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  3. DNAH10
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Respiratory ciliopathies including non-CF bronchiectasis

Gene: DNAH10

Red List (low evidence)
DNAH10 (dynein axonemal heavy chain 10)
EnsemblGeneIds (GRCh38): ENSG00000197653
EnsemblGeneIds (GRCh37): ENSG00000197653
OMIM: 605884, Gene2Phenotype
DNAH10 is in 1 panel

1 review

Achchuthan Shanmugasundram (Genomics England Curator)

Red List (low evidence)

The ClinGen Motile Ciliopathy expert panel has classified the association of autosomal recessive DNAH10 variants to primary ciliary dyskinesia (MONDO:0016575) as 'Limited'. More information can be found in https://search.clinicalgenome.org/CCID:008793.
Sources: ClinGen
Created: 14 Jul 2025, 2:54 p.m. | Last Modified: 14 Jul 2025, 3:07 p.m.
Panel Version: 4.28

Mode of inheritance
BIALLELIC, autosomal or pseudoautosomal

Phenotypes
Spermatogenic failure 56, OMIM:619515; primary ciliary dyskinesia, MONDO:0016575

Created: 14 Jul 2025, 2:54 p.m.
Last Modified: 14 Jul 2025, 3:07 p.m.
Panel version: 4.26

Details

Mode of Inheritance
BIALLELIC, autosomal or pseudoautosomal
Sources
  • ClinGen
Phenotypes
  • Spermatogenic failure 56, OMIM:619515
  • primary ciliary dyskinesia, MONDO:0016575
OMIM
605884
Clinvar variants
Variants in DNAH10
Penetrance
None
Panels with this gene

History Filter Activity

14 Jul 2025, Gel status: 1

Created, Added New Source, Set mode of inheritance, Set Phenotypes

Achchuthan Shanmugasundram (Genomics England Curator)

gene: DNAH10 was added gene: DNAH10 was added to Respiratory ciliopathies including non-CF bronchiectasis. Sources: ClinGen Mode of inheritance for gene: DNAH10 was set to BIALLELIC, autosomal or pseudoautosomal Phenotypes for gene: DNAH10 were set to Spermatogenic failure 56, OMIM:619515; primary ciliary dyskinesia, MONDO:0016575 Review for gene: DNAH10 was set to RED