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[
{
"created": "2023-03-22T15:00:55.693541Z",
"panel_name": "Amelogenesis imperfecta",
"panel_id": 269,
"panel_version": "3.1",
"user_name": "Achchuthan Shanmugasundram",
"item_type": "panel",
"text": "Panel version 3.0 has been signed off on 2023-03-22",
"entity_name": null,
"entity_type": null
},
{
"created": "2023-03-22T14:59:51.288567Z",
"panel_name": "Amelogenesis imperfecta",
"panel_id": 269,
"panel_version": "3.0",
"user_name": "Achchuthan Shanmugasundram",
"item_type": "panel",
"text": "promoted panel to version 3.0",
"entity_name": null,
"entity_type": null
},
{
"created": "2023-02-01T17:07:04.423612Z",
"panel_name": "Amelogenesis imperfecta",
"panel_id": 269,
"panel_version": "2.22",
"user_name": "Achchuthan Shanmugasundram",
"item_type": "entity",
"text": "Tag Q3_21_rating was removed from gene: SP6.",
"entity_name": "SP6",
"entity_type": "gene"
},
{
"created": "2023-02-01T17:06:34.233288Z",
"panel_name": "Amelogenesis imperfecta",
"panel_id": 269,
"panel_version": "2.22",
"user_name": "Achchuthan Shanmugasundram",
"item_type": "entity",
"text": "Tag Q1_22_MOI was removed from gene: PEX6.",
"entity_name": "PEX6",
"entity_type": "gene"
},
{
"created": "2023-02-01T17:05:51.839524Z",
"panel_name": "Amelogenesis imperfecta",
"panel_id": 269,
"panel_version": "2.22",
"user_name": "Achchuthan Shanmugasundram",
"item_type": "entity",
"text": "Tag Q3_21_rating was removed from gene: PEX26.",
"entity_name": "PEX26",
"entity_type": "gene"
},
{
"created": "2023-02-01T17:04:34.714045Z",
"panel_name": "Amelogenesis imperfecta",
"panel_id": 269,
"panel_version": "2.22",
"user_name": "Achchuthan Shanmugasundram",
"item_type": "entity",
"text": "reviewed gene: SP6: Rating: GREEN; Mode of pathogenicity: ; Publications: ; Phenotypes: ; Mode of inheritance: ",
"entity_name": "SP6",
"entity_type": "gene"
},
{
"created": "2023-02-01T17:04:34.700791Z",
"panel_name": "Amelogenesis imperfecta",
"panel_id": 269,
"panel_version": "2.22",
"user_name": "Achchuthan Shanmugasundram",
"item_type": "entity",
"text": "commented on gene: PEX6",
"entity_name": "PEX6",
"entity_type": "gene"
},
{
"created": "2023-02-01T17:04:34.686973Z",
"panel_name": "Amelogenesis imperfecta",
"panel_id": 269,
"panel_version": "2.22",
"user_name": "Achchuthan Shanmugasundram",
"item_type": "entity",
"text": "reviewed gene: PEX26: Rating: GREEN; Mode of pathogenicity: ; Publications: ; Phenotypes: ; Mode of inheritance: ",
"entity_name": "PEX26",
"entity_type": "gene"
},
{
"created": "2023-02-01T17:04:23.350244Z",
"panel_name": "Amelogenesis imperfecta",
"panel_id": 269,
"panel_version": "2.21",
"user_name": "Achchuthan Shanmugasundram",
"item_type": "entity",
"text": "Source Expert Review Green was added to SP6.\nSource NHS GMS was added to SP6.\nRating Changed from Amber List (moderate evidence) to Green List (high evidence)",
"entity_name": "SP6",
"entity_type": "gene"
},
{
"created": "2023-02-01T17:04:23.285066Z",
"panel_name": "Amelogenesis imperfecta",
"panel_id": 269,
"panel_version": "2.21",
"user_name": "Achchuthan Shanmugasundram",
"item_type": "entity",
"text": "Source NHS GMS was added to PEX6.\nMode of inheritance for gene PEX6 was changed from BIALLELIC, autosomal or pseudoautosomal to BOTH monoallelic and biallelic, autosomal or pseudoautosomal",
"entity_name": "PEX6",
"entity_type": "gene"
},
{
"created": "2023-02-01T17:04:23.225660Z",
"panel_name": "Amelogenesis imperfecta",
"panel_id": 269,
"panel_version": "2.21",
"user_name": "Achchuthan Shanmugasundram",
"item_type": "entity",
"text": "Source Expert Review Green was added to PEX26.\nSource NHS GMS was added to PEX26.\nRating Changed from Amber List (moderate evidence) to Green List (high evidence)",
"entity_name": "PEX26",
"entity_type": "gene"
},
{
"created": "2022-04-19T13:56:43.611860Z",
"panel_name": "Amelogenesis imperfecta",
"panel_id": 269,
"panel_version": "2.20",
"user_name": "Arina Puzriakova",
"item_type": "entity",
"text": "Phenotypes for gene: COL17A1 were changed from Epidermolysis bullosa, junctional, non-Herlitz type, 226650 (includes enamel pitting); Amelogenesis Imperfecta; non-Herlitz junctional epidermolysis bullosa (nH-JEB) and amelogenesis imperfecta; hypoplastic amelogenesis imperfecta to Epidermolysis bullosa, junctional 4, intermediate, OMIM:619787 (includes enamel pitting); Hypoplastic amelogenesis imperfecta",
"entity_name": "COL17A1",
"entity_type": "gene"
},
{
"created": "2022-04-01T15:15:35.221914Z",
"panel_name": "Amelogenesis imperfecta",
"panel_id": 269,
"panel_version": "2.19",
"user_name": "Sarah Leigh",
"item_type": "entity",
"text": "Penetrance for gene PEX6 was set from to Complete",
"entity_name": "PEX6",
"entity_type": "gene"
},
{
"created": "2022-04-01T15:11:41.964085Z",
"panel_name": "Amelogenesis imperfecta",
"panel_id": 269,
"panel_version": "2.18",
"user_name": "Sarah Leigh",
"item_type": "entity",
"text": "edited their review of gene: PEX6: Added comment: For Peroxisome biogenesis disorder 4B (OMIM:614863), Falkenberg et al (PMID: 29220678) has identified Allelic Expression Imbalance (AEI) as a mechanism responsible for the condition. Affected patients (7 unrelated cases) were monoallelic for rs61753230 (c.2578C>T, p.Arg860Trp) and rs144286892 (c.∗442_445 delTAAA), with these variants being on the same chromosome (cis). It would appear that rs144286892 causes the over expression of the allele that it is on, resulting in over expression of rs61753230. The unaffected parents analysed were monoallelic for rs61753230 and biallelic for rs144286892, resulting in overexpression of both rs61753230 and wild type alleles (PMID: 29220678). Experimental evidence revealed that rs61753230 has a dominant-negative effect on the function of the PEX1- PEX6 complex in peroxisomal matrix protein import (PMID: 29220678).; Changed mode of pathogenicity: Other; Changed publications to: 29220678",
"entity_name": "PEX6",
"entity_type": "gene"
},
{
"created": "2022-04-01T15:09:56.282604Z",
"panel_name": "Amelogenesis imperfecta",
"panel_id": 269,
"panel_version": "2.18",
"user_name": "Sarah Leigh",
"item_type": "entity",
"text": "Tag Q1_22_MOI tag was added to gene: PEX6.",
"entity_name": "PEX6",
"entity_type": "gene"
},
{
"created": "2022-04-01T15:09:43.838584Z",
"panel_name": "Amelogenesis imperfecta",
"panel_id": 269,
"panel_version": "2.18",
"user_name": "Sarah Leigh",
"item_type": "entity",
"text": "Added comment: Comment on mode of inheritance: The Q1_22_MOI tag has been added to this gene. The mode of inheritance for PEX6 should be set to: BOTH monoallelic and biallelic, autosomal or pseudoautosomal in order to detect the dominant Peroxisome biogenesis disorder 4B. Incomplete penetrance has been noted, in order to highlight that unaffected parents may also carry rs61753230.",
"entity_name": "PEX6",
"entity_type": "gene"
},
{
"created": "2022-04-01T15:09:43.825913Z",
"panel_name": "Amelogenesis imperfecta",
"panel_id": 269,
"panel_version": "2.18",
"user_name": "Sarah Leigh",
"item_type": "entity",
"text": "Mode of inheritance for gene: PEX6 was changed from BIALLELIC, autosomal or pseudoautosomal to BIALLELIC, autosomal or pseudoautosomal",
"entity_name": "PEX6",
"entity_type": "gene"
},
{
"created": "2022-04-01T15:09:30.971760Z",
"panel_name": "Amelogenesis imperfecta",
"panel_id": 269,
"panel_version": "2.17",
"user_name": "Sarah Leigh",
"item_type": "entity",
"text": "Publications for gene: PEX6 were set to 27302843; 26387595; 16530715",
"entity_name": "PEX6",
"entity_type": "gene"
},
{
"created": "2022-04-01T15:02:02.155859Z",
"panel_name": "Amelogenesis imperfecta",
"panel_id": 269,
"panel_version": "2.16",
"user_name": "Sarah Leigh",
"item_type": "entity",
"text": "edited their review of gene: PEX6: Added comment: The review by Claire Smith (University of Leeds)(below), states that amelogenesis imperfecta maybe over looked in patients with Peroxisome biogenesis disorder 4A (Zellweger) (OMIM:614862) and Peroxisome biogenesis disorder 4B (OMIM:6148630), as these conditions are characterized by a severe phenotype and premature death in some cases. With this in mind the Peroxisome biogenesis disorder 4B (OMIM:614863) could be relevant to this panel and such the mode of inheritance should be changed to BOTH monoallelic and biallelic, autosomal or pseudoautosomal in order to detect variants resulting in allelic expression imbalance and dominant-negative effect (PMID: 29220678).; Changed mode of inheritance: BOTH monoallelic and biallelic, autosomal or pseudoautosomal",
"entity_name": "PEX6",
"entity_type": "gene"
},
{
"created": "2022-04-01T14:43:17.926668Z",
"panel_name": "Amelogenesis imperfecta",
"panel_id": 269,
"panel_version": "2.16",
"user_name": "Sarah Leigh",
"item_type": "entity",
"text": "reviewed gene: PEX6: Rating: ; Mode of pathogenicity: None; Publications: ; Phenotypes: Heimler syndrome 2, OMIM:616617; Mode of inheritance: BIALLELIC, autosomal or pseudoautosomal",
"entity_name": "PEX6",
"entity_type": "gene"
},
{
"created": "2022-03-02T18:03:22.068547Z",
"panel_name": "Amelogenesis imperfecta",
"panel_id": 269,
"panel_version": "2.16",
"user_name": "Eleanor Williams",
"item_type": "entity",
