This Panel is marked as Retired
Congenital neutropaenia
Gene: FCGR3B
FCGR3B (Fc fragment of IgG receptor IIIb)
EnsemblGeneIds (GRCh38): ENSG00000162747
EnsemblGeneIds (GRCh37): ENSG00000162747
OMIM: 610665, Gene2Phenotype
FCGR3B is in 4 panels
EnsemblGeneIds (GRCh38): ENSG00000162747
EnsemblGeneIds (GRCh37): ENSG00000162747
OMIM: 610665, Gene2Phenotype
FCGR3B is in 4 panels
3 reviews
Tracy Briggs (Manchester Genomic Medicine Centre)
Sarah Leigh (Genomics England Curator)
Comment when marking as ready: Associated with Neutropenia, alloimmune neonatal on OMIM, no disease association on G2P, two expert reviewers suggest it as red and only found in 1/4 sourcesCreated: 24 May 2016, 8:14 p.m.
Sophie Hambleton (Newcastle University)
Maternal deficiency of the encoded protein can set the stage for transient neonatal isoimmune thrombocytopeniaCreated: 19 Oct 2015, 10:41 p.m.
Publications
Details
- Mode of Inheritance
- Unknown
- Sources
-
- Expert Review Red
- Radboud University Medical Center, Nijmegen
- Phenotypes
-
- Neutropenia,alloimmuneneonatal
- OMIM
- 610665
- Clinvar variants
- Variants in FCGR3B
- Penetrance
- Complete
- Panels with this gene
History Filter Activity
25 May 2016, Gel status: 1
Set Mode of Inheritance
Sarah Leigh (Genomics England Curator)Model of inheritance for gene FCGR3B was set to Unknown
25 May 2016, Gel status: 1
Set Phenotypes
Sarah Leigh (Genomics England Curator)Phenotypes for gene FCGR3B were set to Neutropenia,alloimmuneneonatal
24 May 2016, Gel status: 1
Gene classified by Genomics England curator
Sarah Leigh (Genomics England Curator)This gene has been classified as Red List (Low Evidence).
30 Sep 2015, Gel status: 1
Added New Source
Ellen McDonagh (Genomics England Curator)FCGR3B was added to Congenital neutropaeniapanel. Source: Radboud University Medical Center, Nijmegen
28 Apr 2015, Gel status: 1
Added New Source
GEL ()FCGR3B was added to Congenital neutropaeniapanel. Sources: Radboud University Medical Center, Nijmegen