Familial hidradenitis suppurativa
Gene: IL22
IL22 (interleukin 22)
EnsemblGeneIds (GRCh38): ENSG00000127318
EnsemblGeneIds (GRCh37): ENSG00000127318
OMIM: 605330, Gene2Phenotype
IL22 is in 3 panels
EnsemblGeneIds (GRCh38): ENSG00000127318
EnsemblGeneIds (GRCh37): ENSG00000127318
OMIM: 605330, Gene2Phenotype
IL22 is in 3 panels
2 reviews
John McGrath (KCL)
Rebecca Foulger (Genomics England curator)
Comment on list classification: Kept rating as red based on expert review, and insufficient evidence for disease causation.Created: 6 Jul 2017, 2:12 p.m.
Expression studies in PMID:21148041 suggest a link between IL22 deficiency and acne inversa (hidradenitis suppurativa).Created: 19 Jun 2017, 10:23 a.m.
Details
- Mode of Inheritance
- Unknown
- Sources
-
- Expert Review Red
- Other
- Phenotypes
-
- acne inversa (AI)
- OMIM
- 605330
- Clinvar variants
- Variants in IL22
- Penetrance
- Complete
- Publications
- Panels with this gene
History Filter Activity
6 Jul 2017, Gel status: 1
panel promoted to version 1
Rebecca Foulger (Genomics England curator)6th July 2017: Revised panel and promoted to Version 1.0 based on expert review. Although PSENEN, NCSTN and PSEN1 (all green genes on this panel) collectively only account for approximately 7% of all hidradenitis suppurativa (HS), there is insufficient evidence to promote any further genes to green at this time.
6 Jul 2017, Gel status: 1
Set Mode of Inheritance
Rebecca Foulger (Genomics England curator)Mode of inheritance for IL22 was changed to Unknown
6 Jul 2017, Gel status: 1
Gene classified by Genomics England curator
Rebecca Foulger (Genomics England curator)This gene has been classified as Red List (Low Evidence).
19 Jun 2017, Gel status: 0
Created
Rebecca Foulger (Genomics England curator)IL22 was created by rfoulger
19 Jun 2017, Gel status: 0
Added New Source
Rebecca Foulger (Genomics England curator)IL22 was added to Familial hidradenitis suppurativapanel. Sources: Other