"text": "changed review comment from: Leaving the mode of inheritance as Biallelic. Cases reporting a dental phenotype have all had biallelic variants.\r\nMonoallelic cases have also been reported with geleophysic dysplasia and acromelic dysplasia and therefore the mode of inheritance on the skeletal dysplasia panel covers both mode of inheritance.; to: Leaving the mode of inheritance as Biallelic. Cases reporting a dental phenotype have all had biallelic variants.\r\n\r\nMonoallelic cases have also been reported with geleophysic dysplasia and acromelic dysplasia phenotypes and therefore the mode of inheritance on the skeletal dysplasia panel covers both mode of inheritance.",
"entity_name": "LTBP3",
"entity_type": "gene"
},
{
"created": "2022-03-02T18:02:30.567890Z",
"panel_name": "Amelogenesis imperfecta",
"panel_id": 269,
"panel_version": "2.16",
"user_name": "Eleanor Williams",
"item_type": "entity",
"text": "commented on gene: LTBP3",
"entity_name": "LTBP3",
"entity_type": "gene"
},
{
"created": "2022-03-02T17:59:50.449429Z",
"panel_name": "Amelogenesis imperfecta",
"panel_id": 269,
"panel_version": "2.16",
"user_name": "Eleanor Williams",
"item_type": "entity",
"text": "Publications for gene: LTBP3 were set to 25669657; 28084688",
"entity_name": "LTBP3",
"entity_type": "gene"
},
{
"created": "2022-03-02T17:57:31.670630Z",
"panel_name": "Amelogenesis imperfecta",
"panel_id": 269,
"panel_version": "2.15",
"user_name": "Eleanor Williams",
"item_type": "entity",
"text": "Phenotypes for gene: LTBP3 were changed from Dental anomalies and short stature, 601216; Amelogenesis Imperfecta; syndromic AI with brachyolmia to Dental anomalies and short stature, OMIM:601216; Amelogenesis Imperfecta; syndromic AI with brachyolmia",
"entity_name": "LTBP3",
"entity_type": "gene"
},
{
"created": "2021-08-19T12:56:12.508349Z",
"panel_name": "Amelogenesis imperfecta",
"panel_id": 269,
"panel_version": "2.14",
"user_name": "Eleanor Williams",
"item_type": "entity",
"text": "Classified gene: PEX26 as Amber List (moderate evidence)",
"entity_name": "PEX26",
"entity_type": "gene"
},
{
"created": "2021-08-19T12:56:12.504105Z",
"panel_name": "Amelogenesis imperfecta",
"panel_id": 269,
"panel_version": "2.14",
"user_name": "Eleanor Williams",
"item_type": "entity",
"text": "Added comment: Comment on list classification: Leaving rating as amber for now, but with recommendation for green rating following GMS review. 3 cases now reported with a syndromic amelogenesis imperfecta phenotype.",
"entity_name": "PEX26",
"entity_type": "gene"
},
{
"created": "2021-08-19T12:56:12.484820Z",
"panel_name": "Amelogenesis imperfecta",
"panel_id": 269,
"panel_version": "2.14",
"user_name": "Eleanor Williams",
"item_type": "entity",
"text": "Gene: pex26 has been classified as Amber List (Moderate Evidence).",
"entity_name": "PEX26",
"entity_type": "gene"
},
{
"created": "2021-08-19T12:55:07.854644Z",
"panel_name": "Amelogenesis imperfecta",
"panel_id": 269,
"panel_version": "2.13",
"user_name": "Eleanor Williams",
"item_type": "entity",
"text": "Phenotypes for gene: PEX26 were changed from Peroxisome biogenesis disorder 7A (Zellweger), 614872; Peroxisome biogenesis disorder 7B, 614873; Heimler syndrome; Amelogenesis imperfecta; enamel dysplasia to Amelogenesis Imperfecta, MONDO:0019507; Heimler syndrome",
"entity_name": "PEX26",
"entity_type": "gene"
},
{
"created": "2021-08-19T12:53:23.416264Z",
"panel_name": "Amelogenesis imperfecta",
"panel_id": 269,
"panel_version": "2.12",
"user_name": "Eleanor Williams",
"item_type": "entity",
"text": "Publications for gene: PEX26 were set to 28944237",
"entity_name": "PEX26",
"entity_type": "gene"
},
{
"created": "2021-08-19T12:53:05.652085Z",
"panel_name": "Amelogenesis imperfecta",
"panel_id": 269,
"panel_version": "2.11",
"user_name": "Eleanor Williams",
"item_type": "entity",
"text": "Tag watchlist was removed from gene: PEX26.\nTag Q3_21_rating tag was added to gene: PEX26.",
"entity_name": "PEX26",
"entity_type": "gene"
},
{
"created": "2021-08-19T12:52:47.271462Z",
"panel_name": "Amelogenesis imperfecta",
"panel_id": 269,
"panel_version": "2.11",
"user_name": "Eleanor Williams",
"item_type": "entity",
"text": "commented on gene: PEX26",
"entity_name": "PEX26",
"entity_type": "gene"
},
{
"created": "2021-08-19T12:38:42.605046Z",
"panel_name": "Amelogenesis imperfecta",
"panel_id": 269,
"panel_version": "2.11",
"user_name": "Eleanor Williams",
"item_type": "entity",
"text": "Classified gene: SP6 as Amber List (moderate evidence)",
"entity_name": "SP6",
"entity_type": "gene"
},
{
"created": "2021-08-19T12:38:42.602078Z",
"panel_name": "Amelogenesis imperfecta",
"panel_id": 269,
"panel_version": "2.11",
"user_name": "Eleanor Williams",
"item_type": "entity",
"text": "Added comment: Comment on list classification: Leaving rating as amber, but with recommendation for green rating following GMS review. 2 unrelated cases, plus animal model.",
"entity_name": "SP6",
"entity_type": "gene"
},
{
"created": "2021-08-19T12:38:42.587247Z",
"panel_name": "Amelogenesis imperfecta",
"panel_id": 269,
"panel_version": "2.11",
"user_name": "Eleanor Williams",
"item_type": "entity",
"text": "Gene: sp6 has been classified as Amber List (Moderate Evidence).",
"entity_name": "SP6",
"entity_type": "gene"
},
{
"created": "2021-08-19T12:38:01.348227Z",
"panel_name": "Amelogenesis imperfecta",
"panel_id": 269,
"panel_version": "2.10",
"user_name": "Eleanor Williams",
"item_type": "entity",
"text": "Phenotypes for gene: SP6 were changed from Amelogenesis Imperfecta to Amelogenesis Imperfecta, MONDO:0019507",
"entity_name": "SP6",
"entity_type": "gene"
},
{
"created": "2021-08-19T12:36:50.175510Z",
"panel_name": "Amelogenesis imperfecta",
"panel_id": 269,
"panel_version": "2.9",
"user_name": "Eleanor Williams",
"item_type": "entity",
"text": "Publications for gene: SP6 were set to 32167558; 18156176; 18297738; 22676574",
"entity_name": "SP6",
"entity_type": "gene"
},
{
"created": "2021-08-19T12:36:34.370447Z",
"panel_name": "Amelogenesis imperfecta",
"panel_id": 269,
"panel_version": "2.8",
"user_name": "Eleanor Williams",
"item_type": "entity",
"text": "Tag Q3_21_rating tag was added to gene: SP6.",
"entity_name": "SP6",
"entity_type": "gene"
},
{
"created": "2021-08-19T12:32:55.514570Z",
"panel_name": "Amelogenesis imperfecta",
"panel_id": 269,
"panel_version": "2.8",
"user_name": "Eleanor Williams",
"item_type": "entity",
"text": "edited their review of gene: SP6: Added comment: Additional case from Korea reported in PMID: 33652941 (Kim et al 2021) has the same nucleotide positions affected as in previous case (c.817_818delinsAT, p.(Ala273Met)) in the SP6 gene. The variant was de novo and the child showed unusual root development, taurodontism, and severe hypoplastic AI.; Changed rating: GREEN",
"entity_name": "SP6",
"entity_type": "gene"
},
{
"created": "2021-08-13T06:08:36.541419Z",
"panel_name": "Amelogenesis imperfecta",
"panel_id": 269,
"panel_version": "2.8",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "reviewed gene: SP6: Rating: GREEN; Mode of pathogenicity: None; Publications: 33652941; Phenotypes: Amelogenesis imperfecta; Mode of inheritance: MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted",
"entity_name": "SP6",
"entity_type": "gene"
},
{
"created": "2021-08-13T01:29:29.507048Z",
"panel_name": "Amelogenesis imperfecta",
"panel_id": 269,
"panel_version": "2.8",
"user_name": "Zornitza Stark",
"item_type": "entity",
"text": "reviewed gene: PEX26: Rating: GREEN; Mode of pathogenicity: None; Publications: 33926089; Phenotypes: Heimler syndrome; Mode of inheritance: BIALLELIC, autosomal or pseudoautosomal",
"entity_name": "PEX26",
"entity_type": "gene"
},
{
"created": "2020-06-18T13:29:46.865184Z",
"panel_name": "Amelogenesis imperfecta",
"panel_id": 269,
"panel_version": "2.8",
"user_name": "Eleanor Williams",
"item_type": "entity",
"text": "changed review comment from: Comment on phenotypes: Adding phenotype of Tricho-Dento-Osseous syndrome , Amelogenesis Imperfecta, hypoplastic to this gene at suggestion of Dr Susan Parekh (Consultant in Pediatric Dentistry, GOSH); to: Comment on phenotypes: Adding phenotype of Tricho-Dento-Osseous syndrome , Amelogenesis Imperfecta, hypoplastic to this gene at suggestion of Dr Susan Parekh (Consultant in Pediatric Dentistry, GOSH)",
"entity_name": "DLX3",
"entity_type": "gene"
},
{
"created": "2020-06-12T16:48:56.477223Z",
"panel_name": "Amelogenesis imperfecta",
"panel_id": 269,
"panel_version": "2.8",
"user_name": "Eleanor Williams",
"item_type": "entity",
"text": "Publications for gene: SP6 were set to 32167558",
"entity_name": "SP6",
"entity_type": "gene"
},
{
"created": "2020-06-12T16:48:29.329939Z",
"panel_name": "Amelogenesis imperfecta",
"panel_id": 269,
"panel_version": "2.7",
"user_name": "Eleanor Williams",
"item_type": "entity",
"text": "Classified gene: SP6 as Amber List (moderate evidence)",
"entity_name": "SP6",
"entity_type": "gene"
},
{
"created": "2020-06-12T16:48:29.321312Z",
"panel_name": "Amelogenesis imperfecta",
"panel_id": 269,
"panel_version": "2.7",
"user_name": "Eleanor Williams",
"item_type": "entity",
"text": "Added comment: Comment on list classification: Changing rating from red to amber. 1 case plus rodent models reported.",
"entity_name": "SP6",
"entity_type": "gene"
},
{
"created": "2020-06-12T16:48:29.301102Z",
"panel_name": "Amelogenesis imperfecta",
"panel_id": 269,
"panel_version": "2.7",
"user_name": "Eleanor Williams",
"item_type": "entity",
"text": "Gene: sp6 has been classified as Amber List (Moderate Evidence).",
"entity_name": "SP6",
"entity_type": "gene"
},
{
"created": "2020-06-12T16:47:55.130388Z",
"panel_name": "Amelogenesis imperfecta",
"panel_id": 269,
"panel_version": "2.6",
"user_name": "Eleanor Williams",
"item_type": "entity",
"text": "gene: SP6 was added\ngene: SP6 was added to Amelogenesis imperfecta. Sources: Literature\nMode of inheritance for gene: SP6 was set to MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown\nPublications for gene: SP6 were set to 32167558\nPhenotypes for gene: SP6 were set to Amelogenesis Imperfecta\nReview for gene: SP6 was set to AMBER\nAdded comment: PMID: 32167558 - Smith et al 2020 - report a 2 bp variant c.817_818GC>AA in SP6 in a Caucasian family with autosomal dominant hypoplastic AI which results in a missense change. Report that mice and rat knockouts also show a dental phenotype (PMID: 18156176, 18297738, 22676574 ) \nSources: Literature",
"entity_name": "SP6",
"entity_type": "gene"
},
{
"created": "2020-05-15T01:43:03.086349Z",
"panel_name": "Amelogenesis imperfecta",
"panel_id": 269,
"panel_version": "2.5",
"user_name": "Eleanor Williams",
"item_type": "entity",
"text": "Phenotypes for gene: AMELX were changed from Amelogenesis imperfecta, type 1E, 301200; Amelogenesis Imperfecta, Type IE, 301200; X-linked hypoplastic amelogenesis imperfecta; hypomaturation AI with variable hypoplastic foci; smooth hypoplastic AI to Amelogenesis imperfecta, type 1E, 301200; iX-linked hypoplastic amelogenesis imperfecta; hypomaturation AI with variable hypoplastic foci; smooth hypoplastic AI",
"entity_name": "AMELX",
"entity_type": "gene"
},
{
"created": "2020-02-13T12:04:12.242565Z",
"panel_name": "Amelogenesis imperfecta",
"panel_id": 269,
"panel_version": "2.4",
"user_name": "Eleanor Williams",
"item_type": "panel",
"text": "Panel version has been signed off",
"entity_name": null,
"entity_type": null
},
{
"created": "2020-02-13T12:03:45.645100Z",
"panel_name": "Amelogenesis imperfecta",
"panel_id": 269,
"panel_version": "2.3",
"user_name": "Eleanor Williams",
"item_type": "panel",
"text": "Panel version has been signed off",
"entity_name": null,
"entity_type": null
},
{
"created": "2020-02-13T12:03:28.801352Z",
"panel_name": "Amelogenesis imperfecta",
"panel_id": 269,
"panel_version": "2.2",
"user_name": "Eleanor Williams",
"item_type": "panel",
"text": "Panel types changed to Rare Disease 100K; GMS Rare Disease Virtual; GMS Rare Disease; GMS signed-off",
"entity_name": null,
"entity_type": null
},
{
"created": "2020-01-13T11:30:14.400621Z",
"panel_name": "Amelogenesis imperfecta",
"panel_id": 269,
"panel_version": "2.0",
"user_name": "Louise Daugherty",
"item_type": "entity",
"text": "Tag watchlist was removed from gene: PEX6.",
"entity_name": "PEX6",
"entity_type": "gene"
},
{
"created": "2020-01-13T11:30:05.126148Z",
"panel_name": "Amelogenesis imperfecta",
"panel_id": 269,
"panel_version": "2.0",
"user_name": "Louise Daugherty",
"item_type": "entity",
"text": "commented on gene: PEX6",
"entity_name": "PEX6",
"entity_type": "gene"
},
{
"created": "2019-09-04T13:55:51.194276Z",
"panel_name": "Amelogenesis imperfecta",
"panel_id": 269,
"panel_version": "2.0",
"user_name": "Eleanor Williams",
"item_type": "panel",
"text": "promoted panel to version 2.0",
"entity_name": null,
"entity_type": null
},
{
"created": "2019-09-04T13:54:17.526531Z",
"panel_name": "Amelogenesis imperfecta",
"panel_id": 269,
"panel_version": "1.17",
"user_name": "Eleanor Williams",
"item_type": "panel",
"text": "Panel types changed to Rare Disease 100K; GMS Rare Disease; GMS signed-off",
"entity_name": null,
"entity_type": null
},
{
"created": "2019-08-14T14:47:57.828236Z",
"panel_name": "Amelogenesis imperfecta",
"panel_id": 269,
"panel_version": "1.16",
"user_name": "Eleanor Williams",
"item_type": "panel",
"text": "List of related panels changed from Amelogenesis Imperfecta to Amelogenesis Imperfecta; R340",
"entity_name": null,
"entity_type": null
},
{
"created": "2019-06-11T10:42:00.904891Z",
"panel_name": "Amelogenesis imperfecta",
"panel_id": 269,
"panel_version": "1.14",
"user_name": "Eleanor Williams",
"item_type": "entity",
"text": "Added comment: Comment on phenotypes: Adding phenotype of Tricho-Dento-Osseous syndrome , Amelogenesis Imperfecta, hypoplastic to this gene at suggestion of Dr Susan Parekh (Consultant in Pediatric Dentistry, GOSH)",
"entity_name": "DLX3",
"entity_type": "gene"
},
{
"created": "2019-06-11T10:42:00.878038Z",
"panel_name": "Amelogenesis imperfecta",
"panel_id": 269,
"panel_version": "1.14",
"user_name": "Eleanor Williams",
"item_type": "entity",
"text": "Phenotypes for gene: DLX3 were changed from Amelogenesis imperfecta, type IV, 104510; Amelogenesis Imperfecta, Type IV, 104510; Amelogenesis Imperfecta, Dominant; amelogenesis imperfecta with taurodontism; Trichodontoosseous syndrome, 190320; Tricho-dento-osseous syndrome (TDO) (includes enamel hypoplasia); hypoplastic AI, taurodontism and kinky hair to Amelogenesis imperfecta, type IV, 104510; Amelogenesis Imperfecta, Type IV, 104510; Amelogenesis Imperfecta, Dominant; amelogenesis imperfecta with taurodontism; Trichodontoosseous syndrome, 190320; Tricho-dento-osseous syndrome (TDO) (includes enamel hypoplasia); hypoplastic AI, taurodontism and kinky hair; Tricho-Dento-Osseous syndrome , Amelogenesis Imperfecta, hypoplastic",
"entity_name": "DLX3",
"entity_type": "gene"
},
{
"created": "2019-06-04T10:02:04.685364Z",
"panel_name": "Amelogenesis imperfecta",
"panel_id": 269,
"panel_version": "1.13",
"user_name": "Eleanor Williams",
"item_type": "entity",
"text": "Phenotypes for gene: RELT were changed from amelogenesis imperfecta (hypoplastic) to amelogenesis imperfecta (hypoplastic); Amelogenesis imperfecta, type IIIC, 618386",
"entity_name": "RELT",
"entity_type": "gene"
},
{
"created": "2019-05-15T13:30:08.983259Z",
"panel_name": "Amelogenesis imperfecta",
"panel_id": 269,
"panel_version": "1.12",
"user_name": "Eleanor Williams",
"item_type": "entity",
"text": "Phenotypes for gene: SLC10A7 were changed from skeletal dysplasia and amelogenesis imperfecta to skeletal dysplasia and amelogenesis imperfecta; Short stature, amelogenesis imperfecta, and skeletal dysplasia with scoliosis (SSASKS) 618363; short stature; amelogenesis imperfect hypo mineralised; skeletal dysplasia; scoliosis",
"entity_name": "SLC10A7",
"entity_type": "gene"
},
{
"created": "2019-05-15T13:29:29.105734Z",
"panel_name": "Amelogenesis imperfecta",
"panel_id": 269,
"panel_version": "1.11",
"user_name": "Eleanor Williams",
"item_type": "entity",
"text": "Publications for gene: SLC10A7 were set to 30082715",
"entity_name": "SLC10A7",
"entity_type": "gene"
},
{
"created": "2019-05-15T13:29:12.061409Z",
"panel_name": "Amelogenesis imperfecta",
"panel_id": 269,
"panel_version": "1.10",
"user_name": "Eleanor Williams",
"item_type": "entity",
"text": "Classified gene: SLC10A7 as Green List (high evidence)",
"entity_name": "SLC10A7",
"entity_type": "gene"
},
{
"created": "2019-05-15T13:29:12.058775Z",
"panel_name": "Amelogenesis imperfecta",
"panel_id": 269,
"panel_version": "1.10",
"user_name": "Eleanor Williams",
"item_type": "entity",
"text": "Added comment: Comment on list classification: Upgrading to green as the are now 5 distinct families with identified variants in SLC10A7 and a relevant phenotype. Evidence also from zebrafish and mouse models.",
"entity_name": "SLC10A7",
"entity_type": "gene"
},
{
"created": "2019-05-15T13:29:12.041005Z",
"panel_name": "Amelogenesis imperfecta",
"panel_id": 269,
"panel_version": "1.10",
"user_name": "Eleanor Williams",
"item_type": "entity",
"text": "Gene: slc10a7 has been classified as Green List (High Evidence).",
"entity_name": "SLC10A7",
"entity_type": "gene"
},
{
"created": "2019-05-15T13:26:58.409320Z",
"panel_name": "Amelogenesis imperfecta",
"panel_id": 269,
"panel_version": "1.9",
"user_name": "Eleanor Williams",
"item_type": "entity",
"text": "commented on gene: SLC10A7",
"entity_name": "SLC10A7",
"entity_type": "gene"
},
{
"created": "2019-05-13T12:38:08.597079Z",
"panel_name": "Amelogenesis imperfecta",
"panel_id": 269,
"panel_version": "1.9",
"user_name": "Claire Smith",
"item_type": "entity",
"text": "reviewed gene: SLC10A7: Rating: GREEN; Mode of pathogenicity: None; Publications: PMID: 29878199, 30082715; Phenotypes: OMIM: 618363 Short stature, amelogenesis imperfecta, and skeletal dysplasia with scoliosis (SSASKS), short stature, amelogenesis imperfect hypo mineralised, skeletal dysplasia, scoliosis; Mode of inheritance: BIALLELIC, autosomal or pseudoautosomal",
"entity_name": "SLC10A7",
"entity_type": "gene"
},
{
"created": "2019-03-21T10:49:56.807370Z",
"panel_name": "Amelogenesis imperfecta",
"panel_id": 269,
"panel_version": "1.9",
"user_name": "Eleanor Williams",
"item_type": "entity",
"text": "Publications for gene: RELT were set to PMID: 30506946",
"entity_name": "RELT",
"entity_type": "gene"
},
{
"created": "2019-03-21T10:49:42.434565Z",
"panel_name": "Amelogenesis imperfecta",
"panel_id": 269,
"panel_version": "1.8",
"user_name": "Eleanor Williams",
"item_type": "entity",
