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  2. Complex Parkinsonism (includes pallido-pyramidal syndromes)
  3. VPS35
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Complex Parkinsonism (includes pallido-pyramidal syndromes)

Gene: VPS35

Green List (high evidence)
VPS35 (VPS35, retromer complex component)
EnsemblGeneIds (GRCh38): ENSG00000069329
EnsemblGeneIds (GRCh37): ENSG00000069329
OMIM: 601501, Gene2Phenotype
VPS35 is in 4 panels

1 review

Ellen McDonagh (Genomics England Curator)

Comment on list classification: Is on the Parkinson's Disease NGS Panel in the UCLH National Hospital for Neurology and Neurosurgery & Institute of Neurology (NHNN) Neurogenetics genetic testing manual.
Created: 10 Jun 2016, 10:32 a.m.
Created: 10 Jun 2016, 10:32 a.m.

Panel version: 0.10

Details

Mode of Inheritance
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
Sources
  • Expert Review Green
  • UKGTN
  • Illumina TruGenome Clinical Sequencing Services
  • Radboud University Medical Center, Nijmegen
  • Expert
Phenotypes
  • Parkinson disease 17, 614203
  • Parkinson Disease, Dominant
  • PARKINSON DISEASE 17
  • PARK17
OMIM
601501
Clinvar variants
Variants in VPS35
Penetrance
Complete
Panels with this gene

History Filter Activity

10 Jun 2016, Gel status: 4

Gene classified by Genomics England curator

Ellen McDonagh (Genomics England Curator)

This gene has been classified as Green List (High Evidence).

10 Jun 2016, Gel status: 4

Set Phenotypes

Ellen McDonagh (Genomics England Curator)

Phenotypes for VPS35 were set to Parkinson disease 17, 614203; Parkinson Disease, Dominant; PARKINSON DISEASE 17; PARK17

10 Jun 2016, Gel status: 4

Gene classified by Genomics England curator

Ellen McDonagh (Genomics England Curator)

This gene has been classified as Green List (High Evidence).

24 Jul 2015, Gel status: 3

Added New Source

Ellen McDonagh (Genomics England Curator)

VPS35 was added to Complex Parkinsonism (includes pallido-pyramidal syndromes)panel. Sources: UKGTN

24 Jul 2015, Gel status: 2

Set Mode of Inheritance

Ellen McDonagh (Genomics England Curator)

Model of inheritance for gene VPS35 was changed to MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown

24 Jul 2015, Gel status: 2

Added New Source

Ellen McDonagh (Genomics England Curator)

VPS35 was added to Complex Parkinsonism (includes pallido-pyramidal syndromes)panel. Sources: Illumina TruGenome Clinical Sequencing Services

24 Jul 2015, Gel status: 1

Added New Source

Ellen McDonagh (Genomics England Curator)

VPS35 was added to Complex Parkinsonism (includes pallido-pyramidal syndromes)panel. Sources: Radboud University Medical Center, Nijmegen

24 Jul 2015, Gel status: 0

Added New Source

Ellen McDonagh (Genomics England Curator)

VPS35 was added to Complex Parkinsonism (includes pallido-pyramidal syndromes)panel. Sources: Expert