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Newborns main panel

Gene: CD70

Green List (high evidence)
CD70 (CD70 molecule)
EnsemblGeneIds (GRCh38): ENSG00000125726
EnsemblGeneIds (GRCh37): ENSG00000125726
OMIM: 602840, Gene2Phenotype
CD70 is in 2 panels

1 review

Mafalda Gomes (Genomics England Curator)

The mechanism of pathogenicity is loss-of-function (LOF).
Created: 1 Jun 2023, 2:40 p.m. | Last Modified: 1 Jun 2023, 2:40 p.m.
Panel Version: 0.137
clinical validity. 16 cases PMID: 32603431
Created: 1 Jun 2023, 12:22 p.m. | Last Modified: 1 Jun 2023, 12:22 p.m.
Panel Version: 0.134
Created: 1 Jun 2023, 12:22 p.m.
Last Modified: 1 Jun 2023, 12:22 p.m.
Panel version: 0.137

Details

Mode of Inheritance
BIALLELIC, autosomal or pseudoautosomal
Sources
  • Expert Review Green
Phenotypes
  • Lymphoproliferative syndrome 3
OMIM
602840
Clinvar variants
Variants in CD70
Penetrance
None
Panels with this gene

History Filter Activity

7 Mar 2025, Gel status: 3

Removed Tag

Arina Puzriakova (Genomics England Curator)

Tag special_consideration was removed from gene: CD70.

12 Feb 2025, Gel status: 3

Set Phenotypes

Arina Puzriakova (Genomics England Curator)

Phenotypes for gene: CD70 were changed from Immune dysregulation 3 to Lymphoproliferative syndrome 3

12 Feb 2025, Gel status: 3

Added Tag

Arina Puzriakova (Genomics England Curator)

Tag special_consideration tag was added to gene: CD70.

6 Feb 2024, Gel status: 3

Set Phenotypes

Sarah Leigh (Genomics England Curator)

Phenotypes for gene: CD70 were changed from Lymphoproliferative syndrome 3 to Immune dysregulation 3

14 Sep 2023, Gel status: 3

Set Phenotypes

Mafalda Gomes (Genomics England Curator)

Added phenotypes Lymphoproliferative syndrome 3 for gene: CD70

5 Jul 2023, Gel status: 3

Set Phenotypes

Mafalda Gomes (Genomics England Curator)

Added phenotypes Lymphoproliferative syndrome 3 for gene: CD70

31 May 2023, Gel status: 3

Set Phenotypes

Mafalda Gomes (Genomics England Curator)

Added phenotypes Lymphoproliferative syndrome 3 for gene: CD70

15 May 2023, Gel status: 3

Added New Source, Set Phenotypes, Status Update

Mafalda Gomes (Genomics England Curator)

Source Expert Review Green was added to CD70. Added phenotypes Lymphoproliferative syndrome 3 for gene: CD70 Rating Changed from No List (delete) to Green List (high evidence)

5 May 2023, Gel status: 0

Added New Source, Set Phenotypes, Status Update

Mafalda Gomes (Genomics England Curator)

Source Expert Review Removed was added to CD70. Added phenotypes Lymphoproliferative syndrome 3 for gene: CD70 Rating Changed from Green List (high evidence) to No List (delete)

9 Mar 2023, Gel status: 3

Set Phenotypes

Mafalda Gomes (Genomics England Curator)

Added phenotypes Lymphoproliferative syndrome 3 for gene: CD70

9 Mar 2023, Gel status: 3

Created, Added New Source, Set mode of inheritance

Mafalda Gomes (Genomics England Curator)

gene: CD70 was added gene: CD70 was added to Newborns main panel. Sources: Expert Review Green Mode of inheritance for gene: CD70 was set to BIALLELIC, autosomal or pseudoautosomal