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Newborns main panel

Gene: MSN

Green List (high evidence)
MSN (moesin)
EnsemblGeneIds (GRCh38): ENSG00000147065
EnsemblGeneIds (GRCh37): ENSG00000147065
OMIM: 309845, Gene2Phenotype
MSN is in 3 panels

1 review

Arina Puzriakova (Genomics England Curator)

The mechanism of pathogenicity is loss-of-function (LOF)
Created: 31 Dec 2025, 2:36 p.m. | Last Modified: 31 Dec 2025, 2:36 p.m.
Panel Version: 0.499
https://search.clinicalgenome.org/kb/genes/HGNC:7373
Created: 31 Dec 2025, 2:27 p.m. | Last Modified: 31 Dec 2025, 2:27 p.m.
Panel Version: 0.498
Created: 31 Dec 2025, 2:27 p.m.
Last Modified: 31 Dec 2025, 2:27 p.m.
Panel version: 0.499

Details

Mode of Inheritance
X-LINKED: hemizygous mutation in males, biallelic mutations in females
Sources
  • Expert Review Green
Phenotypes
  • Immunodeficiency 50
OMIM
309845
Clinvar variants
Variants in MSN
Penetrance
None
Panels with this gene

History Filter Activity

31 Dec 2025, Gel status: 3

Created, Added New Source, Set mode of inheritance, Set Phenotypes

Arina Puzriakova (Genomics England Curator)

gene: MSN was added gene: MSN was added to Newborns main panel. Sources: Expert Review Green Mode of inheritance for gene: MSN was set to X-LINKED: hemizygous mutation in males, biallelic mutations in females Phenotypes for gene: MSN were set to Immunodeficiency 50