"text": "Classified gene: RELT as Green List (high evidence)",
"entity_name": "RELT",
"entity_type": "gene"
},
{
"created": "2019-03-21T10:49:42.431071Z",
"panel_name": "Amelogenesis imperfecta",
"panel_id": 269,
"panel_version": "1.8",
"user_name": "Eleanor Williams",
"item_type": "entity",
"text": "Added comment: Comment on list classification: 3 cases with 3 different variants. Segregation of the variant with the disease. Mouse knockout shows a related phenotype.",
"entity_name": "RELT",
"entity_type": "gene"
},
{
"created": "2019-03-21T10:49:42.402636Z",
"panel_name": "Amelogenesis imperfecta",
"panel_id": 269,
"panel_version": "1.8",
"user_name": "Eleanor Williams",
"item_type": "entity",
"text": "Gene: relt has been classified as Green List (High Evidence).",
"entity_name": "RELT",
"entity_type": "gene"
},
{
"created": "2019-03-21T10:46:04.396945Z",
"panel_name": "Amelogenesis imperfecta",
"panel_id": 269,
"panel_version": "1.7",
"user_name": "Eleanor Williams",
"item_type": "entity",
"text": "commented on gene: RELT",
"entity_name": "RELT",
"entity_type": "gene"
},
{
"created": "2019-01-11T11:26:25.867982Z",
"panel_name": "Amelogenesis imperfecta",
"panel_id": 269,
"panel_version": "1.7",
"user_name": "Claire Smith",
"item_type": "entity",
"text": "gene: RELT was added\ngene: RELT was added to Amelogenesis imperfecta. Sources: Literature\nMode of inheritance for gene: RELT was set to BIALLELIC, autosomal or pseudoautosomal\nPublications for gene: RELT were set to PMID: 30506946\nPhenotypes for gene: RELT were set to amelogenesis imperfecta (hypoplastic)\nPenetrance for gene: RELT were set to Complete\nReview for gene: RELT was set to GREEN\nAdded comment: PMID: 30506946 present evidence of three consanguineous Turkish families with irregular hypoplastic amelogenesis imperfecta. The authors also present a Relt-/- mouse model with incisor and molar enamel malformations. RELT should be included as a causative gene in diagnostic panels for AR AI in future. \nSources: Literature",
"entity_name": "RELT",
"entity_type": "gene"
},
{
"created": "2018-11-16T14:33:41.790041Z",
"panel_name": "Amelogenesis imperfecta",
"panel_id": 269,
"panel_version": "1.6",
"user_name": "Ellen McDonagh",
"item_type": "panel",
"text": "Panel name changed from Amelogenesis Imperfecta to Amelogenesis imperfecta\nList of related panels changed from to Amelogenesis Imperfecta\nPanel types changed to Rare Disease 100K; GMS Rare Disease",
"entity_name": null,
"entity_type": null
},
{
"created": "2018-10-11T12:52:38.824146Z",
"panel_name": "Amelogenesis Imperfecta",
"panel_id": 269,
"panel_version": "1.5",
"user_name": "Ellen McDonagh",
"item_type": "entity",
"text": "gene: SLC10A7 was added\ngene: SLC10A7 was added to Amelogenesis Imperfecta. Sources: Literature\nMode of inheritance for gene: SLC10A7 was set to BIALLELIC, autosomal or pseudoautosomal\nPublications for gene: SLC10A7 were set to 30082715\nPhenotypes for gene: SLC10A7 were set to skeletal dysplasia and amelogenesis imperfecta\nAdded comment: PMID: 30082715 reports five different SLC10A7 variants in four patients from four unrelated families and two patients from two distantly related families. The study states that the variants segregated according to a recessive mode of inheritance, however the genotype was not shown on the pedigree diagram. Further evidence was provided in a knockout mouse model that displayed abnormal development of skeletal structures and teeth anomalies. This gene is not related to a disease in OMIM or Gene2Phenotype. \nSources: Literature",
"entity_name": "SLC10A7",
"entity_type": "gene"
},
{
"created": "2018-02-02T13:39:44.847388Z",
"panel_name": "Amelogenesis Imperfecta",
"panel_id": 269,
"panel_version": null,
"user_name": "Sarah Leigh",
"item_type": "panel",
"text": "promoted panel to version 1.0",
"entity_name": null,
"entity_type": null
},
{
"created": "2018-02-02T13:37:30.838302Z",
"panel_name": "Amelogenesis Imperfecta",
"panel_id": 269,
"panel_version": null,
"user_name": "Sarah Leigh",
"item_type": "entity",
"text": "classified CLDN16 as Amber List (moderate evidence)",
"entity_name": "CLDN16",
"entity_type": "gene"
},
{
"created": "2018-02-02T13:37:18.496123Z",
"panel_name": "Amelogenesis Imperfecta",
"panel_id": 269,
"panel_version": null,
"user_name": "Sarah Leigh",
"item_type": "entity",
"text": "marked CLDN16 as ready",
"entity_name": "CLDN16",
"entity_type": "gene"
},
{
"created": "2018-02-02T13:12:02.736378Z",
"panel_name": "Amelogenesis Imperfecta",
"panel_id": 269,
"panel_version": null,
"user_name": "Sarah Leigh",
"item_type": "entity",
"text": "marked CLDN19 as ready",
"entity_name": "CLDN19",
"entity_type": "gene"
},
{
"created": "2018-02-02T13:11:57.603919Z",
"panel_name": "Amelogenesis Imperfecta",
"panel_id": 269,
"panel_version": null,
"user_name": "Sarah Leigh",
"item_type": "entity",
"text": "classified CLDN19 as Amber List (moderate evidence)",
"entity_name": "CLDN19",
"entity_type": "gene"
},
{
"created": "2018-01-08T12:52:18.491752Z",
"panel_name": "Amelogenesis Imperfecta",
"panel_id": 269,
"panel_version": null,
"user_name": "Sarah Leigh",
"item_type": "entity",
"text": "marked LTBP3 as ready",
"entity_name": "LTBP3",
"entity_type": "gene"
},
{
"created": "2018-01-08T12:33:37.529066Z",
"panel_name": "Amelogenesis Imperfecta",
"panel_id": 269,
"panel_version": null,
"user_name": "Sarah Leigh",
"item_type": "entity",
"text": "marked SLC13A5 as ready",
"entity_name": "SLC13A5",
"entity_type": "gene"
},
{
"created": "2018-01-08T12:29:43.517022Z",
"panel_name": "Amelogenesis Imperfecta",
"panel_id": 269,
"panel_version": null,
"user_name": "Sarah Leigh",
"item_type": "entity",
"text": "classified SLC13A5 as Green List (high evidence)",
"entity_name": "SLC13A5",
"entity_type": "gene"
},
{
"created": "2018-01-08T12:03:38.841640Z",
"panel_name": "Amelogenesis Imperfecta",
"panel_id": 269,
"panel_version": null,
"user_name": "Sarah Leigh",
"item_type": "entity",
"text": "reviewed TUFT1",
"entity_name": "TUFT1",
"entity_type": "gene"
},
{
"created": "2018-01-08T11:47:07.200833Z",
"panel_name": "Amelogenesis Imperfecta",
"panel_id": 269,
"panel_version": null,
"user_name": "Sarah Leigh",
"item_type": "entity",
"text": "marked ROGDI as ready",
"entity_name": "ROGDI",
"entity_type": "gene"
},
{
"created": "2018-01-08T11:43:58.926345Z",
"panel_name": "Amelogenesis Imperfecta",
"panel_id": 269,
"panel_version": null,
"user_name": "Sarah Leigh",
"item_type": "entity",
"text": "classified ROGDI as Green List (high evidence)",
"entity_name": "ROGDI",
"entity_type": "gene"
},
{
"created": "2018-01-04T14:54:40.111717Z",
"panel_name": "Amelogenesis Imperfecta",
"panel_id": 269,
"panel_version": null,
"user_name": "Sarah Leigh",
"item_type": "entity",
"text": "marked ORAI1 as ready",
"entity_name": "ORAI1",
"entity_type": "gene"
},
{
"created": "2018-01-04T14:33:31.208574Z",
"panel_name": "Amelogenesis Imperfecta",
"panel_id": 269,
"panel_version": null,
"user_name": "Sarah Leigh",
"item_type": "entity",
"text": "classified ORAI1 as Green List (high evidence)",
"entity_name": "ORAI1",
"entity_type": "gene"
},
{
"created": "2018-01-04T13:08:53.664462Z",
"panel_name": "Amelogenesis Imperfecta",
"panel_id": 269,
"panel_version": null,
"user_name": "Sarah Leigh",
"item_type": "entity",
"text": "marked STIM1 as ready",
"entity_name": "STIM1",
"entity_type": "gene"
},
{
"created": "2017-12-05T15:04:11.459234Z",
"panel_name": "Amelogenesis Imperfecta",
"panel_id": 269,
"panel_version": null,
"user_name": "Ellen McDonagh",
"item_type": "entity",
"text": "marked PEX26 as ready",
"entity_name": "PEX26",
"entity_type": "gene"
},
{
"created": "2017-12-05T15:02:26.942874Z",
"panel_name": "Amelogenesis Imperfecta",
"panel_id": 269,
"panel_version": null,
"user_name": "Ellen McDonagh",
"item_type": "entity",
"text": "marked STIM1 as ready",
"entity_name": "STIM1",
"entity_type": "gene"
},
{
"created": "2017-11-17T13:15:05.284062Z",
"panel_name": "Amelogenesis Imperfecta",
"panel_id": 269,
"panel_version": null,
"user_name": "Claire Smith",
"item_type": "entity",
"text": "reviewed SLC13A5",
"entity_name": "SLC13A5",
"entity_type": "gene"
},
{
"created": "2017-11-17T12:57:46.395949Z",
"panel_name": "Amelogenesis Imperfecta",
"panel_id": 269,
"panel_version": null,
"user_name": "Claire Smith",
"item_type": "entity",
"text": "reviewed STIM1",
"entity_name": "STIM1",
"entity_type": "gene"
},
{
"created": "2017-11-17T10:37:51.245644Z",
"panel_name": "Amelogenesis Imperfecta",
"panel_id": 269,
"panel_version": null,
"user_name": "Claire Smith",
"item_type": "entity",
"text": "reviewed ROGDI",
"entity_name": "ROGDI",
"entity_type": "gene"
},
{
"created": "2017-11-17T09:40:56.590013Z",
"panel_name": "Amelogenesis Imperfecta",
"panel_id": 269,
"panel_version": null,
"user_name": "Claire Smith",
"item_type": "entity",
"text": "reviewed COL17A1",
"entity_name": "COL17A1",
"entity_type": "gene"
},
{
"created": "2017-11-16T15:54:27.529812Z",
"panel_name": "Amelogenesis Imperfecta",
"panel_id": 269,
"panel_version": null,
"user_name": "Claire Smith",
"item_type": "entity",
"text": "reviewed ORAI1",
"entity_name": "ORAI1",
"entity_type": "gene"
},
{
"created": "2017-10-31T14:31:41.342000Z",
"panel_name": "Amelogenesis Imperfecta",
"panel_id": 269,
"panel_version": null,
