderma pigmentosum, variant type, OMIM:278750",
"entity_name": "POLH",
"entity_type": "gene"
},
{
"created": "2021-04-14T10:25:28.859686Z",
"panel_name": "Adult solid tumours cancer susceptibility",
"panel_id": 245,
"panel_version": "2.9",
"user_name": "Arina Puzriakova",
"item_type": "entity",
"text": "Publications for gene: PALB2 were set to ",
"entity_name": "PALB2",
"entity_type": "gene"
},
{
"created": "2021-04-14T09:19:07.580023Z",
"panel_name": "Adult solid tumours cancer susceptibility",
"panel_id": 245,
"panel_version": "2.8",
"user_name": "Arina Puzriakova",
"item_type": "entity",
"text": "Phenotypes for gene: CDKN2A were changed from Familial Malignant Melanoma and Tumors of the Nervous system, Familial Uveal Melanoma to {Melanoma, cutaneous malignant, 2}, OMIM:155601; {Melanoma and neural system tumor syndrome}, OMIM:155755; {Melanoma-pancreatic cancer syndrome}, OMIM:606719",
"entity_name": "CDKN2A",
"entity_type": "gene"
},
{
"created": "2021-01-26T20:53:36.209891Z",
"panel_name": "Adult solid tumours cancer susceptibility",
"panel_id": 245,
"panel_version": "2.7",
"user_name": "Israel Gomy",
"item_type": "entity",
"text": "Deleted their review",
"entity_name": "RABL3",
"entity_type": "gene"
},
{
"created": "2021-01-26T20:53:28.463092Z",
"panel_name": "Adult solid tumours cancer susceptibility",
"panel_id": 245,
"panel_version": "2.7",
"user_name": "Israel Gomy",
"item_type": "entity",
"text": "Deleted their comment",
"entity_name": "RABL3",
"entity_type": "gene"
},
{
"created": "2020-12-02T12:44:27.543514Z",
"panel_name": "Adult solid tumours cancer susceptibility",
"panel_id": 245,
"panel_version": "2.7",
"user_name": "Arina Puzriakova",
"item_type": "entity",
"text": "Phenotypes for gene: DICER1 were changed from DICER1 syndrome, Familial Multinodular Goiter to Goiter, multinodular 1, with or without Sertoli-Leydig cell tumors, OMIM:138800; Pleuropulmonary blastoma, OMIM:601200; Pleuropulmonary blastoma, MONDO:0011014; Rhabdomyosarcoma, embryonal, 2, OMIM:180295; Embryonal rhabdomyosarcoma (disease), MONDO:0009993; DICER1 syndrome",
"entity_name": "DICER1",
"entity_type": "gene"
},
{
"created": "2020-10-27T15:06:33.662447Z",
"panel_name": "Adult solid tumours cancer susceptibility",
"panel_id": 245,
"panel_version": "2.6",
"user_name": "Arina Puzriakova",
"item_type": "entity",
"text": "Phenotypes for gene: PALB2 were changed from breast, pancreas to Fanconi anemia, complementation group N, 610832; {Breast cancer, susceptibility to}, 114480; {Pancreatic cancer, susceptibility to, 3}, 613348; High Risk Breast Cancer; Breast and Ovarian Cancer",
"entity_name": "PALB2",
"entity_type": "gene"
},
{
"created": "2020-09-30T13:44:42.051180Z",
"panel_name": "Adult solid tumours cancer susceptibility",
"panel_id": 245,
"panel_version": "2.5",
"user_name": "Arina Puzriakova",
"item_type": "entity",
"text": "Phenotypes for gene: NOP10 were changed from Dyskeratosis Congenita to Dyskeratosis congenita, autosomal recessive 1, 224230",
"entity_name": "NOP10",
"entity_type": "gene"
},
{
"created": "2020-06-17T13:36:41.295241Z",
"panel_name": "Adult solid tumours cancer susceptibility",
"panel_id": 245,
"panel_version": "2.4",
"user_name": "Ivone Leong",
"item_type": "entity",
"text": "Classified gene: DGCR8 as Red List (low evidence)",
"entity_name": "DGCR8",
"entity_type": "gene"
},
{
"created": "2020-06-17T13:36:41.292035Z",
"panel_name": "Adult solid tumours cancer susceptibility",
"panel_id": 245,
"panel_version": "2.4",
"user_name": "Ivone Leong",
"item_type": "entity",
"text": "Added comment: Comment on list classification: New gene added by Zornitza Stark. Added as a Red gene.",
"entity_name": "DGCR8",
"entity_type": "gene"
},
{
"created": "2020-06-17T13:36:41.259249Z",
"panel_name": "Adult solid tumours cancer susceptibility",
"panel_id": 245,
"panel_version": "2.4",
"user_name": "Ivone Leong",
"item_type": "entity",
"text": "Gene: dgcr8 has been classified as Red List (Low Evidence).",
"entity_name": "DGCR8",
"entity_type": "gene"
},
{
"created": "2020-05-02T02:26:24.312557Z",
"panel_name": "Adult solid tumours cancer susceptibility",
"panel_id": 245,
"panel_version": "2.3",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "gene: DGCR8 was added\ngene: DGCR8 was added to Adult solid tumours cancer susceptibility. Sources: Literature\nMode of inheritance for gene: DGCR8 was set to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted\nPublications for gene: DGCR8 were set to 31805011\nPhenotypes for gene: DGCR8 were set to Early-onset multinodular goiter and schwannomatosis\nReview for gene: DGCR8 was set to RED\nAdded comment: A germline missense variant segregates in one family with autosomal dominant Mendelian tumour susceptibility syndrome: familial multinodular goitre (MNG) with schwannomatosis. The missense is also a recurrent somatic missense variant in Wilms tumour. \nSources: Literature",
"entity_name": "DGCR8",
"entity_type": "gene"
},
{
"created": "2020-02-18T16:59:14.336122Z",
"panel_name": "Adult solid tumours cancer susceptibility",
"panel_id": 245,
"panel_version": "2.3",
"user_name": "Rebecca Foulger",
"item_type": "panel",
"text": "Panel version has been signed off",
"entity_name": null,
"entity_type": null
},
{
"created": "2020-02-04T11:39:02.953621Z",
"panel_name": "Adult solid tumours cancer susceptibility",
"panel_id": 245,
"panel_version": "2.1",
"user_name": "Ellen McDonagh",
"item_type": "panel",
"text": "Panel version has been signed off",
"entity_name": null,
"entity_type": null
},
{
"created": "2019-12-10T17:08:34.302092Z",
"panel_name": "Adult solid tumours cancer susceptibility",
"panel_id": 245,
"panel_version": "2.0",
"user_name": "Ellen McDonagh",
"item_type": "panel",
"text": "promoted panel to version 2.0",
"entity_name": null,
"entity_type": null
},
{
"created": "2019-12-10T17:07:25.364627Z",
"panel_name": "Adult solid tumours cancer susceptibility",
"panel_id": 245,
"panel_version": "1.10",
"user_name": "Ellen McDonagh",
"item_type": "panel",
"text": "Panel types changed to Cancer Germline 100K; GMS Cancer Germline Virtual; GMS signed-off",
"entity_name": null,
"entity_type": null
},
{
"created": "2019-12-10T17:05:31.436465Z",
"panel_name": "Adult solid tumours cancer susceptibility",
"panel_id": 245,
"panel_version": "1.9",
"user_name": "Ellen McDonagh",
"item_type": "entity",
"text": "Phenotypes for gene: RABL3 were changed from PANCREATIC CANCER, SUSCEPTIBILITY TO, 5; PNCA5 OMIM 618680 to {?Pancreatic cancer, susceptibility to, 5} 618680",
"entity_name": "RABL3",
"entity_type": "gene"
},
{
"created": "2019-12-10T17:02:20.609927Z",
"panel_name": "Adult solid tumours cancer susceptibility",
"panel_id": 245,
"panel_version": "1.8",
"user_name": "Ellen McDonagh",
"item_type": "entity",
"text": "Marked gene: RABL3 as ready",
"entity_name": "RABL3",
"entity_type": "gene"
},
{
"created": "2019-12-10T17:02:20.589243Z",
"panel_name": "Adult solid tumours cancer susceptibility",
"panel_id": 245,
"panel_version": "1.8",
"user_name": "Ellen McDonagh",
"item_type": "entity",
"text": "Gene: rabl3 has been classified as Red List (Low Evidence).",
"entity_name": "RABL3",
"entity_type": "gene"
},
{
"created": "2019-12-10T17:02:10.258012Z",
"panel_name": "Adult solid tumours cancer susceptibility",
"panel_id": 245,
"panel_version": "1.8",
"user_name": "Ellen McDonagh",
"item_type": "entity",
"text": "Classified gene: RABL3 as Red List (low evidence)",
"entity_name": "RABL3",
"entity_type": "gene"
},
{
"created": "2019-12-10T17:02:10.253778Z",
"panel_name": "Adult solid tumours cancer susceptibility",
"panel_id": 245,
"panel_version": "1.8",
"user_name": "Ellen McDonagh",
"item_type": "entity",
"text": "Added comment: Comment on list classification: This gene was added by a reviewer and rated Green. Curated and added to the panel as Red, as this is a new publication describing only one family where a variant in this gene was reported as being associated with hereditary pancreatic cancer (PMID: 31406347). This is still displayed in OMIM as {?Pancreatic cancer, susceptibility to, 5} until more evidence arises. Functional evidence for an effect, but as there is only one family, this should remain Red until further evidence arises.",
"entity_name": "RABL3",
"entity_type": "gene"
},
{
"created": "2019-12-10T17:02:10.226664Z",
"panel_name": "Adult solid tumours cancer susceptibility",
"panel_id": 245,
"panel_version": "1.8",
"user_name": "Ellen McDonagh",
"item_type": "entity",
"text": "Gene: rabl3 has been classified as Red List (Low Evidence).",
"entity_name": "RABL3",
"entity_type": "gene"
},
{
"created": "2019-11-27T16:42:01.281546Z",
"panel_name": "Adult solid tumours cancer susceptibility",
"panel_id": 245,
"panel_version": "1.7",
"user_name": "Israel Gomy",
"item_type": "entity",
"text": "gene: RABL3 was added\ngene: RABL3 was added to Adult solid tumours cancer susceptibility. Sources: Literature,Research\nMode of inheritance for gene: RABL3 was set to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted\nPublications for gene: RABL3 were set to 31406347\nPhenotypes for gene: RABL3 were set to PANCREATIC CANCER, SUSCEPTIBILITY TO, 5; PNCA5 OMIM 618680\nPenetrance for gene: RABL3 were set to unknown\nMode of pathogenicity for gene: RABL3 was set to Other\nReview for gene: RABL3 was set to GREEN\nAdded comment: Susceptibility to pancreatic ductal adenocarcinoma (PDAC) may be conferred by mutation in RABL3. Other cancers, including melanoma, breast cancer, and colon cancer, have been reported in RABL3 mutation-carrying individuals, with or without PDAC.\r\n\r\nExpression of S36X-mutant RABL3 in HEK293T cells resulted in enhanced cell proliferation consistent with an oncogenic effect. Zebrafish with truncated rabl3 protein developed cancers at a statistically significant elevated rate compared to wildtype sibs. Other studies in zebrafish confirmed the role of mutant RABL3 in promoting cancer susceptibility. \nSources: Literature, Research",
"entity_name": "RABL3",
"entity_type": "gene"
},
{
"created": "2019-08-13T09:55:08.811955Z",
"panel_name": "Adult solid tumours cancer susceptibility",
"panel_id": 245,
"panel_version": "1.7",
"user_name": "Ivone Leong",
"item_type": "entity",
"text": "Phenotypes for gene: VHL were changed from Familial Paraganglioma and Pheochromocytoma to Familial Paraganglioma and Pheochromocytoma; VON HIPPEL-LINDAU (VHL) SYNDROME, 193300",
"entity_name": "VHL",
"entity_type": "gene"
},
{
"created": "2019-08-06T19:40:45.586775Z",
"panel_name": "Adult solid tumours cancer susceptibility",
"panel_id": 245,
"panel_version": "1.6",
"user_name": "Israel Gomy",
"item_type": "entity",
"text": "reviewed gene: VHL: Rating: ; Mode of pathogenicity: None; Publications: ; Phenotypes: VON HIPPEL-LINDAU (VHL) SYNDROME, OMIM 193300; Mode of inheritance: None",
"entity_name": "VHL",
"entity_type": "gene"
},
{
"created": "2019-08-02T12:34:38.521736Z",
"panel_name": "Adult solid tumours cancer susceptibility",
"panel_id": 245,
"panel_version": "1.5",
"user_name": "Ivone Leong",
"item_type": "entity",
"text": "reviewed gene: SOS2: Rating: AMBER; Mode of pathogenicity: ; Publications: ; Phenotypes: ; Mode of inheritance: ",
"entity_name": "SOS2",
"entity_type": "gene"
},
{
"created": "2019-08-02T12:34:38.504253Z",
"panel_name": "Adult solid tumours cancer susceptibility",
"panel_id": 245,
"panel_version": "1.5",
"user_name": "Ivone Leong",
"item_type": "entity",
"text": "reviewed gene: RIT1: Rating: AMBER; Mode of pathogenicity: ; Publications: ; Phenotypes: ; Mode of inheritance: ",
"entity_name": "RIT1",
"entity_type": "gene"
},
{
"created": "2019-08-02T12:34:38.487163Z",
"panel_name": "Adult solid tumours cancer susceptibility",
"panel_id": 245,
"panel_version": "1.5",
"user_name": "Ivone Leong",
"item_type": "entity",
"text": "reviewed gene: PPP1CB: Rating: AMBER; Mode of pathogenicity: ; Publications: ; Phenotypes: ; Mode of inheritance: ",
"entity_name": "PPP1CB",
"entity_type": "gene"
},
{
"created": "2019-08-02T12:34:38.467865Z",
"panel_name": "Adult solid tumours cancer susceptibility",
"panel_id": 245,
"panel_version": "1.5",
"user_name": "Ivone Leong",
"item_type": "entity",
"text": "reviewed gene: LZTR1: Rating: AMBER; Mode of pathogenicity: ; Publications: ; Phenotypes: ; Mode of inheritance: ",
"entity_name": "LZTR1",
"entity_type": "gene"
},
{
"created": "2019-08-02T12:34:38.448800Z",
"panel_name": "Adult solid tumours cancer susceptibility",
"panel_id": 245,
"panel_version": "1.5",
"user_name": "Ivone Leong",
"item_type": "entity",
"text": "commented on gene: SPRED1: As discussed at the Genomics Cancer Panel Workshop, 16th July 2019: the group agreed that RASopathy associated genes associated with cancer will be included in this panel; however, this gene does not appear to predispose patients to cancer so therefore this has been rated red. ",
"entity_name": "SPRED1",
"entity_type": "gene"
},
{
"created": "2019-08-02T12:34:38.435801Z",
"panel_name": "Adult solid tumours cancer susceptibility",
"panel_id": 245,
"panel_version": "1.5",
"user_name": "Ivone Leong",
"item_type": "entity",
"text": "reviewed gene: MAP2K2: Rating: AMBER; Mode of pathogenicity: ; Publications: ; Phenotypes: ; Mode of inheritance: ",
"entity_name": "MAP2K2",
"entity_type": "gene"
},
{
"created": "2019-08-02T12:34:38.414977Z",
"panel_name": "Adult solid tumours cancer susceptibility",
"panel_id": 245,
"panel_version": "1.5",
"user_name": "Ivone Leong",
"item_type": "entity",
"text": "reviewed gene: MAP2K1: Rating: AMBER; Mode of pathogenicity: ; Publications: ; Phenotypes: ; Mode of inheritance: ",
"entity_name": "MAP2K1",
"entity_type": "gene"
},
{
"created": "2019-08-02T12:34:38.399312Z",
"panel_name": "Adult solid tumours cancer susceptibility",
"panel_id": 245,
"panel_version": "1.5",
"user_name": "Ivone Leong",
"item_type": "entity",
"text": "reviewed gene: BRAF: Rating: AMBER; Mode of pathogenicity: ; Publications: ; Phenotypes: ; Mode of inheritance: ",
"entity_name": "BRAF",
"entity_type": "gene"
},
{
"created": "2019-08-02T12:34:38.378367Z",
"panel_name": "Adult solid tumours cancer susceptibility",
"panel_id": 245,
"panel_version": "1.5",
"user_name": "Ivone Leong",
"item_type": "entity",
"text": "reviewed gene: SOS1: Rating: GREEN; Mode of pathogenicity: ; Publications: ; Phenotypes: ; Mode of inheritance: ",
"entity_name": "SOS1",
"entity_type": "gene"
},
{
"created": "2019-08-02T12:34:38.361161Z",
