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  2. Paroxysmal central nervous system disorders
  3. CSNK1D

Paroxysmal central nervous system disorders

Gene: CSNK1D

Amber List (moderate evidence)
CSNK1D (casein kinase 1 delta)
EnsemblGeneIds (GRCh38): ENSG00000141551
EnsemblGeneIds (GRCh37): ENSG00000141551
OMIM: 600864, Gene2Phenotype
CSNK1D is in 2 panels

5 reviews

Sarah Leigh (Genomics England Curator)

I don't know

The rating of this gene has been updated following NHS Genomic Medicine Service approval.
Created: 8 Mar 2022, 4:30 p.m. | Last Modified: 8 Mar 2022, 4:30 p.m.
Panel Version: 1.36
There is NOT enough evidence for this gene to be rated GREEN and this rating should be reviewed at the next major review.
Based on the review by Zornitza Stark, that rs11552085 mentioned in PMID 25660813 has been reported in multiple individuals in public databases and the other variants have only been reported in two families.
Created: 16 Sep 2020, 7:24 a.m. | Last Modified: 16 Sep 2020, 7:24 a.m.
Panel Version: 1.4
Created: 16 Sep 2020, 7:24 a.m.
Last Modified: 16 Sep 2020, 7:24 a.m.
Panel version: 1.36

Zornitza Stark (Australian Genomics)

I don't know

Two families reported only. The rs11552085 in PMID 25660813 appears to be present in >3,000 hets in gnomad. Gene is rated Amber on another panel.
Created: 11 Sep 2020, 7:45 a.m. | Last Modified: 11 Sep 2020, 7:45 a.m.
Panel Version: 1.4

Mode of inheritance
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted

Phenotypes
Advanced sleep-phase syndrome, familial, 2 615224

Publications

Created: 11 Sep 2020, 7:45 a.m.
Last Modified: 11 Sep 2020, 7:45 a.m.
Panel version: 1.4

James Polke (Neurogenetics Laboratory, Institute of Neurology, London)

Green List (high evidence)

Created: 2 Sep 2019, 2:37 p.m.
Last Modified: 2 Sep 2019, 2:37 p.m.
Panel version: 0.25

Rebecca Foulger (Genomics England curator)

I don't know

Comment on list classification: Promoted CSNK1D from Amber to Green based on Green reviews from both London North GLH, and West Midlands, Oxford and Wessex GLH.
Created: 9 Sep 2019, 3:36 p.m. | Last Modified: 24 Sep 2019, 11:27 a.m.
Panel Version: 0.124
Review and rating from James Polke (Neurogenetics Laboratory, Institute of Neurology, London) was collated (February 2019) on behalf of London North GLH for the GMS Neurology specialist test group.
Created: 2 Sep 2019, 2:39 p.m. | Last Modified: 2 Sep 2019, 2:39 p.m.
Panel Version: 0.26
Review and rating from Tracy Lester (Oxford Medical Genetics Laboratories, Oxford University Hospitals NHS Foundation Trust) was collated (February 2019) on behalf of West Midlands, Oxford and Wessex GLH for the GMS Neurology specialist test group.
Created: 2 Sep 2019, 1:39 p.m. | Last Modified: 2 Sep 2019, 1:39 p.m.
Panel Version: 0.23
Created: 2 Sep 2019, 1:39 p.m.
Last Modified: 24 Sep 2019, 11:27 a.m.
Panel version: 0.26

Tracy Lester (Genetics laboratory, Oxford UK)

Green List (high evidence)

Sleep disorder
Created: 2 Sep 2019, 1:30 p.m. | Last Modified: 2 Sep 2019, 1:30 p.m.
Panel Version: 0.22

Mode of inheritance
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown

Phenotypes
Advanced sleep-phase syndrome, familial, 2, 615224

Publications

Created: 2 Sep 2019, 1:30 p.m.
Last Modified: 2 Sep 2019, 1:30 p.m.
Panel version: 0.22

Details

Mode of Inheritance
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
Sources
  • Expert Review Amber
  • NHS GMS
  • London North GLH
  • Wessex and West Midlands GLH
Phenotypes
  • Advanced sleep-phase syndrome, familial, 2, OMIM:615224
OMIM
600864
Clinvar variants
Variants in CSNK1D
Penetrance
None
Publications
Panels with this gene

History Filter Activity

8 Mar 2022, Gel status: 2

Set Phenotypes

Eleanor Williams (Genomics England Curator)

Phenotypes for gene: CSNK1D were changed from Advanced sleep-phase syndrome, familial, 2, 615224 to Advanced sleep-phase syndrome, familial, 2, OMIM:615224

8 Mar 2022, Gel status: 2

Removed Tag

Eleanor Williams (Genomics England Curator)

Tag for-review was removed from gene: CSNK1D.

8 Mar 2022, Gel status: 2

Added New Source, Status Update

Eleanor Williams (Genomics England Curator)

Source Expert Review Amber was added to CSNK1D. Rating Changed from Green List (high evidence) to Amber List (moderate evidence)

16 Sep 2020, Gel status: 3

Added Tag

Sarah Leigh (Genomics England Curator)

Tag for-review tag was added to gene: CSNK1D.

24 Sep 2019, Gel status: 3

Entity classified by Genomics England curator

Rebecca Foulger (Genomics England curator)

Gene: csnk1d has been classified as Green List (High Evidence).

9 Sep 2019, Gel status: 3

Entity classified by Genomics England curator

Rebecca Foulger (Genomics England curator)

Gene: csnk1d has been classified as Green List (High Evidence).

9 Sep 2019, Gel status: 2

Set publications

Rebecca Foulger (Genomics England curator)

Publications for gene: CSNK1D were set to 25660813; 23636092

9 Sep 2019, Gel status: 2

Set mode of inheritance

Rebecca Foulger (Genomics England curator)

Mode of inheritance for gene: CSNK1D was changed from MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted to MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown

2 Sep 2019, Gel status: 2

Added New Source

Rebecca Foulger (Genomics England curator)

Source NHS GMS was added to CSNK1D.

2 Sep 2019, Gel status: 2

Added New Source

Rebecca Foulger (Genomics England curator)

Source London North GLH was added to CSNK1D.

2 Sep 2019, Gel status: 2

Added New Source

Rebecca Foulger (Genomics England curator)

Source Wessex and West Midlands GLH was added to CSNK1D.

3 Jan 2019, Gel status: 2

Set Phenotypes

Ellen McDonagh (Genomics England Curator)

Added phenotypes Advanced sleep-phase syndrome, familial, 2, 615224 for gene: CSNK1D

3 Jan 2019, Gel status: 2

Created, Added New Source, Set mode of inheritance, Set publications, Set Phenotypes

Ellen McDonagh (Genomics England Curator)

gene: CSNK1D was added gene: CSNK1D was added to Paroxysmal neurological disorders, pain disorders and sleep disorders. Sources: Expert Review Amber Mode of inheritance for gene: CSNK1D was set to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted Publications for gene: CSNK1D were set to 25660813; 23636092 Phenotypes for gene: CSNK1D were set to Advanced sleep-phase syndrome, familial, 2, 615224