Generalised pustular psoriasis
Gene: ZNF750

ZNF750 (zinc finger protein 750)
EnsemblGeneIds (GRCh38): ENSG00000141579
EnsemblGeneIds (GRCh37): ENSG00000141579
OMIM: 610226, Gene2Phenotype
ZNF750 is in 3 panels

3 reviews

catherine smith (Guys and St Thomas' NHS Foundation Trust)

I don't know

Created: 5 Nov 2017, 2:40 a.m.

Panel version: 0

Sarah Leigh (Genomics England Curator)

Comment on publications: PMID 22185198: Two haplotypes of ZNF750 and rare 5' regulatory variants of ZNF750 were found to be associated with psoriasis. These rare 5' regulatory variants, though not causal, might serve as a genetic modifier of psoriasis.
Created: 22 Nov 2016, 3:28 p.m.

Comment when marking as ready: Associated with phenotype in OMIM and as a probable Developmental Disorder Gene / G2P. At least one variant reported.
Created: 4 Nov 2016, 4:23 p.m.

Created: 4 Nov 2016, 4:23 p.m.

Panel version: 0.48

Francesca Capon (King's College London)

I don't know

Created: 15 Dec 2015, 9:32 p.m.

Panel version: 0.18

Details

Mode of Inheritance

Unknown

Sources

Literature
Expert Review Red
Radboud University Medical Center, Nijmegen

Phenotypes

Seborrhea-like dermatitis with psoriasiform elements, 610227

OMIM

610226

Clinvar variants

Variants in ZNF750

Penetrance

Complete

Publications

Panels with this gene