"panel_name": "Adult solid tumours cancer susceptibility",
"panel_id": 245,
"panel_version": "1.5",
"user_name": "Ivone Leong",
"item_type": "entity",
"text": "reviewed gene: SHOC2: Rating: GREEN; Mode of pathogenicity: ; Publications: ; Phenotypes: ; Mode of inheritance: ",
"entity_name": "SHOC2",
"entity_type": "gene"
},
{
"created": "2019-08-02T12:34:38.341574Z",
"panel_name": "Adult solid tumours cancer susceptibility",
"panel_id": 245,
"panel_version": "1.5",
"user_name": "Ivone Leong",
"item_type": "entity",
"text": "reviewed gene: RAF1: Rating: GREEN; Mode of pathogenicity: ; Publications: ; Phenotypes: ; Mode of inheritance: ",
"entity_name": "RAF1",
"entity_type": "gene"
},
{
"created": "2019-08-02T12:34:38.324795Z",
"panel_name": "Adult solid tumours cancer susceptibility",
"panel_id": 245,
"panel_version": "1.5",
"user_name": "Ivone Leong",
"item_type": "entity",
"text": "reviewed gene: PTPN11: Rating: GREEN; Mode of pathogenicity: ; Publications: ; Phenotypes: ; Mode of inheritance: ",
"entity_name": "PTPN11",
"entity_type": "gene"
},
{
"created": "2019-08-02T12:34:38.306574Z",
"panel_name": "Adult solid tumours cancer susceptibility",
"panel_id": 245,
"panel_version": "1.5",
"user_name": "Ivone Leong",
"item_type": "entity",
"text": "reviewed gene: NRAS: Rating: GREEN; Mode of pathogenicity: ; Publications: ; Phenotypes: ; Mode of inheritance: ",
"entity_name": "NRAS",
"entity_type": "gene"
},
{
"created": "2019-08-02T12:34:38.289930Z",
"panel_name": "Adult solid tumours cancer susceptibility",
"panel_id": 245,
"panel_version": "1.5",
"user_name": "Ivone Leong",
"item_type": "entity",
"text": "reviewed gene: KRAS: Rating: GREEN; Mode of pathogenicity: ; Publications: ; Phenotypes: ; Mode of inheritance: ",
"entity_name": "KRAS",
"entity_type": "gene"
},
{
"created": "2019-08-02T12:34:38.274906Z",
"panel_name": "Adult solid tumours cancer susceptibility",
"panel_id": 245,
"panel_version": "1.5",
"user_name": "Ivone Leong",
"item_type": "entity",
"text": "reviewed gene: HRAS: Rating: GREEN; Mode of pathogenicity: ; Publications: ; Phenotypes: ; Mode of inheritance: ",
"entity_name": "HRAS",
"entity_type": "gene"
},
{
"created": "2019-08-02T12:34:38.258608Z",
"panel_name": "Adult solid tumours cancer susceptibility",
"panel_id": 245,
"panel_version": "1.5",
"user_name": "Ivone Leong",
"item_type": "entity",
"text": "reviewed gene: FANCL: Rating: GREEN; Mode of pathogenicity: ; Publications: ; Phenotypes: ; Mode of inheritance: ",
"entity_name": "FANCL",
"entity_type": "gene"
},
{
"created": "2019-08-02T12:34:38.239885Z",
"panel_name": "Adult solid tumours cancer susceptibility",
"panel_id": 245,
"panel_version": "1.5",
"user_name": "Ivone Leong",
"item_type": "entity",
"text": "reviewed gene: FANCI: Rating: GREEN; Mode of pathogenicity: ; Publications: ; Phenotypes: ; Mode of inheritance: ",
"entity_name": "FANCI",
"entity_type": "gene"
},
{
"created": "2019-08-02T12:34:38.223752Z",
"panel_name": "Adult solid tumours cancer susceptibility",
"panel_id": 245,
"panel_version": "1.5",
"user_name": "Ivone Leong",
"item_type": "entity",
"text": "reviewed gene: FANCG: Rating: GREEN; Mode of pathogenicity: ; Publications: ; Phenotypes: ; Mode of inheritance: ",
"entity_name": "FANCG",
"entity_type": "gene"
},
{
"created": "2019-08-02T12:34:38.208522Z",
"panel_name": "Adult solid tumours cancer susceptibility",
"panel_id": 245,
"panel_version": "1.5",
"user_name": "Ivone Leong",
"item_type": "entity",
"text": "reviewed gene: FANCF: Rating: GREEN; Mode of pathogenicity: ; Publications: ; Phenotypes: ; Mode of inheritance: ",
"entity_name": "FANCF",
"entity_type": "gene"
},
{
"created": "2019-08-02T12:34:38.193145Z",
"panel_name": "Adult solid tumours cancer susceptibility",
"panel_id": 245,
"panel_version": "1.5",
"user_name": "Ivone Leong",
"item_type": "entity",
"text": "reviewed gene: FANCE: Rating: GREEN; Mode of pathogenicity: ; Publications: ; Phenotypes: ; Mode of inheritance: ",
"entity_name": "FANCE",
"entity_type": "gene"
},
{
"created": "2019-08-02T12:34:38.177180Z",
"panel_name": "Adult solid tumours cancer susceptibility",
"panel_id": 245,
"panel_version": "1.5",
"user_name": "Ivone Leong",
"item_type": "entity",
"text": "reviewed gene: FANCD2: Rating: GREEN; Mode of pathogenicity: ; Publications: ; Phenotypes: ; Mode of inheritance: ",
"entity_name": "FANCD2",
"entity_type": "gene"
},
{
"created": "2019-08-02T12:34:38.160935Z",
"panel_name": "Adult solid tumours cancer susceptibility",
"panel_id": 245,
"panel_version": "1.5",
"user_name": "Ivone Leong",
"item_type": "entity",
"text": "reviewed gene: FANCC: Rating: GREEN; Mode of pathogenicity: ; Publications: ; Phenotypes: ; Mode of inheritance: ",
"entity_name": "FANCC",
"entity_type": "gene"
},
{
"created": "2019-08-02T12:34:38.142166Z",
"panel_name": "Adult solid tumours cancer susceptibility",
"panel_id": 245,
"panel_version": "1.5",
"user_name": "Ivone Leong",
"item_type": "entity",
"text": "reviewed gene: FANCB: Rating: GREEN; Mode of pathogenicity: ; Publications: ; Phenotypes: ; Mode of inheritance: ",
"entity_name": "FANCB",
"entity_type": "gene"
},
{
"created": "2019-08-02T12:34:38.125549Z",
"panel_name": "Adult solid tumours cancer susceptibility",
"panel_id": 245,
"panel_version": "1.5",
"user_name": "Ivone Leong",
"item_type": "entity",
"text": "reviewed gene: FANCA: Rating: GREEN; Mode of pathogenicity: ; Publications: ; Phenotypes: ; Mode of inheritance: ",
"entity_name": "FANCA",
"entity_type": "gene"
},
{
"created": "2019-08-02T12:34:38.110488Z",
"panel_name": "Adult solid tumours cancer susceptibility",
"panel_id": 245,
"panel_version": "1.5",
"user_name": "Ivone Leong",
"item_type": "entity",
"text": "reviewed gene: WRAP53: Rating: GREEN; Mode of pathogenicity: ; Publications: 22285015; Phenotypes: ; Mode of inheritance: ",
"entity_name": "WRAP53",
"entity_type": "gene"
},
{
"created": "2019-08-02T12:34:38.094133Z",
"panel_name": "Adult solid tumours cancer susceptibility",
"panel_id": 245,
"panel_version": "1.5",
"user_name": "Ivone Leong",
"item_type": "entity",
"text": "reviewed gene: TERC: Rating: GREEN; Mode of pathogenicity: ; Publications: 22285015; Phenotypes: ; Mode of inheritance: ",
"entity_name": "TERC",
"entity_type": "gene"
},
{
"created": "2019-08-02T12:34:38.075263Z",
"panel_name": "Adult solid tumours cancer susceptibility",
"panel_id": 245,
"panel_version": "1.5",
"user_name": "Ivone Leong",
"item_type": "entity",
"text": "reviewed gene: SPRED1: Rating: RED; Mode of pathogenicity: ; Publications: 23875798; Phenotypes: ; Mode of inheritance: ",
"entity_name": "SPRED1",
"entity_type": "gene"
},
{
"created": "2019-08-02T12:34:38.056723Z",
"panel_name": "Adult solid tumours cancer susceptibility",
"panel_id": 245,
"panel_version": "1.5",
"user_name": "Ivone Leong",
"item_type": "entity",
"text": "reviewed gene: POLH: Rating: GREEN; Mode of pathogenicity: ; Publications: 26884178, 24877075, 30511002, 11773631; Phenotypes: ; Mode of inheritance: ",
"entity_name": "POLH",
"entity_type": "gene"
},
{
"created": "2019-08-02T12:34:38.039636Z",
"panel_name": "Adult solid tumours cancer susceptibility",
"panel_id": 245,
"panel_version": "1.5",
"user_name": "Ivone Leong",
"item_type": "entity",
"text": "reviewed gene: RTEL1: Rating: GREEN; Mode of pathogenicity: ; Publications: 24582487; Phenotypes: ; Mode of inheritance: ",
"entity_name": "RTEL1",
"entity_type": "gene"
},
{
"created": "2019-08-02T12:34:38.025295Z",
"panel_name": "Adult solid tumours cancer susceptibility",
"panel_id": 245,
"panel_version": "1.5",
"user_name": "Ivone Leong",
"item_type": "entity",
"text": "reviewed gene: DKC1: Rating: AMBER; Mode of pathogenicity: ; Publications: ; Phenotypes: ; Mode of inheritance: ",
"entity_name": "DKC1",
"entity_type": "gene"
},
{
"created": "2019-08-02T12:34:38.011400Z",
"panel_name": "Adult solid tumours cancer susceptibility",
"panel_id": 245,
"panel_version": "1.5",
"user_name": "Ivone Leong",
"item_type": "entity",
"text": "reviewed gene: ACD: Rating: AMBER; Mode of pathogenicity: ; Publications: 25233904, 25205116; Phenotypes: ; Mode of inheritance: ",
"entity_name": "ACD",
"entity_type": "gene"
},
{
"created": "2019-08-02T12:34:37.997006Z",
"panel_name": "Adult solid tumours cancer susceptibility",
"panel_id": 245,
"panel_version": "1.5",
"user_name": "Ivone Leong",
"item_type": "entity",
"text": "reviewed gene: XPC: Rating: GREEN; Mode of pathogenicity: ; Publications: 26975629, 30565713, 21097776; Phenotypes: ; Mode of inheritance: ",
"entity_name": "XPC",
"entity_type": "gene"
},
{
"created": "2019-08-02T12:34:37.978023Z",
"panel_name": "Adult solid tumours cancer susceptibility",
"panel_id": 245,
"panel_version": "1.5",
"user_name": "Ivone Leong",
"item_type": "entity",
"text": "reviewed gene: XPA: Rating: GREEN; Mode of pathogenicity: ; Publications: 26975629, 30565713, 21097776; Phenotypes: ; Mode of inheritance: ",
"entity_name": "XPA",
"entity_type": "gene"
},
{
"created": "2019-08-02T12:34:37.962590Z",
"panel_name": "Adult solid tumours cancer susceptibility",
"panel_id": 245,
"panel_version": "1.5",
"user_name": "Ivone Leong",
"item_type": "entity",
"text": "reviewed gene: TERT: Rating: GREEN; Mode of pathogenicity: ; Publications: 22285015; Phenotypes: ; Mode of inheritance: ",
"entity_name": "TERT",
"entity_type": "gene"
},
{
"created": "2019-08-02T12:34:37.934068Z",
"panel_name": "Adult solid tumours cancer susceptibility",
"panel_id": 245,
"panel_version": "1.5",
"user_name": "Anna de Burca",
"item_type": "entity",
"text": "reviewed gene: MAP2K2: Rating: AMBER; Mode of pathogenicity: ; Publications: 23875798; Phenotypes: ; Mode of inheritance: ",
"entity_name": "MAP2K2",
"entity_type": "gene"
},
{
"created": "2019-08-02T12:34:37.918711Z",
"panel_name": "Adult solid tumours cancer susceptibility",
"panel_id": 245,
"panel_version": "1.5",
"user_name": "Anna de Burca",
"item_type": "entity",
"text": "reviewed gene: MAP2K1: Rating: AMBER; Mode of pathogenicity: ; Publications: 23875798; Phenotypes: ; Mode of inheritance: ",
"entity_name": "MAP2K1",
"entity_type": "gene"
},
{
"created": "2019-08-02T12:34:37.903534Z",
"panel_name": "Adult solid tumours cancer susceptibility",
"panel_id": 245,
"panel_version": "1.5",
"user_name": "Ivone Leong",
"item_type": "entity",
"text": "reviewed gene: ERCC5: Rating: GREEN; Mode of pathogenicity: ; Publications: 9096355, 7951246, 23255472, 1206391, 10026181, 11841555, 26884178; Phenotypes: ; Mode of inheritance: ",
"entity_name": "ERCC5",
"entity_type": "gene"
},
{
"created": "2019-08-02T12:34:37.887260Z",
"panel_name": "Adult solid tumours cancer susceptibility",
"panel_id": 245,
"panel_version": "1.5",
"user_name": "Ivone Leong",
"item_type": "entity",
"text": "reviewed gene: ERCC3: Rating: GREEN; Mode of pathogenicity: ; Publications: 16947863, 26884178; Phenotypes: ; Mode of inheritance: ",
"entity_name": "ERCC3",
"entity_type": "gene"
},
{
"created": "2019-08-02T12:34:37.872086Z",
"panel_name": "Adult solid tumours cancer susceptibility",
"panel_id": 245,
"panel_version": "1.5",
"user_name": "Ivone Leong",
"item_type": "entity",
"text": "reviewed gene: ERCC2: Rating: GREEN; Mode of pathogenicity: ; Publications: 26884178, 28376890; Phenotypes: ; Mode of inheritance: ",
"entity_name": "ERCC2",
"entity_type": "gene"
},
{
"created": "2019-08-02T12:34:37.857113Z",
"panel_name": "Adult solid tumours cancer susceptibility",
"panel_id": 245,
"panel_version": "1.5",
"user_name": "Ivone Leong",
"item_type": "entity",
"text": "reviewed gene: DDB2: Rating: GREEN; Mode of pathogenicity: ; Publications: 26884178, 21107348, 104693112, 12812979; Phenotypes: ; Mode of inheritance: ",
"entity_name": "DDB2",
"entity_type": "gene"
},
{
"created": "2019-08-02T12:34:37.842706Z",
"panel_name": "Adult solid tumours cancer susceptibility",
"panel_id": 245,
"panel_version": "1.5",
"user_name": "Anna de Burca",
"item_type": "entity",
"text": "reviewed gene: BRAF: Rating: AMBER; Mode of pathogenicity: ; Publications: 23875798; Phenotypes: ; Mode of inheritance: ",
"entity_name": "BRAF",
"entity_type": "gene"
},
{
"created": "2019-08-02T12:34:37.827525Z",
"panel_name": "Adult solid tumours cancer susceptibility",
"panel_id": 245,
"panel_version": "1.5",
"user_name": "Anna de Burca",
"item_type": "entity",
"text": "reviewed gene: SOS1: Rating: GREEN; Mode of pathogenicity: ; Publications: 23875798; Phenotypes: ; Mode of inheritance: ",
"entity_name": "SOS1",
"entity_type": "gene"
},
{
"created": "2019-08-02T12:34:37.812597Z",
"panel_name": "Adult solid tumours cancer susceptibility",
"panel_id": 245,
"panel_version": "1.5",
"user_name": "Anna de Burca",
"item_type": "entity",
"text": "reviewed gene: SHOC2: Rating: GREEN; Mode of pathogenicity: ; Publications: 23875798; Phenotypes: ; Mode of inheritance: ",
"entity_name": "SHOC2",
"entity_type": "gene"
},
{
"created": "2019-08-02T12:34:37.797656Z",
"panel_name": "Adult solid tumours cancer susceptibility",
"panel_id": 245,
"panel_version": "1.5",
"user_name": "Anna de Burca",
"item_type": "entity",
"text": "reviewed gene: RAF1: Rating: GREEN; Mode of pathogenicity: ; Publications: 23875798; Phenotypes: ; Mode of inheritance: ",
"entity_name": "RAF1",
"entity_type": "gene"
},
{
"created": "2019-08-02T12:34:37.781245Z",
"panel_name": "Adult solid tumours cancer susceptibility",
"panel_id": 245,
"panel_version": "1.5",
"user_name": "Anna de Burca",
"item_type": "entity",
"text": "reviewed gene: PTPN11: Rating: GREEN; Mode of pathogenicity: ; Publications: 23875798; Phenotypes: ; Mode of inheritance: ",
"entity_name": "PTPN11",
"entity_type": "gene"
},
{
"created": "2019-08-02T12:34:37.765184Z",
"panel_name": "Adult solid tumours cancer susceptibility",
"panel_id": 245,
"panel_version": "1.5",
"user_name": "Anna de Burca",
"item_type": "entity",
"text": "reviewed gene: NRAS: Rating: GREEN; Mode of pathogenicity: ; Publications: 23875798; Phenotypes: ; Mode of inheritance: ",
"entity_name": "NRAS",
"entity_type": "gene"
},
{
"created": "2019-08-02T12:34:37.743763Z",
"panel_name": "Adult solid tumours cancer susceptibility",
"panel_id": 245,
"panel_version": "1.5",
"user_name": "Anna de Burca",
"item_type": "entity",
"text": "reviewed gene: KRAS: Rating: GREEN; Mode of pathogenicity: ; Publications: 23875798; Phenotypes: ; Mode of inheritance: ",
"entity_name": "KRAS",
"entity_type": "gene"
},
{
"created": "2019-08-02T12:34:37.163667Z",
"panel_name": "Adult solid tumours cancer susceptibility",
"panel_id": 245,
