BRIDGE_SPEED_NEURO_20170705
Gene: KIRREL3

KIRREL3 (kirre like nephrin family adhesion molecule 3)
EnsemblGeneIds (GRCh38): ENSG00000149571
EnsemblGeneIds (GRCh37): ENSG00000149571
OMIM: 607761, Gene2Phenotype
KIRREL3 is in 2 panels

1 review

BRIDGE consortium (NIHRBR-RD)

Green List (high evidence)

This is a pertinent gene from the NIHR BioResource - Rare Diseases Study (NIHRBR-RD) BRIDGE Study : SPEED (Specialist Pathology: Evaluating Exomes in Diagnostics) which covers epilepsies, movement and microcephaly disorders, this gene is on the SPEED_NEURO_20170705 gene list. Evidences used for SPEED NEURO gene list: in_ddg2p_20141118_conf;in_ddg2p_20141118_conf;in_ddg2p_2_4_2017;in_gilissen_2014_known . Main mutation mechanism : Uncertain
Created: 28 Jul 2017, 9:32 a.m.

Mode of inheritance
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown

Publications

Created: 2 Aug 2017, 4:32 p.m.

Panel version: 0.191

Details

Mode of Inheritance

MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown

Sources

Expert Review Green
BRIDGE study SPEED NEURO Tier1 Gene

Phenotypes

Mental retardation, autosomal dominant 4, 612581

OMIM

607761

Clinvar variants

Variants in KIRREL3

Penetrance

Complete

Panels with this gene

History Filter Activity

27 Jul 2017, Gel status: 4

Added New Source

Louise Daugherty (Genomics England Curator)

KIRREL3 was added to BRIDGE_SPEED_NEURO_20170705panel. Sources: BRIDGE study SPEED NEURO Tier1 Gene,Expert Review Green

27 Jul 2017, Gel status: 0

Created