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[
{
"created": "2021-03-03T11:37:07.454289Z",
"panel_name": "Inherited MMR deficiency (Lynch syndrome)",
"panel_id": 503,
"panel_version": "1.9",
"user_name": "Arina Puzriakova",
"item_type": "entity",
"text": "Phenotypes for gene: PMS2 were changed from to Colorectal cancer, hereditary nonpolyposis, type 4, OMIM:614337; Colorectal cancer, hereditary nonpolyposis, type 4, MONDO:0013699; Lynch syndrome 1, MONDO:0007356",
"entity_name": "PMS2",
"entity_type": "gene"
},
{
"created": "2021-03-03T11:34:25.423458Z",
"panel_name": "Inherited MMR deficiency (Lynch syndrome)",
"panel_id": 503,
"panel_version": "1.8",
"user_name": "Arina Puzriakova",
"item_type": "entity",
"text": "Phenotypes for gene: MSH6 were changed from to Colorectal cancer, hereditary nonpolyposis, type 5, OMIM:614350; Colorectal cancer, hereditary nonpolyposis, type 5, MONDO:0013710; Lynch syndrome 1, MONDO:0007356",
"entity_name": "MSH6",
"entity_type": "gene"
},
{
"created": "2021-03-03T11:33:29.551286Z",
"panel_name": "Inherited MMR deficiency (Lynch syndrome)",
"panel_id": 503,
"panel_version": "1.7",
"user_name": "Arina Puzriakova",
"item_type": "entity",
"text": "Phenotypes for gene: MLH1 were changed from Colorectal cancer, hereditary nonpolyposis, type 2, OMIM:609310; Colorectal cancer, hereditary nonpolyposis, type 2, MONDO:0012249 to Colorectal cancer, hereditary nonpolyposis, type 2, OMIM:609310; Colorectal cancer, hereditary nonpolyposis, type 2, MONDO:0012249; Lynch syndrome 1, MONDO:0007356",
"entity_name": "MLH1",
"entity_type": "gene"
},
{
"created": "2021-03-03T11:32:37.372955Z",
"panel_name": "Inherited MMR deficiency (Lynch syndrome)",
"panel_id": 503,
"panel_version": "1.6",
"user_name": "Arina Puzriakova",
"item_type": "entity",
"text": "Phenotypes for gene: MSH2 were changed from to Colorectal cancer, hereditary nonpolyposis, type 1, OMIM:120435; Lynch syndrome 1, MONDO:0007356",
"entity_name": "MSH2",
"entity_type": "gene"
},
{
"created": "2021-03-03T11:29:35.682666Z",
"panel_name": "Inherited MMR deficiency (Lynch syndrome)",
"panel_id": 503,
"panel_version": "1.5",
"user_name": "Arina Puzriakova",
"item_type": "entity",
"text": "Phenotypes for gene: MLH1 were changed from to Colorectal cancer, hereditary nonpolyposis, type 2, OMIM:609310; Colorectal cancer, hereditary nonpolyposis, type 2, MONDO:0012249",
"entity_name": "MLH1",
"entity_type": "gene"
},
{
"created": "2021-03-03T11:20:44.813329Z",
"panel_name": "Inherited MMR deficiency (Lynch syndrome)",
"panel_id": 503,
"panel_version": "1.4",
"user_name": "Arina Puzriakova",
"item_type": "entity",
"text": "Phenotypes for gene: EPCAM were changed from to Colorectal cancer, hereditary nonpolyposis, type 8, OMIM:613244; Colorectal cancer, hereditary nonpolyposis, type 8, MONDO:0013196",
"entity_name": "EPCAM",
"entity_type": "gene"
},
{
"created": "2020-03-04T11:16:21.798174Z",
"panel_name": "Inherited MMR deficiency (Lynch syndrome)",
"panel_id": 503,
"panel_version": "1.3",
"user_name": "Catherine Snow",
"item_type": "panel",
"text": "Panel version has been signed off",
"entity_name": null,
"entity_type": null
},
{
"created": "2019-08-16T09:52:46.990037Z",
"panel_name": "Inherited MMR deficiency (Lynch syndrome)",
"panel_id": 503,
"panel_version": "1.0",
"user_name": "Ivone Leong",
"item_type": "panel",
"text": "promoted panel to version 1.0",
"entity_name": null,
"entity_type": null
},
{
"created": "2019-08-16T09:51:35.146275Z",