"user_name": "Rebecca Foulger",
"item_type": "entity",
"text": "marked LAMB3 as ready",
"entity_name": "LAMB3",
"entity_type": "gene"
},
{
"created": "2017-10-31T14:27:20.924000Z",
"panel_name": "Amelogenesis Imperfecta",
"panel_id": 269,
"panel_version": null,
"user_name": "Rebecca Foulger",
"item_type": "entity",
"text": "marked LAMA3 as ready",
"entity_name": "LAMA3",
"entity_type": "gene"
},
{
"created": "2017-10-31T14:21:51.623000Z",
"panel_name": "Amelogenesis Imperfecta",
"panel_id": 269,
"panel_version": null,
"user_name": "Rebecca Foulger",
"item_type": "entity",
"text": "marked COL17A1 as ready",
"entity_name": "COL17A1",
"entity_type": "gene"
},
{
"created": "2017-10-24T08:21:21.285000Z",
"panel_name": "Amelogenesis Imperfecta",
"panel_id": 269,
"panel_version": null,
"user_name": "Rebecca Foulger",
"item_type": "entity",
"text": "classified AMTN as amber",
"entity_name": "AMTN",
"entity_type": "gene"
},
{
"created": "2017-10-23T12:32:09.901000Z",
"panel_name": "Amelogenesis Imperfecta",
"panel_id": 269,
"panel_version": null,
"user_name": "Rebecca Foulger",
"item_type": "entity",
"text": "classified PEX26 as amber",
"entity_name": "PEX26",
"entity_type": "gene"
},
{
"created": "2017-10-23T12:24:58.576000Z",
"panel_name": "Amelogenesis Imperfecta",
"panel_id": 269,
"panel_version": null,
"user_name": "Rebecca Foulger",
"item_type": "entity",
"text": "edited their review of PEX26",
"entity_name": "PEX26",
"entity_type": "gene"
},
{
"created": "2017-10-23T11:55:13.434000Z",
"panel_name": "Amelogenesis Imperfecta",
"panel_id": 269,
"panel_version": null,
"user_name": "Rebecca Foulger",
"item_type": "entity",
"text": "commented on PEX26",
"entity_name": "PEX26",
"entity_type": "gene"
},
{
"created": "2017-10-23T11:49:58.568000Z",
"panel_name": "Amelogenesis Imperfecta",
"panel_id": 269,
"panel_version": null,
"user_name": "Rebecca Foulger",
"item_type": "entity",
"text": "marked PEX1 as ready",
"entity_name": "PEX1",
"entity_type": "gene"
},
{
"created": "2017-10-23T11:02:32.349000Z",
"panel_name": "Amelogenesis Imperfecta",
"panel_id": 269,
"panel_version": null,
"user_name": "Rebecca Foulger",
"item_type": "entity",
"text": "marked PEX6 as ready",
"entity_name": "PEX6",
"entity_type": "gene"
},
{
"created": "2017-10-23T11:02:11.565000Z",
"panel_name": "Amelogenesis Imperfecta",
"panel_id": 269,
"panel_version": null,
"user_name": "Rebecca Foulger",
"item_type": "entity",
"text": "classified PEX6 as green",
"entity_name": "PEX6",
"entity_type": "gene"
},
{
"created": "2017-10-23T10:50:35.030000Z",
"panel_name": "Amelogenesis Imperfecta",
"panel_id": 269,
"panel_version": null,
"user_name": "Rebecca Foulger",
"item_type": "entity",
"text": "classified STIM1 as green",
"entity_name": "STIM1",
"entity_type": "gene"
},
{
"created": "2017-10-23T10:48:05.497000Z",
"panel_name": "Amelogenesis Imperfecta",
"panel_id": 269,
"panel_version": null,
"user_name": "Rebecca Foulger",
"item_type": "entity",
"text": "commented on STIM1",
"entity_name": "STIM1",
"entity_type": "gene"
},
{
"created": "2017-10-23T07:59:47.056000Z",
"panel_name": "Amelogenesis Imperfecta",
"panel_id": 269,
"panel_version": null,
"user_name": "Rebecca Foulger",
"item_type": "entity",
"text": "edited their review of STIM1",
"entity_name": "STIM1",
"entity_type": "gene"
},
{
"created": "2017-10-23T07:53:58.771000Z",
"panel_name": "Amelogenesis Imperfecta",
"panel_id": 269,
"panel_version": null,
"user_name": "Rebecca Foulger",
"item_type": "entity",
"text": "commented on STIM1",
"entity_name": "STIM1",
"entity_type": "gene"
},
{
"created": "2017-10-20T14:09:21.212000Z",
"panel_name": "Amelogenesis Imperfecta",
"panel_id": 269,
"panel_version": null,
"user_name": "Claire Smith",
"item_type": "entity",
"text": "added PEX26 to panel",
"entity_name": "PEX26",
"entity_type": "gene"
},
{
"created": "2017-10-20T14:09:20.679000Z",
"panel_name": "Amelogenesis Imperfecta",
"panel_id": 269,
"panel_version": null,
"user_name": "Claire Smith",
"item_type": "entity",
"text": "reviewed PEX26",
"entity_name": "PEX26",
"entity_type": "gene"
},
{
"created": "2017-10-20T14:02:10.829000Z",
"panel_name": "Amelogenesis Imperfecta",
"panel_id": 269,
"panel_version": null,
"user_name": "Claire Smith",
"item_type": "entity",
"text": "reviewed PEX1",
"entity_name": "PEX1",
"entity_type": "gene"
},
{
"created": "2017-10-20T13:55:25.575000Z",
"panel_name": "Amelogenesis Imperfecta",
"panel_id": 269,
"panel_version": null,
"user_name": "Claire Smith",
"item_type": "entity",
"text": "reviewed PEX6",
"entity_name": "PEX6",
"entity_type": "gene"
},
{
"created": "2017-10-19T16:01:32.248000Z",
"panel_name": "Amelogenesis Imperfecta",
"panel_id": 269,
"panel_version": null,
"user_name": "Rebecca Foulger",
"item_type": "entity",
"text": "classified PEX6 as amber",
"entity_name": "PEX6",
"entity_type": "gene"
},
{
"created": "2017-10-19T15:35:57.334000Z",
"panel_name": "Amelogenesis Imperfecta",
"panel_id": 269,
"panel_version": null,
"user_name": "Rebecca Foulger",
"item_type": "entity",
"text": "commented on PEX6",
"entity_name": "PEX6",
"entity_type": "gene"
},
{
"created": "2017-10-19T14:55:35.409000Z",
"panel_name": "Amelogenesis Imperfecta",
"panel_id": 269,
"panel_version": null,
"user_name": "Rebecca Foulger",
"item_type": "entity",
"text": "classified PEX1 as green",
"entity_name": "PEX1",
"entity_type": "gene"
},
{
"created": "2017-10-19T14:44:29.392000Z",
"panel_name": "Amelogenesis Imperfecta",
"panel_id": 269,
"panel_version": null,
"user_name": "Rebecca Foulger",
"item_type": "entity",
"text": "commented on PEX1",
"entity_name": "PEX1",
"entity_type": "gene"
},
{
"created": "2017-10-19T14:44:13.153000Z",
"panel_name": "Amelogenesis Imperfecta",
"panel_id": 269,
"panel_version": null,
"user_name": "Rebecca Foulger",
"item_type": "entity",
"text": "commented on PEX1",
"entity_name": "PEX1",
"entity_type": "gene"
},
{
"created": "2017-10-19T14:43:25.930000Z",
"panel_name": "Amelogenesis Imperfecta",
"panel_id": 269,
"panel_version": null,
"user_name": "Rebecca Foulger",
"item_type": "entity",
"text": "commented on PEX1",
"entity_name": "PEX1",
"entity_type": "gene"
},
{
"created": "2017-10-19T13:06:32.968000Z",
"panel_name": "Amelogenesis Imperfecta",
"panel_id": 269,
"panel_version": null,
"user_name": "Rebecca Foulger",
"item_type": "entity",
"text": "classified ITGB4 as amber",
"entity_name": "ITGB4",
"entity_type": "gene"
},
{
"created": "2017-10-19T12:59:54.920000Z",
"panel_name": "Amelogenesis Imperfecta",
"panel_id": 269,
"panel_version": null,
"user_name": "Rebecca Foulger",
"item_type": "entity",
"text": "commented on ITGB4",
"entity_name": "ITGB4",
"entity_type": "gene"
},
{
"created": "2017-10-19T12:49:07.111000Z",
"panel_name": "Amelogenesis Imperfecta",
"panel_id": 269,
"panel_version": null,
"user_name": "Rebecca Foulger",
"item_type": "entity",
"text": "edited their review of ITGB4",
"entity_name": "ITGB4",
"entity_type": "gene"
},
{
"created": "2017-10-19T11:11:38.402000Z",
"panel_name": "Amelogenesis Imperfecta",
"panel_id": 269,
"panel_version": null,
"user_name": "Rebecca Foulger",
"item_type": "entity",
"text": "classified LTBP3 as green",
"entity_name": "LTBP3",
"entity_type": "gene"
},
{
"created": "2017-10-19T11:06:03.156000Z",
"panel_name": "Amelogenesis Imperfecta",
"panel_id": 269,
"panel_version": null,
"user_name": "Rebecca Foulger",
"item_type": "entity",
"text": "commented on LTBP3",
"entity_name": "LTBP3",
"entity_type": "gene"
},
{
"created": "2017-10-19T09:18:46.188000Z",
"panel_name": "Amelogenesis Imperfecta",
"panel_id": 269,
"panel_version": null,
"user_name": "Rebecca Foulger",
"item_type": "entity",
"text": "marked SLC24A4 as ready",
"entity_name": "SLC24A4",
"entity_type": "gene"
},
{
"created": "2017-10-19T09:17:59.116000Z",
"panel_name": "Amelogenesis Imperfecta",
"panel_id": 269,
"panel_version": null,
"user_name": "Rebecca Foulger",
"item_type": "entity",
"text": "classified SLC24A4 as green",
"entity_name": "SLC24A4",
"entity_type": "gene"
},
{
"created": "2017-10-19T09:07:23.833000Z",
"panel_name": "Amelogenesis Imperfecta",
"panel_id": 269,
"panel_version": null,
"user_name": "Rebecca Foulger",
"item_type": "entity",
"text": "commented on SLC24A4",
"entity_name": "SLC24A4",
"entity_type": "gene"
},
{
"created": "2017-10-19T09:07:10.983000Z",
"panel_name": "Amelogenesis Imperfecta",
"panel_id": 269,
"panel_version": null,
"user_name": "Rebecca Foulger",
"item_type": "entity",
"text": "edited their review of SLC24A4",
"entity_name": "SLC24A4",
"entity_type": "gene"
},
{
"created": "2017-10-19T09:01:48.664000Z",
"panel_name": "Amelogenesis Imperfecta",
"panel_id": 269,
"panel_version": null,
"user_name": "Rebecca Foulger",
"item_type": "entity",
"text": "commented on SLC24A4",
"entity_name": "SLC24A4",
"entity_type": "gene"
},
{
"created": "2017-10-19T08:59:04.176000Z",
"panel_name": "Amelogenesis Imperfecta",
"panel_id": 269,
"panel_version": null,
"user_name": "Rebecca Foulger",
"item_type": "entity",
"text": "classified COL17A1 as green",
"entity_name": "COL17A1",
"entity_type": "gene"
},
{
"created": "2017-10-19T08:57:00.733000Z",
"panel_name": "Amelogenesis Imperfecta",
"panel_id": 269,
"panel_version": null,
"user_name": "Rebecca Foulger",
"item_type": "entity",
"text": "commented on COL17A1",
"entity_name": "COL17A1",
