1. Panels
  2. Familial non syndromic congenital heart disease
  3. LEFTY2
STRs in panel
Prev Next

Familial non syndromic congenital heart disease

Gene: LEFTY2

Amber List (moderate evidence)
LEFTY2 (left-right determination factor 2)
EnsemblGeneIds (GRCh38): ENSG00000143768
EnsemblGeneIds (GRCh37): ENSG00000143768
OMIM: 601877, Gene2Phenotype
LEFTY2 is in 6 panels

1 review

Helen Brittain (Genomics England Curator)

I don't know

Only two cases found to date with LR-axis defects.
Created: 4 Jul 2017, 7:24 a.m.

Mode of inheritance
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown

Phenotypes
Heterotaxy syndrome

Publications

Created: 4 Jul 2017, 7:24 a.m.

Panel version: 1.8

Details

Mode of Inheritance
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
Sources
  • Expert Review Amber
  • Illumina TruGenome Clinical Sequencing Services
  • Literature
Phenotypes
  • Heterotaxy syndrome
Tags
watchlist
OMIM
601877
Clinvar variants
Variants in LEFTY2
Penetrance
Complete
Publications
Panels with this gene

History Filter Activity

4 Jul 2017, Gel status: 2

Gene classified by Genomics England curator

Helen Brittain (Genomics England Curator)

This gene has been classified as Amber List (Moderate Evidence).

4 Jul 2017, Gel status: 2

Gene classified by Genomics England curator

Helen Brittain (Genomics England Curator)

This gene has been classified as Amber List (Moderate Evidence).

4 Jul 2017, Gel status: 0

Created

Helen Brittain (Genomics England Curator)

LEFTY2 was created by helen.brittain

4 Jul 2017, Gel status: 1

Added New Source

Helen Brittain (Genomics England Curator)

LEFTY2 was added to Familial non syndromic congenital heart diseasepanel. Sources: Illumina TruGenome Clinical Sequencing Services,Literature