"panel_name": "Inherited MMR deficiency (Lynch syndrome)",
"panel_id": 503,
"panel_version": "0.12",
"user_name": "Ivone Leong",
"item_type": "panel",
"text": "Panel name changed from Inherited MMR deficiency (Lynch syndrome), R210 to Inherited MMR deficiency (Lynch syndrome)\nList of related panels changed from to R210\nPanel types changed to GMS Rare Disease; GMS signed-off",
"entity_name": null,
"entity_type": null
},
{
"created": "2019-07-31T12:31:59.856520Z",
"panel_name": "Inherited MMR deficiency (Lynch syndrome), R210",
"panel_id": 503,
"panel_version": "0.11",
"user_name": "Ivone Leong",
"item_type": "entity",
"text": "commented on gene: PMS2",
"entity_name": "PMS2",
"entity_type": "gene"
},
{
"created": "2019-07-31T12:31:57.242153Z",
"panel_name": "Inherited MMR deficiency (Lynch syndrome), R210",
"panel_id": 503,
"panel_version": "0.11",
"user_name": "Ivone Leong",
"item_type": "entity",
"text": "commented on gene: MSH6",
"entity_name": "MSH6",
"entity_type": "gene"
},
{
"created": "2019-07-31T12:31:54.553745Z",
"panel_name": "Inherited MMR deficiency (Lynch syndrome), R210",
"panel_id": 503,
"panel_version": "0.11",
"user_name": "Ivone Leong",
"item_type": "entity",
"text": "commented on gene: MSH2",
"entity_name": "MSH2",
"entity_type": "gene"
},
{
"created": "2019-07-31T12:31:51.933912Z",
"panel_name": "Inherited MMR deficiency (Lynch syndrome), R210",
"panel_id": 503,
"panel_version": "0.11",
"user_name": "Ivone Leong",
"item_type": "entity",
"text": "commented on gene: MLH1",
"entity_name": "MLH1",
"entity_type": "gene"
},
{
"created": "2019-07-31T12:31:48.565257Z",
"panel_name": "Inherited MMR deficiency (Lynch syndrome), R210",
"panel_id": 503,
"panel_version": "0.11",
"user_name": "Ivone Leong",
"item_type": "entity",
"text": "commented on gene: EPCAM",
"entity_name": "EPCAM",
"entity_type": "gene"
},
{
"created": "2019-07-31T12:30:16.092678Z",
"panel_name": "Inherited MMR deficiency (Lynch syndrome), R210",
"panel_id": 503,
"panel_version": "0.11",
"user_name": "Ivone Leong",
"item_type": "panel",
"text": "Panel name changed from Inherited MMR deficiency (Lynch syndrome) to Inherited MMR deficiency (Lynch syndrome), R210",
"entity_name": null,
"entity_type": null
},
{
"created": "2019-01-30T15:03:17.229190Z",
"panel_name": "Inherited MMR deficiency (Lynch syndrome)",
"panel_id": 503,
"panel_version": "0.9",
"user_name": "Ivone Leong",
"item_type": "entity",
"text": "Mode of inheritance for gene: PMS2 was changed from to MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown",
"entity_name": "PMS2",
"entity_type": "gene"
},
{
"created": "2019-01-30T15:03:07.570528Z",
"panel_name": "Inherited MMR deficiency (Lynch syndrome)",
"panel_id": 503,
"panel_version": "0.8",
"user_name": "Ivone Leong",
"item_type": "entity",
"text": "Mode of inheritance for gene: MSH6 was changed from to MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown",
"entity_name": "MSH6",
"entity_type": "gene"
},
{
"created": "2019-01-30T15:02:30.696458Z",
"panel_name": "Inherited MMR deficiency (Lynch syndrome)",
"panel_id": 503,
"panel_version": "0.7",
"user_name": "Ivone Leong",
"item_type": "entity",
"text": "Mode of inheritance for gene: MSH2 was changed from to MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown",
"entity_name": "MSH2",
"entity_type": "gene"
},
{
"created": "2019-01-30T15:02:20.700991Z",
"panel_name": "Inherited MMR deficiency (Lynch syndrome)",
"panel_id": 503,
"panel_version": "0.6",