"entity_type": "gene"
},
{
"created": "2017-10-19T08:44:31.271000Z",
"panel_name": "Amelogenesis Imperfecta",
"panel_id": 269,
"panel_version": null,
"user_name": "Rebecca Foulger",
"item_type": "entity",
"text": "commented on COL17A1",
"entity_name": "COL17A1",
"entity_type": "gene"
},
{
"created": "2017-10-19T08:29:50.603000Z",
"panel_name": "Amelogenesis Imperfecta",
"panel_id": 269,
"panel_version": null,
"user_name": "Rebecca Foulger",
"item_type": "entity",
"text": "commented on COL17A1",
"entity_name": "COL17A1",
"entity_type": "gene"
},
{
"created": "2017-10-19T07:51:07.863000Z",
"panel_name": "Amelogenesis Imperfecta",
"panel_id": 269,
"panel_version": null,
"user_name": "Rebecca Foulger",
"item_type": "entity",
"text": "classified LAMC2 as amber",
"entity_name": "LAMC2",
"entity_type": "gene"
},
{
"created": "2017-10-18T11:59:07.494000Z",
"panel_name": "Amelogenesis Imperfecta",
"panel_id": 269,
"panel_version": null,
"user_name": "Rebecca Foulger",
"item_type": "entity",
"text": "marked FAM20C as ready",
"entity_name": "FAM20C",
"entity_type": "gene"
},
{
"created": "2017-10-18T11:58:55.167000Z",
"panel_name": "Amelogenesis Imperfecta",
"panel_id": 269,
"panel_version": null,
"user_name": "Rebecca Foulger",
"item_type": "entity",
"text": "classified FAM20C as green",
"entity_name": "FAM20C",
"entity_type": "gene"
},
{
"created": "2017-10-18T11:58:50.912000Z",
"panel_name": "Amelogenesis Imperfecta",
"panel_id": 269,
"panel_version": null,
"user_name": "Rebecca Foulger",
"item_type": "entity",
"text": "classified FAM20C as red",
"entity_name": "FAM20C",
"entity_type": "gene"
},
{
"created": "2017-10-18T11:55:29.967000Z",
"panel_name": "Amelogenesis Imperfecta",
"panel_id": 269,
"panel_version": null,
"user_name": "Rebecca Foulger",
"item_type": "entity",
"text": "commented on FAM20C",
"entity_name": "FAM20C",
"entity_type": "gene"
},
{
"created": "2017-10-18T11:44:27.692000Z",
"panel_name": "Amelogenesis Imperfecta",
"panel_id": 269,
"panel_version": null,
"user_name": "Rebecca Foulger",
"item_type": "entity",
"text": "marked LAMB3 as ready",
"entity_name": "LAMB3",
"entity_type": "gene"
},
{
"created": "2017-10-18T11:42:45.120000Z",
"panel_name": "Amelogenesis Imperfecta",
"panel_id": 269,
"panel_version": null,
"user_name": "Rebecca Foulger",
"item_type": "entity",
"text": "marked GPR68 as ready",
"entity_name": "GPR68",
"entity_type": "gene"
},
{
"created": "2017-10-18T11:41:23.354000Z",
"panel_name": "Amelogenesis Imperfecta",
"panel_id": 269,
"panel_version": null,
"user_name": "Rebecca Foulger",
"item_type": "entity",
"text": "marked ACPT as ready",
"entity_name": "ACPT",
"entity_type": "gene"
},
{
"created": "2017-10-18T11:39:24.696000Z",
"panel_name": "Amelogenesis Imperfecta",
"panel_id": 269,
"panel_version": null,
"user_name": "Rebecca Foulger",
"item_type": "entity",
"text": "marked FAM83H as ready",
"entity_name": "FAM83H",
"entity_type": "gene"
},
{
"created": "2017-10-18T11:38:11.420000Z",
"panel_name": "Amelogenesis Imperfecta",
"panel_id": 269,
"panel_version": null,
"user_name": "Rebecca Foulger",
"item_type": "entity",
"text": "marked LAMC2 as ready",
"entity_name": "LAMC2",
"entity_type": "gene"
},
{
"created": "2017-10-18T11:35:56.423000Z",
"panel_name": "Amelogenesis Imperfecta",
"panel_id": 269,
"panel_version": null,
"user_name": "Rebecca Foulger",
"item_type": "entity",
"text": "classified LAMC2 as red",
"entity_name": "LAMC2",
"entity_type": "gene"
},
{
"created": "2017-10-16T20:52:01.407000Z",
"panel_name": "Amelogenesis Imperfecta",
"panel_id": 269,
"panel_version": null,
"user_name": "emma baple",
"item_type": "entity",
"text": "marked CNNM4 as ready",
"entity_name": "CNNM4",
"entity_type": "gene"
},
{
"created": "2017-10-16T20:51:44.598000Z",
"panel_name": "Amelogenesis Imperfecta",
"panel_id": 269,
"panel_version": null,
"user_name": "emma baple",
"item_type": "entity",
"text": "classified CNNM4 as green",
"entity_name": "CNNM4",
"entity_type": "gene"
},
{
"created": "2017-10-16T20:51:01.327000Z",
"panel_name": "Amelogenesis Imperfecta",
"panel_id": 269,
"panel_version": null,
"user_name": "emma baple",
"item_type": "entity",
"text": "reviewed CNNM4",
"entity_name": "CNNM4",
"entity_type": "gene"
},
{
"created": "2017-09-19T06:53:47.308000Z",
"panel_name": "Amelogenesis Imperfecta",
"panel_id": 269,
"panel_version": null,
"user_name": "Rebecca Foulger",
"item_type": "entity",
"text": "marked LAMA3 as ready",
"entity_name": "LAMA3",
"entity_type": "gene"
},
{
"created": "2017-09-19T06:52:42.512000Z",
"panel_name": "Amelogenesis Imperfecta",
"panel_id": 269,
"panel_version": null,
"user_name": "Rebecca Foulger",
"item_type": "entity",
"text": "classified LAMA3 as green",
"entity_name": "LAMA3",
"entity_type": "gene"
},
{
"created": "2017-09-18T15:56:11.759000Z",
"panel_name": "Amelogenesis Imperfecta",
"panel_id": 269,
"panel_version": null,
"user_name": "Claire Smith",
"item_type": "entity",
"text": "reviewed FAM20C",
"entity_name": "FAM20C",
"entity_type": "gene"
},
{
"created": "2017-09-18T15:36:13.763000Z",
"panel_name": "Amelogenesis Imperfecta",
"panel_id": 269,
"panel_version": null,
"user_name": "Claire Smith",
"item_type": "entity",
"text": "reviewed LAMC2",
"entity_name": "LAMC2",
"entity_type": "gene"
},
{
"created": "2017-09-18T15:20:27.051000Z",
"panel_name": "Amelogenesis Imperfecta",
"panel_id": 269,
"panel_version": null,
"user_name": "Claire Smith",
"item_type": "entity",
"text": "reviewed CNNM4",
"entity_name": "CNNM4",
"entity_type": "gene"
},
{
"created": "2017-09-04T12:58:21.569000Z",
"panel_name": "Amelogenesis Imperfecta",
"panel_id": 269,
"panel_version": null,
"user_name": "Louise Daugherty",
"item_type": "entity",
"text": "commented on C4orf26",
"entity_name": "C4orf26",
"entity_type": "gene"
},
{
"created": "2017-09-04T12:13:36.141000Z",
"panel_name": "Amelogenesis Imperfecta",
"panel_id": 269,
"panel_version": null,
"user_name": "Rebecca Foulger",
"item_type": "entity",
"text": "marked AMBN as ready",
"entity_name": "AMBN",
"entity_type": "gene"
},
{
"created": "2017-09-04T12:13:09.920000Z",
"panel_name": "Amelogenesis Imperfecta",
"panel_id": 269,
"panel_version": null,
"user_name": "Rebecca Foulger",
"item_type": "entity",
"text": "edited their review of AMBN",
"entity_name": "AMBN",
"entity_type": "gene"
},
{
"created": "2017-09-04T12:12:11.706000Z",
"panel_name": "Amelogenesis Imperfecta",
"panel_id": 269,
"panel_version": null,
"user_name": "Rebecca Foulger",
"item_type": "entity",
"text": "classified AMBN as green",
"entity_name": "AMBN",
"entity_type": "gene"
},
{
"created": "2017-08-28T09:35:06.086000Z",
"panel_name": "Amelogenesis Imperfecta",
"panel_id": 269,
"panel_version": null,
"user_name": "Rebecca Foulger",
"item_type": "entity",
"text": "edited their review of GPR68",
"entity_name": "GPR68",
"entity_type": "gene"
},
{
"created": "2017-08-28T09:34:12.589000Z",
"panel_name": "Amelogenesis Imperfecta",
"panel_id": 269,
"panel_version": null,
"user_name": "Rebecca Foulger",
"item_type": "entity",
"text": "classified GPR68 as green",
"entity_name": "GPR68",
"entity_type": "gene"
},
{
"created": "2017-08-28T09:34:12.588000Z",
"panel_name": "Amelogenesis Imperfecta",
"panel_id": 269,
"panel_version": null,
"user_name": "Rebecca Foulger",
"item_type": "entity",
"text": "commented on GPR68",
"entity_name": "GPR68",
"entity_type": "gene"
},
{
"created": "2017-08-16T15:41:26Z",
"panel_name": "Amelogenesis Imperfecta",
"panel_id": 269,
"panel_version": null,
"user_name": "Rebecca Foulger",
"item_type": "entity",
"text": "commented on LAMA3",
"entity_name": "LAMA3",
"entity_type": "gene"
},
{
"created": "2017-08-16T15:36:00.308000Z",
"panel_name": "Amelogenesis Imperfecta",
"panel_id": 269,
"panel_version": null,
"user_name": "Rebecca Foulger",
"item_type": "entity",
"text": "commented on LAMA3",
"entity_name": "LAMA3",
"entity_type": "gene"
},
{
"created": "2017-08-16T15:34:55.693000Z",
"panel_name": "Amelogenesis Imperfecta",
"panel_id": 269,
"panel_version": null,
"user_name": "Rebecca Foulger",
"item_type": "entity",
"text": "commented on LAMA3",
"entity_name": "LAMA3",
"entity_type": "gene"
},
{
"created": "2017-08-16T15:16:30.951000Z",
"panel_name": "Amelogenesis Imperfecta",
"panel_id": 269,
"panel_version": null,
"user_name": "Rebecca Foulger",
"item_type": "entity",
"text": "commented on LAMA3",
"entity_name": "LAMA3",
"entity_type": "gene"
},
{
"created": "2017-08-16T14:36:08.461000Z",
"panel_name": "Amelogenesis Imperfecta",
"panel_id": 269,
"panel_version": null,
"user_name": "Rebecca Foulger",
"item_type": "entity",
"text": "marked ITGB6 as ready",
"entity_name": "ITGB6",
"entity_type": "gene"
},
{
"created": "2017-08-16T14:35:56.812000Z",
"panel_name": "Amelogenesis Imperfecta",
"panel_id": 269,
"panel_version": null,
"user_name": "Rebecca Foulger",
"item_type": "entity",
"text": "classified ITGB6 as green",
"entity_name": "ITGB6",
"entity_type": "gene"
},
{
"created": "2017-08-16T14:22:30.973000Z",
"panel_name": "Amelogenesis Imperfecta",
"panel_id": 269,
"panel_version": null,
"user_name": "Rebecca Foulger",
"item_type": "entity",
"text": "marked AMTN as ready",
"entity_name": "AMTN",
"entity_type": "gene"
},
{
"created": "2017-08-16T14:22:19.841000Z",
"panel_name": "Amelogenesis Imperfecta",
"panel_id": 269,