"panel_version": "1.5",
"user_name": "Anna de Burca",
"item_type": "entity",
"text": "reviewed gene: HRAS: Rating: GREEN; Mode of pathogenicity: ; Publications: 23875798; Phenotypes: ; Mode of inheritance: ",
"entity_name": "HRAS",
"entity_type": "gene"
},
{
"created": "2019-08-02T12:34:37.145960Z",
"panel_name": "Adult solid tumours cancer susceptibility",
"panel_id": 245,
"panel_version": "1.5",
"user_name": "Ivone Leong",
"item_type": "entity",
"text": "reviewed gene: ERCC4: Rating: GREEN; Mode of pathogenicity: ; Publications: ; Phenotypes: ; Mode of inheritance: ",
"entity_name": "ERCC4",
"entity_type": "gene"
},
{
"created": "2019-08-02T12:34:37.129661Z",
"panel_name": "Adult solid tumours cancer susceptibility",
"panel_id": 245,
"panel_version": "1.5",
"user_name": "Ivone Leong",
"item_type": "entity",
"text": "reviewed gene: CBL: Rating: GREEN; Mode of pathogenicity: ; Publications: ; Phenotypes: ; Mode of inheritance: ",
"entity_name": "CBL",
"entity_type": "gene"
},
{
"created": "2019-08-02T12:34:37.113788Z",
"panel_name": "Adult solid tumours cancer susceptibility",
"panel_id": 245,
"panel_version": "1.5",
"user_name": "Anna de Burca",
"item_type": "entity",
"text": "reviewed gene: CBL: Rating: GREEN; Mode of pathogenicity: ; Publications: 23875798; Phenotypes: ; Mode of inheritance: ",
"entity_name": "CBL",
"entity_type": "gene"
},
{
"created": "2019-08-02T12:34:37.099135Z",
"panel_name": "Adult solid tumours cancer susceptibility",
"panel_id": 245,
"panel_version": "1.5",
"user_name": "Ivone Leong",
"item_type": "entity",
"text": "reviewed gene: WT1: Rating: GREEN; Mode of pathogenicity: ; Publications: ; Phenotypes: ; Mode of inheritance: ",
"entity_name": "WT1",
"entity_type": "gene"
},
{
"created": "2019-08-02T12:34:37.084556Z",
"panel_name": "Adult solid tumours cancer susceptibility",
"panel_id": 245,
"panel_version": "1.5",
"user_name": "Ivone Leong",
"item_type": "entity",
"text": "reviewed gene: VHL: Rating: GREEN; Mode of pathogenicity: ; Publications: ; Phenotypes: ; Mode of inheritance: ",
"entity_name": "VHL",
"entity_type": "gene"
},
{
"created": "2019-08-02T12:34:37.065870Z",
"panel_name": "Adult solid tumours cancer susceptibility",
"panel_id": 245,
"panel_version": "1.5",
"user_name": "Ivone Leong",
"item_type": "entity",
"text": "reviewed gene: TSC2: Rating: GREEN; Mode of pathogenicity: ; Publications: ; Phenotypes: ; Mode of inheritance: ",
"entity_name": "TSC2",
"entity_type": "gene"
},
{
"created": "2019-08-02T12:34:37.047926Z",
"panel_name": "Adult solid tumours cancer susceptibility",
"panel_id": 245,
"panel_version": "1.5",
"user_name": "Ivone Leong",
"item_type": "entity",
"text": "reviewed gene: TSC1: Rating: GREEN; Mode of pathogenicity: ; Publications: ; Phenotypes: ; Mode of inheritance: ",
"entity_name": "TSC1",
"entity_type": "gene"
},
{
"created": "2019-08-02T12:34:37.028019Z",
"panel_name": "Adult solid tumours cancer susceptibility",
"panel_id": 245,
"panel_version": "1.5",
"user_name": "Ivone Leong",
"item_type": "entity",
"text": "reviewed gene: TP53: Rating: GREEN; Mode of pathogenicity: ; Publications: ; Phenotypes: ; Mode of inheritance: ",
"entity_name": "TP53",
"entity_type": "gene"
},
{
"created": "2019-08-02T12:34:37.012981Z",
"panel_name": "Adult solid tumours cancer susceptibility",
"panel_id": 245,
"panel_version": "1.5",
"user_name": "Ivone Leong",
"item_type": "entity",
"text": "reviewed gene: TMEM127: Rating: GREEN; Mode of pathogenicity: ; Publications: ; Phenotypes: ; Mode of inheritance: ",
"entity_name": "TMEM127",
"entity_type": "gene"
},
{
"created": "2019-08-02T12:34:36.998157Z",
"panel_name": "Adult solid tumours cancer susceptibility",
"panel_id": 245,
"panel_version": "1.5",
"user_name": "Ivone Leong",
"item_type": "entity",
"text": "reviewed gene: SUFU: Rating: GREEN; Mode of pathogenicity: ; Publications: ; Phenotypes: ; Mode of inheritance: ",
"entity_name": "SUFU",
"entity_type": "gene"
},
{
"created": "2019-08-02T12:34:36.983445Z",
"panel_name": "Adult solid tumours cancer susceptibility",
"panel_id": 245,
"panel_version": "1.5",
"user_name": "Ivone Leong",
"item_type": "entity",
"text": "reviewed gene: STK11: Rating: GREEN; Mode of pathogenicity: ; Publications: ; Phenotypes: ; Mode of inheritance: ",
"entity_name": "STK11",
"entity_type": "gene"
},
{
"created": "2019-08-02T12:34:36.968513Z",
"panel_name": "Adult solid tumours cancer susceptibility",
"panel_id": 245,
"panel_version": "1.5",
"user_name": "Ivone Leong",
"item_type": "entity",
"text": "reviewed gene: SMARCB1: Rating: GREEN; Mode of pathogenicity: ; Publications: ; Phenotypes: ; Mode of inheritance: ",
"entity_name": "SMARCB1",
"entity_type": "gene"
},
{
"created": "2019-08-02T12:34:36.950375Z",
"panel_name": "Adult solid tumours cancer susceptibility",
"panel_id": 245,
"panel_version": "1.5",
"user_name": "Ivone Leong",
"item_type": "entity",
"text": "reviewed gene: SMARCA4: Rating: GREEN; Mode of pathogenicity: ; Publications: ; Phenotypes: ; Mode of inheritance: ",
"entity_name": "SMARCA4",
"entity_type": "gene"
},
{
"created": "2019-08-02T12:34:36.934126Z",
"panel_name": "Adult solid tumours cancer susceptibility",
"panel_id": 245,
"panel_version": "1.5",
"user_name": "Ivone Leong",
"item_type": "entity",
"text": "reviewed gene: SMAD4: Rating: GREEN; Mode of pathogenicity: ; Publications: ; Phenotypes: ; Mode of inheritance: ",
"entity_name": "SMAD4",
"entity_type": "gene"
},
{
"created": "2019-08-02T12:34:36.919037Z",
"panel_name": "Adult solid tumours cancer susceptibility",
"panel_id": 245,
"panel_version": "1.5",
"user_name": "Ivone Leong",
"item_type": "entity",
"text": "reviewed gene: SDHD: Rating: GREEN; Mode of pathogenicity: ; Publications: ; Phenotypes: ; Mode of inheritance: ",
"entity_name": "SDHD",
"entity_type": "gene"
},
{
"created": "2019-08-02T12:34:36.904246Z",
"panel_name": "Adult solid tumours cancer susceptibility",
"panel_id": 245,
"panel_version": "1.5",
"user_name": "Ivone Leong",
"item_type": "entity",
"text": "reviewed gene: SDHC: Rating: GREEN; Mode of pathogenicity: ; Publications: ; Phenotypes: ; Mode of inheritance: ",
"entity_name": "SDHC",
"entity_type": "gene"
},
{
"created": "2019-08-02T12:34:36.889326Z",
"panel_name": "Adult solid tumours cancer susceptibility",
"panel_id": 245,
"panel_version": "1.5",
"user_name": "Ivone Leong",
"item_type": "entity",
"text": "reviewed gene: SDHB: Rating: GREEN; Mode of pathogenicity: ; Publications: ; Phenotypes: ; Mode of inheritance: ",
"entity_name": "SDHB",
"entity_type": "gene"
},
{
"created": "2019-08-02T12:34:36.873938Z",
"panel_name": "Adult solid tumours cancer susceptibility",
"panel_id": 245,
"panel_version": "1.5",
"user_name": "Ivone Leong",
"item_type": "entity",
"text": "reviewed gene: SDHAF2: Rating: GREEN; Mode of pathogenicity: ; Publications: ; Phenotypes: ; Mode of inheritance: ",
"entity_name": "SDHAF2",
"entity_type": "gene"
},
{
"created": "2019-08-02T12:34:36.857492Z",
"panel_name": "Adult solid tumours cancer susceptibility",
"panel_id": 245,
"panel_version": "1.5",
"user_name": "Ivone Leong",
"item_type": "entity",
"text": "reviewed gene: SDHA: Rating: GREEN; Mode of pathogenicity: ; Publications: ; Phenotypes: ; Mode of inheritance: ",
"entity_name": "SDHA",
"entity_type": "gene"
},
{
"created": "2019-08-02T12:34:36.838264Z",
"panel_name": "Adult solid tumours cancer susceptibility",
"panel_id": 245,
"panel_version": "1.5",
"user_name": "Ivone Leong",
"item_type": "entity",
"text": "reviewed gene: RET: Rating: GREEN; Mode of pathogenicity: ; Publications: ; Phenotypes: ; Mode of inheritance: ",
"entity_name": "RET",
"entity_type": "gene"
},
{
"created": "2019-08-02T12:34:36.820752Z",
"panel_name": "Adult solid tumours cancer susceptibility",
"panel_id": 245,
"panel_version": "1.5",
"user_name": "Ivone Leong",
"item_type": "entity",
"text": "reviewed gene: RB1: Rating: GREEN; Mode of pathogenicity: ; Publications: ; Phenotypes: ; Mode of inheritance: ",
"entity_name": "RB1",
"entity_type": "gene"
},
{
"created": "2019-08-02T12:34:36.803794Z",
"panel_name": "Adult solid tumours cancer susceptibility",
"panel_id": 245,
"panel_version": "1.5",
"user_name": "Ivone Leong",
"item_type": "entity",
"text": "reviewed gene: RAD51D: Rating: GREEN; Mode of pathogenicity: ; Publications: ; Phenotypes: ; Mode of inheritance: ",
"entity_name": "RAD51D",
"entity_type": "gene"
},
{
"created": "2019-08-02T12:34:36.786698Z",
"panel_name": "Adult solid tumours cancer susceptibility",
"panel_id": 245,
"panel_version": "1.5",
"user_name": "Ivone Leong",
"item_type": "entity",
"text": "reviewed gene: RAD51C: Rating: GREEN; Mode of pathogenicity: ; Publications: ; Phenotypes: ; Mode of inheritance: ",
"entity_name": "RAD51C",
"entity_type": "gene"
},
{
"created": "2019-08-02T12:34:36.771324Z",
"panel_name": "Adult solid tumours cancer susceptibility",
"panel_id": 245,
"panel_version": "1.5",
"user_name": "Ivone Leong",
"item_type": "entity",
"text": "reviewed gene: PTEN: Rating: GREEN; Mode of pathogenicity: ; Publications: ; Phenotypes: ; Mode of inheritance: ",
"entity_name": "PTEN",
"entity_type": "gene"
},
{
"created": "2019-08-02T12:34:36.754110Z",
"panel_name": "Adult solid tumours cancer susceptibility",
"panel_id": 245,
"panel_version": "1.5",
"user_name": "Ivone Leong",
"item_type": "entity",
"text": "reviewed gene: PTCH1: Rating: GREEN; Mode of pathogenicity: ; Publications: ; Phenotypes: ; Mode of inheritance: ",
"entity_name": "PTCH1",
"entity_type": "gene"
},
{
"created": "2019-08-02T12:34:36.736080Z",
"panel_name": "Adult solid tumours cancer susceptibility",
"panel_id": 245,
"panel_version": "1.5",
"user_name": "Ivone Leong",
"item_type": "entity",
"text": "reviewed gene: POLE: Rating: GREEN; Mode of pathogenicity: ; Publications: ; Phenotypes: ; Mode of inheritance: ",
"entity_name": "POLE",
"entity_type": "gene"
},
{
"created": "2019-08-02T12:34:36.718214Z",
"panel_name": "Adult solid tumours cancer susceptibility",
"panel_id": 245,
"panel_version": "1.5",
"user_name": "Ivone Leong",
"item_type": "entity",
"text": "reviewed gene: POLD1: Rating: GREEN; Mode of pathogenicity: ; Publications: ; Phenotypes: ; Mode of inheritance: ",
"entity_name": "POLD1",
"entity_type": "gene"
},
{
"created": "2019-08-02T12:34:36.700768Z",
"panel_name": "Adult solid tumours cancer susceptibility",
"panel_id": 245,
"panel_version": "1.5",
"user_name": "Ivone Leong",
"item_type": "entity",
"text": "reviewed gene: PMS2: Rating: GREEN; Mode of pathogenicity: ; Publications: ; Phenotypes: ; Mode of inheritance: ",
"entity_name": "PMS2",
"entity_type": "gene"
},
{
"created": "2019-08-02T12:34:36.682689Z",
"panel_name": "Adult solid tumours cancer susceptibility",
"panel_id": 245,
"panel_version": "1.5",
"user_name": "Ivone Leong",
"item_type": "entity",
"text": "reviewed gene: PALB2: Rating: GREEN; Mode of pathogenicity: ; Publications: ; Phenotypes: ; Mode of inheritance: ",
"entity_name": "PALB2",
"entity_type": "gene"
},
{
"created": "2019-08-02T12:34:36.667656Z",
"panel_name": "Adult solid tumours cancer susceptibility",
"panel_id": 245,
"panel_version": "1.5",
"user_name": "Ivone Leong",
"item_type": "entity",
"text": "reviewed gene: NTHL1: Rating: GREEN; Mode of pathogenicity: ; Publications: ; Phenotypes: ; Mode of inheritance: ",
"entity_name": "NTHL1",
"entity_type": "gene"
},
{
"created": "2019-08-02T12:34:36.650360Z",
"panel_name": "Adult solid tumours cancer susceptibility",
"panel_id": 245,
"panel_version": "1.5",
"user_name": "Ivone Leong",
"item_type": "entity",
"text": "reviewed gene: NF2: Rating: GREEN; Mode of pathogenicity: ; Publications: ; Phenotypes: ; Mode of inheritance: ",
"entity_name": "NF2",
"entity_type": "gene"
},
{
"created": "2019-08-02T12:34:36.631749Z",
"panel_name": "Adult solid tumours cancer susceptibility",
"panel_id": 245,
"panel_version": "1.5",
"user_name": "Ivone Leong",
"item_type": "entity",
"text": "reviewed gene: NF1: Rating: GREEN; Mode of pathogenicity: ; Publications: ; Phenotypes: ; Mode of inheritance: ",
"entity_name": "NF1",
"entity_type": "gene"
},
{
"created": "2019-08-02T12:34:36.613499Z",
"panel_name": "Adult solid tumours cancer susceptibility",
"panel_id": 245,
"panel_version": "1.5",
"user_name": "Ivone Leong",
"item_type": "entity",
"text": "reviewed gene: MUTYH: Rating: GREEN; Mode of pathogenicity: ; Publications: ; Phenotypes: ; Mode of inheritance: ",
"entity_name": "MUTYH",
"entity_type": "gene"
},
{
"created": "2019-08-02T12:34:36.595018Z",
"panel_name": "Adult solid tumours cancer susceptibility",
"panel_id": 245,
"panel_version": "1.5",
"user_name": "Ivone Leong",
"item_type": "entity",
"text": "reviewed gene: MSH6: Rating: GREEN; Mode of pathogenicity: ; Publications: ; Phenotypes: ; Mode of inheritance: ",
"entity_name": "MSH6",
"entity_type": "gene"
},
{
"created": "2019-08-02T12:34:36.579544Z",
"panel_name": "Adult solid tumours cancer susceptibility",
"panel_id": 245,
"panel_version": "1.5",
"user_name": "Ivone Leong",
"item_type": "entity",
"text": "reviewed gene: MSH2: Rating: GREEN; Mode of pathogenicity: ; Publications: ; Phenotypes: ; Mode of inheritance: ",
"entity_name": "MSH2",
"entity_type": "gene"
},
{
"created": "2019-08-02T12:34:36.564073Z",
"panel_name": "Adult solid tumours cancer susceptibility",
"panel_id": 245,
"panel_version": "1.5",
"user_name": "Ivone Leong",
"item_type": "entity",
"text": "reviewed gene: MLH1: Rating: GREEN; Mode of pathogenicity: ; Publications: ; Phenotypes: ; Mode of inheritance: ",
"entity_name": "MLH1",
"entity_type": "gene"
},
{
"created": "2019-08-02T12:34:36.544796Z",
"panel_name": "Adult solid tumours cancer susceptibility",
"panel_id": 245,
"panel_version": "1.5",
"user_name": "Ivone Leong",
"item_type": "entity",
"text": "reviewed gene: MET: Rating: GREEN; Mode of pathogenicity: ; Publications: ; Phenotypes: ; Mode of inheritance: ",
"entity_name": "MET",
"entity_type": "gene"
},
{
"created": "2019-08-02T12:34:36.526260Z",
"panel_name": "Adult solid tumours cancer susceptibility",
"panel_id": 245,
"panel_version": "1.5",
"user_name": "Ivone Leong",
"item_type": "entity",
"text": "reviewed gene: MEN1: Rating: GREEN; Mode of pathogenicity: ; Publications: ; Phenotypes: ; Mode of inheritance: ",
"entity_name": "MEN1",
"entity_type": "gene"
},
{
"created": "2019-08-02T12:34:36.507849Z",
"panel_name": "Adult solid tumours cancer susceptibility",
"panel_id": 245,
"panel_version": "1.5",
"user_name": "Ivone Leong",
