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  2. Wilms tumour with features suggestive of predisposition
  3. TRIM28
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Wilms tumour with features suggestive of predisposition

Gene: TRIM28

Green List (high evidence)
TRIM28 (tripartite motif containing 28)
EnsemblGeneIds (GRCh38): ENSG00000130726
EnsemblGeneIds (GRCh37): ENSG00000130726
OMIM: 601742, Gene2Phenotype
TRIM28 is in 2 panels

2 reviews

Arina Puzriakova (Genomics England Curator)

Comment on phenotypes: OMIM phenotype accessed on 20-03-2026
Created: 20 Mar 2026, 11:34 a.m. | Last Modified: 20 Mar 2026, 11:34 a.m.
Panel Version: 1.5
Created: 20 Mar 2026, 11:34 a.m.
Last Modified: 20 Mar 2026, 11:34 a.m.
Panel version: 1.5

Eleanor Williams (Genomics England Curator)

This gene has been added to the panel on the recommendation of the NHS Genomic Medicine Service.
Created: 8 Mar 2022, 2:29 p.m. | Last Modified: 8 Mar 2022, 2:29 p.m.
Panel Version: 0.2
Created: 8 Mar 2022, 2:29 p.m.
Last Modified: 8 Mar 2022, 2:29 p.m.
Panel version: 0.2

Details

Mode of Inheritance
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Sources
  • Expert Review Green
Phenotypes
  • Wilms tumor 7, OMIM:621332
OMIM
601742
Clinvar variants
Variants in TRIM28
Penetrance
None
Publications
Panels with this gene

History Filter Activity

20 Mar 2026, Gel status: 3

Set Phenotypes

Arina Puzriakova (Genomics England Curator)

Phenotypes for gene: TRIM28 were changed from Wilms tumor; Familial Wilms tumor to Wilms tumor 7, OMIM:621332

20 Mar 2026, Gel status: 3

Removed Tag

Arina Puzriakova (Genomics England Curator)

Tag gene-checked was removed from gene: TRIM28.

7 May 2022, Gel status: 3

Added Tag

Eleanor Williams (Genomics England Curator)

Tag gene-checked tag was added to gene: TRIM28.

8 Mar 2022, Gel status: 3

Created, Added New Source, Set mode of inheritance, Set publications, Set Phenotypes

Eleanor Williams (Genomics England Curator)

gene: TRIM28 was added gene: TRIM28 was added to Wilms tumour with features suggestive of predisposition. Sources: Expert Review Green Mode of inheritance for gene: TRIM28 was set to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted Publications for gene: TRIM28 were set to 30885698; 29912901; 30694527 Phenotypes for gene: TRIM28 were set to Wilms tumor; Familial Wilms tumor