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Newborns main panel

Gene: TRAC

Green List (high evidence)
TRAC (T-cell receptor alpha constant)
EnsemblGeneIds (GRCh38): ENSG00000277734
EnsemblGeneIds (GRCh37): ENSG00000229164
OMIM: 186880, Gene2Phenotype
TRAC is in 2 panels

1 review

Arina Puzriakova (Genomics England Curator)

The mechanism of pathogenicity is loss-of-function (LOF)
Created: 31 Dec 2025, 2:36 p.m. | Last Modified: 31 Dec 2025, 2:36 p.m.
Panel Version: 0.499
PMID: 33909184 - 1 family with c.*1G>A, https://lymphosign.com/doi/10.14785/lymphosign-2022-0001 - 1 case, PMID: 21206088 - 2 families with c.*1G>A
Created: 31 Dec 2025, 2:28 p.m. | Last Modified: 31 Dec 2025, 2:28 p.m.
Panel Version: 0.498
Created: 31 Dec 2025, 2:28 p.m.
Last Modified: 31 Dec 2025, 2:28 p.m.
Panel version: 0.499

Details

Mode of Inheritance
BIALLELIC, autosomal or pseudoautosomal
Sources
  • Expert Review Green
Phenotypes
  • Immunodeficiency 7
Transcripts
  • ENST00000611116.2
OMIM
186880
Clinvar variants
Variants in TRAC
Penetrance
None
Panels with this gene

History Filter Activity

13 Jan 2026, Gel status: 3

Set transcript

Arina Puzriakova (Genomics England Curator)

Transcript for gene TRAC was changed from None to ENST00000611116.2

31 Dec 2025, Gel status: 3

Created, Added New Source, Set mode of inheritance, Set Phenotypes

Arina Puzriakova (Genomics England Curator)

gene: TRAC was added gene: TRAC was added to Newborns main panel. Sources: Expert Review Green Mode of inheritance for gene: TRAC was set to BIALLELIC, autosomal or pseudoautosomal Phenotypes for gene: TRAC were set to Immunodeficiency 7