"panel_version": null,
"user_name": "Rebecca Foulger",
"item_type": "entity",
"text": "classified AMTN as red",
"entity_name": "AMTN",
"entity_type": "gene"
},
{
"created": "2017-08-16T14:13:49.301000Z",
"panel_name": "Amelogenesis Imperfecta",
"panel_id": 269,
"panel_version": null,
"user_name": "Rebecca Foulger",
"item_type": "entity",
"text": "classified AMBN as amber",
"entity_name": "AMBN",
"entity_type": "gene"
},
{
"created": "2017-08-16T14:13:49.299000Z",
"panel_name": "Amelogenesis Imperfecta",
"panel_id": 269,
"panel_version": null,
"user_name": "Rebecca Foulger",
"item_type": "entity",
"text": "commented on AMBN",
"entity_name": "AMBN",
"entity_type": "gene"
},
{
"created": "2017-08-16T14:07:41.847000Z",
"panel_name": "Amelogenesis Imperfecta",
"panel_id": 269,
"panel_version": null,
"user_name": "Rebecca Foulger",
"item_type": "entity",
"text": "classified ACPT as green",
"entity_name": "ACPT",
"entity_type": "gene"
},
{
"created": "2017-08-16T14:04:14.736000Z",
"panel_name": "Amelogenesis Imperfecta",
"panel_id": 269,
"panel_version": null,
"user_name": "Rebecca Foulger",
"item_type": "entity",
"text": "commented on ACPT",
"entity_name": "ACPT",
"entity_type": "gene"
},
{
"created": "2017-08-16T14:01:04.333000Z",
"panel_name": "Amelogenesis Imperfecta",
"panel_id": 269,
"panel_version": null,
"user_name": "Rebecca Foulger",
"item_type": "entity",
"text": "commented on ACPT",
"entity_name": "ACPT",
"entity_type": "gene"
},
{
"created": "2017-08-16T13:57:23.401000Z",
"panel_name": "Amelogenesis Imperfecta",
"panel_id": 269,
"panel_version": null,
"user_name": "Rebecca Foulger",
"item_type": "entity",
"text": "commented on ACPT",
"entity_name": "ACPT",
"entity_type": "gene"
},
{
"created": "2017-08-16T13:35:20.436000Z",
"panel_name": "Amelogenesis Imperfecta",
"panel_id": 269,
"panel_version": null,
"user_name": "Rebecca Foulger",
"item_type": "entity",
"text": "classified LAMB3 as green",
"entity_name": "LAMB3",
"entity_type": "gene"
},
{
"created": "2017-08-16T09:39:22.350000Z",
"panel_name": "Amelogenesis Imperfecta",
"panel_id": 269,
"panel_version": null,
"user_name": "Rebecca Foulger",
"item_type": "entity",
"text": "commented on LAMB3",
"entity_name": "LAMB3",
"entity_type": "gene"
},
{
"created": "2017-08-16T09:33:01.025000Z",
"panel_name": "Amelogenesis Imperfecta",
"panel_id": 269,
"panel_version": null,
"user_name": "Rebecca Foulger",
"item_type": "entity",
"text": "marked KLK4 as ready",
"entity_name": "KLK4",
"entity_type": "gene"
},
{
"created": "2017-08-16T09:32:51.030000Z",
"panel_name": "Amelogenesis Imperfecta",
"panel_id": 269,
"panel_version": null,
"user_name": "Rebecca Foulger",
"item_type": "entity",
"text": "classified KLK4 as green",
"entity_name": "KLK4",
"entity_type": "gene"
},
{
"created": "2017-08-16T09:23:22.690000Z",
"panel_name": "Amelogenesis Imperfecta",
"panel_id": 269,
"panel_version": null,
"user_name": "Rebecca Foulger",
"item_type": "entity",
"text": "commented on KLK4",
"entity_name": "KLK4",
"entity_type": "gene"
},
{
"created": "2017-08-16T09:19:23.179000Z",
"panel_name": "Amelogenesis Imperfecta",
"panel_id": 269,
"panel_version": null,
"user_name": "Rebecca Foulger",
"item_type": "entity",
"text": "marked FAM83H as ready",
"entity_name": "FAM83H",
"entity_type": "gene"
},
{
"created": "2017-08-16T09:16:23.982000Z",
"panel_name": "Amelogenesis Imperfecta",
"panel_id": 269,
"panel_version": null,
"user_name": "Rebecca Foulger",
"item_type": "entity",
"text": "classified FAM83H as green",
"entity_name": "FAM83H",
"entity_type": "gene"
},
{
"created": "2017-08-16T08:49:21.501000Z",
"panel_name": "Amelogenesis Imperfecta",
"panel_id": 269,
"panel_version": null,
"user_name": "Rebecca Foulger",
"item_type": "entity",
"text": "commented on FAM83H",
"entity_name": "FAM83H",
"entity_type": "gene"
},
{
"created": "2017-08-16T08:47:44.218000Z",
"panel_name": "Amelogenesis Imperfecta",
"panel_id": 269,
"panel_version": null,
"user_name": "Rebecca Foulger",
"item_type": "entity",
"text": "marked FAM20A as ready",
"entity_name": "FAM20A",
"entity_type": "gene"
},
{
"created": "2017-08-16T08:47:32.108000Z",
"panel_name": "Amelogenesis Imperfecta",
"panel_id": 269,
"panel_version": null,
"user_name": "Rebecca Foulger",
"item_type": "entity",
"text": "classified FAM20A as green",
"entity_name": "FAM20A",
"entity_type": "gene"
},
{
"created": "2017-08-16T08:43:08.141000Z",
"panel_name": "Amelogenesis Imperfecta",
"panel_id": 269,
"panel_version": null,
"user_name": "Rebecca Foulger",
"item_type": "entity",
"text": "marked WDR72 as ready",
"entity_name": "WDR72",
"entity_type": "gene"
},
{
"created": "2017-08-16T08:42:56.358000Z",
"panel_name": "Amelogenesis Imperfecta",
"panel_id": 269,
"panel_version": null,
"user_name": "Rebecca Foulger",
"item_type": "entity",
"text": "classified WDR72 as green",
"entity_name": "WDR72",
"entity_type": "gene"
},
{
"created": "2017-08-16T08:42:56.357000Z",
"panel_name": "Amelogenesis Imperfecta",
"panel_id": 269,
"panel_version": null,
"user_name": "Rebecca Foulger",
"item_type": "entity",
"text": "commented on WDR72",
"entity_name": "WDR72",
"entity_type": "gene"
},
{
"created": "2017-08-16T08:38:04.367000Z",
"panel_name": "Amelogenesis Imperfecta",
"panel_id": 269,
"panel_version": null,
"user_name": "Rebecca Foulger",
"item_type": "entity",
"text": "marked MMP20 as ready",
"entity_name": "MMP20",
"entity_type": "gene"
},
{
"created": "2017-08-16T08:35:02.523000Z",
"panel_name": "Amelogenesis Imperfecta",
"panel_id": 269,
"panel_version": null,
"user_name": "Rebecca Foulger",
"item_type": "entity",
"text": "marked C4orf26 as ready",
"entity_name": "C4orf26",
"entity_type": "gene"
},
{
"created": "2017-08-16T08:34:53.993000Z",
"panel_name": "Amelogenesis Imperfecta",
"panel_id": 269,
"panel_version": null,
"user_name": "Rebecca Foulger",
"item_type": "entity",
"text": "classified C4orf26 as green",
"entity_name": "C4orf26",
"entity_type": "gene"
},
{
"created": "2017-08-03T14:24:47.079000Z",
"panel_name": "Amelogenesis Imperfecta",
"panel_id": 269,
"panel_version": null,
"user_name": "Claire Smith",
"item_type": "entity",
"text": "reviewed ITGB6",
"entity_name": "ITGB6",
"entity_type": "gene"
},
{
"created": "2017-08-03T14:18:24.973000Z",
"panel_name": "Amelogenesis Imperfecta",
"panel_id": 269,
"panel_version": null,
"user_name": "Claire Smith",
"item_type": "entity",
"text": "reviewed SLC24A4",
"entity_name": "SLC24A4",
"entity_type": "gene"
},
{
"created": "2017-08-03T14:14:52.299000Z",
"panel_name": "Amelogenesis Imperfecta",
"panel_id": 269,
"panel_version": null,
"user_name": "Claire Smith",
"item_type": "entity",
"text": "reviewed LAMA3",
"entity_name": "LAMA3",
"entity_type": "gene"
},
{
"created": "2017-08-03T14:01:00.331000Z",
"panel_name": "Amelogenesis Imperfecta",
"panel_id": 269,
"panel_version": null,
"user_name": "Claire Smith",
"item_type": "entity",
"text": "reviewed AMTN",
"entity_name": "AMTN",
"entity_type": "gene"
},
{
"created": "2017-08-03T13:55:16.172000Z",
"panel_name": "Amelogenesis Imperfecta",
"panel_id": 269,
"panel_version": null,
"user_name": "Claire Smith",
"item_type": "entity",
"text": "reviewed GPR68",
"entity_name": "GPR68",
"entity_type": "gene"
},
{
"created": "2017-08-03T13:47:18.735000Z",
"panel_name": "Amelogenesis Imperfecta",
"panel_id": 269,
"panel_version": null,
"user_name": "Claire Smith",
"item_type": "entity",
"text": "reviewed AMBN",
"entity_name": "AMBN",
"entity_type": "gene"
},
{
"created": "2017-08-03T13:40:57.392000Z",
"panel_name": "Amelogenesis Imperfecta",
"panel_id": 269,
"panel_version": null,
"user_name": "Claire Smith",
"item_type": "entity",
"text": "reviewed ACPT",
"entity_name": "ACPT",
"entity_type": "gene"
},
{
"created": "2017-08-03T13:34:09.961000Z",
"panel_name": "Amelogenesis Imperfecta",
"panel_id": 269,
"panel_version": null,
"user_name": "Claire Smith",
"item_type": "entity",
"text": "reviewed LAMB3",
"entity_name": "LAMB3",
"entity_type": "gene"
},
{
"created": "2017-08-03T13:19:27.899000Z",
"panel_name": "Amelogenesis Imperfecta",
"panel_id": 269,
"panel_version": null,
"user_name": "Claire Smith",
"item_type": "entity",
"text": "reviewed KLK4",
"entity_name": "KLK4",
"entity_type": "gene"
},
{
"created": "2017-08-02T15:11:11Z",
"panel_name": "Amelogenesis Imperfecta",
"panel_id": 269,
"panel_version": null,
"user_name": "Claire Smith",
"item_type": "entity",
"text": "reviewed FAM83H",
"entity_name": "FAM83H",
"entity_type": "gene"
},
{
"created": "2017-08-02T15:00:33.591000Z",
"panel_name": "Amelogenesis Imperfecta",
"panel_id": 269,
"panel_version": null,
"user_name": "Claire Smith",
"item_type": "entity",
"text": "reviewed FAM20A",
"entity_name": "FAM20A",
"entity_type": "gene"
},
{
"created": "2017-08-02T14:40:38.957000Z",
"panel_name": "Amelogenesis Imperfecta",
"panel_id": 269,
"panel_version": null,
"user_name": "Claire Smith",
"item_type": "entity",
"text": "reviewed C4orf26",
"entity_name": "C4orf26",
"entity_type": "gene"
},
{
"created": "2017-07-25T12:45:34.178000Z",
"panel_name": "Amelogenesis Imperfecta",
"panel_id": 269,
"panel_version": null,
"user_name": "Rebecca Foulger",
"item_type": "entity",
"text": "commented on MMP20",
"entity_name": "MMP20",
"entity_type": "gene"
},
{
"created": "2017-07-25T12:43:32.527000Z",
"panel_name": "Amelogenesis Imperfecta",