"user_name": "Ivone Leong",
"item_type": "entity",
"text": "Mode of inheritance for gene: MLH1 was changed from to MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown",
"entity_name": "MLH1",
"entity_type": "gene"
},
{
"created": "2019-01-30T15:02:02.260753Z",
"panel_name": "Inherited MMR deficiency (Lynch syndrome)",
"panel_id": 503,
"panel_version": "0.5",
"user_name": "Ivone Leong",
"item_type": "entity",
"text": "Mode of inheritance for gene: EPCAM was changed from to MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown",
"entity_name": "EPCAM",
"entity_type": "gene"
},
{
"created": "2019-01-29T16:57:24.925513Z",
"panel_name": "Inherited MMR deficiency (Lynch syndrome)",
"panel_id": 503,
"panel_version": "0.3",
"user_name": "Rachel Robinson",
"item_type": "entity",
"text": "reviewed gene: PMS2: Rating: GREEN; Mode of pathogenicity: ; Publications: ; Phenotypes: ; Mode of inheritance: ; Current diagnostic: yes",
"entity_name": "PMS2",
"entity_type": "gene"
},
{
"created": "2019-01-29T16:57:24.915302Z",
"panel_name": "Inherited MMR deficiency (Lynch syndrome)",
"panel_id": 503,
"panel_version": "0.3",
"user_name": "Rachel Robinson",
"item_type": "entity",
"text": "reviewed gene: MSH6: Rating: GREEN; Mode of pathogenicity: ; Publications: ; Phenotypes: ; Mode of inheritance: ; Current diagnostic: yes",
"entity_name": "MSH6",
"entity_type": "gene"
},
{
"created": "2019-01-29T16:57:24.905735Z",
"panel_name": "Inherited MMR deficiency (Lynch syndrome)",
"panel_id": 503,
"panel_version": "0.3",
"user_name": "Rachel Robinson",
"item_type": "entity",
"text": "reviewed gene: MSH2: Rating: GREEN; Mode of pathogenicity: ; Publications: ; Phenotypes: ; Mode of inheritance: ; Current diagnostic: yes",
"entity_name": "MSH2",
"entity_type": "gene"
},
{
"created": "2019-01-29T16:57:24.894744Z",
"panel_name": "Inherited MMR deficiency (Lynch syndrome)",
"panel_id": 503,
"panel_version": "0.3",
"user_name": "Rachel Robinson",
"item_type": "entity",
"text": "reviewed gene: MLH1: Rating: GREEN; Mode of pathogenicity: ; Publications: ; Phenotypes: ; Mode of inheritance: ; Current diagnostic: yes",
"entity_name": "MLH1",
"entity_type": "gene"
},
{
"created": "2019-01-29T16:57:24.883775Z",
"panel_name": "Inherited MMR deficiency (Lynch syndrome)",
"panel_id": 503,
"panel_version": "0.3",
"user_name": "Rachel Robinson",
"item_type": "entity",
"text": "reviewed gene: EPCAM: Rating: GREEN; Mode of pathogenicity: ; Publications: ; Phenotypes: ; Mode of inheritance: ; Current diagnostic: yes",
"entity_name": "EPCAM",
"entity_type": "gene"
},
{
"created": "2019-01-29T16:57:24.871523Z",
"panel_name": "Inherited MMR deficiency (Lynch syndrome)",
"panel_id": 503,
"panel_version": "0.3",
"user_name": "Lara Hawkes",
"item_type": "entity",
"text": "reviewed gene: PMS2: Rating: GREEN; Mode of pathogenicity: ; Publications: ; Phenotypes: ; Mode of inheritance: ",
"entity_name": "PMS2",
"entity_type": "gene"
},
{
"created": "2019-01-29T16:57:24.860055Z",
"panel_name": "Inherited MMR deficiency (Lynch syndrome)",
"panel_id": 503,
"panel_version": "0.3",
"user_name": "Lara Hawkes",
"item_type": "entity",
"text": "reviewed gene: MSH6: Rating: GREEN; Mode of pathogenicity: ; Publications: ; Phenotypes: ; Mode of inheritance: ",
"entity_name": "MSH6",
"entity_type": "gene"
},
{
"created": "2019-01-29T16:57:24.847439Z",
"panel_name": "Inherited MMR deficiency (Lynch syndrome)",
"panel_id": 503,
"panel_version": "0.3",
"user_name": "Lara Hawkes",