"item_type": "entity",
"text": "reviewed gene: MAX: Rating: GREEN; Mode of pathogenicity: ; Publications: ; Phenotypes: ; Mode of inheritance: ",
"entity_name": "MAX",
"entity_type": "gene"
},
{
"created": "2019-08-02T12:34:36.488757Z",
"panel_name": "Adult solid tumours cancer susceptibility",
"panel_id": 245,
"panel_version": "1.5",
"user_name": "Ivone Leong",
"item_type": "entity",
"text": "reviewed gene: KIT: Rating: GREEN; Mode of pathogenicity: ; Publications: ; Phenotypes: ; Mode of inheritance: ",
"entity_name": "KIT",
"entity_type": "gene"
},
{
"created": "2019-08-02T12:34:36.470606Z",
"panel_name": "Adult solid tumours cancer susceptibility",
"panel_id": 245,
"panel_version": "1.5",
"user_name": "Ivone Leong",
"item_type": "entity",
"text": "reviewed gene: FLCN: Rating: GREEN; Mode of pathogenicity: ; Publications: ; Phenotypes: ; Mode of inheritance: ",
"entity_name": "FLCN",
"entity_type": "gene"
},
{
"created": "2019-08-02T12:34:36.453674Z",
"panel_name": "Adult solid tumours cancer susceptibility",
"panel_id": 245,
"panel_version": "1.5",
"user_name": "Ivone Leong",
"item_type": "entity",
"text": "reviewed gene: FH: Rating: GREEN; Mode of pathogenicity: ; Publications: ; Phenotypes: ; Mode of inheritance: ",
"entity_name": "FH",
"entity_type": "gene"
},
{
"created": "2019-08-02T12:34:36.434217Z",
"panel_name": "Adult solid tumours cancer susceptibility",
"panel_id": 245,
"panel_version": "1.5",
"user_name": "Ivone Leong",
"item_type": "entity",
"text": "reviewed gene: EPCAM: Rating: GREEN; Mode of pathogenicity: ; Publications: ; Phenotypes: ; Mode of inheritance: ",
"entity_name": "EPCAM",
"entity_type": "gene"
},
{
"created": "2019-08-02T12:34:36.415929Z",
"panel_name": "Adult solid tumours cancer susceptibility",
"panel_id": 245,
"panel_version": "1.5",
"user_name": "Ivone Leong",
"item_type": "entity",
"text": "reviewed gene: DICER1: Rating: GREEN; Mode of pathogenicity: ; Publications: ; Phenotypes: ; Mode of inheritance: ",
"entity_name": "DICER1",
"entity_type": "gene"
},
{
"created": "2019-08-02T12:34:36.394965Z",
"panel_name": "Adult solid tumours cancer susceptibility",
"panel_id": 245,
"panel_version": "1.5",
"user_name": "Ivone Leong",
"item_type": "entity",
"text": "reviewed gene: CDKN2A: Rating: GREEN; Mode of pathogenicity: ; Publications: ; Phenotypes: ; Mode of inheritance: ",
"entity_name": "CDKN2A",
"entity_type": "gene"
},
{
"created": "2019-08-02T12:34:36.378902Z",
"panel_name": "Adult solid tumours cancer susceptibility",
"panel_id": 245,
"panel_version": "1.5",
"user_name": "Ivone Leong",
"item_type": "entity",
"text": "reviewed gene: CDKN1B: Rating: GREEN; Mode of pathogenicity: ; Publications: ; Phenotypes: ; Mode of inheritance: ",
"entity_name": "CDKN1B",
"entity_type": "gene"
},
{
"created": "2019-08-02T12:34:36.362277Z",
"panel_name": "Adult solid tumours cancer susceptibility",
"panel_id": 245,
"panel_version": "1.5",
"user_name": "Ivone Leong",
"item_type": "entity",
"text": "reviewed gene: CDK4: Rating: GREEN; Mode of pathogenicity: ; Publications: ; Phenotypes: ; Mode of inheritance: ",
"entity_name": "CDK4",
"entity_type": "gene"
},
{
"created": "2019-08-02T12:34:36.342809Z",
"panel_name": "Adult solid tumours cancer susceptibility",
"panel_id": 245,
"panel_version": "1.5",
"user_name": "Ivone Leong",
"item_type": "entity",
"text": "reviewed gene: CDH1: Rating: GREEN; Mode of pathogenicity: ; Publications: ; Phenotypes: ; Mode of inheritance: ",
"entity_name": "CDH1",
"entity_type": "gene"
},
{
"created": "2019-08-02T12:34:36.327815Z",
"panel_name": "Adult solid tumours cancer susceptibility",
"panel_id": 245,
"panel_version": "1.5",
"user_name": "Ivone Leong",
"item_type": "entity",
"text": "reviewed gene: CDC73: Rating: GREEN; Mode of pathogenicity: ; Publications: ; Phenotypes: ; Mode of inheritance: ",
"entity_name": "CDC73",
"entity_type": "gene"
},
{
"created": "2019-08-02T12:34:36.311990Z",
"panel_name": "Adult solid tumours cancer susceptibility",
"panel_id": 245,
"panel_version": "1.5",
"user_name": "Ivone Leong",
"item_type": "entity",
"text": "reviewed gene: BRIP1: Rating: GREEN; Mode of pathogenicity: ; Publications: ; Phenotypes: ; Mode of inheritance: ",
"entity_name": "BRIP1",
"entity_type": "gene"
},
{
"created": "2019-08-02T12:34:36.291283Z",
"panel_name": "Adult solid tumours cancer susceptibility",
"panel_id": 245,
"panel_version": "1.5",
"user_name": "Ivone Leong",
"item_type": "entity",
"text": "reviewed gene: BRCA2: Rating: GREEN; Mode of pathogenicity: ; Publications: ; Phenotypes: ; Mode of inheritance: ",
"entity_name": "BRCA2",
"entity_type": "gene"
},
{
"created": "2019-08-02T12:34:36.273343Z",
"panel_name": "Adult solid tumours cancer susceptibility",
"panel_id": 245,
"panel_version": "1.5",
"user_name": "Ivone Leong",
"item_type": "entity",
"text": "reviewed gene: BRCA1: Rating: GREEN; Mode of pathogenicity: ; Publications: ; Phenotypes: ; Mode of inheritance: ",
"entity_name": "BRCA1",
"entity_type": "gene"
},
{
"created": "2019-08-02T12:34:36.258167Z",
"panel_name": "Adult solid tumours cancer susceptibility",
"panel_id": 245,
"panel_version": "1.5",
"user_name": "Ivone Leong",
"item_type": "entity",
"text": "reviewed gene: BMPR1A: Rating: GREEN; Mode of pathogenicity: ; Publications: ; Phenotypes: ; Mode of inheritance: ",
"entity_name": "BMPR1A",
"entity_type": "gene"
},
{
"created": "2019-08-02T12:34:36.241282Z",
"panel_name": "Adult solid tumours cancer susceptibility",
"panel_id": 245,
"panel_version": "1.5",
"user_name": "Ivone Leong",
"item_type": "entity",
"text": "reviewed gene: BAP1: Rating: GREEN; Mode of pathogenicity: ; Publications: ; Phenotypes: ; Mode of inheritance: ",
"entity_name": "BAP1",
"entity_type": "gene"
},
{
"created": "2019-08-02T12:34:36.221846Z",
"panel_name": "Adult solid tumours cancer susceptibility",
"panel_id": 245,
"panel_version": "1.5",
"user_name": "Ivone Leong",
"item_type": "entity",
"text": "reviewed gene: ATM: Rating: GREEN; Mode of pathogenicity: ; Publications: ; Phenotypes: ; Mode of inheritance: ",
"entity_name": "ATM",
"entity_type": "gene"
},
{
"created": "2019-08-02T12:34:36.205342Z",
"panel_name": "Adult solid tumours cancer susceptibility",
"panel_id": 245,
"panel_version": "1.5",
"user_name": "Ivone Leong",
"item_type": "entity",
"text": "reviewed gene: APC: Rating: GREEN; Mode of pathogenicity: ; Publications: ; Phenotypes: ; Mode of inheritance: ",
"entity_name": "APC",
"entity_type": "gene"
},
{
"created": "2019-08-02T12:34:09.796264Z",
"panel_name": "Adult solid tumours cancer susceptibility",
"panel_id": 245,
"panel_version": "1.4",
"user_name": "Ivone Leong",
"item_type": "entity",
"text": "gene: SLX4 was added\ngene: SLX4 was added to Adult solid tumours cancer susceptibility. Sources: NHS GMS,Expert Review Amber\nMode of inheritance for gene: SLX4 was set to BIALLELIC, autosomal or pseudoautosomal\nPhenotypes for gene: SLX4 were set to Fanconi anemia, complementation group P, 613951",
"entity_name": "SLX4",
"entity_type": "gene"
},
{
"created": "2019-08-02T12:34:09.738047Z",
"panel_name": "Adult solid tumours cancer susceptibility",
"panel_id": 245,
"panel_version": "1.4",
"user_name": "Ivone Leong",
"item_type": "entity",
"text": "gene: FANCL was added\ngene: FANCL was added to Adult solid tumours cancer susceptibility. Sources: Expert Review Green,NHS GMS\nMode of inheritance for gene: FANCL was set to BIALLELIC, autosomal or pseudoautosomal\nPublications for gene: FANCL were set to 19686080\nPhenotypes for gene: FANCL were set to Fanconi Anemia",
"entity_name": "FANCL",
"entity_type": "gene"
},
{
"created": "2019-08-02T12:34:09.679548Z",
"panel_name": "Adult solid tumours cancer susceptibility",
"panel_id": 245,
"panel_version": "1.4",
"user_name": "Ivone Leong",
"item_type": "entity",
"text": "gene: FANCI was added\ngene: FANCI was added to Adult solid tumours cancer susceptibility. Sources: Expert Review Green,NHS GMS\nMode of inheritance for gene: FANCI was set to BIALLELIC, autosomal or pseudoautosomal\nPublications for gene: FANCI were set to 19686080\nPhenotypes for gene: FANCI were set to Fanconi Anemia",
"entity_name": "FANCI",
"entity_type": "gene"
},
{
"created": "2019-08-02T12:34:09.627170Z",
"panel_name": "Adult solid tumours cancer susceptibility",
"panel_id": 245,
"panel_version": "1.4",
"user_name": "Ivone Leong",
"item_type": "entity",
"text": "gene: FANCG was added\ngene: FANCG was added to Adult solid tumours cancer susceptibility. Sources: Expert Review Green,NHS GMS\nMode of inheritance for gene: FANCG was set to BIALLELIC, autosomal or pseudoautosomal\nPublications for gene: FANCG were set to 19686080\nPhenotypes for gene: FANCG were set to Fanconi Anemia",
"entity_name": "FANCG",
"entity_type": "gene"
},
{
"created": "2019-08-02T12:34:09.576684Z",
"panel_name": "Adult solid tumours cancer susceptibility",
"panel_id": 245,
"panel_version": "1.4",
"user_name": "Ivone Leong",
"item_type": "entity",
"text": "gene: FANCF was added\ngene: FANCF was added to Adult solid tumours cancer susceptibility. Sources: Expert Review Green,NHS GMS\nMode of inheritance for gene: FANCF was set to BIALLELIC, autosomal or pseudoautosomal\nPublications for gene: FANCF were set to 19686080\nPhenotypes for gene: FANCF were set to Fanconi Anemia",
"entity_name": "FANCF",
"entity_type": "gene"
},
{
"created": "2019-08-02T12:34:09.527275Z",
"panel_name": "Adult solid tumours cancer susceptibility",
"panel_id": 245,
"panel_version": "1.4",
"user_name": "Ivone Leong",
"item_type": "entity",
"text": "gene: FANCE was added\ngene: FANCE was added to Adult solid tumours cancer susceptibility. Sources: Expert Review Green,NHS GMS\nMode of inheritance for gene: FANCE was set to BIALLELIC, autosomal or pseudoautosomal\nPublications for gene: FANCE were set to 19686080\nPhenotypes for gene: FANCE were set to Fanconi Anemia",
"entity_name": "FANCE",
"entity_type": "gene"
},
{
"created": "2019-08-02T12:34:09.460493Z",
"panel_name": "Adult solid tumours cancer susceptibility",
"panel_id": 245,
"panel_version": "1.4",
"user_name": "Ivone Leong",
"item_type": "entity",
"text": "gene: FANCD2 was added\ngene: FANCD2 was added to Adult solid tumours cancer susceptibility. Sources: Expert Review Green,NHS GMS\nMode of inheritance for gene: FANCD2 was set to BIALLELIC, autosomal or pseudoautosomal\nPublications for gene: FANCD2 were set to 19686080\nPhenotypes for gene: FANCD2 were set to Fanconi Anemia",
"entity_name": "FANCD2",
"entity_type": "gene"
},
{
"created": "2019-08-02T12:34:09.408054Z",
"panel_name": "Adult solid tumours cancer susceptibility",
"panel_id": 245,
"panel_version": "1.4",
"user_name": "Ivone Leong",
"item_type": "entity",
"text": "gene: FANCC was added\ngene: FANCC was added to Adult solid tumours cancer susceptibility. Sources: Expert Review Green,NHS GMS\nMode of inheritance for gene: FANCC was set to BIALLELIC, autosomal or pseudoautosomal\nPublications for gene: FANCC were set to 19686080\nPhenotypes for gene: FANCC were set to Fanconi Anemia",
"entity_name": "FANCC",
"entity_type": "gene"
},
{
"created": "2019-08-02T12:34:09.352476Z",
"panel_name": "Adult solid tumours cancer susceptibility",
"panel_id": 245,
"panel_version": "1.4",
"user_name": "Ivone Leong",
"item_type": "entity",
"text": "gene: FANCB was added\ngene: FANCB was added to Adult solid tumours cancer susceptibility. Sources: Expert Review Green,NHS GMS\nMode of inheritance for gene: FANCB was set to X-LINKED: hemizygous mutation in males, monoallelic mutations in females may cause disease (may be less severe, later onset than males)\nPhenotypes for gene: FANCB were set to Fanconi anemia, complementation group B, 300514",
"entity_name": "FANCB",
"entity_type": "gene"
},
{
"created": "2019-08-02T12:34:09.296723Z",
"panel_name": "Adult solid tumours cancer susceptibility",
"panel_id": 245,
"panel_version": "1.4",
"user_name": "Ivone Leong",
"item_type": "entity",
"text": "gene: FANCA was added\ngene: FANCA was added to Adult solid tumours cancer susceptibility. Sources: Expert Review Green,NHS GMS\nMode of inheritance for gene: FANCA was set to BIALLELIC, autosomal or pseudoautosomal\nPublications for gene: FANCA were set to 19686080\nPhenotypes for gene: FANCA were set to Fanconi Anemia",
"entity_name": "FANCA",
"entity_type": "gene"
},
{
"created": "2019-08-02T12:34:09.240894Z",
"panel_name": "Adult solid tumours cancer susceptibility",
"panel_id": 245,
"panel_version": "1.4",
"user_name": "Ivone Leong",
"item_type": "entity",
"text": "gene: WRAP53 was added\ngene: WRAP53 was added to Adult solid tumours cancer susceptibility. Sources: Expert Review Green,NHS GMS\nMode of inheritance for gene: WRAP53 was set to BIALLELIC, autosomal or pseudoautosomal\nPublications for gene: WRAP53 were set to 22285015\nPhenotypes for gene: WRAP53 were set to Dyskeratosis congenita, autosomal recessive 3, 613988",
"entity_name": "WRAP53",
"entity_type": "gene"
},
{
"created": "2019-08-02T12:34:09.187758Z",
"panel_name": "Adult solid tumours cancer susceptibility",
"panel_id": 245,
"panel_version": "1.4",
"user_name": "Ivone Leong",
"item_type": "entity",
"text": "gene: TINF2 was added\ngene: TINF2 was added to Adult solid tumours cancer susceptibility. Sources: NHS GMS,Expert Review Amber\nMode of inheritance for gene: TINF2 was set to MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown\nPhenotypes for gene: TINF2 were set to Dyskeratosis congenita, autosomal dominant 3, 613990",
"entity_name": "TINF2",
"entity_type": "gene"
},
{
"created": "2019-08-02T12:34:09.132528Z",
"panel_name": "Adult solid tumours cancer susceptibility",
"panel_id": 245,
"panel_version": "1.4",
"user_name": "Ivone Leong",
"item_type": "entity",
"text": "gene: TERC was added\ngene: TERC was added to Adult solid tumours cancer susceptibility. Sources: Expert Review Green,NHS GMS\nMode of inheritance for gene: TERC was set to MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown\nPublications for gene: TERC were set to 22285015\nPhenotypes for gene: TERC were set to Dyskeratosis congenita, autosomal dominant 1, 127550",
"entity_name": "TERC",
"entity_type": "gene"
},
{
"created": "2019-08-02T12:34:09.078548Z",
"panel_name": "Adult solid tumours cancer susceptibility",
"panel_id": 245,
"panel_version": "1.4",
"user_name": "Ivone Leong",
"item_type": "entity",