"panel_id": 269,
"panel_version": null,
"user_name": "Rebecca Foulger",
"item_type": "entity",
"text": "marked ENAM as ready",
"entity_name": "ENAM",
"entity_type": "gene"
},
{
"created": "2017-07-25T12:43:19.253000Z",
"panel_name": "Amelogenesis Imperfecta",
"panel_id": 269,
"panel_version": null,
"user_name": "Rebecca Foulger",
"item_type": "entity",
"text": "classified ENAM as green",
"entity_name": "ENAM",
"entity_type": "gene"
},
{
"created": "2017-07-25T12:37:38.713000Z",
"panel_name": "Amelogenesis Imperfecta",
"panel_id": 269,
"panel_version": null,
"user_name": "Rebecca Foulger",
"item_type": "entity",
"text": "marked DLX3 as ready",
"entity_name": "DLX3",
"entity_type": "gene"
},
{
"created": "2017-07-25T12:37:23.254000Z",
"panel_name": "Amelogenesis Imperfecta",
"panel_id": 269,
"panel_version": null,
"user_name": "Rebecca Foulger",
"item_type": "entity",
"text": "classified DLX3 as green",
"entity_name": "DLX3",
"entity_type": "gene"
},
{
"created": "2017-07-25T08:39:25.648000Z",
"panel_name": "Amelogenesis Imperfecta",
"panel_id": 269,
"panel_version": null,
"user_name": "Rebecca Foulger",
"item_type": "entity",
"text": "marked AMELX as ready",
"entity_name": "AMELX",
"entity_type": "gene"
},
{
"created": "2017-07-25T08:38:27.257000Z",
"panel_name": "Amelogenesis Imperfecta",
"panel_id": 269,
"panel_version": null,
"user_name": "Rebecca Foulger",
"item_type": "entity",
"text": "edited their review of AMELX",
"entity_name": "AMELX",
"entity_type": "gene"
},
{
"created": "2017-07-25T08:37:40.469000Z",
"panel_name": "Amelogenesis Imperfecta",
"panel_id": 269,
"panel_version": null,
"user_name": "Rebecca Foulger",
"item_type": "entity",
"text": "classified AMELX as green",
"entity_name": "AMELX",
"entity_type": "gene"
},
{
"created": "2017-07-25T08:33:18.972000Z",
"panel_name": "Amelogenesis Imperfecta",
"panel_id": 269,
"panel_version": null,
"user_name": "Rebecca Foulger",
"item_type": "entity",
"text": "commented on AMELX",
"entity_name": "AMELX",
"entity_type": "gene"
},
{
"created": "2017-07-21T14:56:02.577000Z",
"panel_name": "Amelogenesis Imperfecta",
"panel_id": 269,
"panel_version": null,
"user_name": "Claire Smith",
"item_type": "entity",
"text": "reviewed AMELX",
"entity_name": "AMELX",
"entity_type": "gene"
},
{
"created": "2017-07-21T14:45:09.931000Z",
"panel_name": "Amelogenesis Imperfecta",
"panel_id": 269,
"panel_version": null,
"user_name": "Claire Smith",
"item_type": "entity",
"text": "reviewed WDR72",
"entity_name": "WDR72",
"entity_type": "gene"
},
{
"created": "2017-07-21T14:32:55.728000Z",
"panel_name": "Amelogenesis Imperfecta",
"panel_id": 269,
"panel_version": null,
"user_name": "Claire Smith",
"item_type": "entity",
"text": "reviewed MMP20",
"entity_name": "MMP20",
"entity_type": "gene"
},
{
"created": "2017-07-04T15:49:25.294000Z",
"panel_name": "Amelogenesis Imperfecta",
"panel_id": 269,
"panel_version": null,
"user_name": "Louise Daugherty",
"item_type": "entity",
"text": "commented on ACPT",
"entity_name": "ACPT",
"entity_type": "gene"
},
{
"created": "2017-06-15T11:20:47.421000Z",
"panel_name": "Amelogenesis Imperfecta",
"panel_id": 269,
"panel_version": null,
"user_name": "Rebecca Foulger",
"item_type": "entity",
"text": "commented on DLX3",
"entity_name": "DLX3",
"entity_type": "gene"
},
{
"created": "2017-06-13T15:32:00.846000Z",
"panel_name": "Amelogenesis Imperfecta",
"panel_id": 269,
"panel_version": null,
"user_name": "Claire Smith",
"item_type": "entity",
"text": "reviewed ENAM",
"entity_name": "ENAM",
"entity_type": "gene"
},
{
"created": "2017-06-13T15:10:41.204000Z",
"panel_name": "Amelogenesis Imperfecta",
"panel_id": 269,
"panel_version": null,
"user_name": "Claire Smith",
"item_type": "entity",
"text": "reviewed DLX3",
"entity_name": "DLX3",
"entity_type": "gene"
},
{
"created": "2017-06-12T09:13:28.342000Z",
"panel_name": "Amelogenesis Imperfecta",
"panel_id": 269,
"panel_version": null,
"user_name": "Rebecca Foulger",
"item_type": "entity",
"text": "commented on TP63",
"entity_name": "TP63",
"entity_type": "gene"
},
{
"created": "2017-06-12T09:13:09.464000Z",
"panel_name": "Amelogenesis Imperfecta",
"panel_id": 269,
"panel_version": null,
"user_name": "Rebecca Foulger",
"item_type": "entity",
"text": "commented on KCNJ1",
"entity_name": "KCNJ1",
"entity_type": "gene"
},
{
"created": "2017-06-12T09:12:50.828000Z",
"panel_name": "Amelogenesis Imperfecta",
"panel_id": 269,
"panel_version": null,
"user_name": "Rebecca Foulger",
"item_type": "entity",
"text": "commented on AMTN",
"entity_name": "AMTN",
"entity_type": "gene"
},
{
"created": "2017-06-12T09:12:28.836000Z",
"panel_name": "Amelogenesis Imperfecta",
"panel_id": 269,
"panel_version": null,
"user_name": "Rebecca Foulger",
"item_type": "entity",
"text": "commented on CLDN19",
"entity_name": "CLDN19",
"entity_type": "gene"
},
{
"created": "2017-06-12T09:11:38.353000Z",
"panel_name": "Amelogenesis Imperfecta",
"panel_id": 269,
"panel_version": null,
"user_name": "Rebecca Foulger",
"item_type": "entity",
"text": "commented on CLDN16",
"entity_name": "CLDN16",
"entity_type": "gene"
},
{
"created": "2017-06-12T09:10:58.372000Z",
"panel_name": "Amelogenesis Imperfecta",
"panel_id": 269,
"panel_version": null,
"user_name": "Rebecca Foulger",
"item_type": "entity",
"text": "commented on SLC13A5",
"entity_name": "SLC13A5",
"entity_type": "gene"
},
{
"created": "2017-06-12T09:10:26.045000Z",
"panel_name": "Amelogenesis Imperfecta",
"panel_id": 269,
"panel_version": null,
"user_name": "Rebecca Foulger",
"item_type": "entity",
"text": "commented on TMEM165",
"entity_name": "TMEM165",
"entity_type": "gene"
},
{
"created": "2017-06-12T09:10:06.856000Z",
"panel_name": "Amelogenesis Imperfecta",
"panel_id": 269,
"panel_version": null,
"user_name": "Rebecca Foulger",
"item_type": "entity",
"text": "commented on SMARCD2",
"entity_name": "SMARCD2",
"entity_type": "gene"
},
{
"created": "2017-06-12T09:09:29.841000Z",
"panel_name": "Amelogenesis Imperfecta",
"panel_id": 269,
"panel_version": null,
"user_name": "Rebecca Foulger",
"item_type": "entity",
"text": "commented on ROGDI",
"entity_name": "ROGDI",
"entity_type": "gene"
},
{
"created": "2017-06-08T12:32:35.231000Z",
"panel_name": "Amelogenesis Imperfecta",
"panel_id": 269,
"panel_version": null,
"user_name": "Rebecca Foulger",
"item_type": "entity",
"text": "commented on C4orf26",
"entity_name": "C4orf26",
"entity_type": "gene"
},
{
"created": "2017-06-08T12:30:31.846000Z",
"panel_name": "Amelogenesis Imperfecta",
"panel_id": 269,
"panel_version": null,
"user_name": "Rebecca Foulger",
"item_type": "entity",
"text": "commented on COL17A1",
"entity_name": "COL17A1",
"entity_type": "gene"
},
{
"created": "2017-06-08T10:37:49.884000Z",
"panel_name": "Amelogenesis Imperfecta",
"panel_id": 269,
"panel_version": null,
"user_name": "Rebecca Foulger",
"item_type": "entity",
"text": "commented on FAM20C",
"entity_name": "FAM20C",
"entity_type": "gene"
},
{
"created": "2017-06-08T10:09:44.316000Z",
"panel_name": "Amelogenesis Imperfecta",
"panel_id": 269,
"panel_version": null,
"user_name": "Rebecca Foulger",
"item_type": "entity",
"text": "edited their review of LAMC2",
"entity_name": "LAMC2",
"entity_type": "gene"
},
{
"created": "2017-06-08T10:08:30.133000Z",
"panel_name": "Amelogenesis Imperfecta",
"panel_id": 269,
"panel_version": null,
"user_name": "Rebecca Foulger",
"item_type": "entity",
"text": "commented on LAMC2",
"entity_name": "LAMC2",
"entity_type": "gene"
},
{
"created": "2017-06-08T10:07:15.031000Z",
"panel_name": "Amelogenesis Imperfecta",
"panel_id": 269,
"panel_version": null,
"user_name": "Rebecca Foulger",
"item_type": "entity",
"text": "edited their review of LAMA3",
"entity_name": "LAMA3",
"entity_type": "gene"
},
{
"created": "2017-06-08T10:06:37.506000Z",
"panel_name": "Amelogenesis Imperfecta",
"panel_id": 269,
"panel_version": null,
"user_name": "Rebecca Foulger",
"item_type": "entity",
"text": "commented on LAMA3",
"entity_name": "LAMA3",
"entity_type": "gene"
},
{
"created": "2017-06-08T10:06:13.834000Z",
"panel_name": "Amelogenesis Imperfecta",
"panel_id": 269,
"panel_version": null,
"user_name": "Rebecca Foulger",
"item_type": "entity",
"text": "commented on ITGB6",
"entity_name": "ITGB6",
"entity_type": "gene"
},
{
"created": "2017-06-08T10:05:55.832000Z",
"panel_name": "Amelogenesis Imperfecta",
"panel_id": 269,
"panel_version": null,
"user_name": "Rebecca Foulger",
"item_type": "entity",
"text": "commented on ITGB4",
"entity_name": "ITGB4",
"entity_type": "gene"
},
{
"created": "2017-06-08T10:05:17.642000Z",
"panel_name": "Amelogenesis Imperfecta",
"panel_id": 269,
"panel_version": null,
"user_name": "Rebecca Foulger",
"item_type": "entity",
"text": "commented on FAM20A",
"entity_name": "FAM20A",
"entity_type": "gene"
},
{
"created": "2017-06-08T10:04:36.793000Z",
"panel_name": "Amelogenesis Imperfecta",
"panel_id": 269,
"panel_version": null,
"user_name": "Rebecca Foulger",
"item_type": "entity",
"text": "commented on ENAM",
"entity_name": "ENAM",
"entity_type": "gene"
},
{
"created": "2017-03-14T15:02:52.446000Z",
"panel_name": "Amelogenesis Imperfecta",
"panel_id": 269,
"panel_version": null,
"user_name": "Ellen McDonagh",
"item_type": "panel",
"text": "approved panel",
"entity_name": null,
"entity_type": null
}
]