"item_type": "entity",
"text": "reviewed gene: MSH2: Rating: GREEN; Mode of pathogenicity: ; Publications: ; Phenotypes: ; Mode of inheritance: ",
"entity_name": "MSH2",
"entity_type": "gene"
},
{
"created": "2019-01-29T16:57:24.834719Z",
"panel_name": "Inherited MMR deficiency (Lynch syndrome)",
"panel_id": 503,
"panel_version": "0.3",
"user_name": "Lara Hawkes",
"item_type": "entity",
"text": "reviewed gene: MLH1: Rating: GREEN; Mode of pathogenicity: ; Publications: ; Phenotypes: ; Mode of inheritance: ",
"entity_name": "MLH1",
"entity_type": "gene"
},
{
"created": "2019-01-29T16:57:24.802772Z",
"panel_name": "Inherited MMR deficiency (Lynch syndrome)",
"panel_id": 503,
"panel_version": "0.3",
"user_name": "Lara Hawkes",
"item_type": "entity",
"text": "reviewed gene: EPCAM: Rating: GREEN; Mode of pathogenicity: ; Publications: ; Phenotypes: ; Mode of inheritance: ",
"entity_name": "EPCAM",
"entity_type": "gene"
},
{
"created": "2019-01-29T16:56:55.831738Z",
"panel_name": "Inherited MMR deficiency (Lynch syndrome)",
"panel_id": 503,
"panel_version": "0.2",
"user_name": "Ivone Leong",
"item_type": "entity",
"text": "gene: PMS2 was added\ngene: PMS2 was added to Inherited MMR deficiency (Lynch syndrome). Sources: Expert List,Expert Review Green,NHS GMS\nMode of inheritance for gene: PMS2 was set to ",
"entity_name": "PMS2",
"entity_type": "gene"
},
{
"created": "2019-01-29T16:56:55.787540Z",
"panel_name": "Inherited MMR deficiency (Lynch syndrome)",
"panel_id": 503,
"panel_version": "0.2",
"user_name": "Ivone Leong",
"item_type": "entity",
"text": "gene: MSH6 was added\ngene: MSH6 was added to Inherited MMR deficiency (Lynch syndrome). Sources: Expert List,Expert Review Green,NHS GMS\nMode of inheritance for gene: MSH6 was set to ",
"entity_name": "MSH6",
"entity_type": "gene"
},
{
"created": "2019-01-29T16:56:55.736136Z",
"panel_name": "Inherited MMR deficiency (Lynch syndrome)",
"panel_id": 503,
"panel_version": "0.2",
"user_name": "Ivone Leong",
"item_type": "entity",
"text": "gene: MSH2 was added\ngene: MSH2 was added to Inherited MMR deficiency (Lynch syndrome). Sources: Expert List,Expert Review Green,NHS GMS\nMode of inheritance for gene: MSH2 was set to ",
"entity_name": "MSH2",
"entity_type": "gene"
},
{
"created": "2019-01-29T16:56:55.688836Z",
"panel_name": "Inherited MMR deficiency (Lynch syndrome)",
"panel_id": 503,
"panel_version": "0.2",
"user_name": "Ivone Leong",
"item_type": "entity",
"text": "gene: MLH1 was added\ngene: MLH1 was added to Inherited MMR deficiency (Lynch syndrome). Sources: Expert List,Expert Review Green,NHS GMS\nMode of inheritance for gene: MLH1 was set to ",
"entity_name": "MLH1",
"entity_type": "gene"
},
{
"created": "2019-01-29T16:56:55.638696Z",
"panel_name": "Inherited MMR deficiency (Lynch syndrome)",
"panel_id": 503,
"panel_version": "0.2",
"user_name": "Ivone Leong",
"item_type": "entity",
"text": "gene: EPCAM was added\ngene: EPCAM was added to Inherited MMR deficiency (Lynch syndrome). Sources: Expert List,Expert Review Green,NHS GMS\nMode of inheritance for gene: EPCAM was set to ",
"entity_name": "EPCAM",
"entity_type": "gene"
},
{
"created": "2018-11-16T09:16:46.855607Z",
"panel_name": "Inherited MMR deficiency (Lynch syndrome)",
"panel_id": 503,
"panel_version": "0.0",
"user_name": "Ellen McDonagh",
"item_type": "panel",
"text": "Added Panel Inherited MMR deficiency (Lynch syndrome)\nSet panel types to: GMS Rare Disease",
"entity_name": null,
"entity_type": null
}
]