"text": "gene: SPRED1 was added\ngene: SPRED1 was added to Adult solid tumours cancer susceptibility. Sources: NHS GMS\nMode of inheritance for gene: SPRED1 was set to MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown\nPublications for gene: SPRED1 were set to 23875798\nPhenotypes for gene: SPRED1 were set to Legius syndrome 611431",
"entity_name": "SPRED1",
"entity_type": "gene"
},
{
"created": "2019-08-02T12:34:09.027847Z",
"panel_name": "Adult solid tumours cancer susceptibility",
"panel_id": 245,
"panel_version": "1.4",
"user_name": "Ivone Leong",
"item_type": "entity",
"text": "gene: NOP10 was added\ngene: NOP10 was added to Adult solid tumours cancer susceptibility. Sources: NHS GMS\nMode of inheritance for gene: NOP10 was set to BIALLELIC, autosomal or pseudoautosomal\nPhenotypes for gene: NOP10 were set to Dyskeratosis Congenita",
"entity_name": "NOP10",
"entity_type": "gene"
},
{
"created": "2019-08-02T12:34:08.980534Z",
"panel_name": "Adult solid tumours cancer susceptibility",
"panel_id": 245,
"panel_version": "1.4",
"user_name": "Ivone Leong",
"item_type": "entity",
"text": "gene: POLH was added\ngene: POLH was added to Adult solid tumours cancer susceptibility. Sources: Expert Review Green,NHS GMS\nMode of inheritance for gene: POLH was set to BIALLELIC, autosomal or pseudoautosomal\nPublications for gene: POLH were set to 24877075; 11773631; 26884178; 30511002\nPhenotypes for gene: POLH were set to Xeroderma pigmentosum, variant type, 278750",
"entity_name": "POLH",
"entity_type": "gene"
},
{
"created": "2019-08-02T12:34:08.924743Z",
"panel_name": "Adult solid tumours cancer susceptibility",
"panel_id": 245,
"panel_version": "1.4",
"user_name": "Ivone Leong",
"item_type": "entity",
"text": "gene: RTEL1 was added\ngene: RTEL1 was added to Adult solid tumours cancer susceptibility. Sources: Expert Review Green,NHS GMS\nMode of inheritance for gene: RTEL1 was set to BOTH monoallelic and biallelic, autosomal or pseudoautosomal\nPublications for gene: RTEL1 were set to 24582487\nPhenotypes for gene: RTEL1 were set to Dyskeratosis congenita, autosomal recessive 5 615190; 615190 DC type 4 and 5; 616373 Pulmonary fibrosis and/or bone marrow failure, telomere-related; Dyskeratosis congenita, autosomal dominant 4, 615190; Dyskeratosis congenita, autosomal recessive 5, 615190; 615190 Dyskeratosis congenita; 616373 Pulmonary fibrosis and/or bone marrow failure, telomere-related, 3",
"entity_name": "RTEL1",
"entity_type": "gene"
},
{
"created": "2019-08-02T12:34:08.862312Z",
"panel_name": "Adult solid tumours cancer susceptibility",
"panel_id": 245,
"panel_version": "1.4",
"user_name": "Ivone Leong",
"item_type": "entity",
"text": "gene: PARN was added\ngene: PARN was added to Adult solid tumours cancer susceptibility. Sources: NHS GMS,Expert Review Amber\nMode of inheritance for gene: PARN was set to BOTH monoallelic and biallelic, autosomal or pseudoautosomal\nPhenotypes for gene: PARN were set to 616353 Dyskeratosis congenita, autosomal recessive 6; 616371 Pulmonary fibrosis and/or bone marrow failure, telomere-related, 4",
"entity_name": "PARN",
"entity_type": "gene"
},
{
"created": "2019-08-02T12:34:08.806842Z",
"panel_name": "Adult solid tumours cancer susceptibility",
"panel_id": 245,
"panel_version": "1.4",
"user_name": "Ivone Leong",
"item_type": "entity",
"text": "gene: DKC1 was added\ngene: DKC1 was added to Adult solid tumours cancer susceptibility. Sources: NHS GMS,Expert Review Amber\nMode of inheritance for gene: DKC1 was set to X-LINKED: hemizygous mutation in males, biallelic mutations in females\nPhenotypes for gene: DKC1 were set to Dyskeratosis congenita, autosomal recessive 6, 616353",
"entity_name": "DKC1",
"entity_type": "gene"
},
{
"created": "2019-08-02T12:34:08.745921Z",
"panel_name": "Adult solid tumours cancer susceptibility",
"panel_id": 245,
"panel_version": "1.4",
"user_name": "Ivone Leong",
"item_type": "entity",
"text": "gene: CTC1 was added\ngene: CTC1 was added to Adult solid tumours cancer susceptibility. Sources: NHS GMS,Expert Review Amber\nMode of inheritance for gene: CTC1 was set to BIALLELIC, autosomal or pseudoautosomal\nPhenotypes for gene: CTC1 were set to Dyskeratosis congenita; Cerebroretinal microangiopathy with calcifications and cysts/CTC1 related Dyskeratosis Congenita; Inherited Bone Marrow Failure Syndromes; Dyskeratosis Congenita, Recessive; 612199 Coats plus syndrome",
"entity_name": "CTC1",
"entity_type": "gene"
},
{
"created": "2019-08-02T12:34:08.693673Z",
"panel_name": "Adult solid tumours cancer susceptibility",
"panel_id": 245,
"panel_version": "1.4",
"user_name": "Ivone Leong",
"item_type": "entity",
"text": "gene: ACD was added\ngene: ACD was added to Adult solid tumours cancer susceptibility. Sources: NHS GMS,Expert Review Amber\nMode of inheritance for gene: ACD was set to BOTH monoallelic and biallelic, autosomal or pseudoautosomal\nPublications for gene: ACD were set to 25233904; 25205116\nPhenotypes for gene: ACD were set to 616553 ?Dyskeratosis congenita 6 and 7",
"entity_name": "ACD",
"entity_type": "gene"
},
{
"created": "2019-08-02T12:34:08.635828Z",
"panel_name": "Adult solid tumours cancer susceptibility",
"panel_id": 245,
"panel_version": "1.4",
"user_name": "Ivone Leong",
"item_type": "entity",
"text": "gene: SOS2 was added\ngene: SOS2 was added to Adult solid tumours cancer susceptibility. Sources: NHS GMS,Expert Review Amber\nMode of inheritance for gene: SOS2 was set to MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown\nPhenotypes for gene: SOS2 were set to Noonan syndrome 9 616559",
"entity_name": "SOS2",
"entity_type": "gene"
},
{
"created": "2019-08-02T12:34:08.588679Z",
"panel_name": "Adult solid tumours cancer susceptibility",
"panel_id": 245,
"panel_version": "1.4",
"user_name": "Ivone Leong",
"item_type": "entity",
"text": "gene: RIT1 was added\ngene: RIT1 was added to Adult solid tumours cancer susceptibility. Sources: NHS GMS,Expert Review Amber\nMode of inheritance for gene: RIT1 was set to MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown\nPhenotypes for gene: RIT1 were set to Noonan syndrome 8 615355",
"entity_name": "RIT1",
"entity_type": "gene"
},
{
"created": "2019-08-02T12:34:08.522170Z",
"panel_name": "Adult solid tumours cancer susceptibility",
"panel_id": 245,
"panel_version": "1.4",
"user_name": "Ivone Leong",
"item_type": "entity",
"text": "gene: PPP1CB was added\ngene: PPP1CB was added to Adult solid tumours cancer susceptibility. Sources: NHS GMS,Expert Review Amber\nMode of inheritance for gene: PPP1CB was set to MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown\nPhenotypes for gene: PPP1CB were set to Rasopathy with developmental delay, short stature and sparse slow-growing hair; Noonan syndrome-like disorder with loose anagen hair 2, 617506",
"entity_name": "PPP1CB",
"entity_type": "gene"
},
{
"created": "2019-08-02T12:34:08.474621Z",
"panel_name": "Adult solid tumours cancer susceptibility",
"panel_id": 245,
"panel_version": "1.4",
"user_name": "Ivone Leong",
"item_type": "entity",
"text": "gene: LZTR1 was added\ngene: LZTR1 was added to Adult solid tumours cancer susceptibility. Sources: NHS GMS,Expert Review Amber\nMode of inheritance for gene: LZTR1 was set to BOTH monoallelic and biallelic, autosomal or pseudoautosomal\nPhenotypes for gene: LZTR1 were set to Noonan syndrome 10 616564; Schwannomatosis-2, susceptibility to 615670",
"entity_name": "LZTR1",
"entity_type": "gene"
},
{
"created": "2019-08-02T12:34:08.422399Z",
"panel_name": "Adult solid tumours cancer susceptibility",
"panel_id": 245,
"panel_version": "1.4",
"user_name": "Ivone Leong",
"item_type": "entity",
"text": "gene: XPC was added\ngene: XPC was added to Adult solid tumours cancer susceptibility. Sources: Expert Review Green,NHS GMS\nMode of inheritance for gene: XPC was set to BIALLELIC, autosomal or pseudoautosomal\nPublications for gene: XPC were set to 21097776; 26975629; 30565713\nPhenotypes for gene: XPC were set to Xeroderma pigmentosum, group C, 278720",
"entity_name": "XPC",
"entity_type": "gene"
},
{
"created": "2019-08-02T12:34:08.369432Z",
"panel_name": "Adult solid tumours cancer susceptibility",
"panel_id": 245,
"panel_version": "1.4",
"user_name": "Ivone Leong",
"item_type": "entity",
"text": "gene: XPA was added\ngene: XPA was added to Adult solid tumours cancer susceptibility. Sources: Expert Review Green,NHS GMS\nMode of inheritance for gene: XPA was set to BIALLELIC, autosomal or pseudoautosomal\nPublications for gene: XPA were set to 21097776; 26975629; 30565713\nPhenotypes for gene: XPA were set to Xeroderma pigmentosum, group A, 278700",
"entity_name": "XPA",
"entity_type": "gene"
},
{
"created": "2019-08-02T12:34:08.318426Z",
"panel_name": "Adult solid tumours cancer susceptibility",
"panel_id": 245,
"panel_version": "1.4",
"user_name": "Ivone Leong",
"item_type": "entity",
"text": "gene: TERT was added\ngene: TERT was added to Adult solid tumours cancer susceptibility. Sources: Expert Review Green,NHS GMS\nMode of inheritance for gene: TERT was set to BOTH monoallelic and biallelic, autosomal or pseudoautosomal\nPublications for gene: TERT were set to 22285015\nPhenotypes for gene: TERT were set to {Dyskeratosis congenita, autosomal recessive 4}, 613989; {Dyskeratosis congenita, autosomal dominant 2}, 613989",
"entity_name": "TERT",
"entity_type": "gene"
},
{
"created": "2019-08-02T12:34:08.266245Z",
"panel_name": "Adult solid tumours cancer susceptibility",
"panel_id": 245,
"panel_version": "1.4",
"user_name": "Ivone Leong",
"item_type": "entity",
"text": "gene: MAP2K2 was added\ngene: MAP2K2 was added to Adult solid tumours cancer susceptibility. Sources: NHS GMS,Expert Review Amber\nMode of inheritance for gene: MAP2K2 was set to MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown\nPublications for gene: MAP2K2 were set to 23875798\nPhenotypes for gene: MAP2K2 were set to Cardiofaciocutaneous syndrome 4 615280",
"entity_name": "MAP2K2",
"entity_type": "gene"
},
{
"created": "2019-08-02T12:34:08.211268Z",
"panel_name": "Adult solid tumours cancer susceptibility",
"panel_id": 245,
"panel_version": "1.4",
"user_name": "Ivone Leong",
"item_type": "entity",
"text": "gene: MAP2K1 was added\ngene: MAP2K1 was added to Adult solid tumours cancer susceptibility. Sources: NHS GMS,Expert Review Amber\nMode of inheritance for gene: MAP2K1 was set to MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown\nPublications for gene: MAP2K1 were set to 23875798\nPhenotypes for gene: MAP2K1 were set to Cardiofaciocutaneous Syndrome; Cardio-Facio-Cutaneous syndrome; CFC syndrome; LEOPARD syndrome; Cardiofaciocutaneous syndrome 3; ?Noonan syndrome",
"entity_name": "MAP2K1",
"entity_type": "gene"
},
{
"created": "2019-08-02T12:34:08.162642Z",
"panel_name": "Adult solid tumours cancer susceptibility",
"panel_id": 245,
"panel_version": "1.4",
"user_name": "Ivone Leong",
"item_type": "entity",
"text": "gene: ERCC5 was added\ngene: ERCC5 was added to Adult solid tumours cancer susceptibility. Sources: Expert Review Green,NHS GMS\nMode of inheritance for gene: ERCC5 was set to BIALLELIC, autosomal or pseudoautosomal\nPublications for gene: ERCC5 were set to 26884178; 10026181; 7951246; 11841555; 9096355; 23255472; 1206391\nPhenotypes for gene: ERCC5 were set to Xeroderma pigmentosum, group G, 278780",
"entity_name": "ERCC5",
"entity_type": "gene"
},
{
"created": "2019-08-02T12:34:08.112162Z",
"panel_name": "Adult solid tumours cancer susceptibility",
"panel_id": 245,
"panel_version": "1.4",
"user_name": "Ivone Leong",
"item_type": "entity",
"text": "gene: ERCC3 was added\ngene: ERCC3 was added to Adult solid tumours cancer susceptibility. Sources: Expert Review Green,NHS GMS\nMode of inheritance for gene: ERCC3 was set to BIALLELIC, autosomal or pseudoautosomal\nPublications for gene: ERCC3 were set to 26884178; 16947863\nPhenotypes for gene: ERCC3 were set to Xeroderma pigmentosum, group B, 610651",
"entity_name": "ERCC3",
"entity_type": "gene"
},
{
"created": "2019-08-02T12:34:08.061237Z",
"panel_name": "Adult solid tumours cancer susceptibility",
"panel_id": 245,
"panel_version": "1.4",
"user_name": "Ivone Leong",
"item_type": "entity",
"text": "gene: ERCC2 was added\ngene: ERCC2 was added to Adult solid tumours cancer susceptibility. Sources: Expert Review Green,NHS GMS\nMode of inheritance for gene: ERCC2 was set to BIALLELIC, autosomal or pseudoautosomal\nPublications for gene: ERCC2 were set to 26884178; 28376890\nPhenotypes for gene: ERCC2 were set to Xeroderma pigmentosum, group D, 278730",
"entity_name": "ERCC2",
"entity_type": "gene"
},
{
"created": "2019-08-02T12:34:08.011360Z",
"panel_name": "Adult solid tumours cancer susceptibility",
"panel_id": 245,
"panel_version": "1.4",
"user_name": "Ivone Leong",
"item_type": "entity",
"text": "gene: ERCC1 was added\ngene: ERCC1 was added to Adult solid tumours cancer susceptibility. Sources: NHS GMS,Expert Review Amber\nMode of inheritance for gene: ERCC1 was set to BIALLELIC, autosomal or pseudoautosomal\nPhenotypes for gene: ERCC1 were set to Xeroderma Pigmentosa; Cerebrooculofacioskeletal syndrome 4, 610758",
"entity_name": "ERCC1",
"entity_type": "gene"
},
{
"created": "2019-08-02T12:34:07.963520Z",
"panel_name": "Adult solid tumours cancer susceptibility",
"panel_id": 245,
"panel_version": "1.4",
"user_name": "Ivone Leong",
"item_type": "entity",
"text": "gene: DDB2 was added\ngene: DDB2 was added to Adult solid tumours cancer susceptibility. Sources: Expert Review Green,NHS GMS\nMode of inheritance for gene: DDB2 was set to BIALLELIC, autosomal or pseudoautosomal\nPublications for gene: DDB2 were set to 12812979; 21107348; 26884178; 104693112\nPhenotypes for gene: DDB2 were set to Xeroderma pigmentosum, group E, DDB-negative subtype, 278740",
"entity_name": "DDB2",
"entity_type": "gene"
},
{
"created": "2019-08-02T12:34:07.918495Z",
"panel_name": "Adult solid tumours cancer susceptibility",
"panel_id": 245,
"panel_version": "1.4",
"user_name": "Ivone Leong",
"item_type": "entity",
"text": "gene: BRAF was added\ngene: BRAF was added to Adult solid tumours cancer susceptibility. Sources: NHS GMS,Expert Review Amber\nMode of inheritance for gene: BRAF was set to MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown\nPublications for gene: BRAF were set to 23875798\nPhenotypes for gene: BRAF were set to Cardiofaciocutaneous syndrome 115150; Noonan syndrome 7 613706; LEOPARD syndrome 3 613707",
"entity_name": "BRAF",
"entity_type": "gene"
},
{
"created": "2019-08-02T12:34:07.872985Z",
