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  3. FLT4
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Meiges disease

Gene: FLT4

Green List (high evidence)
FLT4 (fms related tyrosine kinase 4)
EnsemblGeneIds (GRCh38): ENSG00000037280
EnsemblGeneIds (GRCh37): ENSG00000037280
OMIM: 136352, Gene2Phenotype
FLT4 is in 10 panels

2 reviews

Pia Ostergaard (St George's)

Green List (high evidence)

Mode of inheritance
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown

Phenotypes
Primary lymphoedema; Milroy disease

Publications

Created: 5 Nov 2017, 2:40 a.m.

Panel version: 0

Sarah Leigh (Genomics England Curator)

Comment on phenotypes: Also associated with Hemangioma, capillary infantile, somatic 602089
Created: 8 Aug 2016, 8:40 a.m.
Created: 8 Aug 2016, 8:40 a.m.

Panel version: 1.5

Details

Mode of Inheritance
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Sources
  • Expert Review Green
  • UKGTN
  • Radboud University Medical Center, Nijmegen
Phenotypes
  • Lymphedema, hereditary, IA 153100
OMIM
136352
Clinvar variants
Variants in FLT4
Penetrance
Complete
Publications
Panels with this gene

History Filter Activity

8 Aug 2016, Gel status: 4

Set Phenotypes

Sarah Leigh (Genomics England Curator)

Phenotypes for FLT4 were set to Lymphedema, hereditary, IA 153100

8 Aug 2016, Gel status: 4

Set publications

Sarah Leigh (Genomics England Curator)

Publications for FLT4 were set to 23074044

8 Aug 2016, Gel status: 4

Set Mode of Inheritance

Sarah Leigh (Genomics England Curator)

Mode of inheritance for FLT4 was changed to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted

29 Jul 2016, Gel status: 4

panel promoted to version 1

Richard Scott (Genomics England Curator)

Ready for version 1

29 Jul 2016, Gel status: 4

Gene classified by Genomics England curator

Richard Scott (Genomics England Curator)

This gene has been classified as Green List (High Evidence).

29 Jul 2016, Gel status: 4

Gene classified by Genomics England curator

Richard Scott (Genomics England Curator)

This gene has been classified as Green List (High Evidence).

7 Oct 2015, Gel status: 2

Added New Source

Ellen McDonagh (Genomics England Curator)

FLT4 was added to Meiges diseasepanel. Source: UKGTN

7 Oct 2015, Gel status: 1

Added New Source

Ellen McDonagh (Genomics England Curator)

FLT4 was added to Meiges diseasepanel. Sources: Radboud University Medical Center, Nijmegen