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  3. CDON
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Structural eye disease

Gene: CDON

Green List (high evidence)
CDON (cell adhesion associated, oncogene regulated)
EnsemblGeneIds (GRCh38): ENSG00000064309
EnsemblGeneIds (GRCh37): ENSG00000064309
OMIM: 608707, Gene2Phenotype
CDON is in 7 panels

2 reviews

Ivone Leong (Genomics England Curator)

The rating of this gene has been updated following NHS Genomic Medicine Service approval.
Created: 8 Mar 2022, 10:32 a.m. | Last Modified: 8 Mar 2022, 10:32 a.m.
Panel Version: 1.113
Comment on list classification: New gene added by Nicola Ragge (Birmingham Women's and Children's NHS Foundation Hospital Trust). This gene should be promoted from Amber to Green at the next review.
Created: 20 Jan 2021, 10:44 a.m. | Last Modified: 20 Jan 2021, 10:44 a.m.
Panel Version: 1.36
Created: 20 Jan 2021, 10:44 a.m.
Last Modified: 20 Jan 2021, 10:44 a.m.
Panel version: 1.113

Nicola Ragge (Birmingham Women's and Children's NHS Foundation Hospital Trust)

Green List (high evidence)

Reis et al. 2020: one family with compound het splice variants; Islam et al. 2020 one family with homozygous stopgain variant segregating in parents; Berkun et al. 2019 one family with homozygous stopgain. ; Zhang et al. 2009 demonstrated that Cdo -/- mice have coloboma
Created: 20 Jan 2022, 11:38 a.m. | Last Modified: 20 Jan 2022, 11:38 a.m.
Panel Version: 1.101
Reis et al. 2020: one family with compound het splice variants; Islam et al. 2020 one family with homozygous stopgain variant segregating in parents; Berkun et al. 2019 one family with homozygous stopgain. ; Zhang et al. 2009 demonstrated that Cdo -/- mice have coloboma
Created: 20 Jan 2021, 10:29 a.m. | Last Modified: 20 Jan 2021, 10:29 a.m.
Panel Version: 1.29

Mode of inheritance
BIALLELIC, autosomal or pseudoautosomal

Phenotypes
Holoprosencephaly 11, MIM:614226

Publications

Created: 20 Jan 2021, 10:29 a.m.
Last Modified: 20 Jan 2021, 10:29 a.m.
Panel version: 1.101

Details

Mode of Inheritance
BIALLELIC, autosomal or pseudoautosomal
Sources
  • Expert Review Green
  • Expert list
Phenotypes
  • Holoprosencephaly 11, OMIM:614226, MONDO:0013642
OMIM
608707
Clinvar variants
Variants in CDON
Penetrance
None
Publications
Panels with this gene

History Filter Activity

8 Mar 2022, Gel status: 3

Removed Tag, Removed Tag

Ivone Leong (Genomics England Curator)

Tag for-review was removed from gene: CDON. Tag Q1_22_NHS_review was removed from gene: CDON.

8 Mar 2022, Gel status: 3

Added New Source, Status Update

Ivone Leong (Genomics England Curator)

Source Expert Review Green was added to CDON. Rating Changed from Amber List (moderate evidence) to Green List (high evidence)

1 Mar 2022, Gel status: 2

Added Tag

Ivone Leong (Genomics England Curator)

Tag Q1_22_NHS_review tag was added to gene: CDON.

20 Jan 2021, Gel status: 2

Entity classified by Genomics England curator

Ivone Leong (Genomics England Curator)

Gene: cdon has been classified as Amber List (Moderate Evidence).

20 Jan 2021, Gel status: 1

Added Tag

Ivone Leong (Genomics England Curator)

Tag for-review tag was added to gene: CDON.

20 Jan 2021, Gel status: 1

Created, Added New Source, Set mode of inheritance, Set publications, Set Phenotypes

Ivone Leong (Genomics England Curator)

gene: CDON was added gene: CDON was added to Structural eye disease. Sources: Expert list Mode of inheritance for gene: CDON was set to BIALLELIC, autosomal or pseudoautosomal Publications for gene: CDON were set to 31502381; 19754878; 32729136 Phenotypes for gene: CDON were set to Holoprosencephaly 11, OMIM:614226, MONDO:0013642