"panel_name": "Adult solid tumours cancer susceptibility",
"panel_id": 245,
"panel_version": "1.4",
"user_name": "Ivone Leong",
"item_type": "entity",
"text": "gene: SOS1 was added\ngene: SOS1 was added to Adult solid tumours cancer susceptibility. Sources: Expert Review Green,NHS GMS\nMode of inheritance for gene: SOS1 was set to MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown\nPublications for gene: SOS1 were set to 23875798\nPhenotypes for gene: SOS1 were set to Noonan syndrome 4 610733",
"entity_name": "SOS1",
"entity_type": "gene"
},
{
"created": "2019-08-02T12:34:07.820634Z",
"panel_name": "Adult solid tumours cancer susceptibility",
"panel_id": 245,
"panel_version": "1.4",
"user_name": "Ivone Leong",
"item_type": "entity",
"text": "gene: SHOC2 was added\ngene: SHOC2 was added to Adult solid tumours cancer susceptibility. Sources: Expert Review Green,NHS GMS\nMode of inheritance for gene: SHOC2 was set to MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown\nPublications for gene: SHOC2 were set to 23875798\nPhenotypes for gene: SHOC2 were set to Noonan-like syndrome with loose anagen hair",
"entity_name": "SHOC2",
"entity_type": "gene"
},
{
"created": "2019-08-02T12:34:07.775441Z",
"panel_name": "Adult solid tumours cancer susceptibility",
"panel_id": 245,
"panel_version": "1.4",
"user_name": "Ivone Leong",
"item_type": "entity",
"text": "gene: RAF1 was added\ngene: RAF1 was added to Adult solid tumours cancer susceptibility. Sources: Expert Review Green,NHS GMS\nMode of inheritance for gene: RAF1 was set to MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown\nPublications for gene: RAF1 were set to 23875798\nPhenotypes for gene: RAF1 were set to LEOPARD syndrome 2 611554; Noonan syndrome 5 611553",
"entity_name": "RAF1",
"entity_type": "gene"
},
{
"created": "2019-08-02T12:34:07.727305Z",
"panel_name": "Adult solid tumours cancer susceptibility",
"panel_id": 245,
"panel_version": "1.4",
"user_name": "Ivone Leong",
"item_type": "entity",
"text": "gene: PTPN11 was added\ngene: PTPN11 was added to Adult solid tumours cancer susceptibility. Sources: Expert Review Green,NHS GMS\nMode of inheritance for gene: PTPN11 was set to MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown\nPublications for gene: PTPN11 were set to 23875798\nPhenotypes for gene: PTPN11 were set to Noonan syndrome",
"entity_name": "PTPN11",
"entity_type": "gene"
},
{
"created": "2019-08-02T12:34:07.673355Z",
"panel_name": "Adult solid tumours cancer susceptibility",
"panel_id": 245,
"panel_version": "1.4",
"user_name": "Ivone Leong",
"item_type": "entity",
"text": "gene: NRAS was added\ngene: NRAS was added to Adult solid tumours cancer susceptibility. Sources: Expert Review Green,NHS GMS\nMode of inheritance for gene: NRAS was set to MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown\nPublications for gene: NRAS were set to 23875798\nPhenotypes for gene: NRAS were set to Cardio-Facio-cutanenous syndrome; Noonan syndrome 6 613224; CFC Syndrome",
"entity_name": "NRAS",
"entity_type": "gene"
},
{
"created": "2019-08-02T12:34:07.622485Z",
"panel_name": "Adult solid tumours cancer susceptibility",
"panel_id": 245,
"panel_version": "1.4",
"user_name": "Ivone Leong",
"item_type": "entity",
"text": "gene: KRAS was added\ngene: KRAS was added to Adult solid tumours cancer susceptibility. Sources: Expert Review Green,NHS GMS\nMode of inheritance for gene: KRAS was set to MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown\nPublications for gene: KRAS were set to 23875798\nPhenotypes for gene: KRAS were set to Noonan syndrome 3 609942; Cardiofaciocutaneous syndrome 2 615278",
"entity_name": "KRAS",
"entity_type": "gene"
},
{
"created": "2019-08-02T12:34:07.573747Z",
"panel_name": "Adult solid tumours cancer susceptibility",
"panel_id": 245,
"panel_version": "1.4",
"user_name": "Ivone Leong",
"item_type": "entity",
"text": "gene: HRAS was added\ngene: HRAS was added to Adult solid tumours cancer susceptibility. Sources: Expert Review Green,NHS GMS\nMode of inheritance for gene: HRAS was set to MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown\nPublications for gene: HRAS were set to 23875798\nPhenotypes for gene: HRAS were set to Costello syndrome",
"entity_name": "HRAS",
"entity_type": "gene"
},
{
"created": "2019-08-02T12:34:07.525664Z",
"panel_name": "Adult solid tumours cancer susceptibility",
"panel_id": 245,
"panel_version": "1.4",
"user_name": "Ivone Leong",
"item_type": "entity",
"text": "gene: ERCC4 was added\ngene: ERCC4 was added to Adult solid tumours cancer susceptibility. Sources: Expert Review Green,NHS GMS\nMode of inheritance for gene: ERCC4 was set to BIALLELIC, autosomal or pseudoautosomal\nPhenotypes for gene: ERCC4 were set to Fanconi anemia, complementation group Q, 615272; Xeroderma pigmentosum, group F, 278760",
"entity_name": "ERCC4",
"entity_type": "gene"
},
{
"created": "2019-08-02T12:34:07.474678Z",
"panel_name": "Adult solid tumours cancer susceptibility",
"panel_id": 245,
"panel_version": "1.4",
"user_name": "Ivone Leong",
"item_type": "entity",
"text": "gene: CBL was added\ngene: CBL was added to Adult solid tumours cancer susceptibility. Sources: Expert Review Green,NHS GMS\nMode of inheritance for gene: CBL was set to MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown\nPublications for gene: CBL were set to 23875798\nPhenotypes for gene: CBL were set to Noonan syndrome-like disorder with or without juvenile myelomonocytic leukemia 613563",
"entity_name": "CBL",
"entity_type": "gene"
},
{
"created": "2019-08-02T12:34:07.420061Z",
"panel_name": "Adult solid tumours cancer susceptibility",
"panel_id": 245,
"panel_version": "1.4",
"user_name": "Ivone Leong",
"item_type": "entity",
"text": "Source NHS GMS was added to EXT2.",
"entity_name": "EXT2",
"entity_type": "gene"
},
{
"created": "2019-08-02T12:34:07.362057Z",
"panel_name": "Adult solid tumours cancer susceptibility",
"panel_id": 245,
"panel_version": "1.4",
"user_name": "Ivone Leong",
"item_type": "entity",
"text": "Source NHS GMS was added to EXT1.",
"entity_name": "EXT1",
"entity_type": "gene"
},
{
"created": "2019-08-02T12:34:07.296618Z",
"panel_name": "Adult solid tumours cancer susceptibility",
"panel_id": 245,
"panel_version": "1.4",
"user_name": "Ivone Leong",
"item_type": "entity",
"text": "Source NHS GMS was added to CHEK2.",
"entity_name": "CHEK2",
"entity_type": "gene"
},
{
"created": "2019-08-02T12:34:07.228327Z",
"panel_name": "Adult solid tumours cancer susceptibility",
"panel_id": 245,
"panel_version": "1.4",
"user_name": "Ivone Leong",
"item_type": "entity",
"text": "Source NHS GMS was added to AIP.",
"entity_name": "AIP",
"entity_type": "gene"
},
{
"created": "2019-08-02T12:34:07.149961Z",
"panel_name": "Adult solid tumours cancer susceptibility",
"panel_id": 245,
"panel_version": "1.4",
"user_name": "Ivone Leong",
"item_type": "entity",
"text": "Source NHS GMS was added to WT1.",
"entity_name": "WT1",
"entity_type": "gene"
},
{
"created": "2019-08-02T12:34:07.086808Z",
"panel_name": "Adult solid tumours cancer susceptibility",
"panel_id": 245,
"panel_version": "1.4",
"user_name": "Ivone Leong",
"item_type": "entity",
"text": "Source NHS GMS was added to VHL.",
"entity_name": "VHL",
"entity_type": "gene"
},
{
"created": "2019-08-02T12:34:07.022063Z",
"panel_name": "Adult solid tumours cancer susceptibility",
"panel_id": 245,
"panel_version": "1.4",
"user_name": "Ivone Leong",
"item_type": "entity",
"text": "Source NHS GMS was added to TSC2.",
"entity_name": "TSC2",
"entity_type": "gene"
},
{
"created": "2019-08-02T12:34:06.965171Z",
"panel_name": "Adult solid tumours cancer susceptibility",
"panel_id": 245,
"panel_version": "1.4",
"user_name": "Ivone Leong",
"item_type": "entity",
"text": "Source NHS GMS was added to TSC1.",
"entity_name": "TSC1",
"entity_type": "gene"
},
{
"created": "2019-08-02T12:34:06.902893Z",
"panel_name": "Adult solid tumours cancer susceptibility",
"panel_id": 245,
"panel_version": "1.4",
"user_name": "Ivone Leong",
"item_type": "entity",
"text": "Source NHS GMS was added to TP53.",
"entity_name": "TP53",
"entity_type": "gene"
},
{
"created": "2019-08-02T12:34:06.835271Z",
"panel_name": "Adult solid tumours cancer susceptibility",
"panel_id": 245,
"panel_version": "1.4",
"user_name": "Ivone Leong",
"item_type": "entity",
"text": "Source NHS GMS was added to TMEM127.",
"entity_name": "TMEM127",
"entity_type": "gene"
},
{
"created": "2019-08-02T12:34:06.770497Z",
"panel_name": "Adult solid tumours cancer susceptibility",
"panel_id": 245,
"panel_version": "1.4",
"user_name": "Ivone Leong",
"item_type": "entity",
"text": "Source NHS GMS was added to SUFU.",
"entity_name": "SUFU",
"entity_type": "gene"
},
{
"created": "2019-08-02T12:34:06.712803Z",
"panel_name": "Adult solid tumours cancer susceptibility",
"panel_id": 245,
"panel_version": "1.4",
"user_name": "Ivone Leong",
"item_type": "entity",
"text": "Source NHS GMS was added to STK11.",
"entity_name": "STK11",
"entity_type": "gene"
},
{
"created": "2019-08-02T12:34:06.640409Z",
"panel_name": "Adult solid tumours cancer susceptibility",
"panel_id": 245,
"panel_version": "1.4",
"user_name": "Ivone Leong",
"item_type": "entity",
"text": "Source NHS GMS was added to SMARCB1.",
"entity_name": "SMARCB1",
"entity_type": "gene"
},
{
"created": "2019-08-02T12:34:06.586418Z",
"panel_name": "Adult solid tumours cancer susceptibility",
"panel_id": 245,
"panel_version": "1.4",
"user_name": "Ivone Leong",
"item_type": "entity",
"text": "Source NHS GMS was added to SMARCA4.",
"entity_name": "SMARCA4",
"entity_type": "gene"
},
{
"created": "2019-08-02T12:34:06.534606Z",
"panel_name": "Adult solid tumours cancer susceptibility",
"panel_id": 245,
"panel_version": "1.4",
"user_name": "Ivone Leong",
"item_type": "entity",
"text": "Source NHS GMS was added to SMAD4.",
"entity_name": "SMAD4",
"entity_type": "gene"
},
{
"created": "2019-08-02T12:34:06.483146Z",
"panel_name": "Adult solid tumours cancer susceptibility",
"panel_id": 245,
"panel_version": "1.4",
"user_name": "Ivone Leong",
"item_type": "entity",
"text": "Source NHS GMS was added to SDHD.",
"entity_name": "SDHD",
"entity_type": "gene"
},
{
"created": "2019-08-02T12:34:06.430713Z",
"panel_name": "Adult solid tumours cancer susceptibility",
"panel_id": 245,
"panel_version": "1.4",
"user_name": "Ivone Leong",
"item_type": "entity",
"text": "Source NHS GMS was added to SDHC.",
"entity_name": "SDHC",
"entity_type": "gene"
},
{
"created": "2019-08-02T12:34:06.376714Z",
"panel_name": "Adult solid tumours cancer susceptibility",
"panel_id": 245,
"panel_version": "1.4",
"user_name": "Ivone Leong",
"item_type": "entity",
"text": "Source NHS GMS was added to SDHB.",
"entity_name": "SDHB",
"entity_type": "gene"
},
{
"created": "2019-08-02T12:34:06.327512Z",
"panel_name": "Adult solid tumours cancer susceptibility",
"panel_id": 245,
"panel_version": "1.4",
"user_name": "Ivone Leong",
"item_type": "entity",
"text": "Source NHS GMS was added to SDHAF2.",
"entity_name": "SDHAF2",
"entity_type": "gene"
},
{
"created": "2019-08-02T12:34:06.276194Z",
"panel_name": "Adult solid tumours cancer susceptibility",
"panel_id": 245,
"panel_version": "1.4",
"user_name": "Ivone Leong",
"item_type": "entity",
"text": "Source NHS GMS was added to SDHA.",
"entity_name": "SDHA",
"entity_type": "gene"
},
{
"created": "2019-08-02T12:34:06.223310Z",
"panel_name": "Adult solid tumours cancer susceptibility",
"panel_id": 245,
"panel_version": "1.4",
"user_name": "Ivone Leong",
"item_type": "entity",
"text": "Source NHS GMS was added to RET.",
"entity_name": "RET",
"entity_type": "gene"
},
{
"created": "2019-08-02T12:34:06.161179Z",
"panel_name": "Adult solid tumours cancer susceptibility",
"panel_id": 245,
"panel_version": "1.4",
"user_name": "Ivone Leong",
"item_type": "entity",
"text": "Source NHS GMS was added to RB1.",
"entity_name": "RB1",
"entity_type": "gene"
},
{
"created": "2019-08-02T12:34:06.092214Z",
"panel_name": "Adult solid tumours cancer susceptibility",
"panel_id": 245,
"panel_version": "1.4",
"user_name": "Ivone Leong",
"item_type": "entity",
"text": "Source NHS GMS was added to RAD51D.",
"entity_name": "RAD51D",
"entity_type": "gene"
},
{
"created": "2019-08-02T12:34:06.032882Z",
"panel_name": "Adult solid tumours cancer susceptibility",
"panel_id": 245,
"panel_version": "1.4",
"user_name": "Ivone Leong",
"item_type": "entity",
"text": "Source NHS GMS was added to RAD51C.",
"entity_name": "RAD51C",
"entity_type": "gene"
},
{
"created": "2019-08-02T12:34:05.975848Z",
"panel_name": "Adult solid tumours cancer susceptibility",
"panel_id": 245,
"panel_version": "1.4",
"user_name": "Ivone Leong",
"item_type": "entity",
"text": "Source NHS GMS was added to PTEN.",
"entity_name": "PTEN",
"entity_type": "gene"
},
{
"created": "2019-08-02T12:34:05.923944Z",
"panel_name": "Adult solid tumours cancer susceptibility",
"panel_id": 245,
"panel_version": "1.4",
"user_name": "Ivone Leong",
"item_type": "entity",
"text": "Source NHS GMS was added to PTCH1.",
"entity_name": "PTCH1",
"entity_type": "gene"
},
{
"created": "2019-08-02T12:34:05.873240Z",
"panel_name": "Adult solid tumours cancer susceptibility",
"panel_id": 245,
"panel_version": "1.4",
"user_name": "Ivone Leong",
"item_type": "entity",
"text": "Source NHS GMS was added to POLE.",
"entity_name": "POLE",
"entity_type": "gene"
},
{
"created": "2019-08-02T12:34:05.814970Z",
"panel_name": "Adult solid tumours cancer susceptibility",
"panel_id": 245,
"panel_version": "1.4",
"user_name": "Ivone Leong",
"item_type": "entity",
"text": "Source NHS GMS was added to POLD1.",
"entity_name": "POLD1",
"entity_type": "gene"
},
{
"created": "2019-08-02T12:34:05.764500Z",
"panel_name": "Adult solid tumours cancer susceptibility",
"panel_id": 245,
"panel_version": "1.4",
"user_name": "Ivone Leong",
"item_type": "entity",
"text": "Source NHS GMS was added to PMS2.",
"entity_name": "PMS2",
"entity_type": "gene"
},
{
"created": "2019-08-02T12:34:05.693865Z",
"panel_name": "Adult solid tumours cancer susceptibility",
"panel_id": 245,
"panel_version": "1.4",
"user_name": "Ivone Leong",
"item_type": "entity",
"text": "Source NHS GMS was added to PALB2.",
"entity_name": "PALB2",
"entity_type": "gene"
},
{
"created": "2019-08-02T12:34:05.643270Z",
"panel_name": "Adult solid tumours cancer susceptibility",
"panel_id": 245,
"panel_version": "1.4",
"user_name": "Ivone Leong",
"item_type": "entity",
"text": "Source NHS GMS was added to NTHL1.",
