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Renal and urinary tract disorders

Region: ISCA-37432-Loss

17q12 recurrent (RCAD syndrome) region (includes HNF1B) Loss

Green List (high evidence)
Chromosome: 17
GRCh38 Position: 36458167-37854616
Haploinsufficiency Score: Sufficient evidence suggesting dosage sensitivity is associated with clinical phenotype
Triplosensitivity Score:
Required percent of overlap: 60%
Variant types: CNV Loss

1 review

Arina Puzriakova (Genomics England Curator)

The required percent of overlap for this region has been changed from 80% to 60% and the genomic location has been updated inline with ClinGen following NHS Genomic Medicine Service approval.
Created: 16 Mar 2022, 1:08 p.m. | Last Modified: 16 Mar 2022, 1:08 p.m.
Panel Version: 1.22
Created: 16 Mar 2022, 1:08 p.m.
Last Modified: 16 Mar 2022, 1:08 p.m.
Panel version: 1.22

Details

ISCA ID
ISCA-37432-Loss
ISCA Region Name
17q12 recurrent (RCAD syndrome) region (includes HNF1B) Loss
Chromosome
17
GRCh38 Coordinates
36458167-37854616
Haploinsufficiency Score
Sufficient evidence suggesting dosage sensitivity is associated with clinical phenotype
Triplosensitivity Score
Required percent of overlap
60%
Mode of Inheritance
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
Sources
  • Expert Review Green
Phenotypes
  • Autism Spectrum Disorder
  • global developmental delay
  • RCAD syndrome
  • delayed development, intellectual disability
  • Chromosome 17q12 deletion syndrome
  • utero-vaginal atresia
  • Mayer-Rokitansky-Kster-Hauser (MRKH) syndrome in females
  • Schizophrenia
  • 614527
  • Renal cysts and diabetes syndrome
Clinvar variants
Variants in
Penetrance
None
Variant types
CNV Loss

History Filter Activity

16 Mar 2022, Gel status: 3

Changed GRCh38, Changed Required Overlap Percentage

Arina Puzriakova (Genomics England Curator)

GRCh38 position for ISCA-37432-Loss was changed from 36458167-37854617 to 36458167-37854616. Required Overlap Percentage for ISCA-37432-Loss was changed from 80 to 60.

30 Jan 2019, Gel status: 4

Panel promoted to version 1.0

Eleanor Williams (Genomics England Curator)

Checked against the component panels, and ready to be promoted to version 1.

20 Dec 2018, Gel status: 4

Created, Added New Source, Set mode of inheritance, Set Phenotypes

Ellen McDonagh (Genomics England Curator)

Region: ISCA-37432-Loss was added Region: ISCA-37432-Loss was added to Renal and urinary tract disorders. Sources: Expert Review Green Mode of inheritance for Region: ISCA-37432-Loss was set to MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown Phenotypes for Region: ISCA-37432-Loss were set to Autism Spectrum Disorder; global developmental delay; RCAD syndrome; delayed development, intellectual disability; Chromosome 17q12 deletion syndrome; utero-vaginal atresia; Mayer-Rokitansky-Kster-Hauser (MRKH) syndrome in females; Schizophrenia; 614527; Renal cysts and diabetes syndrome