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Newborns main panel

Gene: IL36RN

Amber List (moderate evidence)
IL36RN (interleukin 36 receptor antagonist)
EnsemblGeneIds (GRCh38): ENSG00000136695
EnsemblGeneIds (GRCh37): ENSG00000136695
OMIM: 605507, Gene2Phenotype
IL36RN is in 6 panels

1 review

Mafalda Gomes (Genomics England Curator)

The mechanism of pathogenicity is loss-of-function (LOF).
Created: 1 Jun 2023, 2:40 p.m. | Last Modified: 1 Jun 2023, 2:40 p.m.
Panel Version: 0.137
PMID: 31286990 - 1 case and review of 12 others
Created: 1 Jun 2023, 12:22 p.m. | Last Modified: 1 Jun 2023, 12:22 p.m.
Panel Version: 0.134
Created: 1 Jun 2023, 12:22 p.m.
Last Modified: 1 Jun 2023, 12:22 p.m.
Panel version: 0.137

Details

Mode of Inheritance
BIALLELIC, autosomal or pseudoautosomal
Sources
  • Expert Review Amber
Phenotypes
  • pustular psoriasis-14
OMIM
605507
Clinvar variants
Variants in IL36RN
Penetrance
None
Panels with this gene

History Filter Activity

14 Sep 2023, Gel status: 2

Added New Source, Set Phenotypes, Status Update

Mafalda Gomes (Genomics England Curator)

Source Expert Review Amber was added to IL36RN. Added phenotypes pustular psoriasis-14 for gene: IL36RN Rating Changed from Green List (high evidence) to Amber List (moderate evidence)

5 Jul 2023, Gel status: 3

Added New Source, Set Phenotypes, Status Update

Mafalda Gomes (Genomics England Curator)

Source Expert Review Green was added to IL36RN. Added phenotypes pustular psoriasis-14 for gene: IL36RN Rating Changed from Amber List (moderate evidence) to Green List (high evidence)

31 May 2023, Gel status: 2

Added New Source, Set Phenotypes, Status Update

Mafalda Gomes (Genomics England Curator)

Source Expert Review Amber was added to IL36RN. Added phenotypes pustular psoriasis-14 for gene: IL36RN Rating Changed from Green List (high evidence) to Amber List (moderate evidence)

15 May 2023, Gel status: 3

Added New Source, Set Phenotypes, Status Update

Mafalda Gomes (Genomics England Curator)

Source Expert Review Green was added to IL36RN. Added phenotypes pustular psoriasis-14 for gene: IL36RN Rating Changed from No List (delete) to Green List (high evidence)

9 Mar 2023, Gel status: 0

Created, Added New Source, Set mode of inheritance

Mafalda Gomes (Genomics England Curator)

gene: IL36RN was added gene: IL36RN was added to Newborns main panel. Sources: Expert Review Removed Mode of inheritance for gene: IL36RN was set to BIALLELIC, autosomal or pseudoautosomal