"entity_name": "NTHL1",
"entity_type": "gene"
},
{
"created": "2019-08-02T12:34:05.592942Z",
"panel_name": "Adult solid tumours cancer susceptibility",
"panel_id": 245,
"panel_version": "1.4",
"user_name": "Ivone Leong",
"item_type": "entity",
"text": "Source NHS GMS was added to NF2.",
"entity_name": "NF2",
"entity_type": "gene"
},
{
"created": "2019-08-02T12:34:05.542202Z",
"panel_name": "Adult solid tumours cancer susceptibility",
"panel_id": 245,
"panel_version": "1.4",
"user_name": "Ivone Leong",
"item_type": "entity",
"text": "Source NHS GMS was added to NF1.",
"entity_name": "NF1",
"entity_type": "gene"
},
{
"created": "2019-08-02T12:34:05.491614Z",
"panel_name": "Adult solid tumours cancer susceptibility",
"panel_id": 245,
"panel_version": "1.4",
"user_name": "Ivone Leong",
"item_type": "entity",
"text": "Source NHS GMS was added to MUTYH.",
"entity_name": "MUTYH",
"entity_type": "gene"
},
{
"created": "2019-08-02T12:34:05.441967Z",
"panel_name": "Adult solid tumours cancer susceptibility",
"panel_id": 245,
"panel_version": "1.4",
"user_name": "Ivone Leong",
"item_type": "entity",
"text": "Source NHS GMS was added to MSH6.",
"entity_name": "MSH6",
"entity_type": "gene"
},
{
"created": "2019-08-02T12:34:05.388853Z",
"panel_name": "Adult solid tumours cancer susceptibility",
"panel_id": 245,
"panel_version": "1.4",
"user_name": "Ivone Leong",
"item_type": "entity",
"text": "Source NHS GMS was added to MSH2.",
"entity_name": "MSH2",
"entity_type": "gene"
},
{
"created": "2019-08-02T12:34:05.330613Z",
"panel_name": "Adult solid tumours cancer susceptibility",
"panel_id": 245,
"panel_version": "1.4",
"user_name": "Ivone Leong",
"item_type": "entity",
"text": "Source NHS GMS was added to MLH1.",
"entity_name": "MLH1",
"entity_type": "gene"
},
{
"created": "2019-08-02T12:34:05.277639Z",
"panel_name": "Adult solid tumours cancer susceptibility",
"panel_id": 245,
"panel_version": "1.4",
"user_name": "Ivone Leong",
"item_type": "entity",
"text": "Source NHS GMS was added to MET.",
"entity_name": "MET",
"entity_type": "gene"
},
{
"created": "2019-08-02T12:34:05.223165Z",
"panel_name": "Adult solid tumours cancer susceptibility",
"panel_id": 245,
"panel_version": "1.4",
"user_name": "Ivone Leong",
"item_type": "entity",
"text": "Source NHS GMS was added to MEN1.",
"entity_name": "MEN1",
"entity_type": "gene"
},
{
"created": "2019-08-02T12:34:05.170238Z",
"panel_name": "Adult solid tumours cancer susceptibility",
"panel_id": 245,
"panel_version": "1.4",
"user_name": "Ivone Leong",
"item_type": "entity",
"text": "Source NHS GMS was added to MAX.",
"entity_name": "MAX",
"entity_type": "gene"
},
{
"created": "2019-08-02T12:34:05.116664Z",
"panel_name": "Adult solid tumours cancer susceptibility",
"panel_id": 245,
"panel_version": "1.4",
"user_name": "Ivone Leong",
"item_type": "entity",
"text": "Source NHS GMS was added to KIT.",
"entity_name": "KIT",
"entity_type": "gene"
},
{
"created": "2019-08-02T12:34:05.063735Z",
"panel_name": "Adult solid tumours cancer susceptibility",
"panel_id": 245,
"panel_version": "1.4",
"user_name": "Ivone Leong",
"item_type": "entity",
"text": "Source NHS GMS was added to FLCN.",
"entity_name": "FLCN",
"entity_type": "gene"
},
{
"created": "2019-08-02T12:34:05.008205Z",
"panel_name": "Adult solid tumours cancer susceptibility",
"panel_id": 245,
"panel_version": "1.4",
"user_name": "Ivone Leong",
"item_type": "entity",
"text": "Source NHS GMS was added to FH.",
"entity_name": "FH",
"entity_type": "gene"
},
{
"created": "2019-08-02T12:34:04.948878Z",
"panel_name": "Adult solid tumours cancer susceptibility",
"panel_id": 245,
"panel_version": "1.4",
"user_name": "Ivone Leong",
"item_type": "entity",
"text": "Source NHS GMS was added to EPCAM.",
"entity_name": "EPCAM",
"entity_type": "gene"
},
{
"created": "2019-08-02T12:34:04.895087Z",
"panel_name": "Adult solid tumours cancer susceptibility",
"panel_id": 245,
"panel_version": "1.4",
"user_name": "Ivone Leong",
"item_type": "entity",
"text": "Source NHS GMS was added to DICER1.",
"entity_name": "DICER1",
"entity_type": "gene"
},
{
"created": "2019-08-02T12:34:04.842077Z",
"panel_name": "Adult solid tumours cancer susceptibility",
"panel_id": 245,
"panel_version": "1.4",
"user_name": "Ivone Leong",
"item_type": "entity",
"text": "Source NHS GMS was added to CDKN2A.",
"entity_name": "CDKN2A",
"entity_type": "gene"
},
{
"created": "2019-08-02T12:34:04.791528Z",
"panel_name": "Adult solid tumours cancer susceptibility",
"panel_id": 245,
"panel_version": "1.4",
"user_name": "Ivone Leong",
"item_type": "entity",
"text": "Source NHS GMS was added to CDKN1B.",
"entity_name": "CDKN1B",
"entity_type": "gene"
},
{
"created": "2019-08-02T12:34:04.725238Z",
"panel_name": "Adult solid tumours cancer susceptibility",
"panel_id": 245,
"panel_version": "1.4",
"user_name": "Ivone Leong",
"item_type": "entity",
"text": "Source NHS GMS was added to CDK4.",
"entity_name": "CDK4",
"entity_type": "gene"
},
{
"created": "2019-08-02T12:34:04.673929Z",
"panel_name": "Adult solid tumours cancer susceptibility",
"panel_id": 245,
"panel_version": "1.4",
"user_name": "Ivone Leong",
"item_type": "entity",
"text": "Source NHS GMS was added to CDH1.",
"entity_name": "CDH1",
"entity_type": "gene"
},
{
"created": "2019-08-02T12:34:04.620978Z",
"panel_name": "Adult solid tumours cancer susceptibility",
"panel_id": 245,
"panel_version": "1.4",
"user_name": "Ivone Leong",
"item_type": "entity",
"text": "Source NHS GMS was added to CDC73.",
"entity_name": "CDC73",
"entity_type": "gene"
},
{
"created": "2019-08-02T12:34:04.568748Z",
"panel_name": "Adult solid tumours cancer susceptibility",
"panel_id": 245,
"panel_version": "1.4",
"user_name": "Ivone Leong",
"item_type": "entity",
"text": "Source NHS GMS was added to BRIP1.",
"entity_name": "BRIP1",
"entity_type": "gene"
},
{
"created": "2019-08-02T12:34:04.517513Z",
"panel_name": "Adult solid tumours cancer susceptibility",
"panel_id": 245,
"panel_version": "1.4",
"user_name": "Ivone Leong",
"item_type": "entity",
"text": "Source NHS GMS was added to BRCA2.",
"entity_name": "BRCA2",
"entity_type": "gene"
},
{
"created": "2019-08-02T12:34:04.462506Z",
"panel_name": "Adult solid tumours cancer susceptibility",
"panel_id": 245,
"panel_version": "1.4",
"user_name": "Ivone Leong",
"item_type": "entity",
"text": "Source NHS GMS was added to BRCA1.",
"entity_name": "BRCA1",
"entity_type": "gene"
},
{
"created": "2019-08-02T12:34:04.408057Z",
"panel_name": "Adult solid tumours cancer susceptibility",
"panel_id": 245,
"panel_version": "1.4",
"user_name": "Ivone Leong",
"item_type": "entity",
"text": "Source NHS GMS was added to BMPR1A.",
"entity_name": "BMPR1A",
"entity_type": "gene"
},
{
"created": "2019-08-02T12:34:04.356361Z",
"panel_name": "Adult solid tumours cancer susceptibility",
"panel_id": 245,
"panel_version": "1.4",
"user_name": "Ivone Leong",
"item_type": "entity",
"text": "Source NHS GMS was added to BAP1.",
"entity_name": "BAP1",
"entity_type": "gene"
},
{
"created": "2019-08-02T12:34:04.302609Z",
"panel_name": "Adult solid tumours cancer susceptibility",
"panel_id": 245,
"panel_version": "1.4",
"user_name": "Ivone Leong",
"item_type": "entity",
"text": "Source NHS GMS was added to ATM.",
"entity_name": "ATM",
"entity_type": "gene"
},
{
"created": "2019-08-02T12:34:04.236755Z",
"panel_name": "Adult solid tumours cancer susceptibility",
"panel_id": 245,
"panel_version": "1.4",
"user_name": "Ivone Leong",
"item_type": "entity",
"text": "Source NHS GMS was added to APC.",
"entity_name": "APC",
"entity_type": "gene"
},
{
"created": "2019-04-25T15:33:31.468380Z",
"panel_name": "Adult solid tumours cancer susceptibility",
"panel_id": 245,
"panel_version": "1.3",
"user_name": "Ellen McDonagh",
"item_type": "panel",
"text": "Panel types changed to Cancer Germline 100K; GMS Cancer Germline Virtual",
"entity_name": null,
"entity_type": null
},
{
"created": "2019-03-28T17:03:17.887191Z",
"panel_name": "Adult solid tumours cancer susceptibility",
"panel_id": 245,
"panel_version": "1.2",
"user_name": "Ellen McDonagh",
"item_type": "entity",
"text": "commented on gene: PDGFRA",
"entity_name": "PDGFRA",
"entity_type": "gene"
},
{
"created": "2019-03-28T17:02:37.355709Z",
"panel_name": "Adult solid tumours cancer susceptibility",
"panel_id": 245,
"panel_version": "1.2",
"user_name": "Ellen McDonagh",
"item_type": "entity",
"text": "commented on gene: EXT2",
"entity_name": "EXT2",
"entity_type": "gene"
},
{
"created": "2019-03-28T17:02:32.172231Z",
"panel_name": "Adult solid tumours cancer susceptibility",
"panel_id": 245,
"panel_version": "1.2",
"user_name": "Ellen McDonagh",
"item_type": "entity",
"text": "commented on gene: EXT1",
"entity_name": "EXT1",
"entity_type": "gene"
},
{
"created": "2019-03-28T17:02:23.550917Z",
"panel_name": "Adult solid tumours cancer susceptibility",
"panel_id": 245,
"panel_version": "1.2",
"user_name": "Ellen McDonagh",
"item_type": "entity",
"text": "commented on gene: AIP",
"entity_name": "AIP",
"entity_type": "gene"
},
{
"created": "2019-03-28T15:47:34.504120Z",
"panel_name": "Adult solid tumours cancer susceptibility",
"panel_id": 245,
"panel_version": "1.2",
"user_name": "Ellen McDonagh",
"item_type": "entity",
"text": "gene: PDGFRA was added\ngene: PDGFRA was added to Adult solid tumours cancer susceptibility. Sources: Literature\nMode of inheritance for gene: PDGFRA was set to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted\nPhenotypes for gene: PDGFRA were set to Gastrointestinal stromal tumor",
"entity_name": "PDGFRA",
"entity_type": "gene"
},
{
"created": "2019-03-28T15:47:34.460597Z",
"panel_name": "Adult solid tumours cancer susceptibility",
"panel_id": 245,
"panel_version": "1.2",
"user_name": "Ellen McDonagh",
"item_type": "entity",
"text": "gene: EXT2 was added\ngene: EXT2 was added to Adult solid tumours cancer susceptibility. Sources: Other,Expert Review Amber\nMode of inheritance for gene: EXT2 was set to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted\nPublications for gene: EXT2 were set to 27636706; 29529714; 23770606; 7726168\nPhenotypes for gene: EXT2 were set to Exostoses, multiple, type 2",
"entity_name": "EXT2",
"entity_type": "gene"
},
{
"created": "2019-03-28T15:47:34.416133Z",
"panel_name": "Adult solid tumours cancer susceptibility",
"panel_id": 245,
"panel_version": "1.2",
"user_name": "Ellen McDonagh",
"item_type": "entity",
"text": "gene: EXT1 was added\ngene: EXT1 was added to Adult solid tumours cancer susceptibility. Sources: Other,Expert Review Amber\nMode of inheritance for gene: EXT1 was set to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted\nPublications for gene: EXT1 were set to 29529714; 10441575; 23770606\nPhenotypes for gene: EXT1 were set to Chondrosarcoma 215300",
"entity_name": "EXT1",
"entity_type": "gene"
},
{
"created": "2019-03-28T15:47:34.369984Z",
"panel_name": "Adult solid tumours cancer susceptibility",
"panel_id": 245,
"panel_version": "1.2",
"user_name": "Ellen McDonagh",
"item_type": "entity",
"text": "gene: AIP was added\ngene: AIP was added to Adult solid tumours cancer susceptibility. Sources: Expert Review Amber,Literature\nMode of inheritance for gene: AIP was set to MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown\nPublications for gene: AIP were set to 17360484\nPhenotypes for gene: AIP were set to Pituitary adenoma 1, multiple types 102200",
"entity_name": "AIP",
"entity_type": "gene"
},
{
"created": "2019-03-28T14:47:38.758597Z",
"panel_name": "Adult solid tumours cancer susceptibility",
"panel_id": 245,
"panel_version": "1.1",
"user_name": "Ellen McDonagh",
"item_type": "panel",
"text": "Panel name changed from Adult solid tumours pertinent cancer susceptibility to Adult solid tumours cancer susceptibility\nList of related panels changed from Carcinoma of unknown primary; Other to Carcinoma of unknown primary; Other; Adult solid tumours pertinent cancer susceptibility",
"entity_name": null,
"entity_type": null
},
{
"created": "2018-09-07T12:04:24.554700Z",
"panel_name": "Adult solid tumours pertinent cancer susceptibility",
"panel_id": 245,
"panel_version": "1.0",
"user_name": "Louise Daugherty",
"item_type": "panel",
"text": "promoted panel to version 1.0",
"entity_name": null,
"entity_type": null
},
{
"created": "2018-08-20T11:54:35.688395Z",
"panel_name": "Adult solid tumours pertinent cancer susceptibility",
"panel_id": 245,
"panel_version": null,
"user_name": "Ellen McDonagh",
"item_type": "entity",
"text": "classified CHEK2 as Amber List (moderate evidence)",
"entity_name": "CHEK2",
"entity_type": "gene"
},
{
"created": "2018-08-20T11:54:06.720622Z",
"panel_name": "Adult solid tumours pertinent cancer susceptibility",
"panel_id": 245,
"panel_version": null,
"user_name": "Ellen McDonagh",
"item_type": "entity",
"text": "commented on gene: CDKN1B",
"entity_name": "CDKN1B",
"entity_type": "gene"
},
{
"created": "2017-07-27T11:04:35.329000Z",
"panel_name": "Adult solid tumours pertinent cancer susceptibility",
"panel_id": 245,
"panel_version": null,
"user_name": "Ellen McDonagh",
"item_type": "entity",
"text": "commented on CDKN1B",
"entity_name": "CDKN1B",
"entity_type": "gene"
},
{
"created": "2017-07-27T10:58:50.104000Z",
"panel_name": "Adult solid tumours pertinent cancer susceptibility",
"panel_id": 245,
"panel_version": null,
"user_name": "Ellen McDonagh",
"item_type": "entity",
"text": "commented on ATM",
"entity_name": "ATM",
"entity_type": "gene"
},
{
"created": "2017-07-05T15:48:10.338000Z",
"panel_name": "Adult solid tumours pertinent cancer susceptibility",
"panel_id": 245,
"panel_version": null,
"user_name": "Ellen McDonagh",
"item_type": "panel",
"text": "approved panel",
"entity_name": null,
"entity_type": null
},
{
"created": "2017-07-05T12:19:17.523000Z",
"panel_name": "Adult solid tumours pertinent cancer susceptibility",
"panel_id": 245,
"panel_version": null,
"user_name": "Clare Turnbull",
"item_type": "entity",
"text": "reviewed RAD51D",
"entity_name": "RAD51D",
"entity_type": "gene"
},
{
"created": "2017-07-05T12:19:17.274000Z",
"panel_name": "Adult solid tumours pertinent cancer susceptibility",
"panel_id": 245,
"panel_version": null,
"user_name": "Clare Turnbull",
"item_type": "entity",
"text": "reviewed CDKN1B",
"entity_name": "CDKN1B",
"entity_type": "gene"
},
{
"created": "2017-07-05T12:19:17.029000Z",
"panel_name": "Adult solid tumours pertinent cancer susceptibility",
"panel_id": 245,
"panel_version": null,
