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  3. VTN
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Atypical haemolytic uraemic syndrome

Gene: VTN

Red List (low evidence)
VTN (vitronectin)
EnsemblGeneIds (GRCh38): ENSG00000109072
EnsemblGeneIds (GRCh37): ENSG00000109072
OMIM: 193190, Gene2Phenotype
VTN is in 1 panel

2 reviews

David Kavanagh (Newcastle upon Tyne NHS hospitals trust)

Red List (low evidence)

Gene burden testing has identified an enrichment for rare genetic variants in this gene in aHUS.
No familial inheritance described.
Should be regarded as ascertainment study until replication studies validate.
Created: 6 Aug 2019, 9:12 a.m. | Last Modified: 6 Aug 2019, 9:12 a.m.
Panel Version: 1.9

Mode of inheritance
Unknown

Phenotypes
aHUS

Publications

Created: 6 Aug 2019, 9:12 a.m.
Last Modified: 6 Aug 2019, 9:12 a.m.
Panel version: 1.9

Eleanor Williams (Genomics England Curator)

I don't know

This gene was part of an initial gene list collated by Valerie Wilson, The National Renal Complement Therapeutics Centre, February 2019 on behalf of Yorkshire and North East GLH for the GMS Renal Specialist Test Group; Gene Symbol submitted: VTN; Suggested initial gene rating: none provided;
Created: 12 Feb 2019, 12:40 p.m.
Created: 12 Feb 2019, 12:40 p.m.

Panel version: 1.7

Details

Mode of Inheritance
Unknown
Sources
  • NHS GMS
Phenotypes
  • Atypical haemolytic uraemic syndrome
  • aHUS
OMIM
193190
Clinvar variants
Variants in VTN
Penetrance
None
Publications
Panels with this gene

History Filter Activity

14 Aug 2019, Gel status: 1

Set Phenotypes

Eleanor Williams (Genomics England Curator)

Phenotypes for gene: VTN were changed from to Atypical haemolytic uraemic syndrome; aHUS

14 Aug 2019, Gel status: 1

Set publications

Eleanor Williams (Genomics England Curator)

Publications for gene: VTN were set to

14 Aug 2019, Gel status: 1

Set mode of inheritance

Eleanor Williams (Genomics England Curator)

Mode of inheritance for gene: VTN was changed from to Unknown

12 Feb 2019, Gel status: 1

Created, Added New Source, Set mode of inheritance

Eleanor Williams (Genomics England Curator)

gene: VTN was added gene: VTN was added to Atypical haemolytic uraemic syndrome. Sources: NHS GMS Mode of inheritance for gene: VTN was set to