Hereditary diffuse gastric cancer
Gene: CTNNA1

CTNNA1 (catenin alpha 1)
EnsemblGeneIds (GRCh38): ENSG00000044115
EnsemblGeneIds (GRCh37): ENSG00000044115
OMIM: 116805, Gene2Phenotype
CTNNA1 is in 3 panels

1 review

Arina Puzriakova (Genomics England Curator)

Green List (high evidence)

The rating of this gene has been updated to Green and the mode of inheritance set to MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown following NHS Genomic Medicine Service approval.
Created: 11 Oct 2023, 11:55 a.m. | Last Modified: 11 Oct 2023, 11:55 a.m.

Panel Version: 1.3

Mode of inheritance
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown

Created: 11 Oct 2023, 11:55 a.m.
Last Modified: 11 Oct 2023, 11:55 a.m.
Panel version: 1.3

Details

Mode of Inheritance

MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown

Sources

NHS GMS
Expert Review Green

Phenotypes

CTNNA1-related diffuse gastric and lobular breast cancer syndrome, MONDO:0100256

OMIM

116805

Clinvar variants

Variants in CTNNA1

Penetrance

None

Panels with this gene

History Filter Activity

17 Dec 2025, Gel status: 3

Set Phenotypes

Achchuthan Shanmugasundram (Genomics England Curator)

Phenotypes for gene: CTNNA1 were changed from to CTNNA1-related diffuse gastric and lobular breast cancer syndrome, MONDO:0100256

11 Oct 2023, Gel status: 3

Created, Added New Source, Set mode of inheritance

Arina Puzriakova (Genomics England Curator)

gene: CTNNA1 was added gene: CTNNA1 was added to CDH1-related cancer syndrome. Sources: Expert Review Green,NHS GMS Mode of inheritance for gene: CTNNA1 was set to MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown

Hereditary diffuse gastric cancer Gene: CTNNA1