"user_name": "Clare Turnbull",
"item_type": "entity",
"text": "reviewed NTHL1",
"entity_name": "NTHL1",
"entity_type": "gene"
},
{
"created": "2017-07-05T12:19:16.782000Z",
"panel_name": "Adult solid tumours pertinent cancer susceptibility",
"panel_id": 245,
"panel_version": null,
"user_name": "Clare Turnbull",
"item_type": "entity",
"text": "reviewed MUTYH",
"entity_name": "MUTYH",
"entity_type": "gene"
},
{
"created": "2017-07-05T12:19:16.519000Z",
"panel_name": "Adult solid tumours pertinent cancer susceptibility",
"panel_id": 245,
"panel_version": null,
"user_name": "Clare Turnbull",
"item_type": "entity",
"text": "reviewed POLE",
"entity_name": "POLE",
"entity_type": "gene"
},
{
"created": "2017-07-05T12:19:16.275000Z",
"panel_name": "Adult solid tumours pertinent cancer susceptibility",
"panel_id": 245,
"panel_version": null,
"user_name": "Clare Turnbull",
"item_type": "entity",
"text": "reviewed WT1",
"entity_name": "WT1",
"entity_type": "gene"
},
{
"created": "2017-07-05T12:19:16.028000Z",
"panel_name": "Adult solid tumours pertinent cancer susceptibility",
"panel_id": 245,
"panel_version": null,
"user_name": "Clare Turnbull",
"item_type": "entity",
"text": "reviewed VHL",
"entity_name": "VHL",
"entity_type": "gene"
},
{
"created": "2017-07-05T12:19:15.789000Z",
"panel_name": "Adult solid tumours pertinent cancer susceptibility",
"panel_id": 245,
"panel_version": null,
"user_name": "Clare Turnbull",
"item_type": "entity",
"text": "reviewed TSC2",
"entity_name": "TSC2",
"entity_type": "gene"
},
{
"created": "2017-07-05T12:19:15.541000Z",
"panel_name": "Adult solid tumours pertinent cancer susceptibility",
"panel_id": 245,
"panel_version": null,
"user_name": "Clare Turnbull",
"item_type": "entity",
"text": "reviewed TSC1",
"entity_name": "TSC1",
"entity_type": "gene"
},
{
"created": "2017-07-05T12:19:15.298000Z",
"panel_name": "Adult solid tumours pertinent cancer susceptibility",
"panel_id": 245,
"panel_version": null,
"user_name": "Clare Turnbull",
"item_type": "entity",
"text": "reviewed TP53",
"entity_name": "TP53",
"entity_type": "gene"
},
{
"created": "2017-07-05T12:19:15.042000Z",
"panel_name": "Adult solid tumours pertinent cancer susceptibility",
"panel_id": 245,
"panel_version": null,
"user_name": "Clare Turnbull",
"item_type": "entity",
"text": "reviewed TMEM127",
"entity_name": "TMEM127",
"entity_type": "gene"
},
{
"created": "2017-07-05T12:19:14.799000Z",
"panel_name": "Adult solid tumours pertinent cancer susceptibility",
"panel_id": 245,
"panel_version": null,
"user_name": "Clare Turnbull",
"item_type": "entity",
"text": "reviewed SUFU",
"entity_name": "SUFU",
"entity_type": "gene"
},
{
"created": "2017-07-05T12:19:14.557000Z",
"panel_name": "Adult solid tumours pertinent cancer susceptibility",
"panel_id": 245,
"panel_version": null,
"user_name": "Clare Turnbull",
"item_type": "entity",
"text": "reviewed STK11",
"entity_name": "STK11",
"entity_type": "gene"
},
{
"created": "2017-07-05T12:19:14.317000Z",
"panel_name": "Adult solid tumours pertinent cancer susceptibility",
"panel_id": 245,
"panel_version": null,
"user_name": "Clare Turnbull",
"item_type": "entity",
"text": "reviewed SMARCB1",
"entity_name": "SMARCB1",
"entity_type": "gene"
},
{
"created": "2017-07-05T12:19:14.070000Z",
"panel_name": "Adult solid tumours pertinent cancer susceptibility",
"panel_id": 245,
"panel_version": null,
"user_name": "Clare Turnbull",
"item_type": "entity",
"text": "reviewed SMARCA4",
"entity_name": "SMARCA4",
"entity_type": "gene"
},
{
"created": "2017-07-05T12:19:13.828000Z",
"panel_name": "Adult solid tumours pertinent cancer susceptibility",
"panel_id": 245,
"panel_version": null,
"user_name": "Clare Turnbull",
"item_type": "entity",
"text": "reviewed SMAD4",
"entity_name": "SMAD4",
"entity_type": "gene"
},
{
"created": "2017-07-05T12:19:13.579000Z",
"panel_name": "Adult solid tumours pertinent cancer susceptibility",
"panel_id": 245,
"panel_version": null,
"user_name": "Clare Turnbull",
"item_type": "entity",
"text": "reviewed SDHD",
"entity_name": "SDHD",
"entity_type": "gene"
},
{
"created": "2017-07-05T12:19:13.329000Z",
"panel_name": "Adult solid tumours pertinent cancer susceptibility",
"panel_id": 245,
"panel_version": null,
"user_name": "Clare Turnbull",
"item_type": "entity",
"text": "reviewed SDHC",
"entity_name": "SDHC",
"entity_type": "gene"
},
{
"created": "2017-07-05T12:19:13.088000Z",
"panel_name": "Adult solid tumours pertinent cancer susceptibility",
"panel_id": 245,
"panel_version": null,
"user_name": "Clare Turnbull",
"item_type": "entity",
"text": "reviewed SDHB",
"entity_name": "SDHB",
"entity_type": "gene"
},
{
"created": "2017-07-05T12:19:12.824000Z",
"panel_name": "Adult solid tumours pertinent cancer susceptibility",
"panel_id": 245,
"panel_version": null,
"user_name": "Clare Turnbull",
"item_type": "entity",
"text": "reviewed SDHAF2",
"entity_name": "SDHAF2",
"entity_type": "gene"
},
{
"created": "2017-07-05T12:19:12.587000Z",
"panel_name": "Adult solid tumours pertinent cancer susceptibility",
"panel_id": 245,
"panel_version": null,
"user_name": "Clare Turnbull",
"item_type": "entity",
"text": "reviewed SDHA",
"entity_name": "SDHA",
"entity_type": "gene"
},
{
"created": "2017-07-05T12:19:12.347000Z",
"panel_name": "Adult solid tumours pertinent cancer susceptibility",
"panel_id": 245,
"panel_version": null,
"user_name": "Clare Turnbull",
"item_type": "entity",
"text": "reviewed RET",
"entity_name": "RET",
"entity_type": "gene"
},
{
"created": "2017-07-05T12:19:12.111000Z",
"panel_name": "Adult solid tumours pertinent cancer susceptibility",
"panel_id": 245,
"panel_version": null,
"user_name": "Clare Turnbull",
"item_type": "entity",
"text": "reviewed RB1",
"entity_name": "RB1",
"entity_type": "gene"
},
{
"created": "2017-07-05T12:19:11.873000Z",
"panel_name": "Adult solid tumours pertinent cancer susceptibility",
"panel_id": 245,
"panel_version": null,
"user_name": "Clare Turnbull",
"item_type": "entity",
"text": "reviewed RAD51C",
"entity_name": "RAD51C",
"entity_type": "gene"
},
{
"created": "2017-07-05T12:19:11.605000Z",
"panel_name": "Adult solid tumours pertinent cancer susceptibility",
"panel_id": 245,
"panel_version": null,
"user_name": "Clare Turnbull",
"item_type": "entity",
"text": "reviewed PTEN",
"entity_name": "PTEN",
"entity_type": "gene"
},
{
"created": "2017-07-05T12:19:11.362000Z",
"panel_name": "Adult solid tumours pertinent cancer susceptibility",
"panel_id": 245,
"panel_version": null,
"user_name": "Clare Turnbull",
"item_type": "entity",
"text": "reviewed PTCH1",
"entity_name": "PTCH1",
"entity_type": "gene"
},
{
"created": "2017-07-05T12:19:11.122000Z",
"panel_name": "Adult solid tumours pertinent cancer susceptibility",
"panel_id": 245,
"panel_version": null,
"user_name": "Clare Turnbull",
"item_type": "entity",
"text": "reviewed POLD1",
"entity_name": "POLD1",
"entity_type": "gene"
},
{
"created": "2017-07-05T12:19:10.871000Z",
"panel_name": "Adult solid tumours pertinent cancer susceptibility",
"panel_id": 245,
"panel_version": null,
"user_name": "Clare Turnbull",
"item_type": "entity",
"text": "reviewed PMS2",
"entity_name": "PMS2",
"entity_type": "gene"
},
{
"created": "2017-07-05T12:19:10.633000Z",
"panel_name": "Adult solid tumours pertinent cancer susceptibility",
"panel_id": 245,
"panel_version": null,
"user_name": "Clare Turnbull",
"item_type": "entity",
"text": "reviewed PALB2",
"entity_name": "PALB2",
"entity_type": "gene"
},
{
"created": "2017-07-05T12:19:10.394000Z",
"panel_name": "Adult solid tumours pertinent cancer susceptibility",
"panel_id": 245,
"panel_version": null,
"user_name": "Clare Turnbull",
"item_type": "entity",
"text": "reviewed NF2",
"entity_name": "NF2",
"entity_type": "gene"
},
{
"created": "2017-07-05T12:19:10.151000Z",
"panel_name": "Adult solid tumours pertinent cancer susceptibility",
"panel_id": 245,
"panel_version": null,
"user_name": "Clare Turnbull",
"item_type": "entity",
"text": "reviewed NF1",
"entity_name": "NF1",
"entity_type": "gene"
},
{
"created": "2017-07-05T12:19:09.905000Z",
"panel_name": "Adult solid tumours pertinent cancer susceptibility",
"panel_id": 245,
"panel_version": null,
"user_name": "Clare Turnbull",
"item_type": "entity",
"text": "reviewed MSH6",
"entity_name": "MSH6",
"entity_type": "gene"
},
{
"created": "2017-07-05T12:19:09.663000Z",
"panel_name": "Adult solid tumours pertinent cancer susceptibility",
"panel_id": 245,
"panel_version": null,
"user_name": "Clare Turnbull",
"item_type": "entity",
"text": "reviewed MSH2",
"entity_name": "MSH2",
"entity_type": "gene"
},
{
"created": "2017-07-05T12:19:09.419000Z",
"panel_name": "Adult solid tumours pertinent cancer susceptibility",
"panel_id": 245,
"panel_version": null,
"user_name": "Clare Turnbull",
"item_type": "entity",
"text": "reviewed MLH1",
"entity_name": "MLH1",
"entity_type": "gene"
},
{
"created": "2017-07-05T12:19:09.177000Z",
"panel_name": "Adult solid tumours pertinent cancer susceptibility",
"panel_id": 245,
"panel_version": null,
"user_name": "Clare Turnbull",
"item_type": "entity",
"text": "reviewed MET",
"entity_name": "MET",
"entity_type": "gene"
},
{
"created": "2017-07-05T12:19:08.919000Z",
"panel_name": "Adult solid tumours pertinent cancer susceptibility",
"panel_id": 245,
"panel_version": null,
"user_name": "Clare Turnbull",
"item_type": "entity",
"text": "reviewed MEN1",
"entity_name": "MEN1",
"entity_type": "gene"
},
{
"created": "2017-07-05T12:19:08.674000Z",
"panel_name": "Adult solid tumours pertinent cancer susceptibility",
"panel_id": 245,
"panel_version": null,
"user_name": "Clare Turnbull",
"item_type": "entity",
"text": "reviewed MAX",
"entity_name": "MAX",
"entity_type": "gene"
},
{
"created": "2017-07-05T12:19:08.434000Z",
"panel_name": "Adult solid tumours pertinent cancer susceptibility",
"panel_id": 245,
"panel_version": null,
"user_name": "Clare Turnbull",
"item_type": "entity",
"text": "reviewed KIT",
"entity_name": "KIT",
"entity_type": "gene"
},
{
"created": "2017-07-05T12:19:08.201000Z",
"panel_name": "Adult solid tumours pertinent cancer susceptibility",
"panel_id": 245,
"panel_version": null,
"user_name": "Clare Turnbull",
"item_type": "entity",
"text": "reviewed FLCN",
"entity_name": "FLCN",
"entity_type": "gene"
},
{
"created": "2017-07-05T12:19:07.965000Z",
"panel_name": "Adult solid tumours pertinent cancer susceptibility",
"panel_id": 245,
"panel_version": null,
"user_name": "Clare Turnbull",
"item_type": "entity",
"text": "reviewed FH",
"entity_name": "FH",
"entity_type": "gene"
},
{
"created": "2017-07-05T12:19:07.725000Z",
"panel_name": "Adult solid tumours pertinent cancer susceptibility",
"panel_id": 245,
"panel_version": null,
"user_name": "Clare Turnbull",
"item_type": "entity",
"text": "reviewed EPCAM",
"entity_name": "EPCAM",
"entity_type": "gene"
},
{
"created": "2017-07-05T12:19:07.449000Z",
"panel_name": "Adult solid tumours pertinent cancer susceptibility",
"panel_id": 245,
"panel_version": null,
"user_name": "Clare Turnbull",
"item_type": "entity",
"text": "reviewed DICER1",
"entity_name": "DICER1",
"entity_type": "gene"
},
{
"created": "2017-07-05T12:19:07.214000Z",
"panel_name": "Adult solid tumours pertinent cancer susceptibility",
"panel_id": 245,
"panel_version": null,
"user_name": "Clare Turnbull",
"item_type": "entity",
"text": "reviewed CHEK2",
"entity_name": "CHEK2",
"entity_type": "gene"
},
{
"created": "2017-07-05T12:19:06.978000Z",
"panel_name": "Adult solid tumours pertinent cancer susceptibility",
"panel_id": 245,
"panel_version": null,
"user_name": "Clare Turnbull",
"item_type": "entity",
"text": "reviewed CDKN2A",
"entity_name": "CDKN2A",
"entity_type": "gene"
},
{
"created": "2017-07-05T12:19:06.746000Z",
"panel_name": "Adult solid tumours pertinent cancer susceptibility",
"panel_id": 245,
"panel_version": null,
"user_name": "Clare Turnbull",
"item_type": "entity",
"text": "reviewed CDK4",
"entity_name": "CDK4",
"entity_type": "gene"
},
{
"created": "2017-07-05T12:19:06.466000Z",
"panel_name": "Adult solid tumours pertinent cancer susceptibility",
"panel_id": 245,
"panel_version": null,
"user_name": "Clare Turnbull",
"item_type": "entity",
"text": "reviewed CDH1",
"entity_name": "CDH1",
"entity_type": "gene"
},
{
"created": "2017-07-05T12:19:06.198000Z",
"panel_name": "Adult solid tumours pertinent cancer susceptibility",
"panel_id": 245,
"panel_version": null,
"user_name": "Clare Turnbull",
"item_type": "entity",
"text": "reviewed CDC73",
"entity_name": "CDC73",
"entity_type": "gene"
},
{
"created": "2017-07-05T12:19:05.823000Z",
"panel_name": "Adult solid tumours pertinent cancer susceptibility",
"panel_id": 245,
"panel_version": null,
"user_name": "Clare Turnbull",
"item_type": "entity",
"text": "reviewed BRIP1",
"entity_name": "BRIP1",
"entity_type": "gene"
},
{
"created": "2017-07-05T12:19:05.596000Z",
"panel_name": "Adult solid tumours pertinent cancer susceptibility",
"panel_id": 245,
"panel_version": null,
"user_name": "Clare Turnbull",
"item_type": "entity",
"text": "reviewed BRCA2",
"entity_name": "BRCA2",
"entity_type": "gene"
},
{
"created": "2017-07-05T12:19:05.336000Z",
"panel_name": "Adult solid tumours pertinent cancer susceptibility",
"panel_id": 245,
"panel_version": null,
"user_name": "Clare Turnbull",
"item_type": "entity",
"text": "reviewed BRCA1",
"entity_name": "BRCA1",
"entity_type": "gene"
},
{
"created": "2017-07-05T12:19:04.988000Z",
"panel_name": "Adult solid tumours pertinent cancer susceptibility",
"panel_id": 245,
"panel_version": null,
"user_name": "Clare Turnbull",
"item_type": "entity",
"text": "reviewed BMPR1A",
"entity_name": "BMPR1A",
"entity_type": "gene"
},
{
"created": "2017-07-05T12:19:04.761000Z",
"panel_name": "Adult solid tumours pertinent cancer susceptibility",
"panel_id": 245,
"panel_version": null,
"user_name": "Clare Turnbull",
"item_type": "entity",
"text": "reviewed BAP1",
"entity_name": "BAP1",
"entity_type": "gene"
},
{
"created": "2017-07-05T12:19:04.534000Z",
"panel_name": "Adult solid tumours pertinent cancer susceptibility",
"panel_id": 245,
"panel_version": null,
"user_name": "Clare Turnbull",
"item_type": "entity",
"text": "reviewed ATM",
"entity_name": "ATM",
"entity_type": "gene"
},
{
"created": "2017-07-05T12:19:04.292000Z",
"panel_name": "Adult solid tumours pertinent cancer susceptibility",
"panel_id": 245,
"panel_version": null,
"user_name": "Clare Turnbull",
"item_type": "entity",
"text": "reviewed APC",
"entity_name": "APC",
"entity_type": "gene"
}
]