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Newborns main panel

Gene: KLF11

Red List (low evidence)
KLF11 (Kruppel like factor 11)
EnsemblGeneIds (GRCh38): ENSG00000172059
EnsemblGeneIds (GRCh37): ENSG00000172059
OMIM: 603301, Gene2Phenotype
KLF11 is in 4 panels

1 review

Mafalda Gomes (Genomics England Curator)

refuted by clingen
Created: 1 Jun 2023, 12:22 p.m. | Last Modified: 1 Jun 2023, 3:22 p.m.
Panel Version: 0.137
Created: 1 Jun 2023, 12:22 p.m.
Last Modified: 1 Jun 2023, 3:22 p.m.
Panel version: 0.134

Details

Mode of Inheritance
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
Sources
  • Expert Review Red
Phenotypes
  • Maturity-onset diabetes of the young, type VII
OMIM
603301
Clinvar variants
Variants in KLF11
Penetrance
None
Mode of Pathogenicity
Loss-of-function variants (as defined in pop up message) DO NOT cause this phenotype - please provide details in the comments
Panels with this gene

History Filter Activity

6 Feb 2024, Gel status: 1

Entity classified by Genomics England curator

Ivone Leong (Genomics England Curator)

Gene: klf11 has been classified as Red List (Low Evidence).

14 Sep 2023, Gel status: 2

Set mode of pathogenicity, Set Phenotypes

Mafalda Gomes (Genomics England Curator)

Mode of pathogenicity for gene KLF11 was changed from None to Loss-of-function variants (as defined in pop up message) DO NOT cause this phenotype - please provide details in the comments Added phenotypes Maturity-onset diabetes of the young, type VII for gene: KLF11

14 Jul 2023, Gel status: 2

Set mode of pathogenicity

Mafalda Gomes (Genomics England Curator)

Mode of pathogenicity for gene: KLF11 was changed from Loss-of-function variants (as defined in pop up message) DO NOT cause this phenotype - please provide details in the comments to None

5 Jul 2023, Gel status: 2

Added New Source, Set mode of pathogenicity, Set Phenotypes, Status Update

Mafalda Gomes (Genomics England Curator)

Source Expert Review Amber was added to KLF11. Mode of pathogenicity for gene KLF11 was changed from to Loss-of-function variants (as defined in pop up message) DO NOT cause this phenotype - please provide details in the comments Added phenotypes Maturity-onset diabetes of the young, type VII for gene: KLF11 Rating Changed from Red List (low evidence) to Amber List (moderate evidence)

31 May 2023, Gel status: 1

Added New Source, Set Phenotypes, Status Update

Mafalda Gomes (Genomics England Curator)

Source Expert Review Red was added to KLF11. Added phenotypes Maturity-onset diabetes of the young, type VII for gene: KLF11 Rating Changed from No List (delete) to Red List (low evidence)

5 May 2023, Gel status: 0

Added New Source, Status Update

Mafalda Gomes (Genomics England Curator)

Source Expert Review Removed was added to KLF11. Rating Changed from Amber List (moderate evidence) to No List (delete)

9 Mar 2023, Gel status: 2

Set Phenotypes

Mafalda Gomes (Genomics England Curator)

Added phenotypes Maturity-onset diabetes of the young, type VII for gene: KLF11

9 Mar 2023, Gel status: 2

Created, Added New Source, Set mode of inheritance

Mafalda Gomes (Genomics England Curator)

gene: KLF11 was added gene: KLF11 was added to Newborns main panel. Sources: Expert Review Amber Mode of inheritance for gene: KLF11 was set to MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown